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LMU 38 – Unravelling the Potential of Omega-3 Fats and Antioxidants in Alzheimer’s Prevention: Insights from Groundbreaking Research

Omega-3 fats and antioxidant supplements prompt

LMU 38 – Unravelling the Potential of Omega-3 Fats and Antioxidants in Alzheimer's Prevention: Insights from Groundbreaking Research

Source: FASEB journal July 2015.

Lifestyle Medicine Update (January 18, 2017)


In the intricate realm of Alzheimer’s disease prevention, today’s spotlight rests on a research paper that graced the pages of the Federation of American Societies for Experimental Biology (FASEB) journal in July of 2015. The study, a groundbreaking human endeavor, sheds light on the profound impact of specific supplements in thwarting critical elements of Alzheimer’s disease progression. Within the current medical landscape, devoid of a definitive Alzheimer’s cure, the focus has shifted to proactive prevention as a primary line of defence against this pernicious cognitive affliction.

Deciphering Alzheimer’s Hallmarks: The Battle Against Beta-Amyloid Plaque

Central to the Alzheimer’s narrative lies the ominous presence of beta-amyloid plaque accumulation within the brain. Beyond its emblematic status, beta-amyloid plaque’s role extends to generating free radicals, hastening the disease’s march by inflicting destruction upon vital brain cells.

Omega-3 Fats and Alzheimer’s: Forging a Connection

The investigative journey traces its origins to prior evidence, which points towards certain omega-3 fats, notably DHA sourced from fish and fish oil. This compellingly suggests their role in mitigating beta-amyloid plaque production within the brain. Population studies further illuminate the panorama, spotlighting individuals who consistently embrace omega-3 fat consumption (approximately 500 mg daily) across their lifespan. Their resilience against Alzheimer’s disease as they age serves as a testament to these fats’ potential prowess.

The Vitamin E Factor: A Promising Shield

Vitamin E has also etched its mark in the Alzheimer’s defence realm. Noteworthy studies illustrate that Vitamin E supplementation, at the dose of 2,000 IU per day, has orchestrated a deceleration in Alzheimer’s disease progression. Whether administered singularly or synergistically with conventional Alzheimer’s medications, Vitamin E emerges as a potential ally in the battle against cognitive deterioration.

Venturing into Unchartered Territory: The FASEB Study

The cornerstone of our discourse rests within a pivotal study, gracing the pages of The FASEB journal, meticulously orchestrated by Milan Fiala and colleagues from the University of California/Los Angeles. The study’s focus hinged on 12 participants beset by minor cognitive impairment, two harboring pre-mild cognitive impairment, and seven grappling with full-fledged Alzheimer’s disease. Over a span of 4 to 17 months, these individuals embarked on a journey of supplementation, embracing omega-3 fatty acids and antioxidants.

Unveiling Immune Response: A Triumph in Alzheimer’s Prevention

The study’s orchestration heralded a triumph that echoed throughout the scientific community. Omega-3 fats and antioxidants not only elicited an immune response, but they also catalyzed a dynamic shift within the body’s immune cells. Monocytes, a subset of white blood cells, surged in their consumption of beta-amyloid plaque within the brain, mirroring a marked increase in response to omega-3 and antioxidant stimulus. The culmination materialized as a palpable reduction in beta-amyloid plaque levels, a resounding victory against Alzheimer’s pathogenesis.

Deciphering the Clinical Landscape: From Minor Cognitive Impairment to Alzheimer’s Disease

Looking more closely at the study, it becomes evident that the efficacy’s realm rests on a spectrum. The impact was most potent for those teetering on the precipice of cognitive decline, poised at the crossroads between minor cognitive impairment and the full embodiment of Alzheimer’s disease. The results cast a promising light on early memory loss and mild cognitive impairment, signifying a beacon of hope in Alzheimer’s prevention.

Translating Science into Practice: A Nutritional Arsenal

Embracing a tangible facet of this study involves a smart drink infusion, encompassing a synergistic blend:

  • 1000 mg DHA
  • 1000 mg EPA
  • Antioxidants hailing from pomegranate, chokeberry, and resveratrol
  • 400 IU of Vitamin D

Conclusions: A Glimmer of Promise in Alzheimer’s Prevention

The symphony of research underscores the formidable role of nutrition in forging a defence against Alzheimer’s disease. The convergence of omega-3 fats and antioxidants, as exhibited in the FASEB study, echoes the potential to deter beta-amyloid plaque buildup. This promising trajectory holds significance for us all as we chart a course towards Alzheimer’s prevention, particularly in the realm of early memory loss and mild cognitive impairment.


Omega-3 supplementation increases amyloid-beta phagocytosis and resolving d1 in patients with minor cognitive impairment. July 25, 2015. The FASEB journal vol 29 no.7:2681-2689.

Dr. James Meschino


Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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