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LMU 295 – Glucosamine Linked to Reduced Cancer Risk in Large UK Biobank Study (2022)

LMU-295

Glucosamine Linked to Reduced Cancer Risk in Large UK Biobank Study (2022)

Source: Journal, Frontiers of Nutrition (November 2022)

Lifestyle Medicine Update (July 18, 2023)

Glucosamine and Reduced Cancer Risk

In 2020, a published paper in the Annals of Rheumatology reported that regular use of glucosamine supplements was associated with:

  • A significantly reduced risk of dying from cancercardiovascular, respiratory, and intestinal tract diseases.
  • A 15% reduction in all-cause mortality compared to non-users of glucosamine supplements.

The data was derived from approximately 500,000 individuals being followed in the UK Biobank study.

UK Biobank Study Update on Glucosamine and Cancer

  • In November 2022, the UK Biobank study was updated and published in the Frontiers of Nutrition journal, with a specific focus on glucosamine’s potential protective role against cancer.
  • The UK Biobank study is one of the largest population studies in the world, aiming to improve disease prevention, diagnosis, and treatment, as well as promote health across society.
  • The original study included over 500,000 participants from the UK, aged 38 to 73, who were followed from 2006 to 2010 until March 2021. None of the participants had cancer at the study’s beginning.
  • After controlling for other cancer risk factors, the study showed that individuals who routinely took glucosamine supplements exhibited significant benefits:
  1. 5% decrease in overall cancer risk
  2. 32% lower risk of kidney cancer mortality
  3. 16% lower risk of lung cancer mortality
  4. 24% lower risk of rectal cancer mortality

Glucosamine and Anti-Cancer Properties

Glucosamine has shown important anti-cancer properties in experimental and animal studies, including:

  • Inhibition of proliferation in various types of human cancer cells
  • Inducing programmed cell death (apoptosis) in many cancer cell types
  • Reversal of tumor drug-resistance
  • Inhibition of tumor blood vessel formation (anti-tumorigenesis)
  • Blocking cancer cells’ ability to invade neighboring tissues by inhibiting destructive enzymes (matrix metalloproteinases)

Several epidemiological studies in the US and the UK have indicated that glucosamine is linked to reduced cancer mortality, with some studies reporting a 15% reduction in overall cancer risk.

Glucosamine Availability and Usage

  • Glucosamine is available as a prescription drug in most European countries but as an over-the-counter supplement in Australia, the US, and Canada.
  • Usage rates vary, with about 20% of Australian adults using glucosamine supplements, approximately 2% of US adults, and an estimated 5-7% of the adult population in Canada.

Complementary Natural Agents

Some glucosamine supplements contain three natural anti-inflammatory agents (Quercetin, Bromelain, and MSM), which have their own unique anti-cancer properties in various studies.

Recommendation

  • Based on the evidence, it may be beneficial for individuals to consider taking a glucosamine supplement with natural anti-inflammatory agents around the age of 40, as this is the time when the body naturally produces less glucosamine.

References

  1. Zhou J et al. Association between glucosamine use and cancer mortality: A large prospective cohort study. Front Nutr. 2022. 9 Link
  2. Li Z-H et al. Associations of regular glucosamine use with all-cause and specific mortality: a large prospective cohort study. Ann Rheum Dis. 2020; 79(6): 829-863. Link
  3. Bromelain Anti-cancer Properties: Link
  4. Quercetin Anti-Cancer Properties: Link
  5. MSM Anti-Cancer Properties: Link

Eat Smart, Live Well, Look Great,

Dr. Meschino

Glucosamine and Reduced Cancer Risk

In 2020, a published paper in the Annals of Rheumatology reported that regular use of glucosamine supplements was associated with:

  • A significantly reduced risk of dying from cancer, cardiovascular, respiratory, and intestinal tract diseases.
  •  A 15% reduction in all-cause mortality compared to non-users of glucosamine supplements.

The data was derived from approximately 500,000 individuals being followed in the UK Biobank study.

UK Biobank Study Update on Glucosamine and Cancer

  • In November 2022, the UK Biobank study was updated and published in the Frontiers of Nutrition journal, with a specific focus on glucosamine’s potential protective role against cancer.
  • The UK Biobank study is one of the largest population studies in the world, aiming to improve disease prevention, diagnosis, and treatment, as well as promote health across society.
  • The original study included over 500,000 participants from the UK, aged 38 to 73, who were followed from 2006 to 2010 until March 2021. None of the participants had cancer at the study’s beginning.
  • After controlling for other cancer risk factors, the study showed that individuals who routinely took glucosamine supplements exhibited significant benefits:
    1. 5% decrease in overall cancer risk
    2. 32% lower risk of kidney cancer mortality
    3. 16% lower risk of lung cancer mortality
    4. 24% lower risk of rectal cancer mortality

Glucosamine and Anti-Cancer Properties

Glucosamine has shown important anti-cancer properties in experimental and animal studies, including:

    • Inhibition of proliferation in various types of human cancer cells
    • Inducing programmed cell death (apoptosis) in many cancer cell types
    • Reversal of tumor drug-resistance
    • Inhibition of tumor blood vessel formation (anti-tumorigenesis)
    • Blocking cancer cells’ ability to invade neighboring tissues by inhibiting destructive enzymes (matrix metalloproteinases)

Several epidemiological studies in the US and the UK have indicated that glucosamine is linked to reduced cancer mortality, with some studies reporting a 15% reduction in overall cancer risk.

Glucosamine Availability and Usage

  • Glucosamine is available as a prescription drug in most European countries but as an over-the-counter supplement in Australia, the US, and Canada.
  • Usage rates vary, with about 20% of Australian adults using glucosamine supplements, approximately 2% of US adults, and an estimated 5-7% of the adult population in Canada.

Complementary Natural Agents

Some glucosamine supplements contain three natural anti-inflammatory agents (Quercetin, Bromelain, and MSM), which have their own unique anti-cancer properties in various studies.

