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LMU 117 – Unlocking the Potential of B-Vitamins: A Ray of Hope for Schizophrenia Management


LMU 117 – Unlocking the Potential of B-Vitamins: A Ray of Hope for Schizophrenia Management

Source: Journal of Psychiatric Neuroscience and Therapeutics (January 19, 2019)

Lifestyle Medicine Update (January 25, 2019)


The enigmatic labyrinth of schizophrenia, a complex mental disorder, has long captivated the attention of medical minds. The pursuit of effective treatments continues, fuelled by the unyielding quest to improve the lives of those ensnared by its grasp. Amidst this landscape of inquiry, a duo of natural supplements emerges—L-Taurine and B-vitamins—garnering attention for their potential to weave threads of improvement in the fabric of schizophrenia management.

Unveiling L-Taurine’s Promising Role

In a prior exploration through the realm of Lifestyle Medicine, the spotlight shone upon L-Taurine—an amino acid that ignited hopes for a novel approach in the management of schizophrenia. With a mere addition of 3,000 mg per day of L-Taurine to the repertoire of antipsychotic drugs, a flicker of improvement illuminated the path for young individuals resistant to the solace of drug treatment alone.

The Illuminating Journey of B-Vitamins

As the pursuit of solutions gathers momentum, another beacon of promise emerges—B-vitamins. Nestled within the pages of the Journal of Psychiatric Neuroscience and Therapeutics, a revelation unfurls. A study, stemming from the observation that individuals with schizophrenia often harbor elevated blood levels of homocysteine, beckons our attention. A tapestry of inquiry unfolds as researchers embark on a journey to investigate the potential of B-vitamins in the intricate dance of schizophrenia management.

B-Vitamins: The Protectors of Balance

Within the cocoon of the study, 120 patients on the cusp of their first episode of psychosis stand as the canvas for exploration. A randomized, double-blind, placebo-controlled voyage commences, steering half the patients toward a daily B-vitamin supplement concoction. The elixir, a potent blend of folic acid (5 mg), vitamin B12 (400 mcg), and vitamin B6 (50 mg), is designed to balance the scales for those grappling with the tumultuous waves of first-episode psychosis.

Homocysteine: A Crucial Nexus

In this intricate narrative, the players are folic acid, B12, and B6—key actors in the orchestra of B-vitamins. Their significance lies in their ability to tame homocysteine levels—a biochemical entity often elevated in the realms of schizophrenia. Armed with the knowledge that these vitamins wield the power to usher homocysteine back into the embrace of normalcy, the researchers embark on a journey to decipher the potential link between high homocysteine and the intricate tapestry of schizophrenia.

A Glimpse into the Outcome

The pages of the study unfold to reveal a significant transformation—homocysteine levels receding within a span of 12 weeks for those fortunate enough to embrace the B-vitamin cocktail. As the biochemical tides shifted, attention-vigilant scores surged, heralding a newfound clarity for the beneficiaries of the supplement. Amidst the canvas, a spotlight shines upon the female participants with affective psychosis. Their neurocognitive landscape witnesses an evolution—a testament to the protective mantle woven by the B-vitamins.

A Cautionary Melody: High Homocysteine’s Echoes

As the echoes of this study resonate, a poignant melody emerges—every individual’s journey bears the signature of their homocysteine levels. The tapestry of evidence cautions us to cast a vigilant gaze upon these levels, invoking the importance of an annual homocysteine blood test. Elevated homocysteine, a harbinger of heart disease, stroke, osteoporosis, and dementia, holds sway over the orchestra of well-being. The symphony of B-vitamins and targeted supplementation can orchestrate a transformation, offering a beacon of hope for those ensnared by its grip.

Epilogue: Illuminating the Path Forward

The realm of schizophrenia management emerges as a landscape ripe with promise and prudence. L-Taurine and B-vitamins cast their silhouettes upon the stage, their potential woven into the fabric of well-being. As we journey forward, let the lessons of cautious optimism guide us, igniting a spark of curiosity to explore the realm of natural supplements as allies in the quest for improved mental health.


Allott K, McGorry P.D, Yuen HP et al. The vitamins in psychosis study: A randomized, double-blind, placebo-controlled trial of the effects on vitamin B12, B6 and folic acid on symptoms and neurocognition in first-episode psychosis. Journal of Psychiatric Neuroscience and Therapeutics (January 19, 2019) Published online January 9, 2019. [Read the study here](

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino


Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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