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LMU 83 – Unlocking the Power of Leucine: A Small Molecule with a Mighty Impact on Muscle


LMU 83 – Unlocking the Power of Leucine: A Small Molecule with a Mighty Impact on Muscle

Source: American Journal of Clinical Nutrition (February 2018)

Lifestyle Medicine Update (March 17, 2018)


As the sands of time sweep us into the realm of aging, one universal truth stands firm: “little things make the big difference.” This adage resonates anew in the realm of scientific discovery, particularly in the research we’re exploring today. Nestled within the February 2018 edition of the American Journal of Clinical Nutrition, a revelation has unfolded—a revelation that holds the potential to reshape how we navigate the journey of growing older. This revelation comes in the form of an amino acid, a building block of life found in dairy products, which emerges as a powerful ally in the fight against the gradual decline of muscle mass and strength that plagues many as they age. This discovery is poised to mark a turning point, as it shines a spotlight on a seemingly small player with the ability to exert a monumental influence on our physical well-being.

The Battle Against Muscle Mass Decline: A New Contender Emerges

Aging, a profound journey marked by wisdom and experience, carries with it a less-welcomed companion: the gradual loss of muscle mass and strength. This decline, while seemingly inevitable, has drawn the attention of researchers and scientists who are striving to rewrite the narrative. The stark reality is that beyond the age of 40, a steady erosion of muscle mass and strength often begins, and by the time individuals reach their 60s, 70s, or 80s, the impact can be substantial. This process strips individuals of stability, predisposing them to falls, inhibiting the performance of daily tasks, and contributing to a slew of health issues including weight gain, pre-diabetes, type 2 diabetes, and its associated complications.

Unveiling the Science Behind Muscle Loss

The underpinning of this muscle mass decline is rooted in the hormonal shifts that occur with aging. Key hormones like Growth Hormone, Testosterone, Estrogen, Progesterone, and Insulin-like Growth Factor-1, known for their role in muscle development, take a hit as the aging process advances. The result? Our precious muscle mass becomes vulnerable to breakdown. However, amid this landscape of hormonal decline emerges a noteworthy contender: Leucine, an amino acid residing in dairy products. Leucine’s potency lies in its ability to activate muscle protein synthesis, even within the aging population. Remarkably, this action can counteract the age-related muscle loss—a revelation that carries profound implications for the well-being of older individuals.

Leucine: The Muscle Savior

What sets Leucine apart is its unique capability to initiate the mTOR pathway in muscle cells, a process that propels muscle protein synthesis into action. This phenomenon is so powerful that even individuals who don’t engage in exercise can witness the reversal of age-related muscle loss. Leucine emerges as the catalyst, triggering the cellular processes needed to restore muscle mass and amplify strength. Of course, when coupled with resistance training, Leucine’s impact is magnified, paving the way for a dynamic duo that reclaims the vitality of aging muscles.

The Magic Number: Unlocking Leucine’s Potential

So, how much Leucine is needed to harness its transformative effects? The answer underscores a significant issue: suboptimal Leucine intake across the aging population. With advancing years, protein and Leucine consumption tend to dwindle, often plummeting to a single protein-rich meal per day. However, a groundbreaking study published in the American Journal of Clinical Nutrition demonstrated that by simply ingesting 3-4 grams of Leucine during breakfast and lunch, a marked improvement in muscle mass and strength was observed among older participants—even those who abstained from resistance exercise. This revelation is particularly pertinent considering that the average older individual consumes less than 2 grams of Leucine during these meals. The goal? Elevate this intake to a target of 4 grams whenever feasible.

Incorporating Leucine: A Small Step with Profound Impact

Amid the quest to amplify daily Leucine intake, simple strategies emerge that promise to pack a punch in the battle against muscle loss. One such approach involves adding 4 ounces of non-fat Greek yogurt to both breakfast and lunch. This seemingly small act injects the missing 2 grams of Leucine while simultaneously introducing 8-9 grams of total protein—an equation primed to boost muscle health. Another effective avenue entails incorporating a daily whey protein shake, which brims with Leucine and a complementary blend of amino acids that bolster muscle protein synthesis. By blending one scoop or 25 grams of whey protein powder with water and ice cubes, the missing Leucine can be seamlessly integrated into daily nutrition, without the burden of excess calories.

A New Dawn of Strength and Vitality

As the threads of scientific inquiry are woven into the fabric of practical application, a new chapter emerges in the tale of aging. The revelation of Leucine’s power serves as a beacon of hope for those navigating the terrain of muscle loss. Amid the delicate dance of time, the potency of Leucine promises to preserve strength, safeguard muscle mass, and cultivate a higher quality of life. Indeed, it’s the little things, like a scoop of protein powder or a cup of Greek yogurt, which hold the potential to create the most significant difference in our journey through the tapestry of aging.


  1. American Journal of Clinical Nutrition (Feb 2018) – [Link to the study](
  2. Leucine in Greek Yogurt – [Link to source] (

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino


Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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