Recommendation

  • Based on the evidence, it may be beneficial for individuals to consider taking a glucosamine supplement with natural anti-inflammatory agents around the age of 40, as this is the time when the body naturally produces less glucosamine.

References

  1. Zhou J et al. Association between glucosamine use and cancer mortality: A large prospective cohort study. Front Nutr. 2022. 9 Link
  2. Li Z-H et al. Associations of regular glucosamine use with all-cause and specific mortality: a large prospective cohort study. Ann Rheum Dis. 2020; 79(6): 829-863. Link
  3. Bromelain Anti-cancer Properties: Link
  4. Quercetin Anti-Cancer Properties: Link
  5. MSM Anti-Cancer Properties: Link

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 294 – Protecting Against Parkinson’s: The Role of Glutathione

LMU-294

Protecting Against Parkinson's: The Role of Glutathione and Aging

Source: International Journal of Molecular Science (2021)

Lifestyle Medicine Update (July 5, 2023)

Parkinson’s Disease – A Growing Concern

Parkinson’s disease, the second most common neurodegenerative condition after Alzheimer’s, affects one in five hundred
adults over fifty. By the year 2030, approximately nine million people are estimated to be afflicted with this condition as aging populations grow in many countries. The disease is caused by a combination of genetic and environmental factors, with unmitigated free radicals (oxidative stress) playing a significant role in its development.

The Role of Free Radicals and Glutathione

Glutathione Treatment as an Effective Approach

  • Researchers have been investigating ways to increase brain glutathione levels in older subjects to protect brain cells from free radical damage and manage existing cases of Parkinson’s disease.
  • A 2021 meta-analysis confirmed that glutathione treatment is effective in improving muscle and movement function, including tremor reduction, in Parkinson’s patients.
  • Glutathione treatment not only reduces Parkinson’s disease symptoms but also inhibits steps involved in the underlying cause of the disease.

Optimizing Glutathione Levels

The Importance of Glutathione Supplementation

References:

  1. Wang H-L et al. Potential use of glutathione as a treatment for Parkinson’s disease. Exp Ther Med. 2021;21(2): 125 Link
  2. Smeyne M. Glutathione metabolism and Parkinson’s disease. Free Radic Biol Med. 2013; 62: 13-25
  3. Aoyama K. Glutathione in the brain. Int J Mol Sci. 2021; 22(9): 5010 Link

Eat Smart, Live Well, Look Great,

Dr. Meschino

Parkinson’s Disease – A Growing Concern

Parkinson’s disease, the second most common neurodegenerative condition after Alzheimer’s, affects one in five hundred
adults over fifty. By the year 2030, approximately nine million people are estimated to be afflicted with this condition as aging populations grow in many countries. The disease is caused by a combination of genetic and environmental factors, with unmitigated free radicals (oxidative stress) playing a significant role in its development.

The Role of Free Radicals and Glutathione

  • High levels of free radicals within dopamine-producing brain cells lead to their death, triggering the onset and progression of Parkinson’s disease.
  • Age-related decline in brain glutathione levels contributes to elevated free radicals during the aging process, increasing the risk of Parkinson’s disease and other neurodegenerative conditions.

Glutathione Treatment as an Effective Approach

  • Researchers have been investigating ways to increase brain glutathione levels in older subjects to protect brain cells from free radical damage and manage existing cases of Parkinson’s disease.
  • A 2021 meta-analysis confirmed that glutathione treatment is effective in improving muscle and movement function, including tremor reduction, in Parkinson’s patients.
  • Glutathione treatment not only reduces Parkinson’s disease symptoms but also inhibits steps involved in the underlying cause of the disease.

Optimizing Glutathione Levels

  • Glutathione supplements are largely broken down in the intestinal tract and do not reach the bloodstream intact.
  • The best way to raise brain glutathione levels through oral supplementation is by taking N-acetylcysteine (NAC), which easily crosses the blood-brain barrier and stimulates glutathione synthesis.
  • Other nutrients like Alpha-lipoic acid, Silymarin (from Milk thistle), and L-Glutamine also raise blood and tissue levels of glutathione.

 The Importance of Glutathione Supplementation

  • Due to the decline in glutathione levels with age and its crucial role in quenching damaging free radicals in the body and brain cells, supplementation is recommended around the age of 45-50.
  • A beneficial supplement capsule combines N-acetylcysteine (NAC), Alpha-lipoic acid, Silymarin, and L-Glutamine to synergistically raise glutathione levels and promote anti-aging and health benefits.

References:

  1. Wang H-L et al. Potential use of glutathione as a treatment for Parkinson’s disease. Exp Ther Med. 2021;21(2): 125 Link
  2. Smeyne M. Glutathione metabolism and Parkinson’s disease. Free Radic Biol Med. 2013; 62: 13-25
  3. Aoyama K. Glutathione in the brain. Int J Mol Sci. 2021; 22(9): 5010 Link

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 293 – Bacopa Monnieri Supplementation for Memory Support and Improvement in Aging

LMU-293

Bacopa Monnieri Supplementation for Memory Support and Improvement in Aging

Source: Frontiers of Aging Neuroscience Journal (2021)

Lifestyle Medicine Update (June 20, 2023)

Introduction:

As people age, memory decline and cognitive impairment can become common issues. Bacopa monnieri, an Indian herb with documented benefits, is a lesser known but promising option for memory support. This article aims to shed light on the potential of Bacopa monnieri supplementation for memory preservation and enhancement in aging individuals, backed by experimental and human clinical studies.

Bacosides A and B:

Bacopa monnieri extracts contain medicinal compounds called Bacosides A and B. These compounds could cross the blood-brain barrier and exert protective effects on brain cells. Products include memory preservation and the repair of damaged brain cells. The herb’s unique properties include detoxifying toxic metals within brain cells and potent antioxidant properties to combat free radicals. It also reduces brain inflammation, improves brain blood flow, and increases levels of the memory chemical acetylcholine. Bacopa monnieri boosts the brain’s protective antioxidants like Superoxide Dismutase, Catalase, and Glutathione Peroxidase.

