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LMU 98 – Unveiling the Shield: A French Study Redefines Cancer Prevention through Nutrition and Lifestyle

LMU-98

LMU 98 – Unveiling the Shield: A French Study Redefines Cancer Prevention through Nutrition and Lifestyle

Source: American Association for Cancer Research journal (July 2018)

Lifestyle Medicine Update (August 3, 2018)

Introduction

In the ever-evolving landscape of cancer prevention, a pivotal French study surfaced in July 2018, capturing attention with its revelations. Published in the prestigious American Association for Cancer Research journal, this research probed the intricate interplay between nutrition, lifestyle, and cancer risk. Against the backdrop of rising cancer incidences, this study embarked on a journey to decipher the impact of adhering to dietary recommendations on cancer prevention.

A Panoramic Gaze: The Scope of the Study

With a canvas spanning 41,543 participants aged 40 and above, residing in France, this study weaved a narrative of cancer prevention. Their collective tapestry held a common thread—they had not encountered the spectre of cancer before the study’s initiation. As these individuals journeyed through almost eight years, from May 2009 to January 2017, their dietary choices and lifestyles underwent scrutiny. In this span, 488 breast cancers, 222 prostate cancers, and 118 colorectal cancer cases emerged—a backdrop against which the story of cancer prevention would be painted.

A Beacon of Health: Guided by the American Institute for Cancer Research

The heart of this study lay in contrasting the outcomes of diverse dietary programs with the recommendations championed by the American Institute for Cancer Research. Amid the contenders were renowned regimes—the Mediterranean Diet, the Alternate Healthy Eating Index, and the French Nutrition and Health Program. As the findings unfurled, a beacon of insight emerged—those who embraced the American Institute for Cancer Research’s guidelines reaped the most promising cancer prevention outcomes. This revelation illuminated the path to shielding against the incursions of cancer.

Statistics Unveiled: The Power of a Point

Quantifying the impact, the study’s architects uncovered a staggering correlation. For each incremental rise of one point in the American Institute for Cancer Research score, an astonishing 12% decrease in overall cancer risk danced to the fore. Delving deeper, the intricate dance of statistics heralded a 14% drop in breast cancer risk and a parallel 12% dip in prostate cancer risk. The thread of prevention intertwined with every digit, weaving a mosaic of hope.

A Symphony of Seven: The Nutritional Commandments

Within the study’s embrace lay the American Institute for Cancer Research’s seven nutritional and lifestyle commandments, echoing with resonance. These directives sculpted the roadmap to cancer resilience, entwining health and prevention:

  1. Remain at a healthy weight
  2. Be physically active
  3. Eat a diet rich in whole grains, vegetables, fruits, and beans
  4. Limit consumption of fast foods and other processed foods high in fat, starches, or sugars
  5. Limit consumption of red meat and processed meat
  6. Limit consumption of sugar-sweetened drinks
  7. Limit alcohol consumption

Dismantling a Common Elixir: Alcohol and Cancer

A spotlight shone on the role of alcohol—a common elixir embraced under the aegis of health. However, as researchers unravelled the tapestry of risk, a startling truth emerged. The reduction of cancer risk among adherents of the American Institute for Cancer Research’s guidelines stemmed, in part, from avoiding alcohol. Recent research cascaded with harmony—alcohol stood implicated in various cancers, shattering the illusion of a benign elixir. With the echoes of World Cancer Research Fund (WCRF) resonating, the symphony bore witness to the link between alcohol and cancers of the oropharynx, esophagus, liver, colorectal, post-menopausal breast, stomach, premenopausal breast, and prostate.

A Mosaic of Protection: The Study’s Conclusion

From the depths of data emerged a mosaic of protection. The findings etched a narrative that transcended dietary regimes and embraced holistic health. A diet weaved with healthy eating, physical activity, and the avoidance of alcohol emerged as a formidable arsenal against cancer risk. The symphony of resilience resonated—breast, prostate, and colorectal cancers confronted a tapestry of prevention woven from nutritional threads.

A Vision for the Future: The Power of Adherence

In the broader canvas of developed nations, the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) crafted an estimate—a future where 35% of breast cancers and 45% of colorectal cancers could be thwarted through unwavering adherence to prudent nutritional recommendations. Amid these numerical marvels, the beacon of the seven recommendations illuminated the path to a future marred by fewer cancer diagnoses.

Conclusion: An Overture of Hope

As the pages of the study beckon us to delve into its revelations, a symphony of hope unfurls. The French study’s journey through nutrition, lifestyle, and cancer prevention reaffirms the power we hold within our choices. Each morsel of nutrition, each step of exercise, each decision to abstain—all coalesce into an overture of hope against cancer’s pervasive shadow.

References

  1. Céline Lavalette et al. (2018). Cancer-Specific and General Nutritional Scores and Cancer Risk: Results from the Prospective NutriNet-Santé Cohort. Cancer Research. [Link] (http://cancerres.aacrjournals.org/content/78/15/4427)
  2. American Institute for Cancer Research. Recommendations to Prevent Cancer. [Link] (http://www.aicr.org/reduce-your-cancer-risk/recommendations-for-cancer-prevention/)

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 97 – Nature’s Armor: A Bounty of Fruits and Vegetables in the Fight Against Breast Cancer

LMU-97

LMU 97 – Nature's Armor: A Bounty of Fruits and Vegetables in the Fight Against Breast Cancer

Source: International Journal of Cancer (July 2018)

Lifestyle Medicine Update (July 27, 2018)

Introduction

In the relentless quest to combat breast cancer, a landmark study emerged in July 2018, illuminating the remarkable armor that nature’s offerings provide. While previous investigations hinted at the link between fruit and vegetable consumption and reduced breast cancer risk, limitations loomed over their conclusions. Enter the pivotal study led by Maryam Farvid, et al., gracing the pages of the International Journal of Cancer. This groundbreaking research offers an unparalleled panorama of the pivotal role that a diet rich in fruits and vegetables plays in the arena of breast cancer prevention.

A Culmination of Insights: The Power of Abundant Produce

As the pages of the International Journal of Cancer unfurled, the contours of a comprehensive study came into view. Driven by a thirst for knowledge, the researchers delved into data culled from the Nurses’ Health Study (NHS, 1980-2012) and NHSII (1991-2013). Over 182,000 women, aged 27-59 at the study’s inception, embarked on a journey of dietary disclosure every four years, weaving a tapestry of nutritional insights. Yet, this journey ventured beyond diet, encompassing the labyrinth of breast cancer risk factors—from age and weight to smoking status and familial cancer history. A symphony of variables converged to unravel a profound truth—one that would redefine the canvas of breast cancer prevention.

