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LMU 102 – Soy (Genistein) Benefits for Fatty Liver and Health Improvement


LMU 102 – Soy (Genistein) Benefits for Fatty Liver and Health Improvement

Source: Clinical Nutrition (journal) August 2018

Lifestyle Medicine Update (September 1, 2018)


Soybeans contain isoflavones, including genistein and daidzein, which offer potential health advantages, from cancer prevention to cholesterol reduction.

Anti-Cancer and Cholesterol-Lowering Effects:

Isoflavones, particularly genistein, display anti-cancer properties and can help lower cholesterol, especially when replacing high-fat animal products in the diet.

Genistein’s Impact on Blood Sugar and Triglycerides:

A significant study published in Clinical Nutrition (August 2018) showcased genistein’s potential to enhance blood sugar regulation and reduce triglycerides in pre-diabetic patients with fatty liver (NASH).

Study Details and Results:

The double-blind clinical trial involved 82 subjects with pre-diabetes and NASH. Half took 250 mg of genistein supplement for 8 weeks, revealing improved blood sugar control, lowered triglyceride levels, reduced inflammation markers, and decreased oxidative stress.

Complementary Health Improvements:

Beyond blood sugar and triglyceride benefits, the genistein group also experienced reductions in belly fat and percentage body fat.

Natural Sources of Soy Isoflavones:

Regularly consuming soy-based foods (edamame, tofu, soy nuts, tempeh, etc.) can provide 50-75 mg of soy isoflavones daily. Replacing high-fat animal proteins with these options can improve cholesterol levels and reduce cancer risk.

Accumulative Benefits over Time:

Long-term consumption of soy isoflavones, including genistein, through dietary choices can offer accumulated health advantages by accumulating in key body tissues.

Considering Genistein Supplements:

If dealing with fatty liver, pre-diabetes, or type 2 diabetes, discussing the Clinical Nutrition study with a healthcare professional can help determine the potential benefits of incorporating a genistein supplement.

Conclusion: Leveraging Soy’s Power for Health Improvement

Soy, rich in genistein and isoflavones, presents a range of health benefits from combating cancer to enhancing blood sugar control and reducing triglycerides. Incorporating soy-based foods into the diet offers a natural way to reap these advantages, with the potential option of considering genistein supplements under medical guidance.


Amant S, Effekharri MH et al. Genistein supplementation improves insulin resistance and inflammatory state in non-alcoholic fatty liver patients: A Randomized, controlled trial. Clinical Nutrition. 2018. 37;4:1210-1215.

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino


Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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