Human Clinical Studies:

A 2021 research paper published in Frontiers of Aging and Neuroscience reviewed several human clinical studies on Bacopa monnieri’s impact on memory function. The studies demonstrated that supplementation with Bacopa monnieri improved immediate and delayed recall memory in aging individuals. Additionally, it enhanced brain processing speed and sustained attention over 12 weeks to 3 months, indicating its quick effects after supplementation begins.

Combination with Other Supplements:

Maintaining optimal levels of the memory chemical acetylcholine becomes challenging after the age of 50-55 due to the
reduced effectiveness of the blood-brain barrier. Combining Bacopa monnieri with other memory-support supplements can be beneficial. Suggested supplements include CDP-choline, Phosphatidylserine, and Huperzine A. This combination aids in guarding against age-related brain deterioration, executive function decline, and processing speed impairment.

Conclusion:

Bacopa monnieri has shown impressive results in preserving and enhancing memory function in aging individuals. Its ability to cross the blood-brain barrier and exert protective effects on brain cells sets it apart from other memory-support supplements. With its antioxidant properties and memory chemical enhancement, Bacopa monnieri can significantly support brain health. For individuals over fifty, a daily supplementation regimen that includes Bacopa monnieri, CDP-choline, Phosphatidylserine, and Huperzine A is a worthwhile consideration to combat age-related cognitive decline and memory problems.


Eat Smart, Live Well, Look Great,

Dr. Meschino

Introduction:

As people age, memory decline and cognitive impairment can become common issues. Bacopa monnieri, an Indian herb with documented benefits, is a lesser known but promising option for memory support. This article aims to shed light on the potential of Bacopa monnieri supplementation for memory preservation and enhancement in aging individuals, backed by experimental and human clinical studies.

Bacosides A and B:

Bacopa monnieri extracts contain medicinal compounds called Bacosides A and B. These compounds could cross the blood-brain barrier and exert protective effects on brain cells. Products include memory preservation and the repair of damaged brain cells. The herb’s unique properties include detoxifying toxic metals within brain cells and potent antioxidant properties to combat free radicals. It also reduces brain inflammation, improves brain blood flow, and increases levels of the memory chemical acetylcholine. Bacopa monnieri boosts the brain’s protective antioxidants like Superoxide Dismutase, Catalase, and Glutathione Peroxidase.

Human Clinical Studies:

A 2021 research paper published in Frontiers of Aging and Neuroscience reviewed several human clinical studies on Bacopa monnieri’s impact on memory function. The studies demonstrated that supplementation with Bacopa monnieri improved immediate and delayed recall memory in aging individuals. Additionally, it enhanced brain processing speed and sustained attention over 12 weeks to 3 months, indicating its quick effects after supplementation begins.

Combination with Other Supplements:

Maintaining optimal levels of the memory chemical acetylcholine becomes challenging after the age of 50-55 due to the
reduced effectiveness of the blood-brain barrier. Combining Bacopa monnieri with other memory-support supplements can be beneficial. Suggested supplements include CDP-choline, Phosphatidylserine, and Huperzine A. This combination aids in guarding against age-related brain deterioration, executive function decline, and processing speed impairment.

Conclusion:

Bacopa monnieri has shown impressive results in preserving and enhancing memory function in aging individuals. Its ability to cross the blood-brain barrier and exert protective effects on brain cells sets it apart from other memory-support supplements. With its antioxidant properties and memory chemical enhancement, Bacopa monnieri can significantly support brain health. For individuals over fifty, a daily supplementation regimen that includes Bacopa monnieri, CDP-choline, Phosphatidylserine, and Huperzine A is a worthwhile consideration to combat age-related cognitive decline and memory problems.

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 292 – Exercise and Diabetes Prevention: Insights from a 2023 Study

LMU-292

Exercise and Diabetes Prevention: Insights from a 2023 Study

Source: British Journal of Sports Medicine (2023)

Lifestyle Medicine Update (June 14, 2023)

Introduction

In today’s fast-paced world, health has become a paramount concern for individuals of all ages. Among various health-promoting practices, exercise stands out as one of the most effective preventive measures against a myriad of chronic diseases, including type 2 diabetes. The significance of exercise as preventive medicine has repeatedly been reiterated by healthcare professionals and researchers. In this context, the study published in the British Journal of Sports Medicine in 2023 by M. Luo et al. sheds new light on the association between exercise and diabetes risk, supplying valuable insights that can positively change public health policies and individual lifestyle choices.

Study Details

The research by M. Luo and colleagues involved a comprehensive analysis of data from the UK Biobank study. The UK Biobank, a large-scale biomedical database, has extensive health information from over 500,000 participants, including genetic data, lifestyle factors, and medical history. For this specific study, 59,325 adults were selected as the participants, making it one of the largest studies to investigate the relationship between physical activity and diabetes risk.

Researchers employed ultramodern technology to gather correct and reliable data on participants’ physical activity. Each participant was asked to wear an accelerometer, a small and portable device that accurately measures movements and physical activity levels. The accelerometers were worn for a prolonged period of seven years, allowing for a detailed examination of the participants’ daily activity patterns.

 Key Findings

The results of the study unveiled a striking correlation between physical activity and type 2 diabetes risk. Participants who engaged in moderate-to-vigorous physical activity for over one hour per day experienced a remarkable 74% reduction in the risk of developing type 2 diabetes compared to those who engaged in less than 5 minutes per day of such activity. This finding emphasizes the importance of incorporating regular, sustained, and moderately intense physical activity into daily routines to safeguard against the development of this prevalent metabolic disorder.

 Furthermore, the research delved deeper into the influence of genetic factors on diabetes risk. It is well-established that genetic predisposition plays a role in deciding an individual’s susceptibility to type 2 diabetes. However, the study’s intriguing revelation was that even individuals with a high genetic risk for type 2 diabetes could substantially mitigate their risk through consistent and substantial physical activity. Typically, individuals with a high genetic risk are believed to be 2.4 times more likely to develop type 2 diabetes; yet, the protective effects of exercise were still clear in this subgroup, offering hope and motivation for those who may be at higher risk due to their genetic makeup.