The Nourishing Shield: Fruits and Vegetables Unveiled

As the data danced in the hands of researchers, the symphony of fruits and vegetables assumed center stage. The findings transcended mere consumption, revealing a staggering reality. Women who embraced a diet crowned by more than 5.5 servings of these nutritional gems daily wielded an 11% lower risk of breast cancer compared to their counterparts who embraced 2.5 or fewer servings. Each serving, whether a cup of raw leafy vegetables or half a cup of succulent fruits, wove a thread of protection against the ominous spectre of breast cancer. Yet, certain protagonists emerged from this nutritional ensemble—cruciferous vegetables, radiant in their green glory, and the sun-kissed brilliance of yellow and orange vegetables. Their embrace showcased a formidable association with reduced breast cancer risk, charting a path toward wellness.

A Multifaceted Arsenal: Fruits, Vegetables, and Aggressive Tumors

Unravelling the secrets within fruits and vegetables, the study ventured into the realm of tumor aggression. Here, the narrative took an unexpected turn. The warriors of health not only lowered breast cancer risk but also thwarted the ascent of more aggressive adversaries—ER-negative, HER2-positive, and basal-like tumors. This revelation etched the narrative of fruits and vegetables as custodians of health, fending off not only the conventional foe but also its fiercer incarnations.

Beyond Fiber: Unveiling the Nutrient Ensemble

In the theater of health, the spotlight often fixated on fiber as a guardian against breast cancer risk. However, this journey yielded a surprising twist—fruits and vegetables wielded their magic independently of their fiber content. Within their vibrant embrace, antioxidants, phytonutrients, and micronutrients wove an intricate tapestry of protection. This symphony of constituents stood as potent agents in the battle against breast cancer, casting light upon the path of prevention.

Guiding Lights: Lifestyle Factors and Beyond

As the study’s revelations echoed, they harmonized with other voices advocating for wellness. Beyond the world of fruits and vegetables, a chorus of lifestyle factors emerged as guiding lights in the symphony of prevention. An ideal weight, an alliance with regular exercise, a diet forsaking saturated fats, trans-fats, deep-fried fare, and alcohol, along with the maintenance of optimal vitamin D levels, painted a roadmap toward breast cancer resilience. The canvas of health embraced myriad hues, with each brushstroke imbued with the power to rewrite destinies.

A Call to Nourishment: A Tale of Transformation

The study’s narrative serves as a clarion call—a plea for transformation through nourishment. As individuals, we hold the palette of our health, capable of painting resilience against the canvas of life’s challenges. The fruits and vegetables that grace our tables extend an invitation—a dance of flavors that holds the promise of shielding against breast cancer’s incursions.

Conclusion: The Symphony of Wellness

In the grand symphony of health, the harmonious melodies of fruits and vegetables resound with remarkable potency. The research of Maryam Farvid and her team has cast a spotlight on a nutritional duo that transcends taste, serving as sentinels against breast cancer’s shadows. As we journey through life’s landscapes, the fruits and vegetables we embrace bear the promise of guarding our well-being—a testament to the power of nature’s offerings.

References

  1. Maryam S. Farvid et al. (2018). Fruit and vegetable consumption and breast cancer incidence: Repeated measures over 30 years of follow-up. International Journal of Cancer. [Link] (https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31653)

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 96 – Oranges: The Unexpected Guardians Against Macular Degeneration

LMU-96

LMU 96 – Oranges: The Unexpected Guardians Against Macular Degeneration

Source: American Journal of Clinical Nutrition (July 2018)

Lifestyle Medicine Update (July 20, 2018)

Introduction

In the vast tapestry of health, certain revelations shine like beacons, illuminating pathways towards better lives. A groundbreaking study emerged in 2018, etching a remarkable connection between oranges and the prevention of macular degeneration. Macular degeneration, a relentless adversary stealing sight from those over 55, finds no cure. Yet, within the vibrant hues of oranges, a potential shield against this threat emerges, capturing the attention of the eye disease research community.

Oranges’ Power Against Macular Degeneration

Within the annals of scientific literature, the American Journal of Clinical Nutrition heralded a game-changing study in 2018. Its focus? The transformative power of oranges in the realm of macular degeneration prevention. This ailment, a silent thief of sight, occupies the forefront as a leading cause of blindness among those in their golden years. Armed with a 15-year journey of exploration, the researchers navigated the intriguing landscape where oranges and macular degeneration intersect.

A Journey Through Research: Oranges and Macular Degeneration

Embarking on a journey to unearth the secrets held within oranges, the researchers engaged over 2,000 Australian adults aged over 50. These individuals became participants in a 15-year odyssey, a testament to science’s unwavering dedication to unravelling mysteries. The findings, unveiled with precision, showcased a remarkable statistic—a more than 60% reduced risk of developing advanced macular degeneration over 15 years for those who savored at least one serving of oranges daily. Even a weekly rendezvous with an orange bore significant benefits, echoing a simple yet powerful truth.

Nutrition and Lifestyle: Building Blocks of Protection

Amid the cacophony of health’s myriad factors, diet and lifestyle emerge as architects of protection. The footprint of macular degeneration bears testament to this truth. Diabetes, obesity, high blood pressure, high cholesterol, and smoking stand as looming shadows, casting risks upon the canvas of our lives. Counteracting these threats involves maintaining a lean physique, embracing exercise, nurturing a cholesterol-friendly diet, and eschewing the vice of smoking. Through these pillars, the risk of this formidable eye ailment retreats.

The Role of Free Radicals and Antioxidants

The narrative of macular degeneration is not solely penned by the hands of genetics and lifestyle. Free radicals, spawned by the sun’s ultraviolet embrace, wreak havoc upon the eyes. It is within this realm that antioxidants arise as steadfast allies, waging a battle against free radical incursions. A chorus of nutrients—vitamin C, vitamin E, beta-carotene, zinc, lutein, and zeaxanthin—forms the vanguard of this defence. United, they halt or slow the inexorable march of macular degeneration, while also safeguarding against cataract development.

