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LMU 292 – Exercise and Diabetes Prevention: Insights from a 2023 Study


Exercise and Diabetes Prevention: Insights from a 2023 Study

Source: British Journal of Sports Medicine (2023)

Lifestyle Medicine Update (June 14, 2023)


In today’s fast-paced world, health has become a paramount concern for individuals of all ages. Among various health-promoting practices, exercise stands out as one of the most effective preventive measures against a myriad of chronic diseases, including type 2 diabetes. The significance of exercise as preventive medicine has repeatedly been reiterated by healthcare professionals and researchers. In this context, the study published in the British Journal of Sports Medicine in 2023 by M. Luo et al. sheds new light on the association between exercise and diabetes risk, supplying valuable insights that can positively change public health policies and individual lifestyle choices.

Study Details

The research by M. Luo and colleagues involved a comprehensive analysis of data from the UK Biobank study. The UK Biobank, a large-scale biomedical database, has extensive health information from over 500,000 participants, including genetic data, lifestyle factors, and medical history. For this specific study, 59,325 adults were selected as the participants, making it one of the largest studies to investigate the relationship between physical activity and diabetes risk.

Researchers employed ultramodern technology to gather correct and reliable data on participants’ physical activity. Each participant was asked to wear an accelerometer, a small and portable device that accurately measures movements and physical activity levels. The accelerometers were worn for a prolonged period of seven years, allowing for a detailed examination of the participants’ daily activity patterns.

 Key Findings

The results of the study unveiled a striking correlation between physical activity and type 2 diabetes risk. Participants who engaged in moderate-to-vigorous physical activity for over one hour per day experienced a remarkable 74% reduction in the risk of developing type 2 diabetes compared to those who engaged in less than 5 minutes per day of such activity. This finding emphasizes the importance of incorporating regular, sustained, and moderately intense physical activity into daily routines to safeguard against the development of this prevalent metabolic disorder.

 Furthermore, the research delved deeper into the influence of genetic factors on diabetes risk. It is well-established that genetic predisposition plays a role in deciding an individual’s susceptibility to type 2 diabetes. However, the study’s intriguing revelation was that even individuals with a high genetic risk for type 2 diabetes could substantially mitigate their risk through consistent and substantial physical activity. Typically, individuals with a high genetic risk are believed to be 2.4 times more likely to develop type 2 diabetes; yet, the protective effects of exercise were still clear in this subgroup, offering hope and motivation for those who may be at higher risk due to their genetic makeup.

Comments from Researchers

One of the researchers involved in the study expressed enthusiasm over the potential implications of their findings. They said, We are unable to control our genetic risk and family history, but this finding provides promising and positive news that through an active lifestyle, one can ‘fight off’ much of the excessive risk for type 2 diabetes. This optimistic outlook resonates with the growing body of research that underscores the transformative power of lifestyle interventions.

Benefits of Moderate-to-Vigorous Exercise for Diabetes Prevention

The study findings raise the question: How does moderate-to-vigorous exercise exert its protective effects against diabetes? To answer this, we must explore the physiological changes that occur during physical activity:

  1. Improving Insulin Sensitivity:

    Insulin, a hormone produced by the pancreas, plays a crucial role in regulating blood glucose levels. Insulin sensitivity refers to how effectively our cells respond to insulin’s action in transporting glucose from the bloodstream into cells. Regular exercise enhances insulin sensitivity, which allows the body to use glucose more efficiently, ultimately reducing blood sugar levels and lowering the risk of diabetes.

  2. Enhancing Fat-Burning:

    Obesity and excess body weight are proven risk factors for insulin resistance, a condition where cells become less responsive to insulin. Engaging in moderate-to-vigorous physical activity promotes fat burning and helps prevent weight gain, thus reducing the risk of developing insulin resistance and type 2 diabetes.

  3. Activation of Sirtuin Longevity Genes:

    Sirtuins are a group of proteins that regulate various cellular processes, including those involved in metabolism and aging. Some sirtuins are known to be involved in regulating insulin sensitivity and glucose metabolism. Exercise activates these longevity genes, positively affecting overall cardiometabolic health and reducing the likelihood of developing diabetes.


The findings of the 2023 study published in the British Journal of Sports Medicine reinforce the idea that our genes do not solely decide our destiny. While genetic factors can influence disease risk, lifestyle choices and behaviors have the power to modulate gene expression and influence health outcomes significantly. Regular, moderate-to-vigorous physical activity can combat the risk of type 2 diabetes and improve overall health and quality of life.

These insights hold profound implications for public health initiatives, healthcare providers, and individuals alike. Encouraging and promoting physical activity should be a cornerstone of preventive healthcare strategies to tackle the growing burden of diabetes and other chronic diseases. The integration of exercise into daily routines is not only an investment in individual health but also an investment in the well-being of societies at large.

In conclusion, the study serves as a clarion call to action, urging individuals to embrace an active lifestyle and empowering them to take charge of their health destinies. As we navigate the challenges of modern living, let us not forget the simple yet transformative power of exercise in promoting health, longevity, and a vibrant quality of life.


Luo M et al. Accelerometer-measured intensity-specific physical activity, genetic risk, and incident type 2 diabetes: A prospective study. Br J Sports Med. (2023) Accelerometer-measured intensity-specific physical activity, genetic risk, and incident type 2 diabetes: a prospective cohort study | British Journal of Sports Medicine (

Exercise Mitigates Genetic Risk for Type 2 Diabetes. (June 5, 2023) Exercise Mitigates Genetic Risk for Type 2 Diabetes – Neuroscience News

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Dr. James Meschino


Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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