Comments from Researchers

One of the researchers involved in the study expressed enthusiasm over the potential implications of their findings. They said, We are unable to control our genetic risk and family history, but this finding provides promising and positive news that through an active lifestyle, one can ‘fight off’ much of the excessive risk for type 2 diabetes. This optimistic outlook resonates with the growing body of research that underscores the transformative power of lifestyle interventions.

Benefits of Moderate-to-Vigorous Exercise for Diabetes Prevention

The study findings raise the question: How does moderate-to-vigorous exercise exert its protective effects against diabetes? To answer this, we must explore the physiological changes that occur during physical activity:

  1. Improving Insulin Sensitivity:

    Insulin, a hormone produced by the pancreas, plays a crucial role in regulating blood glucose levels. Insulin sensitivity refers to how effectively our cells respond to insulin’s action in transporting glucose from the bloodstream into cells. Regular exercise enhances insulin sensitivity, which allows the body to use glucose more efficiently, ultimately reducing blood sugar levels and lowering the risk of diabetes.

  2. Enhancing Fat-Burning:

    Obesity and excess body weight are proven risk factors for insulin resistance, a condition where cells become less responsive to insulin. Engaging in moderate-to-vigorous physical activity promotes fat burning and helps prevent weight gain, thus reducing the risk of developing insulin resistance and type 2 diabetes.

  3. Activation of Sirtuin Longevity Genes:

    Sirtuins are a group of proteins that regulate various cellular processes, including those involved in metabolism and aging. Some sirtuins are known to be involved in regulating insulin sensitivity and glucose metabolism. Exercise activates these longevity genes, positively affecting overall cardiometabolic health and reducing the likelihood of developing diabetes.

Conclusion

The findings of the 2023 study published in the British Journal of Sports Medicine reinforce the idea that our genes do not solely decide our destiny. While genetic factors can influence disease risk, lifestyle choices and behaviors have the power to modulate gene expression and influence health outcomes significantly. Regular, moderate-to-vigorous physical activity can combat the risk of type 2 diabetes and improve overall health and quality of life.

These insights hold profound implications for public health initiatives, healthcare providers, and individuals alike. Encouraging and promoting physical activity should be a cornerstone of preventive healthcare strategies to tackle the growing burden of diabetes and other chronic diseases. The integration of exercise into daily routines is not only an investment in individual health but also an investment in the well-being of societies at large.

In conclusion, the study serves as a clarion call to action, urging individuals to embrace an active lifestyle and empowering them to take charge of their health destinies. As we navigate the challenges of modern living, let us not forget the simple yet transformative power of exercise in promoting health, longevity, and a vibrant quality of life.

References:

Luo M et al. Accelerometer-measured intensity-specific physical activity, genetic risk, and incident type 2 diabetes: A prospective study. Br J Sports Med. (2023) Accelerometer-measured intensity-specific physical activity, genetic risk, and incident type 2 diabetes: a prospective cohort study | British Journal of Sports Medicine (bmj.com)

Exercise Mitigates Genetic Risk for Type 2 Diabetes. NeuroscienceNews.com (June 5, 2023) Exercise Mitigates Genetic Risk for Type 2 Diabetes – Neuroscience News

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 291 – Folic Acid Supplementation Improves Efficacy of Anti-Depression Drugs

LMU-291

Folic Acid Supplementation Improves Efficacy of Anti-Depression Drugs

Source: Journal of Clinical Psychiatry (2023)

Lifestyle Medicine Update (June 6, 2023)

On May 9 2023 the Journal of Clinical Psychiatry published a review paper of relevant studies that tested the B-vitamin, folic acid, as an adjunctive treatment for major depressive disorder. More specifically the researchers looked at a special form of folic acid known as methylfolate, which the study showed improved the efficacy of anti-depressant drugs in patients who were previously shown to be unresponsive to the use of anti-depressant drugs alone.

In other words, there is a population of patients who suffer from depression who do not respond to anti-depressant drugs, but when methylfolate supplementation is added to antidepressant drug therapy, the response rate improves significantly. We have seen studies like this over the years, but this is the first review paper that has integrated the findings of all relevant previous studies into one overall review, which also included recommendations for psychiatrists to consider. These findings are not surprising as anti-depressant drugs generally work by slowing down the breakdown of the brain neurotransmitter known as serotonin, which helps to raise brain levels of this feel-good brain chemical. But there are no drugs that increase the synthesis of serotonin. We know that folic acid is required to synthesize various neurotransmitters, including serotonin. The same is true for vitamin B12, which has been shown to help improve cognition and mood in people suffering from low vitamin B12 levels. The supplement known as 5-hydroxytryptophan (5HTP) has also been shown to raise serotonin levels and improve certain types of depression. Omega-3 fats also play a role in preventing and reversing depression to some degree by improving nerve cell fluidity and reducing brain inflammation, as two of the purported mechanisms.

But this paper only reviewed the studies using methylfolate, a special form of folic acid. The researchers commented that methylfolate is required to make a cofactor known as tetrahydrobiopterin that is required to synthesize various neurotransmitters, including serotonin. They also noted that methyfolate supplementation was particularly useful in patients with drug-resistant major depression, who were overweight and/or had high levels of inflammatory blood markers. In concert with these findings, overweight patients are known to secrete higher amounts of inflammatory chemicals, called cytokines, which are known to interfere with the synthesis of certain neurotransmitters, including serotonin. Thus, overweight patients with depression are often unresponsive or less responsive to anti-depressant drugs due to higher inflammatory chemicals (prostaglandins and cytokines) in their body, and thus, in these cases, are shown to benefit by the addition of methylfolate supplementation to their treatment plan. The researchers suggest that the addition of methylfolate supplementation to the treatment regime helps the brain overcome the adverse effects of inflammatory cytokines, enabling the brains of these individuals to resume more normalized synthesis of serotonin. This is something that drugs cannot do.