Flavonoids: Nature’s Canvas of Protection

Within the canvas of nutrition, the 2018 study painted a portrait of flavonoids, vibrant compounds manifesting in various foods. Tea, apples, red wine, and oranges all contributed to this symphony of nutrients. Yet, in this chorus, only one voice soared—the orange. Its presence proved significant, with consumption emerging as a protective force against macular degeneration. The singular act of enjoying an orange daily or more offered a 60% lower risk of encountering this affliction over the 15-year span.

A Taste of Wisdom: One Orange a Day

The profound lesson embedded within the 2018 study is as simple as it is transformative. The consumption of a single orange daily may well serve as a cornerstone of ocular health. As the curtains rise on life’s stages, the role of oranges transcends taste, becoming guardians against the spectre of macular degeneration—a relentless foe lurking as we age.

Conclusion: Savoring Health Through Oranges

In the grand tapestry of health and wellness, oranges emerge as unsung heroes, bearing the gift of sight preservation. The symphony of research, painted across years of exploration, underscores the potent connection between oranges and macular degeneration’s deterrence. As the scientific and medical communities unravel these revelations, one truth remains—an orange a day may offer a vibrant shield, fending off the dark shroud of blindness.

References

  1. Bamini Gopinath et al. (2018). Dietary flavonoids and the prevalence and 15-y incidence of age-related macular degeneration. American Journal of Clinical Nutrition. [Link] (https://academic.oup.com/ajcn/advance-article-abstract/doi/10.1093/ajcn/nqy114/5049680)
  2. 2018 Study Summary: [Link] (https://www.sciencedaily.com/releases/2018/07/180712100504.htm)
  3. AREDS Study – National Eye Institute: [Link] (https://academic.oup.com/ajcn/article-abstract/108/2/381/5049680)
  4. Macular Degeneration Risk Factors: [Link] (https://www.medicinenet.com/macular_degeneration/article.htm)
  5. UV-light and Macular Degeneration Risk from Free Radicals: [Link] (https://www.ncbi.nlm.nih.gov/pubmed/21646979)

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 95 – The Omega-3 Secret: A Youthful Shield Against High Blood Pressure

LMU-95

LMU 95 – The Omega-3 Secret: A Youthful Shield Against High Blood Pressure

Source: Journal of Hypertension (July 2018)

Lifestyle Medicine Update (July 13, 2018)

Introduction

In the realm of health and wellness, discoveries often serve as guideposts towards brighter futures. The year 2018 marked a pivotal moment when the Journal of Hypertension unveiled a revelation with far-reaching implications. The study, nestled in its pages, illuminated the remarkable power of omega-3 fats in the prevention of early-onset high blood pressure. Embarking on a journey through this research, we navigate the corridors of cardiovascular health, where omega-3 fats emerge as youthful guardians against the surge of hypertension.

Omega-3 and Early-Onset Hypertension: A Connection Unveiled

Among the myriad of studies that grace the scientific landscape, one stood out—a beacon of insight into early-onset high blood pressure prevention. This study, published in the Journal of Hypertension in July 2018, beckoned researchers to examine the link between omega-3 fat consumption in youth and the prevention of hypertension. Armed with a cohort of over 2,000 young individuals aged 21 to 40 years, the researchers embarked on a quest to unearth the secrets of omega-3 fats and their impact on blood pressure.

The Study’s Unveiling: Tracking Blood Pressure and Omega-3 Index

A multi-pronged approach was employed, where blood pressure monitoring played a central role. These young participants underwent office visits and were adorned with a 24-hour blood pressure monitoring device, capturing the ebb and flow of their blood pressure throughout the day. Additionally, blood samples were drawn to assess the omega-3 fat content in their red blood cells—a parameter known as the omega-3 index.

Decoding the Omega-3 Index: A Simple Metric

The omega-3 index unravels a profound metric within the realm of cardiovascular health. Comprising a fundamental aspect of red blood cell membranes, the omega-3 fats are evaluated as a percentage of all fats present. If the omega-3 fats constitute 8% of the total, the individual bears an omega-3 index of 8%, a measure that unveils the cardiovascular tapestry. The index’s simplicity mirrors its significance, serving as a pivotal indicator of health.

Omega-3 Index: A Shield Against Hypertension

The study’s findings converged with those of prior research, where an omega-3 index of 8% or higher stood as a sentinel against hypertension in older individuals. However, the 2018 study ventured beyond the threshold of age, encapsulating the transformative potential of omega-3 fats in youthful lives. Even in the bloom of youth, ages 21 to 40, a higher omega-3 index emerged as a shield, warding off the onset of borderline high blood pressure (pre-hypertension) or high blood pressure (hypertension). Amidst the inevitable march of aging, vessels often succumb to stiffening, heightening the risk of hypertension. Yet, those with an omega-3 index of 8% or more appeared to stand resilient against age’s pressure.

Omega-3’s Symphony for Blood Pressure Harmony

As the symphony of health unfolds, omega-3 fats emerge as a key orchestrator in maintaining blood pressure within the safe confines. In the body’s intricate tapestry, omega-3 fats metamorphose into miniature hormones known as prostaglandin series-3. This transformation ushers in a cascade of relaxation and expansion within blood vessels—a phenomenon known as dilation. Reduced resistance to blood flow ensues, and blood pressure finds equilibrium. Yet, omega-3’s role transcends mere relaxation, extending to a reduction in inflammation, inhibition of platelet aggregation, and prevention of excessive blood stickiness. With inflammation and sticky blood as potential culprits in cardiovascular diseases, omega-3 fats stand as formidable allies in the fight against heart ailments.

Pursuing the Optimal Omega-3 Index

Guiding individuals towards the optimal omega-3 index requires a multifaceted approach. A daily intake of 2,000 mg of omega-3 fats from fish and supplements surfaces as a pragmatic strategy. Fish with rich omega-3 content, such as salmon, mackerel, and sardines, seize the limelight. For those seeking the convenience of supplements, a blend comprising fish oil, flaxseed oil, and borage seed oil emerges as a potent ally. Regular intake elevates the omega-3 index, a metric fraught with significance.

