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LMU 278 – Revitalizing the Mind: Navigating Alzheimer’s with Nicotinamide Ribose

LMU-278

Revitalizing the Mind: Navigating Alzheimer's with Nicotinamide Ribose

Source: Journal Aging Cell (December 14, 2022)

Lifestyle Medicine Update (March 8, 2023)

Introduction:

In the intricate tapestry of health, an elixir known as Nicotinamide Ribose (NR) emerges as a protagonist in the quest against Alzheimer’s disease. The tale begins with an illuminating study in the December 2022 edition of Aging Cell, revealing NR’s journey across the blood-brain barrier, weaving a narrative of hope in preventing cognitive decline.

The Symphony of Energy: NAD+ and the Brain

  • The Dance of Niacin (B3)
  • Niacin, a humble nutrient, transforms into Nicotinamide Adenine Dinucleotide (NAD+) within our cells, orchestrating a symphony crucial for energy production. As we age, however, this symphony falters, with declining NAD+ levels compromising optimal energy
    production and the activation of longevity genes.

  •  NR’s Entrance: A 2022 Overture
  • The 2022 study in Aging Cell whispers tales of NR’s entrance, showing promise in raising brain NAD+ levels. A daily supplement of 500 mg of Nicotinamide Ribose for six weeks painted a canvas of lower inflammation biomarkers, reduced amyloid plaque, and inhibited tau protein breakdown—key players in the Alzheimer’s narrative.

Decoding the Alzheimer’s Enigma: NAD+ and Brain Health

  • Sirtuins: The Epigenetic Guardians
  • Sirtuin genes, akin to epigenetic guardians, modulate brain genes, curbing inflammation, and thwarting the synthesis of amyloid plaque and tau protein coalescence. The decline in NAD+ levels sets the stage for Alzheimer’s hallmarks—brain inflammation, amyloid plaque synthesis, and tau protein entanglement.

  • NR’s Impact: A Symphony in the Blood
  • In a mesmerizing turn of events, NR supplementation demonstrated a significant decline in Alzheimer’s biomarkers within extracellular vesicles for neuronal origin (NEVs). These NEVs, originating from the brain, provided a window into the reduced risk of Alzheimer’s disease after NR’s six-week serenade.

A Glimpse into Tomorrow: NR and Alzheimer’s Prevention

  • Cognitive Aging and Research: A Beacon of Hope
  • The Delaware Center for Cognitive Aging and Research ventures further into the unknown, exploring NR’s potential to reverse early-stage memory loss. This ongoing exploration holds the promise of a groundbreaking chapter in Alzheimer’s prevention.

  • The Niacin Trilogy: NR, Nicotinamide, NMN
  • Beyond NR’s limelight, its cousins, nicotinamide and Nicotinamide Mononucleotide (NMN), join the stage, hinting at a trio of nutrients showing great promise in raising NAD+ levels.

The Personal Symphony: A Supplemental Prelude

  • Personal Wellness Symphony
  • In the personal symphony of health, a high-potency multiple vitamin and mineral supplement enriched with antioxidants becomes a daily overture. A B-50 complex, featuring 50 mg of niacin, takes center stage, showcasing its potential in preventing Alzheimer’s disease.

  • Sublingual Serenade: The Future of Nutrient Delivery
  • The stage is set for sublingual supplements—offering a lower dosage but direct absorption into the bloodstream. A future episode will delve into this novel nutrient delivery method, unlocking new possibilities for optimal health.

Epilogue: Niacin’s Melody in Alzheimer’s Prevention

As the curtain falls on this chapter, the promise of niacin supplementation, its metabolites, and the enchanting Nicotinamide Ribose echoes as a melody of hope in the symphony against Alzheimer’s disease.

References:

  1. Vreones M et al. [Oral nicotinamide ribose raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin.](https://onlinelibrary.wiley.com/doi/10.1111/acel.13754) Aging Cell. December 14, 2022.
  2. Nicotinamide Ribose supplement linked to reduced biomarkers for Alzheimer’s disease. [Neurosciencenews.com February 23, 2023](https://neurosciencenews.com/nicotinamide-riboside-alzheimers-22550/)

Eat Smart, Live Well, Look Great,

Dr. Meschino

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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