They explain to their psychiatric colleagues that the effective dosage of methylfolate in major depressive patients who are unresponsive to anti-depressant drug therapy is 15 mg per day.  The recommendation is to add methylfolate to standard anti-depressant drug treatment in cases where patients are unresponsive to anti-depressant drug treatment alone.It should be noted that a number of common vitamins and minerals are essential to the synthesis of brain neurotransmitters, such as serotonin, dopamine and other important brain chemicals. More specifically, the B-vitamins, folic acid, vitamin B12, vitamin B6, vitamin B3, and pantothenic acid, along with vitamin C and magnesium are required for the synthesis of many brain neurotransmitters, as well as enabling the brain cells to generate the energy required for normal brain function. This is one more reason why I think people should consider taking a high potency multi-vitamin and mineral each day that includes a B-50 complex as well increased antioxidant dosages, such as vitamin C and vitamin E. Regarding methylfolate supplementation, if you have suffered from depression and antidepressant medications have not been effective or provided only a partial response, then you may want to discuss with your doctor adding 15 mg/d of methylfolate as an adjunctive treatment, especially if your blood homocysteine level is high, or your blood ESR and/or your CRP blood levels are elevated (these are markers of inflammation). As a final comment, the review paper published in the Journal of Clinical Psychiatry in May 2023 underscores our growing understanding that certain natural supplements can cross the blood-brain-barrier and produce important effects on brain function and brain health and even help to slow and reverse important aspects of brain aging.

I have provided a link to the methylfolate review paper in the text below.

 

References:

Maletic V et al. A review of L-methylfolate as adjunctive therapy in the treatment of major depressive disorder. J Clinical Psychiatry. May 9 2023.

A Review of l-Methylfolate as Adjunctive Therapy in the Treatment of Major Depressive Disorder

B-vitamin may help boost anti-depressant efficacy. Medscape (June 2, 2023) Batya Swift Yasgur. https://www.medscape.com/viewarticle/992700?ecd=wnl_tp10_daily_230603_MSCPEDIT_etid5489702&uac=342474MN&impID=5489702

 

Eat Smart, Live Well, Look Great,
Dr. Meschino

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 290 – Reishi Mushroom Extract Bolsters Immune Function in Post-operative Breast and Colon Cancer Patients, Improving Overall Outcomes: An important finding for those over 50

LMU-290

Reishi Mushroom Extract Bolsters Immune Function in Post-operative Breast and Colon Cancer Patients, Improving Overall Outcomes: An important finding for those over 50

Source: Journal of Clinical and Translational Oncology (2021)

Lifestyle Medicine Update (May 31, 2023)

A research paper published in the journal Clinical and Translational Oncology in 2021 showed that when breast and lung cancer patients were provided with a Reishi Mushroom Extract supplement after their surgery, it significantly bolstered their immune system function compared to the patients who did not receive the Reishi Mushroom Extract supplement. This is important because T-lymphocyte function and other markers of immune function have been shown to be important predictive markers for overall survival in cancer patients and the non-cancer patients.

More specifically, the patients given Reishi Mushoom Extract daily showed higher levels of certain T-lymphocytes that fight cancer and infection and they also showed lower levels of immune-suppressing prostaglandins (COX-2) and cytokines (TGF-beta1) compared to patients not ingesting Reishi Mushroom Extract. Reishi Mushroom Extract also improved the AGR and NLR ratios (Albumin-to-globulin; and neutrophil-to-lymphocyte ratios), which have been shown to be important predictors of cancer progression and overall survival. In other words, a higher Albumin-to-Globulin Ratio and a lower Neutrophil-to-Lymphocyte ration are associated with reduced risk of cancer recurrence and improved overall chances of survival.

 

 The Albumin-to-Globulin ratio partially represents the nutritional status of the immune system, and the Neutrophil-to-Lymphocyte ratio indicates the background level of inflammation generated by neutrophils, which promotes cancer growth and progression. This study is not only important for cancer survivors, but for anyone who is over 50 years of age. By age 50 the thymus gland has undergone involution, having shrunk down to a fraction of its original size and is largely non-functional. Prior to age 45 or 50 the thymus gland modulates function of our T-lymphocytes, making them highly effective killing machines that can identify and kill emerging cancer cells, as well as viruses, bacteria, and other foreign agents. But after age of 50, our lymphocytes are less intelligent and capable due to the loss of thymus gland modulation. This is one of the reasons why we become more prone to virulent, life-threatening infections and cancer as we age.

 

Studies such as this one show that we can bolster our T-lymphocyte function and other aspects of immune function that help to ward off cancer via supplementation with Reishi Mushroom Extract as well as other well-documented immune modulating natural agents. Immune support after age 50 is something you should strongly consider in my opinion. I personally take a supplement each day containing Reishi mushroom extract, astraglus, indole-3-carbinol and Milk thistle each day to support my own immune system and detoxification enzyme function. I have included the reference for this breast and lung cancer study in the text below, as well as the references for the AGR and NLR ratios, as related to cancer risk.

References:

Deng Y. et al. Dynamic biomarkers indicate the immunological benefits provided by Ganoderma spore powder in post-operative breast and lung cancer patients. Clinical and Translational Oncology. 2021; 23: 1481-1490 https://link.springer.com/article/10.1007/s12094-020-02547-9

AG Ratio

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706002/

NL Ratio

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998851/#:~:text=The%20neutrophil%2Dto%2Dlymphocyte%20ratio%20(NLR)%2C%20calculated,supported%20by%20lymphocytes%20%5B1%5D.

 

Eat Smart, Live Well, Look Great,
Dr. Meschino

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 289 – NAC Administration Improves Parkinson’s Disease: The importance of preventing the age-related decline in brain glutathione

LMU-289

NAC Administration Improves Parkinson’s Disease: The importance of preventing the age-related decline in brain glutathione

Source: J Clinical Pharmacology & Therapeutics (2019)

Lifestyle Medicine Update (November 15, 2022)

As outlined in the 2021 review paper in the International Journal of Molecular Science, entitled Glutathione in the Brain (Aoyama K), a decline in brain glutathione levels in the aging process has emerged as a significant factor in various neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, ALS, and other conditions. Glutathione plays a very important role in protecting brain cells from free radicals, and it supports other important brain functions.

