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LMU 19 – Coenzyme Q10: A Vital Nutrient for Heart Health and Beyond


LMU 19 – Coenzyme Q10: A Vital Nutrient for Heart Health and Beyond

Source: Journal Nurse Prescribing (2013)

Lifestyle Medicine Update August 14, 2016


Coenzyme Q10, commonly known as CoQ10, plays a pivotal role as a vitamin-like substance produced naturally within the human body. It is essential for converting food into energy in almost all cells. Unfortunately, as we age, our bodies natural production of CoQ10 declines. By the time we reach our 50s, this reduction in CoQ10 levels can contribute to the development of various health disorders. This article aims to shed light on the significance of CoQ10 in maintaining optimal health, particularly for the heart and explores its potential benefits in various health conditions.

The Heart-Muscle Connection

One critical aspect of CoQ10’s function is its impact on the heart muscle. As CoQ10 levels decline, our cells become less efficient in producing the necessary energy to maintain their function. This deficiency is particularly significant for the heart, which requires substantial energy to perform its continuous pumping action. Consequently, the heart muscle may gradually weaken, potentially leading to congestive heart failure as we age. Congestive heart failure is the leading cause of hospital admissions for people over 65.

However, research has shown that CoQ10 supplementation can reverse this condition and significantly improve cardiac function and quality of life in congestive heart failure patients. CoQ10 has been an approved treatment for congestive heart failure in Japan since the 1970s, underscoring its effectiveness in restoring heart muscle function. Analogous to inserting a missing piston back into a car’s engine, CoQ10 replenishment allows the heart muscle to pump optimally again, providing more strength and efficiency.

Lowering Blood Pressure and Reducing Plaque Build-Up

Beyond its impact on the heart muscle, CoQ10 supplementation has demonstrated benefits in reducing high blood pressure. Studies have shown that it can lower systolic blood pressure by an average of 17 points and diastolic pressure by 10. This effect is attributed to CoQ10’s ability to stimulate the release of nitric oxide in the artery walls, which promotes artery relaxation and improved blood circulation with reduced resistance.

Furthermore, CoQ10 acts as an antioxidant, preventing free radical damage to cholesterol in the bloodstream. By reducing plaque build-up in the artery walls, CoQ10 decreases the risk of heart attacks and ischemic strokes.

Managing Cholesterol-Lowering Statin Drugs Side Effects

CoQ10 supplementation has also been associated with reducing muscle pain, a common side effect of cholesterol-lowering statin drugs. Statin drugs block CoQ10 synthesis in the body, leading to potential CoQ10 depletion and increasing the risk of muscle damage and congestive heart failure. By taking CoQ10 supplements with statins, patients can help prevent these adverse effects and maintain their CoQ10 levels.

Wider Health Implications

Beyond cardiovascular health, CoQ10 has demonstrated potential benefits in managing Parkinson’s disease, fibromyalgia, migraines, and male infertility problems. Various clinical trials and studies support CoQ10’s positive role in preventing and managing cardiovascular disease. None of these studies have reported significant adverse effects following oral supplementation with CoQ10.

Optimizing CoQ10 Intake

For general health optimization, it is recommended that individuals over the age of 45 take at least 30 mg of CoQ10 daily, while those over 60 increase their daily dose to 60 mg. Most authorities suggest a daily intake of 90-100 mg for patients taking cholesterol-lowering statins to maintain CoQ10 levels in the body.

Patients with specific health conditions, such as congestive heart failure, high blood pressure, Parkinson’s disease, and fibromyalgia, may require therapeutic doses of CoQ10. In such cases, it is essential to incorporate CoQ10 into the overall medical management under the supervision of attending physicians.


In conclusion, Coenzyme Q10, or CoQ10, is a critical nutrient for maintaining energy production in almost all body cells. Its significance in heart health is particularly noteworthy, as it can help prevent and manage congestive heart failure, lower blood pressure, and reduce plaque build-up in arteries. Additionally, CoQ10 supplementation may alleviate muscle pain caused by cholesterol-lowering statin drugs.

This vitamin-like substance has shown promise in various other health conditions and is the subject of numerous peer-reviewed medical articles. Given the extensive research supporting its benefits and the absence of significant adverse effects, CoQ10 is a promising aid in preventing and managing cardiovascular diseases.

To delve deeper into CoQ10, you can access the research paper linked below for a comprehensive review of its applications and benefits.


Mantle D. Pharmacology of coenzyme Q10: Relevance to cardiovascular and other disorders. Nurse Prescribing. 2013; 11(12):602-607.

Dr. James Meschino


Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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