A Battle Against Escalating Trends

Amidst the nuances of cardiovascular health, a disconcerting trend emerges—high blood pressure’s ascent among the young, ages 20-39 years. From 4% to a staggering 19%, the incidence of hypertension paints a stark picture. Here, the omega-3 index stands as a beacon of hope, offering a pathway to reverse this disquieting trajectory. Alongside exercise, weight maintenance, refraining from smoking, moderate alcohol consumption, and mindful sodium intake, the omega-3 index emerges as a potent tool in averting the menace of early-onset hypertension.

Conclusion: A Lifelong Symphony of Health

The echoes of the 2018 study resonate across generations, unveiling the potential of omega-3 fats in preserving youthful cardiovascular vitality. As we traverse the contours of life, omega-3 fats accompany us, orchestrating a symphony of health. A higher omega-3 index emerges as a shield, fending off hypertension’s advances and paving the way for vibrant living. In the quest for wellness, omega-3 fats extend an invitation—to weave them into the fabric of life, nurturing resilience against the tide of high blood pressure.

References

  1. Journal of Hypertension: [Link] (https://www.ncbi.nlm.nih.gov/pubmed/?term=Whole+blood+omega-3+fatty+acid+concentrations+are+inversely+associated+with+blood+pressure+in+young%2C+healthy+adults)
  2. Omega-3 Index Research Review: [Link] (https://www.docsopinion.com/2015/10/05/the-omega-3-index/)
  3. Higher Blood Pressure In Young Adults 20-39: [Link] (https://medlineplus.gov/magazine/issues/fall11/articles/fall11pg10-11.html)

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 94 – Sunshine Vitamin Shields Against Colorectal Cancer: The Vitamin D Revelation

LMU-94

LMU 94 – Sunshine Vitamin Shields Against Colorectal Cancer: The Vitamin D Revelation

Source: Journal of the National Cancer Institute (2018)

Lifestyle Medicine Update (July 7, 2018)

Introduction

Colorectal cancer, the third leading cause of cancer-related deaths in North America and many developed nations, casts a shadow over countless lives. However, the tides are turning as groundbreaking research delves into the protective potential of a humble nutrient: vitamin D. A 2018 study published in the Journal of the National Cancer Institute has unveiled compelling evidence, propelling vitamin D into the spotlight as a formidable guardian against colorectal cancer. In this exploration, we journey through the study’s revelations, spotlighting the profound impact of optimal vitamin D levels on cancer prevention.

A Link Between Lifestyle and Colorectal Cancer

Colorectal cancer’s intricate dance with nutrition and lifestyle comes to the forefront. Beyond genetics, faulty nutrition and lifestyle factors weave the tapestry of this ailment. Inadequate physical activity, excess weight, smoking, and heavy alcohol consumption emerge as key players. A staggering 70-90% of cases could potentially be thwarted through prudent dietary and lifestyle choices.

The Vitamin D Vanguard: Illuminating the Role

Among various nutritional factors, the spotlight has long shone on vitamin D’s potential in preventing colorectal cancer. While preliminary studies hinted at the link, the quest for definitive data persisted. Enter a comprehensive 2018 study that amalgamated insights from 17 cohort studies, enrolling over 5,000 colorectal cancer cases and 7,000 controls. The amalgamation of these studies, tracking 12,000 individuals over an average follow-up of 5.5 years, unfurled a revelation. Individuals commencing with a blood vitamin D level exceeding 50-63 nmol/L (20 – 25 ng/mL) enjoyed a striking 22% reduction in colorectal cancer risk, in comparison to those falling within the same range.

Vitamin D Beyond Osteoporosis: A Colorectal Ally

Vitamin D’s reputation as an osteoporosis defender is well-known, advocating for blood levels between 50-63 nmol/L (20-25 ng/mL). However, the quest for colorectal cancer prevention demands a higher threshold. Achieving an additional 22% reduction in colorectal cancer risk calls for maintaining a year-round vitamin D level beyond this range. To this end, experts advise aiming for a blood vitamin D level of at least 85 nmol/L (34 ng/mL), with higher levels potentially beneficial for high-risk individuals.

Unveiling Vitamin D’s Anti-Cancer Arsenal

Venturing into the realm of scientific intricacies, vitamin D’s multi-faceted role in combating colorectal cancer emerges. Evident through human and experimental studies, its anti-cancer prowess encompasses various dimensions:

  1. Slowing Cell Division: Vitamin D’s hand slows the frantic pace of colon cell division, reducing genetic errors and the risk of cancerous transformation.
  2. Encouraging Cellular Death: Emerging cancer cells face an adversary in vitamin D, prompting programmed cell death or apoptosis.
  3. Nurturing Maturity: Vitamin D’s touch guides emerging cells towards full maturity, a process known as cellular differentiation, which curbs cancer susceptibility.
  4. Blocking Cancer Pathways: Vitamin D erects barriers against the Wnt pathway, a crucial player in colon cancer development.
  5. Taming Inflammation: Vitamin D’s anti-inflammatory prowess stands as a sentinel against inflammation-associated cancer risks.
  6. Strengthening Immunity: The vitamin’s supportive hand uplifts immune function, a pivotal aspect of cancer prevention.
  7. Countering Metastasis: Vitamin D reins in the synthesis of factors driving colon cancer metastasis, such as VEGF, curbing new blood vessel formation to sustain tumors.

A Clarion Call for Public Health Guidelines

The implications of the 2018 study resonate deeply, urging individuals and health agencies to reevaluate guidelines. With colorectal cancer’s menacing shadow, optimizing vitamin D levels emerges as a formidable strategy. Experts echo the call to maintain a blood vitamin D level above 63 nmol/L (25 ng/mL). Achieving this feat involves embracing nourishing practices, including consuming fish regularly, integrating vitamin D-fortified low-fat dairy products, and supplementing vitamin D. While sunlight exposure contributes, concerns about skin cancer risk make dietary and supplemental sources the preferred routes.

Conclusion

As science unravels the mysteries of cancer prevention, vitamin D emerges as a beacon of hope in the fight against colorectal cancer. The 2018 study’s findings pierce through the haze, revealing a tangible path towards safeguarding health. With an enhanced understanding of vitamin D’s profound anti-cancer effects, individuals are empowered to chart a course towards a brighter, healthier future. As public health guidelines undergo transformation, the chapter of colorectal cancer takes a turn towards hope and resilience, with vitamin D as its steadfast ally.