Thus, the age-related decline in brain glutathione appears to leave brain cells vulnerable to the development of these serious neurodegenerative conditions. As such, researchers have looked at ways to raise blood and brain glutathione levels to prevent and/or improve the management of neurodegenerative conditions. In this regard, a 2019 study published in the journal Clinical Pharmacology & Therapeutics, showed improvement in symptoms of Parkinson’s disease when patients were administered a glutathione-raising natural supplement known as NAC (N-acetylcysteine).

In this study forty-two Parkinson’s disease patients were randomly assigned to the treatment group or the placebo group. The treatment group received intravenous infusions of NAC (50 mg/kg) weekly and took an oral supplement of NAC twice daily (500 mg, twice daily) for 3 months. The placebo group received standard Parkinson’s disease care only without the addition of NAC. Over the three-month period, the patients receiving the NAC treatment saw improvement in their overall Parkinson’s disease symptoms. In addition, brain imaging showed that the patients receiving NAC treatment to raise their glutathione levels also saw significant improvement in their dopamine transporter binding activity (DAT). What does this mean? As Parkinson’s disease progresses, the dopamine transporter, which pumps dopamine back into nerve cells typically becomes less and less active and effective, leading to a further depletion of dopamine in key regions of the brain affected by Parkinson’s disease. The administration of NAC actually improved dopamine transporter activity, helping nerve cells maintain more optimal dopamine levels.  And in doing so, Parkinson’s symptoms improved. This study suggests that NAC treatment not only helps to increase brain levels of glutathione (helping to prevent nerve cell death from free radicals), but it also improves function of the dopamine transporter, helping to optimize brain cell levels of dopamine, and hence reduce tremors, and improve balance and coordination and other features of the disease.

For me, the take home message is to prevent the age-related decline in glutathione from happening in the first place. The age-related decline in glutathione is strongly tied to an increased risk of Alzheimer’s disease, Parkinson’s disease, ALS, and other serious neurodegenerative conditions. Brain cells are particularly vulnerable to free radical damage simply because they use 20% of the body’s oxygen at any given moment, and oxygen free radicals (ROS -reactive oxygen species) are a known to damage brain cells and contribute to the development and progression of Alzheimer’s disease, Parkinson’s disease, ALS and other neurodegenerative conditions. Glutathione is the brain’s most important antioxidant, helping to quench free radicals before they can do extensive brain cell damage –it’s really that simple. As science continues to explore novel ways to fortify the aging brain with glutathione, we can take some logical steps right now, after the age of 40, according to current evidence. And that is to take a glutathione-raising supplement each day that contains:

  • NAC – N-acetylcysteine
  • Alpha-lipoic Acid
  • L-Glutamine
  • Milk Thistle (standardized to at least 80% Silymarin Flavonoid Content)

These four natural agents have been shown to raise blood and tissue levels of glutathione and exert other independent disease-prevention effects. Maintaining your glutathione status after the age 40 is one more strategy to consider in your pursuit of healthy life expectancy and quality of life as you age.

I have included the references on glutathione and NAC in brain aging and the Parkinson’s disease study I referred to in this update.

Thanks for watching and I’ll see you next time.

References:

Monti D et al. N-acetyl cysteine is associated with dopaminergic improvement in Parkinson’s disease. Clin Pharmacol Ther. 2019;106(4): 884-890 https://pubmed.ncbi.nlm.nih.gov/31206613/

Aoyama K. Glutathione in the brain. Int J Mol Sci. 2021, 22(9): 5010 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125908/

Iskusnykh I.Y. et al. Glutathione in brain disorders and aging. J Molecules. 2022, 27(1): 324

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746815/#:~:text=Impairment%20of%20glutathione%20function%20in,%2C%20stroke%2C%20and%20Alzheimer’s%20disease.

Ikeda K et al. Dopamine transporter imaging in Parkinson Disease: Progressive changes and therapeutic modification after anti-parkinsonian medication. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630131/#:~:text=Clinical%20Role%20of%20Dopamine%20Transporter%20Imaging&text=DAT%20is%20the%20most%20important,release%20from%20the%20presynaptic%20terminal.

Dopamine Transporter (DAT)

https://en.wikipedia.org/wiki/Dopamine_transporter

 

Eat Smart, Live Well, Look Great,
Dr. Meschino

 

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 288 Supplement Formula Shown to Improve Early Alzheimer’s Disease

LMU-288

Supplement Formula Shown to Improve Early Alzheimer’s Disease

Source: American Journal of Alzheimer’s Disease (2009)

Lifestyle Medicine Update (May 17, 2023)

A one-year study published in the American Journal of Alzheimer’s disease showed that providing a specific natural supplement to early-stage Alzheimer’s patients improved many aspects of their cognition and performance. The patients taking the natural supplement showed improvement in Dementia Rating Scale, Clock-drawing Tests and their care givers reported improvement inneuropsychiatric parameters (NPI – Neuropsychiatric Inventory) and maintenance of performance in the Activities of Daily Living (ADL). For patients who remained on the supplement for an additional four months (16 months in total) sustained improvement was documented by their caregivers. The natural supplement contained the B-vitamins Folic Acid and Vitamin B6, along with vitamin E, SAMe, N-acetylcysteine and Acetyl-L-Carnitine. Although this was a small open-trial study the outcomes were very significant and the rationale to use this supplement formulation is explained quite eloquently by the researchers.

