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LMU 131 – The Unexpected Link: Glucosamine’s Heart-Protective Potential


LMU 131 – The Unexpected Link: Glucosamine's Heart-Protective Potential

Source: British Medical Journal (May 2019)

Lifestyle Medicine Update (June 5, 2019)


In the realm of health and wellness, the pursuit of effective strategies to prevent chronic conditions like joint arthritis is a common endeavor. However, a recent revelation has emerged, bridging the gap between joint health and cardiovascular wellness. A study published in the British Medical Journal in May 2019 has unearthed an intriguing connection—the possibility that regular glucosamine supplementation, often sought to manage joint pain and stiffness, might also harbor the potential to reduce the risk of heart attacks and strokes by an impressive 22%. This unexpected link beckons further exploration into the multifaceted benefits of glucosamine, underscoring its potential as a heart-protective agent.

From Joint Health to Heart Health: A Startling Discovery

Amid the panorama of health supplements, glucosamine has garnered popularity as a go-to remedy for joint-related ailments, with around 20% of adults aged 40 to 69 years turning to its potential benefits. However, the narrative took an unexpected turn with the emergence of a groundbreaking study in the British Medical Journal. The study delves into uncharted territory, suggesting that glucosamine’s effects may extend beyond joint health, encompassing the realm of cardiovascular wellness. Intriguingly, individuals who embraced daily glucosamine supplementation to alleviate joint discomfort were met with an astonishing revelation—their propensity to develop heart disease or experience a stroke was notably diminished.

Scientific Exploration: The Method Behind the Revelation

To unravel this intricate web of connections, researchers embarked on a rigorous journey. Their path involved analyzing the dietary patterns and lifestyles of a vast cohort of almost half a million adults aged 40 to 69 in the UK. This diverse group was followed for an average of seven years, allowing the researchers to discern patterns and correlations. The study’s scope extended beyond the realm of joint health, encompassing cardiovascular events, painting a comprehensive picture of the potential interplay between glucosamine supplementation and heart health.

Variables Considered: A Multifaceted Perspective

The research methodology left no stone unturned, considering an array of variables that could sway the outcomes. Factors ranging from age, gender, race, income, smoking, alcohol consumption, body mass index, body weight, physical activity levels, and dietary habits to the presence or absence of diabetes, high cholesterol, and high blood pressure were meticulously considered. The goal was to isolate the potential impact of glucosamine supplementation from the myriad factors that influence heart health.

The Revelation: A 22% Reduction in Risk

The study’s results unveiled a remarkable connection—one that holds the promise of transforming heart health paradigms. Those who faithfully incorporated glucosamine supplementation into their daily routines experienced a significant 22% reduction in the risk of mortality due to heart attacks or strokes. However, the researchers approach their findings with caution, acknowledging the complexity of the human body’s responses and the need for further exploration. Their statement underscores the necessity for clinical trials to substantiate the hypothesis and unlock the mechanisms that underlie this intriguing link.

Beyond the Study: The Science of Possibilities

This newfound correlation between glucosamine and cardiovascular wellness finds support from the scientific realm. Animal studies have unearthed a realm of possibilities, revealing that glucosamine may hold the power to extend lifespan and furnish protective effects against the onset of cardiovascular diseases. The substance’s potent anti-inflammatory properties serve as a plausible explanation for these findings. However, the intrigue doesn’t stop there. The researchers unveil the multifaceted nature of glucosamine’s potential, underscoring properties that could contribute to a reduced risk of heart attacks and strokes.

A Balancing Act: Realizing the Potential

While the findings of this study hold promise, it’s essential to view them within a broader context. The researchers emphasize the need for additional evidence before conclusively affirming glucosamine’s role in preventing heart diseases. The paramount importance of holistic heart health cannot be understated. Managing known risk factors, from cholesterol levels to blood pressure, and embracing a healthy lifestyle encompassing exercise, cessation of smoking, and balanced nutrition remain pivotal.

Conclusion: A Promising Pathway

As the curtain falls on this chapter of scientific inquiry, a newfound appreciation for glucosamine emerges—a substance that transcends its role in joint health. While not a standalone solution, the potential of glucosamine as a heart-protective agent is a beacon of hope. This revelation adds another proactive layer to the pursuit of cardiovascular wellness, offering individuals a potential avenue to complement their efforts and lower the risk of heart attacks and strokes.


Ma, H., Li, X., Zhou, T., et al. The BMJ: Association of habitual glucosamine use with risk of cardiovascular disease: Prospective study in UK Biobank.

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino


Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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