References

McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M et al. Circulating vitamin D and colorectal cancer risk: An international pooling project of 17 cohorts. JNCI. June 2018

[Link] (https://academic.oup.com/jnci/advance-article-abstract/doi/10.1093/jnci/djy087/5035027?redirectedFrom=fulltext)

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 93 – Unlocking Mental Wellness: The Omega-3 Connection to Depression and PTSD

LMU-93

LMU 93 – Unlocking Mental Wellness: The Omega-3 Connection to Depression and PTSD

Source: American Journal of Clinical Nutrition (2008); Australian and New Zealand Journal of Psychiatry (2008); Journal of Affective Disorder (2016 and 2017)

Lifestyle Medicine Update (June 29, 2018)

Introduction

In the realm of mental health, a remarkable revelation has emerged over the past few years – the potent influence of omega-3 fatty acids on conditions like depression, post-traumatic stress disorder (PTSD), anxiety, and psychosis. As we delve into this update, a panorama of enlightening studies awaits, shedding light on the profound impact of omega-3 fats on depression and PTSD.

EPA: A Key Player in Mental Wellbeing

Our journey begins with a seminal study published in 2008 in the American Journal of Clinical Nutrition, which thrust the spotlight on a specific omega-3 fatty acid: eicosapentaenoic acid (EPA). The study, encompassing nearly 1400 older participants with a mean age of 74.6 years, utilized a standard depression index scale. With depression affecting 8-16% of older adults, often underdiagnosed and undertreated, the findings were eye-opening. Lower blood levels of EPA were associated with higher depression rates, underscoring the potential role of EPA in mental wellness. EPA, renowned for its anti-inflammatory properties and enhancement of brain cell function, holds promise as a shield against the grip of depression, especially in aging brains. (1)

Omega-3s vs. Depression: A Powerful Partnership

A subsequent pivotal study, featured in the Australian and New Zealand Journal of Psychiatry in 2007, presented a head-to-head comparison between EPA and a widely known antidepressant, Fluoxetine (Prozac). In a cohort of 60 patients with major depression, those treated with EPA (1000 mg/d), Fluoxetine (20 mg/d), or a combination of both over 8 weeks, yielded intriguing results. Notably, the EPA group exhibited equivalent treatment benefits to the Fluoxetine group. However, the most promising outcomes were observed in the combination therapy group, boasting an impressive 81% response rate – a significant enhancement over the individual therapy groups’ 50% response rate. (2)

Unveiling Hope for PTSD

The omega-3 narrative extends to the realm of post-traumatic stress disorder (PTSD), with a breakthrough study in 2016 highlighting the significance of EPA and DHA (docosahexaenoic acid). Involving 110 PTSD patients grappling with persistent symptoms following conventional treatment, this study illuminated a path to relief. The provision of an omega-3 fat supplement enriched with EPA and DHA was associated with a reduction in PTSD symptom severity, offering renewed hope for those affected. (3)

Taming the Heart and Mind: A Dual Approach to PTSD

A year later, in 2017, yet another exploration into the realm of PTSD revealed a fascinating interplay between omega-3 fats and physiological symptoms. Involving 83 PTSD patients, this study centered on the administration of EPA (147 mg) and DHA (1470 mg) per day for 12 weeks. The results were astonishing – a key physiological PTSD symptom, elevated heart rate, experienced relief. Patients with elevated red blood cell EPA levels witnessed a significant reduction in their pounding heart rates, potentially paving the way for a holistic approach to PTSD management. (4)

A Transformative Path Forward

In the pursuit of mental wellness, the evidence resoundingly underscores the pivotal role of omega-3 fatty acids, particularly EPA. Integrating omega-3 supplementation into the complementary management of depression and PTSD offers a pathway to improved outcomes. As we age, fortifying brain levels of omega-3s through supplementation could potentially stave off depression, a prevalent concern among older individuals. The risks associated with omega-3 supplementation are minimal, barring potential interactions with anticoagulant medications, which should be addressed under medical guidance.

Conclusion

The narrative of mental health takes an exciting turn with the unveiling of omega-3 fatty acids as protagonists in the battle against depression and PTSD. Through studies that highlight the impact of EPA, both singularly and in combination with conventional treatments, a realm of possibilities emerges. Omega-3 supplementation stands as a beacon of hope, promising to enhance mental wellness, ease symptoms, and potentially prevent the onset of debilitating conditions. As science continues to illuminate the omega-3 saga, individuals are empowered to embark on a journey towards mental resilience and a brighter tomorrow.

References

  1. 2008 Study: American Journal of Clinical Nutrition (Depression)
    [Link] (https://academic.oup.com/ajcn/article/87/5/1156/4650735)
  2. 2008 Study: Australian and New Zealand Journal of Psychiatry (Depression)
    [Link] (https://www.tandfonline.com/doi/full/10.1080/00048670701827275)
  3. 2016 Study: Journal of Affective Disorders (PTSD)
    [Link] (https://www.jad-journal.com/article/S0165-0327(16)30995-8/fulltext)
  4. 2017 Study: Journal of Affective Disorders (PTSD)
    [Link] (https://www.jad-journal.com/article/S0165-0327(16)30239-7/fulltext)

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 92 – Beyond the Restless Legs: Unveiling New Insights and Natural Solutions

LMU-92

LMU 92 – Beyond the Restless Legs: Unveiling New Insights and Natural Solutions

Source: Journal Sleep and Breathing (2015)

Lifestyle Medicine Update (June 20, 2018)

Introduction

Restless Legs Syndrome (RLS), also known as Willis-Ekbom Disease, is a condition that casts a shadow over the lives of millions, causing discomfort and impairing quality of life. Its prevalence in the United States is estimated at 7-10%, possibly even reaching 15%, with a slightly higher occurrence among women. This condition presents itself through distressing sensations in the legs and an uncontrollable urge to move them. Often exacerbated during the evening and night hours, RLS disrupts sleep, leading to daytime fatigue, reduced productivity, and a host of challenges that can culminate in depression and anxiety.

Beneath the Surface: The Role of Nutrient Imbalances

While the link between low iron levels and RLS has been well-established, not all cases can be attributed to iron deficiency alone. A pivotal study published in 2015 in the journal Sleep and Breathing uncovered a less explored factor – vitamin D deficiency. This discovery opened a new avenue for understanding and managing RLS. The study demonstrated that raising blood vitamin D levels above 50nmol/L significantly alleviated RLS symptoms in individuals whose levels had been below this threshold. Such findings bear significant weight considering the potential addiction and withdrawal risks associated with commonly prescribed RLS drugs.