As they indicated, we know that folic acid, SAMe, and vitamin B6 are required by the brain to make key neurotransmitters required for healthy brain function and to keep homocysteine levels down. High homocysteine is an established risk factor for Alzheimer’s disease, as it damages brain cells and brain blood vessels. Vitamin E is an important brain antioxidant and previous studies have shown that Vitamin E supplementation can slow the progression of Alzheimer’s disease in the early stages.Other studies show that Alzheimer’s patients often inherit a defect in the ability to make sufficient glutathione, which is the brain’s most important antioxidant, protecting brain cells from free radicals that lead to brain cell death. Supplementing with N-acetylcysteine (NAC) is known to raise brain levels of glutathione. Other studies have shown that Acetyl-L-Carnitine helps preserve energy production in brain cells (by protecting the mitochondria – the cell’s energy factories) and it further helps to support glutathione synthesis and synthesis of the memory chemical acetylcholine.

The researchers argue that decreasing free radical damage to brain cells and damage from homocysteine should be critical strategies used in the management of Alzheimer’s disease. But these strategies are not considered in the usual conventional medical management. They also argue that only supplements of this nature can preserve energy function (mitochondrial effects) in brain cells and support synthesis of important neurotransmitters, including the memory chemical acetylcholine, as well as glutathione synthesis. Only targeted supplements can address these important aspects of the disease. To date the use or Alzheimer’s drugs alone has not significantly altered the progression of Alzheimer’s disease and thus, the addition of natural supplements that can counter key aspects of the disease not addressed by drug therapy, should be considered in the treatment plan for patients with mild cognitive impairment and early-stage Alzheimer’s patients to help stabilize and/or slow disease progression.

In addition to these nutrients, I believe that everyone over the age of 50 should also take a supplement that includes:

  • CDP-choline
  • Phosphatidylserine
  • Huperzine A
  • Bacopa monneiri,

which I have seen reverse a number of cases of mild cognitive impairment. More importantly, evidence suggests that these nutrients may help prevent age-related memory loss.

I have included the reference for this study in the text below.

References:

Chan A et al. Efficacy of a vitamin/nutraceutical formulation for early-stage Alzheimer’s disease: A 1-year, open-label pilot study with a 16-month caregiver extension. Am J Alzheimer’s Disease. 2009; 23(6): 571-585.

https://journals.sagepub.com/doi/epdf/10.1177/1533317508325093

Eat Smart, Live Well, Look Great,
Dr. Meschino


Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 287 – Glutathione Helps Guard Against Age-Related Decline in Kidney Function

LMU-287

Glutathione Helps Guard Against Age-Related Decline in Kidney Function

Source: American Journal of Tanslational Research (2021)

Lifestyle Medicine Update (May 11, 2023)

It is well documented that as we age most people experience a decline in kidney function, as the kidneys are one of the fastest aging organs. The decline in kidney function usually begins after age 30-40 and often accelerates after age 50-60. Researchers at Johns Hopkins University estimate that more than 50 percent of individuals over 75 years of age have clinically significant decline in kidney function, and many don’t know they have the problem (mild insufficiency of kidney disease or chronic kidney disease), but it is major risk factor for heart attack.

According to the National Kidney Foundation, kidney disease kills more people each year than breast and prostate cancer. Advanced or End-stage kidney disease is a various serious matter, requiring dialysis or even a kidney transplant, so if you are planning to live a long, healthy, functional life, you have to have a plan in place to preserve your kidney function as best you can, as the aging process can really impact it in a negative way. It’s a highly vulnerable organ. Risk factors for kidney disease include, high blood pressure, diabetes, kidney stones, a family history of kidney failure, prolonged use of over-the-counter pain medications, and being over the age of 60. Patients with certain autoimmune conditions are also at increased risk for kidney damage and declining kidney function.

In recent years what has become apparent is the fact that free radical damage to various kidney cells and kidney structures is a main contributor to the decline in kidney function seen in aging and in various health conditions (i.e., diabetes, autoimmune conditions affecting the kidneys).  A large 2012 study (J Rejuvenation Research) showed that higher blood markers of free radical damage (i.e., MDA or malondialdehyde) were strongly correlated with the rate of decline in kidney function with aging. This means that the higher the free radical concentration, the faster was the decline in kidney function with aging. Studies also show that the kidneys are heavily reliant on the antioxidant known as glutathione to protect them against free radicals as well as the release of kidney-damaging inflammatory cytokines (TNF, IL-1. IL-6 etc.).  Unfortunately, as we age our glutathione levels decline, which appears to be an important factor in the more rapid decline in kidney function we typically see as people age.

So, the good news is that this can be prevented or reversed to some extent with targeted dietary supplements. In line with this thinking a number of studies have been conducted in recent years to assess the value of providing patients with existing acute and chronic kidney disease with supplements known to increase glutathione synthesis. For example, a large review paper published in the American Journal of Translational Research in 2021 concluded that providing patients with chronic kidney disease with N-acetylcysteine (NAC) improved their kidney function over time and reduced their risk of heart attack and other adverse cardiovascular events.N-acetylcysteine (NAC) is an essential ingredient for kidney cells to increase their glutathione synthesis and whether administered intravenously or orally, NAC supplementation is shown to help reverse the loss of kidney function and reduce inflammatory cytokine levels in these high-risk kidney disease patients.  But it’s not only supplementation with NAC that has been shown to raise kidney levels of glutathione and reverse kidney function decline from various causes. Supplementation with other natural agents that raise glutathione levels have also been shown to be effective. These would include, alpha-lipoic acid, silymarin (from Milk thistle) and L-glutamine. In addition to raising kidney glutathione levels, some of these nutrients provide additional types of protection. For instance, alpha-lipoic acid also acts as a direct antioxidant. The same is true for silymarin flavonoid from Milk thistle, and its cell rejuvenation effects and have been shown to improve the management of diabetes-induced kidney disease. Other studies also show the importance of supplementation with Coenzyme Q10 to protect kidney function, as well as ingesting choline (i.e., Lecithin capsules), which the kidneys convert into betaine. Betaine is a very important kidney osmoprotectant, helping to guard against kidney cell dehydration, which otherwise leads to cell death.

