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LMU 132 – Unveiling the Immune Modulator: Vitamin D’s Role in Autoimmune Health


LMU 132 – Unveiling the Immune Modulator: Vitamin D's Role in Autoimmune Health

Source: Frontiers in Immunology (March 2019)

Lifestyle Medicine Update (June 15, 2019)


The intricate dance of the human immune system is a delicate balance that safeguards the body against invaders while preserving its own tissues. However, for around 6% of the population plagued by autoimmune diseases, this balance falters, leading to the immune system’s misdirected assault on its own cells. The emergence of new drugs in recent years has transformed the management of these conditions, but there’s an unexpected addition to the arsenal—vitamin D supplementation. In the evolving landscape of autoimmune health, vitamin D has emerged as a potential game-changer, with mounting evidence of its pivotal role in taming the immune response.

Autoimmune Ailments: The Battle Within

Autoimmune diseases cast a shadow over the lives of millions, as the immune system turns traitor, attacking normal tissues instead of defending them. From lupus to rheumatoid arthritis, these conditions can disrupt lives and health. In a bid to alleviate the burden, researchers and healthcare professionals have been exploring novel strategies, leading to the development of new drugs that tackle autoimmune conditions head-on. Amid these advancements, an unexpected contender has taken center stage—vitamin D.

Vitamin D’s Immune Influence: Unveiling the Mechanism

In recent years, the scientific community has uncovered a hitherto unforeseen facet of vitamin D’s role—it wields a direct impact on a specific type of immune cell known as dendritic cells. These cells are key instigators in the autoimmune process when they deviate from their intended path. Vitamin D, it seems, can step in as a regulator, influencing dendritic cells’ behavior. Research has highlighted the vitamin’s ability to inhibit the production and expression of co-stimulatory molecules and specific receptors on dendritic cells, molecules that fan the flames of inflammation, a hallmark of autoimmune diseases. By restraining these inflammation-propelling elements, vitamin D exerts a calming influence on the autoimmune cascade.

A New Chapter: Vitamin D and CD31 Adhesion Molecule

The narrative takes an intriguing turn in the March issue of the journal Frontiers in Immunology, where researchers unveil another layer of vitamin D’s immune-modulating prowess. Their study unveils a previously unknown role—encouraging dendritic cells to exhibit a molecule on their surface, known as the CD31 adhesion molecule. This molecule serves as a direct messenger of anti-inflammation to another key player in the immune symphony—the CD4 cell. In the tumult of autoimmune disease, dendritic cells and their counterparts orchestrate the transformation of CD4 cells into aggressive warriors that unleash torrents of inflammatory substances, triggering a domino effect of immune turmoil. By fostering the expression of CD31 molecules on dendritic cells’ surfaces, vitamin D indirectly communicates with CD4 cells, hindering them from rallying the immune troops against the body’s own tissues. CD31 assumes the role of an inhibitory messenger, curbing the inflammatory chorus that characterizes autoimmune conditions.

Clinical Wisdom: The Role of Rheumatologists

In the field of rheumatology, where autoimmune diseases hold sway, healthcare professionals are embracing the potential of vitamin D as a complementary tool. It’s not uncommon for rheumatologists to incorporate vitamin D supplementation into their treatment regimens. The rationale is clear—vitamin D’s multifaceted influence on the immune response resonates with the complex tapestry of autoimmune conditions. While a general guideline of 2,000 IU of vitamin D per day is often recommended, personalized approaches are gaining traction. Tailoring dosages based on the specific autoimmune disease and individual vitamin D levels optimizes the potential benefits.

From Prevention to Intervention: Vitamin D’s Spectrum

The connection between vitamin D levels and autoimmune risk is a subject of growing interest. Low vitamin D levels are closely associated with heightened susceptibility to autoimmune diseases. For those aiming at prevention, maintaining vitamin D blood levels within the range of 80 to 150 nmol/L (32 – 60 ng/ml) could be a strategic step. As the pieces of the puzzle fall into place, it’s becoming evident that vitamin D’s impact extends beyond immune modulation—it’s a guardian of autoimmune health.

Conclusion: A Promising Path Forward

As science delves deeper into the intricate nuances of the immune system, the role of vitamin D becomes ever more captivating. Its influence on dendritic cells and CD4 cells paints a vivid picture of immune orchestration. While vitamin D is not a panacea, it’s undoubtedly a piece of the puzzle in the realm of autoimmune health. As healthcare professionals fine-tune treatment plans and individuals strive for proactive wellness, vitamin D emerges as a potential ally, offering hope and new avenues in the fight against autoimmune diseases.


Louise Saul, Iris Mair, Alasdair Ivens, Pamela Brown, Kay Samuel, John D. M. Campbell, Daniel Y. Soong, Nadine Kamenjarin, Richard J. Mellanby. 1,25- dihydroxyvitamin D3 Restrains CD4 T Cell Priming Ability of CD11c Dendritic Cells by Upregulating Expression of CD31. Frontiers in Immunology, 2019; 10.3389/fimmu.2019.00600

Eat Smart, Live Well, Look Great

Dr. Meschino

Dr. James Meschino


Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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