A Safer Alternative: Corrective Supplementation

The standard pharmaceutical treatments for RLS involve medications like Gabapentin, Benzodiazepines (e.g. Valium), and Opioids (e.g. Oxycodone). However, a more natural approach might lie in addressing the nutrient imbalances at the core of RLS. The key is accurate diagnosis – individuals with RLS should undergo assessments of both iron and vitamin D levels. If serum ferritin registers below 20ng/ml and/or vitamin D blood levels fall under 50nmol/L, targeted supplementation could be the solution. Studies suggest that this strategy holds the potential to resolve a substantial portion of RLS cases without resorting to medications with potential adverse effects.

Gut Health: A New Frontier for RLS Management

Beyond vitamin D and iron, an intriguing connection emerges between gut health and RLS. Emerging research indicates that probiotic and prebiotic supplements might hold promise for alleviating RLS symptoms. A significant proportion of RLS cases (possibly 69%) are accompanied by bacterial overgrowth, a phenomenon often observed in conditions like irritable bowel syndrome (IBS). As the gut-brain axis gains prominence in medical research, exploring the link between gut health and RLS offers a new angle for holistic intervention.

Lifestyle Choices: Navigating Triggers and Aggravators

While nutrient imbalances play a crucial role in RLS, lifestyle choices also play a part. Consuming alcohol, nicotine, and caffeine are known to exacerbate RLS symptoms and should be minimized or avoided by those affected. Moreover, RLS can be connected to other health conditions, including end-stage renal disease, neuropathy, and the use of specific medications. Pregnancy, particularly in the last trimester, can also trigger RLS symptoms, though they usually abate within four weeks after delivery.

Taking Control of RLS

For those grappling with RLS, a multi-faceted approach to management is crucial. Beyond the conventional treatment avenues, the following steps can pave the way to relief:

  1. Assess Nutrient Levels: If you are experiencing RLS, it’s imperative to consult your healthcare provider for thorough iron and vitamin D assessments. Correcting deficiencies through supplementation, under medical guidance, can be transformative.
  2. Mind Gut Health: Recognize the potential link between gut health and RLS. Considering probiotic and prebiotic supplements may be a wise step, especially if bacterial overgrowth is suspected.
  3. Lifestyle Choices: Limit alcohol, nicotine, and caffeine intake to minimize the impact of triggers. These substances can exacerbate RLS symptoms and hinder your journey toward relief.

Conclusion

Restless Legs Syndrome is an enigmatic condition that can cast a dark cloud over an individual’s life. However, as science unveils new insights into its causes and potential solutions, a sense of hope emerges. With the discovery of the impact of vitamin D deficiency and the role of gut health in RLS, individuals now have alternative avenues for management. By addressing nutrient imbalances, making informed lifestyle choices, and exploring the gut-brain connection, RLS sufferers can reclaim their quality of life and find relief without resorting to potentially addictive medications.

References

  1. National Institute of Neurological Disorders and Stroke
    [Link] (https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Restless-Legs-Syndrome-Fact-Sheet)
  2. Addiction and Withdrawal Side Effects of RLS Drugs:
    [Link] (https://americanaddictioncenters.org/neurontin-abuse/)
  3. IBS, Bacterial Overgrowth and Restless Leg Syndrome and Use of Probiotics:
    [Link1] (https://www.ncbi.nlm.nih.gov/pubmed/2157090),
    [Link2] (https://www.ncbi.nlm.nih.gov/pubmed/21381407),
    [Link3] (https://www.ncbi.nlm.nih.gov/pubmed/25244414)
  4. Vitamin D Supplementation Improves RSL: Wali S, Shukr A, Boudal A, et al. The effect of vitamin D supplements on the severity of restless leg syndrome. Sleep Breath. Vol 2:579-83. 2015
    [Link] (https://www.ncbi.nlm.nih.gov/pubmed/25148866)
  5. Iron Supplementation Improves RLS Wang J, O’Reilly, Venkataramen R et al. Efficacy of oral iron in patients with restless leg syndrome and low-normal ferritin: A randomized, double-blind, placebo-controlled study. Sleep Med. Vol 9:973-5. 2009.
    [Link] (https://www.ncbi.nlm.nih.gov/pubmed/19230757)

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 91 – Harnessing Gut Health: Probiotics Show Promise in Easing Seasonal Allergies

LMU-91

LMU 91 – Harnessing Gut Health: Probiotics Show Promise in Easing Seasonal Allergies

Source: American Journal of Clinical Nutrition (2017)

Lifestyle Medicine Update (June 7, 2018)

Introduction

Seasonal allergies, commonly referred to as hay fever or allergic rhinitis, afflict millions of individuals worldwide, causing discomfort and disrupting their quality of life. While antihistamines and decongestants have been the go-to treatments, they often come with unwanted side effects. A ray of hope emerges from a 2017 study published in the prestigious American Journal of Clinical Nutrition, shedding light on the potential of probiotic supplements to alleviate hay fever symptoms and enhance overall well-being during allergy season.

The Power of Probiotics: A Pathway to Immune Health

Probiotics have long been recognized for their positive impact on immune function and digestive well-being. Beyond this, intriguing experimental evidence suggested a connection between probiotic supplementation and the modulation of regulatory T-cells, a specific type of immune cell. These findings paved the way for the study’s researchers to delve deeper into the possible benefits of probiotics for individuals suffering from seasonal allergies.

Unveiling the Study

In pursuit of tangible evidence, a team of researchers embarked on a comprehensive study involving 173 healthy adults plagued by seasonal allergies. The participants were divided into two groups through random selection. One group was administered a carefully crafted combination probiotic supplement, housing both Lactobacillus and Bifidobacteria strains. This probiotic-rich group consumed the supplement twice daily over an eight-week period. The second group, serving as the control, received a placebo counterpart.

To ensure the efficacy of the probiotic supplementation, the researchers analyzed participants’ stool samples to monitor the presence and concentrations of friendly gut bacteria in the large bowel. This step not only validated adherence to the supplement regimen but also provided insights into the potential mechanisms at play.