To make a long story short, by age 40-50 it makes sense to support your kidney glutathione levels by taking a supplement that contains a combination of:

  • NAC (N-acetylcysteine)
  • Alpha-lipoic acid
  • L-Glutamine
  • Milk thistle (standardized to 80% silymarin content)

 

Taking a supplement containing CoQ10 is also advisable, along with one to two capsules per day of lecithin (1200 mg capsules). Kidney function is typically screened for by blood tests assessing your eGFR and creatinine levels. For individuals with established kidney disease, you should show the references I have provided below to your specialist and ask for their consent to use these supplements to help stabilize and/or improve your kidney function.

Thanks for watching and I’ll see you next time.

References:

National Kidney Foundation: Decline in Kidney Function with Aging and Incidence of Kidney Disease
https://www.kidney.org/news/monthly/wkd_aging#:~:text=Kidney%20disease%20can%20develop%20at,believed%20to%20have%20kidney%20disease.

Aging and Kidney Function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744545/

Decreased Glutathione in Aging:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457589/

NAC Supplementation and Kidney Function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129408/

Silymarin in Diabetic Nephropathy
https://pubmed.ncbi.nlm.nih.gov/25340091/

Alpha Lipoic Acid in Renal Damage – Ferroptosis
https://www.frontiersin.org/articles/10.3389/fphys.2021.680544/full

Alpha Lipoic Acid in Diabetic Nephropathy
https://pubmed.ncbi.nlm.nih.gov/23531536/

L-Glutamine Raises Glutathione Levels
https://biomedres.us/pdfs/BJSTR.MS.ID.002293.pdf

CoQ10 Supplementation in Kidney Disease
https://pubmed.ncbi.nlm.nih.gov/35643375/#:~:text=Oral%20Coenzyme%20Q10%20supplementation%20leads,to%20primary%20Coenzyme%20Q10%20deficiency
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587473/

Betaine in Kidney and Liver Function:
https://karger.com/cpb/article/32/Suppl.%201/32/71803/Betaine-Transport-in-Kidney-and-Liver-Use-of

Betaine in Kidney Function (osmoprotectant)
https://karger.com/cpb/article/32/Suppl.%201/32/71803/Betaine-Transport-in-Kidney-and-Liver-Use-of

Eat Smart, Live Well, Look Great,
Dr. Meschino

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 286 – Probiotic Supplement Decrease Inflammation and Free Radical Damage Normally Caused by Chronic Sleep Deprivation

LMU-286

Probiotic Supplement Decrease Inflammation and Free Radical Damage Normally Caused by Chronic Sleep Deprivation

Source: Journal Nutrients (2023)

Lifestyle Medicine Update (May 2, 2023)

A study published in the journal Nutrients in 2023, by researchers at the university of Camerino in Italy, showed that a multi-strain probiotic supplement may counter the negative effects of sleep deprivation on brain free radical damage as well as brain inflammation and inflammation throughout the body. A great deal of evidence shows that chronic sleep restriction is linked to a low-grade inflammation throughout the body and in the brain, (as triggered by brain immune cells called microglia cells).

As well, insufficient sleep can lead to the accumulation of free radicals in our cells, which cause extensive damage, including to brain cells. Extensive free radical damage in the brain is key feature of many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, MS, ALS, and others. Thus, reducing brain free radicals and brain inflammation is considered to be a very desirable preventive strategy.Chronic sleep deprivation is defined as sleeping less than seven hours per night, more than four hours per night. Previous studies have shown that probiotic supplementation can reduce inflammation through multiple pathways, including rebalancing of gut flora, improving gut permeability, and modulating immune function with lower production of inflammation-promoting cytokines seen in the bloodstream. Other studies have shown that probiotic supplements improve the function of brain microglia cells, which helps prevent brain inflammation.

How does sleep deprivation cause inflammation?

Studies suggest that sleep deprivation can alter the composition of gut microflora, increasing the ratio of unhealthy gut bacteria to friendly gut bacteria. It also appears to induce a breakdown of the gut barrier, and these changes together enable the passage of bacteria and their end-products into the blood stream, which trigger inflammatory reactions in the body and the brain. In mice bred to develop Alzheimer’s disease, probiotic supplements boosted brain antioxidant defences by turning on Sirtuin Longevity genes that activate the synthesis of important brain antioxidants like glutathione. In the 2023 study, researchers administered a multi-strain probiotic supplement to normal sleeping mice and in mice exposed to chronic sleep restriction and assessed the extent of free radical damage and inflammation in their brains and in the bloodstream. The results showed, as expected, that chronic sleep deprivation resulted in increased free radicals and inflammation and altered gut–brain axis, altering hormone levels. But in the chronic sleep deprived mice given the probiotic supplement, the probiotic supplement boosted their brain antioxidant function, reducing free radical damage to the brain, and it positively affected the gut-brain axis, resulting in lower blood markers of inflammation.

 So, I think there are two important messages here:

  1. Don’t become chronically sleep deprived, as a great deal of evidence shows that it has very negative effects on your gut and your brain, with increasing amounts of inflammatory cytokines and free radical damage. Inflammation and free radical damage promote arthritic changes, autoimmune states, neurodegenerative diseases, a weakening of the immune system, more rapid aging, and a host of other problems.
  2. The use of a multi-strain probiotic supplement can help to maintain a healthier gut, reduce inflammation, and have a positive influence on brain antioxidant protection and brain inflammation. For many people taking a digestive enzyme supplement that also contains prebiotics can enhance the positive effects of probiotic supplementation. Prebiotics are the food (soluble fiber) that the friendly gut bacteria eat in order to thrive and reproduce in the large intestine. So, combining a probiotic supplement with a digestive enzyme-prebiotic supplement may provide an even greater benefit for some people.

I have included the references for this information in the text below.

 

References:

Zheng Y et al. Probiotics supplementation attenuates inflammation and oxidative stress induced by chronic sleep restriction. J Nutrient. 2023, 15(6): 1518 https://www.mdpi.com/2072-6643/15/6/1518

Probiotic supplementation reduces inflammation and oxidative stress caused by chronic sleep loss. Neuroscience News.com. April 15, 2023. https://neurosciencenews.com/probiotics-inflammation-sleep-23021/  

 

Eat Smart, Live Well, Look Great,
Dr. Meschino

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.