Understanding the Link: Phosphatidylserine and Memory Loss

As we age, our memory can sometimes falter, partly due to declining levels of phosphatidylserine—a crucial phospholipid found in brain cells’ outer membrane. Normally constituting 5-10% of brain phospholipids, maintaining adequate levels of phosphatidylserine throughout life is vital for youthful brain function.

Insights from Research: Phosphatidylserine Supplementation

A comprehensive review published in the journal Frontiers in Aging Neuroscience delved into the potential of phosphatidylserine supplementation in supporting brain health and tackling memory-related issues. The review highlights phosphatidylserine’s role in binding to various brain proteins, positively impacting brain function. Furthermore, it notes the association between abnormal phosphatidylserine regulation and neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, major depressive disorder, stroke, and autism spectrum disorder.

Evidence of Efficacy: Phosphatidylserine in Action

Numerous studies cited in the review demonstrate phosphatidylserine supplementation’s benefits for conditions like Alzheimer’s disease, major depressive disorder, Parkinson’s disease, and ADHD. Notably, phosphatidylserine supplementation has shown to reduce neuroinflammation, a common feature in neurodegenerative disorders. Moreover, clinical trials have indicated improvements in cognitive function and memory loss in older individuals, Alzheimer’s patients, and those with Parkinson’s disease.

Practical Applications: Memory Support Supplements

Considering the evidence, it’s suggested that individuals aged 50-55 or older consider incorporating memory support supplements containing phosphatidylserine, CDP-choline, Huperzine A, and Bacopa monnieri. These natural ingredients synergize to maintain youthful acetylcholine levels, inhibit age-related brain changes, and potentially alleviate memory loss associated with conditions like Mild Cognitive Impairment, early-stage Alzheimer’s, and Parkinson’s disease.

Looking Ahead: Proactive Memory Care

Rather than waiting for memory issues to arise, adopting a proactive approach by supplementing with memory support formulations after age 50 or 55 can be beneficial. These supplements not only guard against memory loss but also support overall brain function as one ages.

References:

1. Ma X et al. “Phosphatidylserine, inflammation, and central nervous system disease.” Frontiers in Aging Neuroscience. 2022: 14 (August 3, 2022). [Link](https://www.frontiersin.org/articles/10.3389/fnagi.2022.975176/full)
2. Kim BK and Park SK. “Phosphatidylserine modulates response to oxidative stress through hormesis and increases lifespan via DAF-16 in Caenorhabditis elegans.” Biogerontology. 2020; 21 (2): 231-244. [Link](https://pubmed.ncbi.nlm.nih.gov/31915963/#:~:text=Phosphatidylserine%20is%20one%20of%20the,Alzheimer’s%20disease%20in%20the%20elderly)