Results that Bring Relief

The study’s outcomes unfolded with promising implications. Participants who suffered from mild seasonal allergies reaped the most significant benefits from the probiotic intervention. This discovery is particularly uplifting given that hay fever affects a staggering 40-60 million individuals in the United States alone. Characterized by an exaggerated immune response to airborne allergens, hay fever triggers symptoms like sneezing, runny nose, itchy eyes, and fatigue. The study’s findings offer hope to this substantial demographic, potentially providing them with a more natural avenue to manage their symptoms.

Beyond the Seasonal Sniffles: A Glimpse into the Future

While standard medical interventions for hay fever center around antihistamines and decongestants, these remedies often bring along undesirable side effects, ranging from drowsiness and dizziness to dry mouth and difficulties with urination. Probiotic supplements, in contrast, could represent a gentler, side effect-free alternative. For those who have grown tired of battling the discomfort of hay fever with conventional treatments, the option of incorporating probiotics into their daily routine might prove to be a game-changer.

Promising Pathways Ahead

The implications of this study extend beyond the realm of hay fever management. The probiotic supplement’s potential to enhance gut health and support overall immune function carries significant implications for general wellness. Strengthening the body’s defence mechanisms through a balanced and well-nurtured gut ecosystem could unlock various health benefits, from increased resistance to infections to improved digestion.

Embracing a New Paradigm

The potential shown by this research ushers in a new era of hay fever management. No longer limited to drowsy antihistamines and decongestants, individuals may soon have access to a natural and side effect-free solution. A simple regimen of probiotic supplements, housing the right strains, could significantly reduce the burden of hay fever symptoms.

Conclusion

The 2017 study published in the American Journal of Clinical Nutrition illuminates a promising path for individuals plagued by seasonal allergies. With its focus on the immune-modulating potential of probiotics, the study hints at a future where the discomfort of hay fever can be eased without the baggage of unwanted side effects. As the medical community delves deeper into the interplay between gut health and overall well-being, probiotics emerge as a beacon of hope, promising relief not only for hay fever sufferers but also for those seeking to bolster their immune defences naturally.

References

Dennis-Wall JC et al. Probiotics ( Lactobacillus Gasseri KS-13, Bifidobacterium Bifidum G9-1, and Bifidobacterium Longum MM-2) Improve Rhinoconjunctivitis-Specific Quality of Life in Individuals With Seasonal Allergies: A Double-Blind, Placebo-Controlled, Randomized Trial. Am J Clin Nutr 105 (3): 758-767  Feb 22, 2017.
[Link] (https://www.ncbi.nlm.nih.gov/labs/articles/28228426/)

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 90 – The Health Benefits of Substituting Soy Protein for Animal Protein

LMU-90

LMU 90 – The Health Benefits of Substituting Soy Protein for Animal Protein

Source: Sports and Exercise Nutrition (Textbook fourth edition – 2013)

Lifestyle Medicine Update (May 19, 2018)

Introduction:

In the last century, dietary habits in North America and many developed regions have evolved significantly. Historically, protein intake was evenly split between animal and plant sources. However, modern diets now consist of two-thirds animal-based proteins. While these animal proteins provide essential amino acids vital for bodily functions, they also often come with a downside: saturated fats, linked to heart diseases and certain cancers. This article explores the consequences of this dietary shift and introduces soy protein as a promising alternative. Soy, found in products like tofu and miso, offers all essential amino acids while potentially improving heart health and reducing cancer risk.

The Protein Dilemma:

  • Animal-based protein offers optimal concentrations of essential amino acids for key bodily protein synthesis.
  • However, many animal products are high in saturated fats, increasing the risk of heart diseases and certain cancers.
  • Animal foods lack protective phytonutrients, leaving us vulnerable to various health threats.
  • Combining plant foods like grains and legumes can provide all essential amino acids.
  • Soy protein, derived from soybeans, stands out as the only plant-based source containing all required amino acids.

The Benefits of Soy Protein:

  • Substituting soy protein for animal protein has shown health benefits in controlled clinical trials.
  • It reduces blood pressure, triglycerides, total cholesterol, and oxidized LDL-cholesterol.
  • Soy protein raises HDL-cholesterol, promoting the removal of artery-clogging cholesterol.
  • It lowers blood homocysteine levels, reducing the risk of heart attacks and strokes.
  • Higher soy consumption is linked to the prevention of prostate and breast cancer, and breast cancer recurrence.
  • Isoflavones and protease inhibitors in soy are key anti-cancer agents.

Health Strategies:

  • Cut back on high-fat animal foods (except omega-3-containing fish).
  • Eliminate deep-fried, breaded, and battered foods, as well as creamy salad dressings.
  • Opt for skinless chicken breast, turkey breast, Cornish hen, egg whites, and low-fat dairy.
  • Incorporate soy foods like tofu, soy-based veggie products, miso, tempeh, and edamame.
  • Consider soy protein shakes to increase protein intake if necessary.
  • Textured vegetable protein can replace meat in various dishes like sauces and lasagnas.

Substituting soy products for animal products is a simple yet effective way to maintain ideal cholesterol levels and reduce the risk factors for heart disease. Numerous clinical trials support the health benefits of this dietary shift.

References

  1. Sasaki A, Nagatake T, Egami R et al. Obesity suppresses cell-competition-mediated apical elimination of RasV-12-transformed cells from epithelial tissues. Cell Reports, vol 23, issue 4. P:974-982. April 2018. [DOI]

    2. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30480-7


Eat Smart, Live Well, Look Great,

Dr. Meschino

Introduction:

In the last century, dietary habits in North America and many developed regions have evolved significantly. Historically, protein intake was evenly split between animal and plant sources. However, modern diets now consist of two-thirds animal-based proteins. While these animal proteins provide essential amino acids vital for bodily functions, they also often come with a downside: saturated fats, linked to heart diseases and certain cancers. This article explores the consequences of this dietary shift and introduces soy protein as a promising alternative. Soy, found in products like tofu and miso, offers all essential amino acids while potentially improving heart health and reducing cancer risk.

The Protein Dilemma:

  • Animal-based protein offers optimal concentrations of essential amino acids for key bodily protein synthesis.
  • However, many animal products are high in saturated fats, increasing the risk of heart diseases and certain cancers.
  • Animal foods lack protective phytonutrients, leaving us vulnerable to various health threats.
  • Combining plant foods like grains and legumes can provide all essential amino acids.
  • Soy protein, derived from soybeans, stands out as the only plant-based source containing all required amino acids.

The Benefits of Soy Protein:

  • Substituting soy protein for animal protein has shown health benefits in controlled clinical trials.
  • It reduces blood pressure, triglycerides, total cholesterol, and oxidized LDL-cholesterol.
  • Soy protein raises HDL-cholesterol, promoting the removal of artery-clogging cholesterol.
  • It lowers blood homocysteine levels, reducing the risk of heart attacks and strokes.
  • Higher soy consumption is linked to the prevention of prostate and breast cancer, and breast cancer recurrence.
  • Isoflavones and protease inhibitors in soy are key anti-cancer agents.

Health Strategies:

  • Cut back on high-fat animal foods (except omega-3-containing fish).
  • Eliminate deep-fried, breaded, and battered foods, as well as creamy salad dressings.
  • Opt for skinless chicken breast, turkey breast, Cornish hen, egg whites, and low-fat dairy.
  • Incorporate soy foods like tofu, soy-based veggie products, miso, tempeh, and edamame.
  • Consider soy protein shakes to increase protein intake if necessary.
  • Textured vegetable protein can replace meat in various dishes like sauces and lasagnas.

Substituting soy products for animal products is a simple yet effective way to maintain ideal cholesterol levels and reduce the risk factors for heart disease. Numerous clinical trials support the health benefits of this dietary shift.

 

References

  1. Sasaki A, Nagatake T, Egami R et al. Obesity suppresses cell-competition-mediated apical elimination of RasV-12-transformed cells from epithelial tissues. Cell Reports, vol 23, issue 4. P:974-982. April 2018. [DOI]
    https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30480-7

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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Posted on by

LMU 89 – The Dietary Connection to Cancer: Decoding the Link between High-Fat Diet, Obesity, and Tumor Initiation

LMU-89

LMU 89 – The Dietary Connection to Cancer: Decoding the Link between High-Fat Diet, Obesity, and Tumor Initiation

NMU 89 – How the High-fat North American Diet Shown to Initiate Colon, Breast and Pancreatic Cancer

Lidestyle Medicine Update (May 5, 2018)

Introduction:

The intricate interplay between diet, obesity, and cancer continues to bewilder researchers and health enthusiasts alike. Amidst the labyrinthine web of factors, a remarkable study emerged, shedding light on the perplexing connection between the typical high-fat North American diet, obesity, and the elevated risk of specific cancers. Published in the esteemed journal Cell Reports in April 2018, this study unveils a trail of insights that could rewrite our understanding of cancer initiation and progression.

The Lurking Threat: Colon, Breast, and Pancreatic Cancer

Colon cancer, breast cancer, and pancreatic cancer loom large as formidable adversaries on the global health horizon. With colon cancer ranking as the second leading cause of cancer death, breast cancer gripping women’s lives with its stealthy clutches, and pancreatic cancer leaving a trail of despair with its grim prognosis, the stakes are undeniably high.

The Unravelling: A Journey through Cancer Development

The narrative of cancer is woven through stages, each unveiling a different facet of the enigmatic disease. The initiation stage marks the birth of a cancer cell—a transformation from normalcy to malignancy. This nascent malignant cell may lie dormant, biding its time, or sprout into a full-fledged tumor. This pivotal moment, known as the tumor promotion stage, propels the narrative into one of proliferation and progression. Metastasis, the bittersweet dance of cancer cells through the body’s corridors, adds a sinister layer to the tale. Amidst this intricacy, questions lingered—how does a high-fat diet, coupled with obesity, trigger the genesis of cancer?

Epithelial Defence Against Cancer (EDAC): A Guardian Unveiled

In the midst of these queries, the study unfurled a groundbreaking revelation—the ability of normal colon, breast, and pancreatic cells to sense the emergence of malignant cells in their vicinity. Dubbed “epithelial defence against cancer” (EDAC), this process harnessed the power of healthy cells to stand as silent sentinels against impending malignancy. An orchestra of anti-tumor activity unfolded, orchestrated by these vigilant guardians. Yet, obesity and the habitual consumption of a high-fat diet cast a pall over this defensive prowess.

The Fat Culprits: Saturated Fats and Linoleic Acid

The study spotlighted certain fats as the orchestrators of this subversion—saturated fats and omega-6 fat linoleic acid emerged as the villains. These fats held the capacity to disarm the guardian cells, rendering them powerless against the burgeoning malignant cells. Linoleic acid, notorious for constituting 7% of the North American diet, emerged as a prime culprit. Vegetable oils, rich repositories of this fat, beckoned for alternatives—olive oil, canola oil, and the protective embrace of flaxseed oil, abundant in omega-3 fat alpha-linolenic acid.

A Symphony of Inflammation and Energy

The narrative unfolded to reveal more layers—high-fat diets intertwined with inflammation, birthing a dance of inflammatory fibroblasts and macrophage cells. Omega-6 fat’s role in the production of the notorious prostaglandin series-2 further fuelled the flames of cancer development. The stage was set—a symphony of energy production, metabolic survival, and the intricate dance of cancer initiation played out on the cellular canvas.

The Remarkable Anomaly: Lung Cancer

The study’s pages bore witness to an intriguing anomaly—a high-fat diet’s inability to hinder lung cells’ pursuit of eradication against malignant cells. Here, the link between obesity, high-fat diet, and lung cancer remained tenuous, evoking questions that nudged at the peripheries of understanding.

A Glimpse into the Future: Cancer Preventive Medicine

As the study’s tapestry unfurled, it beckoned us to glimpse into the future—cell competition and cancer preventive medicine standing intertwined. The realms of obesity and diet, once entwined with the mysteries of cancer initiation, now stood illuminated by the beacon of EDAC and its intricate dynamics.

Conclusion: Navigating the Path Forward

With this revelation, the compass of cancer research takes a new bearing. The pages of Cell Reports in April 2018 stand as a testament to the intricate dance of cellular defence, the subversion orchestrated by fats, and the symphony of inflammation and energy that weave the narrative of cancer initiation. As the journey to decode the enigma of cancer continues, this study offers a vital thread to weave into the tapestry of cancer prevention and holistic well-being.

References

1. Sasaki A, Nagatake T, Egami R et al. Obesity suppresses cell-competition-mediated apical elimination of RasV-12-transformed cells from epithelial tissues. Cell Reports, vol 23, issue 4. P:974-982. April 2018. 

[DOI](https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30480-7)

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements