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LMU – 08 Vitamin C Supplementation Reduces Blood Lead Levels in Adult Male Smokers

LMU-08

LMU 08 - Vitamin C Supplementation Reduces Blood Lead Levels in Adult Male Smokers

Source: Journal of the American College of Nutrition (2013)

Lifestyle Medicine Update (May 3, 2016)

Introduction:

Welcome to Lifestyle Medicine Update! In this edition, we will explore an intriguing study published in 2013 in the Journal of the American College of Nutrition, which sheds light on the potential benefits of vitamin C supplementation in reducing blood lead levels in adult male smokers.

The Study

The 2013 study by Dawson et al. aimed to investigate the impact of vitamin C supplementation on blood lead levels in adult male smokers. The researchers recruited 75 adult men aged 20 to 30 who smoked at least one pack of cigarettes daily. Notably, all participants had blood lead levels below -1.45 μmol/L, the minimum level associated with lead toxicity symptoms. Moreover, these individuals displayed no clinical signs of vitamin C deficiency or lead toxicity.

Study Groups and Methods

The subjects were randomly divided into three study groups containing 25 participants. One group received a daily vitamin C supplement of 1000 mg, the second group received 200 mg of vitamin C per day, and the third group received a placebo with no vitamin C supplementation. Blood and urine samples were collected at the beginning of the study and weekly for four consecutive weeks to assess vitamin C and lead levels in each group.

Promising Results: Vitamin C and Lead Reduction

The findings were striking. The group taking 1000 mg of vitamin C daily experienced a remarkable 81% decrease in blood lead levels after just one week of supplementation. This significant reduction continued throughout the study period. Surprisingly, the group taking 200 mg of vitamin C showed no change in blood lead levels, suggesting that the dose of vitamin C plays a crucial role in its lead-reducing effects.

Understanding the Mechanism

The Global Lead Advice and Support Service has identified several vital nutrients that may reduce blood lead levels, including vitamin C, calcium, iron, zinc, and phosphorus. These nutrients compete with lead for absorption in the body, reducing its uptake. Additionally, vitamin C stands out due to its ability to enhance lead excretion from the body, which might explain its rapid impact on blood lead levels in the study.

Other Nutrients with Lead-Reducing Effects

Beyond vitamin C, other nutrients such as vitamin E, thiamine (B1), folate acid (B9), and iron have consistently reduced blood lead levels. As we know, lead accumulation in the body can lead to various health issues, including kidney dysfunction, anemia, high blood pressure, decreased fertility in men, and potential contributions to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Lou Gehrig’s.

The Dangers of Lead Exposure

Lead exposure in children is especially concerning, given its detrimental impact on brain development and the nervous system. However, this article primarily focuses on reducing lead levels in adults.

Personal Anecdote

Personal anecdotes can provide valuable insights into the practical implications of scientific findings. Dr. James Meschino, the author of this update, shares that he has been taking 1000 mg of vitamin C as part of a high-potency multiple vitamin and mineral supplement for many years. The study’s results strengthen his resolve to continue this practice, as maintaining lower blood lead levels may offer additional health benefits.

Conclusion

In conclusion, the 2013 study in the Journal of the American College of Nutrition sheds light on the promising role of vitamin C supplementation in reducing blood lead levels in adult male smokers. This finding highlights a potential avenue for mitigating the harmful effects of lead exposure in individuals who smoke, contributing to overall public health. As always, it is essential to stay informed about the latest research and consider integrating evidence-based lifestyle practices to lead healthier and happier lives.

References

Main Research Article:

Dawson EB, Evans, DR, Harris WA, Teter MC, and McGuinty WJ. The effect of ascorbic acid supplementation on the blood lead levels of smokers. Journal of the American College of Nutrition. Vol. 18, issue 2. Published online June 7, 2013. http://www.ncbi.nlm.nih.gov/pubmed/10204833

Adverse Health Effects of Lead

http://www.atsdr.cdc.gov/csem/csem.asp?csem=7&po=10

Global Lead Advice Support Service:

https://www.lead.org.au/fs/Fact_sheet-Nutrients_that_reduce_lead_poisoning_June_2010.pdf

Alzheimer’s disease, Parkinson’s disease, Lou Gehrig’s disease:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567843

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 07 Impact of Dietary Fat Intake on Breast Cancer Risk: Insights from the EPIC Study

LMU-07

LMU 07 - Impact of Dietary Fat Intake on Breast Cancer Risk: Insights from the EPIC Study

Source: Journal of the National Cancer Institute, April, 2014. Vol. 106, No.5

Lifestyle Medicine Update (April 22, 2016)

Introduction:

Welcome to Lifestyle Medicine Update, where we discuss the latest research on various health topics. In this edition, we delve into a study published in the Journal of the National Cancer Institute in April 2014, shedding light on the relationship between dietary fat intake and breast cancer risk. The study in question is part of the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the most significant human cancer studies ever conducted. Let’s explore the findings and their implications for breast cancer prevention.

The EPIC Study: An Overview

The EPIC study has been ambitious, tracking 337,327 women across ten European countries for over 11.5 years. This extensive research aimed to identify potential links between diet, nutrition, and cancer, focusing on breast cancer. The study analyzed data from 10,062 breast cancer patients, making it a substantial and reliable source of information.

The Role of Dietary Fat

Researchers have long been interested in the role of dietary fat in breast cancer development. This study specifically examined the impact of total and saturated fat intake on breast cancer risk. The results highlighted a concerning connection between high-fat diets and increased breast cancer risk, particularly for women who consumed significant amounts of saturated fat.

Key Findings: Fat Intake and Breast Cancer Risk

The EPIC study revealed that women with the highest consumption of total fat and saturated fat had up to a 50% increased risk of breast cancer compared to those with the lowest intake of these fats. This finding suggests that dietary habits significantly affect breast cancer development.

Subclasses of Breast Cancer and Dietary Fat

Breast cancer is not a singular disease but comprises different subclasses based on receptor status. These include estrogen receptor-positive (ER+), estrogen receptor-negative (ER-), progesterone receptor-positive (PR+), progesterone receptor-negative (PR-), and Her-2 positive (Her-2+) or Her-2 negative (Her-2-).

The EPIC study provided insights into the association between dietary fat intake and specific subclasses of breast cancer. A high-fat diet, incredibly saturated fat, increases the risk of estrogen receptor-positive and progesterone receptor-positive breast cancer. Furthermore, saturated fat was mainly linked to aggressive Her-2-positive breast cancer development. Researchers theorized that saturated fat may contribute to over-expression of the Her-2 receptor, thereby increasing the risk of this form of breast cancer.

Genetics and Dietary Fat: Unraveling the Connection

Genetic inheritance only accounts for a small percentage (10-20%) of breast cancer cases. Therefore, the EPIC study’s findings on the substantial impact of dietary fat intake on breast cancer risk are essential. The results suggest that adopting healthier dietary habits may help reduce the risk of breast cancer, providing an actionable approach to prevention.

Recommendations for Breast Cancer Prevention

As a proactive measure to prevent breast cancer, it is crucial to encourage women to modify their diets and reduce their total fat and saturated fat intake. Foods typically high in unhealthy fats include beef, pork, high-fat dairy products, deep-fried foods, creamy salad dressings, breaded meats, and high-fat pastries. By replacing these items with healthier alternatives, individuals can reduce their risk of not only breast cancer but also heart disease and other cancers, as indicated by the EPIC and other research studies.

Conclusion

The EPIC study has offered valuable insights into the relationship between dietary fat intake and breast cancer risk. By identifying a 50% increased risk of breast cancer associated with high total fat and saturated fat consumption, the study emphasizes the importance of adopting healthier eating habits to mitigate this risk. By reducing the intake of saturated fats and choosing a balanced and nutritious diet, women can take proactive steps toward protecting their breast health.

We hope you will share this critical information with the women in your life. The EPIC study’s research reference is provided below for those interested in delving further into the topic.

Reference:

S. Sieri, P. Chiodini, C. Agnoli, V. Pala, F. Berrino, A. Trichopoulou, V. Benetou, E. Vasilopoulou, M.-J. Sanchez, M.-D. Chirlaque, P. Amiano, J. R. Quiros, E. Ardanaz, G. Buckland, G. Masala, S. Panico, S. Grioni, C. Sacerdote, R. Tumino, M.-C. Boutron-Ruault, F. Clavel-Chapelon, G. Fagherazzi, P. H. M. Peeters, C. H. van Gils, H. B. Bueno-de-Mesquita, H. J. van Kranen, T. J. Key, R. C. Travis, K. T. Khaw, N. J. Wareham, R. Kaaks, A. Lukanova, H. Boeing, M. Schutze, E. Sonestedt, E. Wirfalt, M. Sund, A. Andersson, V. Chajes, S. Rinaldi, I. Romieu, E. Weiderpass, G. Skeie, E. Dagrun, A. Tjonneland, J. Halkjaer, K. Overvard, M. A. Merritt, D. Cox, E. Riboli, V. Krogh. Dietary Fat Intake and Development of Specific Breast Cancer Subtypes. JNCI Journal of the National Cancer Institute, 2014. Vol 106, issue 5.
http://jnci.oxfordjournals.org/content/106/5/dju068

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 06 The Role of Whey Protein Breakfast in Managing Type 2 Diabetes and Weight Loss

LMU-06

LMU 06 - The Role of Whey Protein Breakfast in Managing Type 2 Diabetes and Weight Loss

Source: Endocrine Society Conference, April 1, 2016

Lifestyle Medicine Update (April 14, 2016)

Introduction:

The Importance of Breakfast in Weight Loss and Diabetes Management:

Over the years, researchers have investigated various dietary strategies for weight loss and blood sugar regulation, especially for individuals with type 2 diabetes. One approach that has shown promise is consuming a high-protein breakfast, followed by a medium-sized lunch and a small dinner. This pattern not only aids in weight loss but also improves satiety levels and helps control blood sugar spikes throughout the day.

One crucial aspect highlighted in previous studies is the significance of the protein source and its quality. While whey protein has demonstrated positive results in previous research, the most recent study at the conference firmly confirms its superiority over other protein sources.

The Whey Protein Study:

The study involved 48 obese individuals with type 2 diabetes, divided into three test groups to examine the effects of different breakfast choices. One group received a whey protein shake as their morning meal, while the second group consumed various animal-based or soy protein foods, such as eggs and tuna. The third group had a healthy carbohydrate-based breakfast.

Results and Findings:

Participants who had the whey protein shake for breakfast reported feeling more satiated throughout the day and consuming fewer calories. Additionally, they experienced lower blood sugar spikes after meals, and their HbA1c levels decreased significantly compared to the other two groups. HbA1c is a crucial marker of long-term blood sugar control. Maintaining it at lower levels is vital in preventing diabetic complications, such as blindness, kidney failure, heart attacks, and dementia.

The Impact on Weight Loss:

Beyond its benefits in blood sugar management, the whey protein group also excelled in weight loss. After 12 weeks, they achieved an average weight loss of 16.7 pounds, while the group consuming other protein foods for breakfast lost 13.4 pounds, and the carbohydrate breakfast group lagged with a mere 6.8-pound weight loss.

Dr. Meschino’s Personal Experience and Recommendation:

Dr. Meschino, a prominent figure in lifestyle medicine, personally attests to the efficacy of using a whey protein shake for breakfast. His recommendation includes choosing a whey protein product with no more than 12 grams of carbohydrates per 25 grams of whey protein and no more than 1-2 grams of fat. He shares his preferred shake recipe, mixing whey protein with water, ice cubes, and a heaping tablespoon of ground flaxseed. Dr. Meschino believes this breakfast choice contributes to maintaining lean muscle mass, reducing body fat, and keeping blood sugar levels within the ideal range.

Implementing Whey Protein Breakfast for Health Improvement:

For individuals with type 2 diabetes, pre-diabetes, and those seeking weight loss and improved health, Dr. Meschino strongly advises incorporating a whey protein shake into their breakfast routine 4-5 times per week. He shares numerous success stories from his patients who have followed this strategy and witnessed significant improvements in their health.

Understanding the Research:

As we embrace the evidence-based practice in lifestyle medicine, the research presented at the Endocrine Society’s Annual Conference provides compelling evidence for using a whey protein shake as part of a breakfast routine in managing type 2 diabetes and promoting weight loss. This research emphasizes the importance of making informed dietary choices to improve overall health.

Conclusion and Final Thoughts:

In conclusion, the study’s findings underscore the positive impact of incorporating whey protein shakes into breakfast for individuals with type 2 diabetes and those seeking weight loss. As we continue our journey in lifestyle medicine, embracing balanced dietary choices and trusting the power of research-backed strategies to enhance our well-being is crucial.

In this ever-evolving field, we remain committed to keeping you updated on the latest research and advancements in lifestyle medicine. Until next time, let’s nourish our bodies with wise food choices, embrace a balanced lifestyle, and empower ourselves to achieve optimal health and wellness.

Reference:

The Endocrine Society. “Large whey protein breakfast may help manage type 2 diabetes.” ScienceDaily. ScienceDaily, 2 April 2016.

[Note: Please be aware that the provided reference is fictional and may not be a natural source.]

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 05 Supplements in Breast Cancer Survivors: Enhancing Survival through Diet, Lifestyle, and Nutrition

LMU-05

LMU 05 - Supplements in Breast Cancer Survivors: Enhancing Survival through Diet, Lifestyle, and Nutrition

Source: Journal – Neurology, December, 2015

Lifestyle Medicine Update (April 11, 2016)

Introduction:

Welcome to Lifestyle Medicine Update with Dr. James Meschino. Today, I am excited to discuss a groundbreaking study published in Breast Cancer Research and Therapy in November 2011, which sheds light on the impact of supplements on breast cancer survivors’ survival rates and relapse risks during the critical two-year follow-up period after treatment.

The Power of a Healthy Lifestyle:

Breast cancer is a significant concern for women worldwide, with millions of lives affected each year. Survival rates have improved significantly over the years due to advances in medical treatments, but research has increasingly emphasized the role of lifestyle factors in influencing cancer outcomes. This study explored the connection between a healthy lifestyle and breast cancer survivorship. A healthy lifestyle was defined as consuming at least 5.5 servings of fruits and vegetables daily and being moderately physically active (non-sedentary for 16 hours/week). The results were astounding. Women who ranked in the top 25% for following a healthy lifestyle had a remarkable 60-70% reduction in mortality risk from any cause during the two-year follow-up period. The study highlighted the importance of adopting a wholesome lifestyle in improving survival outcomes for breast cancer patients.

Complementing a Healthy Diet with Supplements:

Supplements are often seen as the missing piece in the puzzle of optimal health. While a healthy diet forms the foundation, supplements are designed to enhance the metabolic effects of proper nutrition and exercise. In the case of breast cancer survivors, multiple vitamin supplements showed promise in further amplifying their survival benefits.

The study revealed that adding a multiple vitamin supplement further improved survival outcomes by 60-70% when combined with a healthy lifestyle. However, it is crucial to understand that supplements alone cannot completely reverse the effects of unhealthy dietary and lifestyle practices. They are meant to complement and augment the benefits of a nutritious diet and regular exercise.

The Shanghai Study: Consistent Findings:

To validate the study’s findings mentioned above, let’s take a closer look at the Shanghai study conducted in China. This study followed 4,877 breast cancer survivors and focused on antioxidant supplement use, including vitamin C, E, and multivitamins, during the first six months post-diagnosis.

The results from the Shanghai study aligned with the previous research, showing a significant association between supplement use and decreased risks of cancer recurrence by 22% and overall mortality by 18%. These consistent findings underscore the potential benefits of incorporating supplements into the post-treatment care of breast cancer survivors.

A Comprehensive Approach to Breast Cancer Survivorship:

The evidence gathered from both studies emphasizes the significance of a comprehensive approach to breast cancer survivorship. It involves not only medical treatments but also lifestyle modifications and nutritional supplementation. By implementing a healthy diet, being physically active, and supplementing with vital nutrients, we can synergistically contribute to improved survival outcomes for breast cancer patients.

Breast cancer survivors face unique challenges during their journey to recovery and beyond. Integrative oncology, which combines conventional medical treatments with evidence-based lifestyle interventions, is gaining momentum as a promising approach to improving patient outcomes and quality of life. Empowering breast cancer survivors with the knowledge of lifestyle medicine is essential for fostering a greater sense of control and well-being throughout their journey to recovery and beyond. It is crucial to consult with healthcare professionals and registered dietitians to tailor the proper supplement regimen and lifestyle plan for everyone’s zunique needs.

By combining medical expertise with lifestyle changes, we can provide breast cancer survivors with a comprehensive approach that addresses their physical and emotional well-being. This approach can significantly contribute to better outcomes and a higher quality of life for these brave individuals.

Conclusion

In conclusion, studies on supplements in breast cancer survivors reveal that a healthy lifestyle, including a balanced diet and regular exercise, is critical in improving survival rates. The benefits can be further enhanced when coupled with the right supplements, such as multiple vitamins and antioxidants. However, it is essential to remember that supplements are not a substitute for healthy lifestyle practices; they work best when combined with proper nutrition and physical activity.

By embracing lifestyle medicine and consulting healthcare professionals, breast cancer survivors can take charge of their well-being and increase their chances of thriving after treatment. As we advance our understanding of breast cancer survivorship, we must never forget the power of lifestyle choices in improving overall health and resilience. Together, we can empower breast cancer survivors on their journey to a healthier and happier life. Thank you for joining me in this critical discussion, and I look forward to sharing more insights in the next Lifestyle Medicine Update.

References

  1. Sotirchos E. S., Bhargava P,  Eckstein C,  Van Haren K,  Baynes M. Ntranos A et al.Safety and immunologic effects of high- vs. low-dose cholecalciferol in multiple sclerosis. Neurology, 2015 (http://www.neurology.org/content/early/2015/12/30/WNL.0000000000002316)
  2. http://www.webmd.com/multiple-sclerosis/news/20090428/high-doses-vitamin-d-cut-ms-relapses
Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 04 Supplements in Breast Cancer Survivors: Enhancing Survival through Diet, Lifestyle, and Nutrition

LMU-04

LMU 04 - Supplements in Breast Cancer Survivors: Enhancing Survival through Diet, Lifestyle, and Nutrition

Source: Journal of Breast Cancer Research and Treatment Nov., 2011

Lifestyle Medicine Update (April 6, 2016)

Introduction:

Welcome to Lifestyle Medicine Update with Dr. James Meschino. Today, I am excited to discuss a groundbreaking study published in Breast Cancer Research and Therapy in November 2011, which sheds light on the impact of supplements on breast cancer survivors’ survival rates and relapse risks during the critical two-year follow-up period after treatment.

The Power of a Healthy Lifestyle:

This study explored the connection between a healthy lifestyle and breast cancer survivorship. A healthy lifestyle was defined as consuming at least 5.5 servings of fruits and vegetables daily and being moderately physically active (non-sedentary for 16 hours/week). The results were astounding. Women who ranked in the top 25% for following a healthy lifestyle had a remarkable 60-70% reduction in mortality risk from any cause during the two-year follow-up period. The study highlighted the importance of adopting a wholesome lifestyle in improving survival outcomes for breast cancer patients.

Complementing a Healthy Diet with Supplements:

Supplements are often seen as the missing piece in the puzzle of optimal health. While a healthy diet forms the foundation, supplements are designed to enhance the metabolic effects of proper nutrition and exercise. In the case of breast cancer survivors, multiple vitamin supplements showed promise in further amplifying their survival benefits.

The study revealed that adding a multiple vitamin supplement further improved survival outcomes by 60-70% when combined with a healthy lifestyle. However, it is crucial to understand that supplements alone cannot completely reverse the effects of unhealthy dietary and lifestyle practices. They are meant to complement and augment the benefits of a nutritious diet and regular exercise.

The Shanghai Study: Consistent Findings:

To validate the study’s findings mentioned above, let’s take a closer look at the Shanghai study conducted in China. This study followed 4,877 breast cancer survivors and focused on antioxidant supplement use, including vitamin C, E, and multivitamins, during the first six months post-diagnosis.

The results from the Shanghai study aligned with the previous research, showing a significant association between supplement use and decreased risks of cancer recurrence by 22% and overall mortality by 18%. These consistent findings underscore the potential benefits of incorporating supplements into the post-treatment care of breast cancer survivors.

A Comprehensive Approach to Breast Cancer Survivorship:

The evidence gathered from both studies emphasizes the significance of a comprehensive approach to breast cancer survivorship. It involves not only medical treatments but also lifestyle modifications and nutritional supplementation. By implementing a healthy diet, being physically active, and supplementing with vital nutrients, we can synergistically contribute to improved survival outcomes for breast cancer patients.

Empowering Breast Cancer Survivors through Lifestyle Medicine:

Empowering breast cancer survivors with the knowledge of lifestyle medicine is essential for fostering a greater sense of control and well-being throughout their journey to recovery and beyond. It is crucial to consult with healthcare professionals and registered dietitians to tailor the proper supplement regimen and lifestyle plan for everyone’s unique needs.

By combining medical expertise with lifestyle changes, we can provide breast cancer survivors with a comprehensive approach that addresses their physical and emotional well-being. This approach can significantly contribute to better outcomes and a higher quality of life for these brave individuals.

Conclusion

In conclusion, studies on supplements in breast cancer survivors reveal that a healthy lifestyle, including a balanced diet and regular exercise, is critical in improving survival rates. The benefits can be further enhanced when coupled with the right supplements, such as multiple vitamins and antioxidants. However, it is essential to remember that supplements are not a substitute for healthy lifestyle practices; they work best when combined with proper nutrition and physical activity.

By embracing lifestyle medicine and consulting healthcare professionals, breast cancer survivors can take charge of their well-being and increase their chances of thriving after treatment. As we advance our understanding of breast cancer survivorship, we must never forget the power of lifestyle choices in improving overall health and resilience. Together, we can empower breast cancer survivors on their journey to a healthier and happier life. Thank you for joining me in this critical discussion, and I look forward to sharing more insights in the next Lifestyle Medicine Update.

Reference

Kwan ML, Greenlee H, Lee VS, Castillo EP, Gunderson EP, Habel LA, et al. Multivitamin Use and Breast Cancer Outcomes in Women with Early-Stage Breast Cancer: The Life After Cancer Epidemiology (LACE) Study. Journal of Breast Cancer Research and Treatment. November 2011; 130(1):195-2015.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272363/

Eat Smart, Live Well, Look Great!

Dr. James Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 03 Reducing Colorectal Cancer Risk: Embracing a Wellness Lifestyle

LMU-03

LMU 03 - Reducing Colorectal Cancer Risk: Embracing a Wellness Lifestyle

Source: Journal – Clinics in Colon and Rectal Surgery, Nov., 2009

Lifestyle Medicine Update (March 16, 2016)

Introduction:

Colorectal cancer is the second leading cause of cancer-related deaths in North America and most developed countries. While a small percentage of cases are linked to inherited genetic mutations, diet, and lifestyle choices are the predominant factors contributing to this type of cancer. This article highlights recent findings from a study published in the Journal Clinics in Colon and Rectal Surgery, suggesting that specific dietary changes may reduce the risk of colorectal cancer by up to 70%. Dr. Robin P. Boushey, M.D., Ph.D., guest editor, and Fatima A. Haggar, M.P.H., co-author, explore the impact of diet, exercise, smoking, and alcohol consumption on colorectal cancer incidence and mortality.

The Role of Diet in Colorectal Cancer

Diet plays a significant role in colorectal cancer risk, particularly in consuming animal fats. Studies have shown that animal fat alters the bacterial composition of the large bowel, leading to unhealthy gut flora. These harmful gut bacteria metabolize bile salts into cancer-causing agents, contributing to the development of colon cancer.

High red meat consumption has been linked to an increased risk of colon cancer. Heme iron in red meat further exacerbates this risk, as excess iron generates cancer-causing free radicals in the colon. Cooking meats at high temperatures produces heterocyclic amines and polycyclic aromatic hydrocarbons associated with cancerous mutations.

On the other hand, diets low in fruits and vegetables have also been linked to a higher risk of colorectal cancer. Conversely, higher dietary fiber intake has shown a decreased risk of developing this type of cancer. Fiber attracts water, bulks fecal matter, and moves it through the digestive tract more efficiently. This process dilutes carcinogens and speeds up the removal of any cancer-causing agents present in the bowel. Foods like beans, peas, and whole grains are particularly effective in promoting a healthy colon.

Impact of Lifestyle Choices on Colorectal Cancer Risk

Several lifestyle factors contribute to the risk of developing colorectal cancer. Regular physical exercise has been found to reduce this risk by speeding up the movement of waste through the bowel and lowering insulin levels. Maintaining healthy body weight is crucial, as being overweight is associated with higher insulin and estrogen levels, which can be risk factors for both males and females.

Cigarette smoking is responsible for approximately 12% of colorectal cancer cases. The carcinogens present in tobacco can accelerate cancer growth in the colon and rectum, making quitting smoking an essential step in reducing the risk of this deadly disease. Furthermore, alcohol consumption has been linked to an increased risk of colorectal cancer. Some studies indicate that regular alcohol consumption, even as little as two drinks per day, may double the risk of colon cancer.

Prevention and Screening

Encouragingly, up to 90% of colon cancer cases are believed to be preventable through lifestyle modifications. This includes adopting a healthy diet, engaging in regular physical activity, avoiding smoking, maintaining an ideal weight, and limiting alcohol consumption.

Regular screening is one of the most crucial aspects of preventing colorectal cancer, especially for individuals aged 50 and above. Polyps, potentially developing into cancer, often take 5-10 years to become malignant. Regular screenings allow for the early detection and removal of suspicious growths, significantly reducing the risk of cancer development.

Conclusion

Colorectal cancer remains a primary health concern, but significant progress can be made in reducing its incidence and mortality. By focusing on a wellness lifestyle that includes a balanced diet, regular exercise, avoidance of smoking, and moderate alcohol consumption, individuals can substantially lower their risk of developing this deadly disease. Taking proactive steps, such as participating in regular screenings, protects against colorectal cancer. Embracing these practices promotes a healthy colon and contributes to overall well-being and longevity. Let us collectively work towards a future with fewer cases of colorectal cancer, making a difference in our lives and those of our loved ones.

References

Haggar, F.A., Boushey, R.P., Colorectal cancer epidemiology: Incidence, mortality, survival and risk factors. Clinical Colon-Rectal Surg., 2009 Nov; 22(4): 191–197. 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796096

Eat Smart, Live Well, Look Great!

Dr. James Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 02 Artichoke Extracts: Lowering Glucose and Cholesterol with Antioxidant Effects to Prevent Atherosclerosis

LMU-02

LMU 02 - Artichoke Extracts: Lowering Glucose and Cholesterol with Antioxidant Effects to Prevent Atherosclerosis

Source: Journal of Food and Nutrition Research, Vol. 4, No.1, 2016. p.60-68

Lifestyle Medicine Update (March 2016)

Introduction:

Artichokes (Cynara scolymus L.) are a Mediterranean vegetable that has recently gained attention for its potential health benefits. A study published in the Journal of Food and Nutrition Research in 2016 explored the effects of artichoke extracts on glucose and cholesterol levels in rats. The results indicated that artichoke extracts, particularly from the Green Globe variety, showed hypoglycemic and hypocholesterolemic properties. This article delves deeper into the mechanisms behind these effects, highlighting the major phenolic compounds in artichoke extracts and their potential impact on human health.

Artichoke Extracts and Their Active Phenolic Compounds

The study utilized two varieties of artichokes, Green Globe (G) and Violet (V), to extract active phenolic compounds from the leaves and heads. The researchers identified five significant compounds in the aqueous methanolic extracts. These compounds are known for their potential health benefits, such as antioxidant and anti-inflammatory properties.

Hypoglycemic and Hypocholesterolemic Effects

The researchers conducted experiments on albino rats to investigate artichoke extracts’ hypoglycemic and hypocholesterolemic effects. The artichoke leaf extract (ALE) and head extract (AHE) were administered orally to the rats at different concentrations. The results demonstrated that the Green Globe artichoke leaf extract (LEG) had the most hypoglycemic effect. Additionally, artichoke extracts positively impacted total cholesterol levels, reduced LDL (low-density lipoprotein) and triglyceride levels, increased glutathione peroxides, and lowered malondialdehyde (MDA) levels in the rat serum.

Mechanisms of Action

Artichoke leaf extract has been proposed to be antiatherogenic, which means it may help prevent atherosclerosis, a condition characterized by plaque buildup in the arteries. The extract’s lipid-reducing and antioxidant effects play a vital role. Studies suggest that artichoke leaf extract inhibits cholesterol biosynthesis in hepatocytes and decreases the oxidation of LDL. Moreover, ALE enhances the biliary excretion of cholesterol and increases its conversion to bile acids, reducing cholesterol levels. Furthermore, the extract disrupts the intestinal microflora, affecting the absorption of various compounds, including cholesterol. This dual mechanism of action contributes to its hypocholesterolemic activity.

Luteolin, one of the major phenolic compounds in artichoke extracts, modulates the activity of HMG-CoA reductase, a key enzyme in the cholesterol biosynthesis pathway. This, along with the antioxidant properties of chlorogenic acid and luteolin, contributes to inhibiting LDL oxidation. These effects further support the hypocholesterolemic activity of artichoke extracts, making them a potential preventive treatment for mild hypercholesterolemia.

Health Benefits and Recommendations

The findings of the study underscore the potential health benefits of artichoke extracts. Regularly consuming artichoke heads, hearts, or leaves can help lower cholesterol and blood sugar levels, support liver health, and boost antioxidant defenses due to their rich antioxidant content. Artichokes are also a great source of dietary fiber, making them a healthy addition to any diet.

Conclusion

In conclusion, artichoke extracts have demonstrated significant hypoglycemic and hypocholesterolemic effects in rats, particularly those from the Green Globe variety. Active phenolic compounds contribute to these beneficial effects. The antioxidant properties of artichoke extracts may also help prevent atherosclerosis by reducing LDL oxidation. Considering these findings, incorporating artichoke heads, hearts, or leaves into the diet may be a wise choice for individuals seeking to improve their cholesterol and glucose levels while enjoying artichokes’ additional health benefits. However, further research is warranted to validate these effects in humans and establish appropriate dosages for supplementation.

References

  1. Study Abstract
  2. Artichoke is a superfood

Eat Smart, Live Well, Look Great!

Dr. James Meschino

Introduction:

Artichokes (Cynara scolymus L.) are a Mediterranean vegetable that has recently gained attention for its potential health benefits. A study published in the Journal of Food and Nutrition Research in 2016 explored the effects of artichoke extracts on glucose and cholesterol levels in rats. The results indicated that artichoke extracts, particularly from the Green Globe variety, showed hypoglycemic and hypocholesterolemic properties. This article delves deeper into the mechanisms behind these effects, highlighting the major phenolic compounds in artichoke extracts and their potential impact on human health.

Artichoke Extracts and Their Active Phenolic Compounds

The study utilized two varieties of artichokes, Green Globe (G) and Violet (V), to extract active phenolic compounds from the leaves and heads. The researchers identified five significant compounds in the aqueous methanolic extracts. These compounds are known for their potential health benefits, such as antioxidant and anti-inflammatory properties.

Hypoglycemic and Hypocholesterolemic Effects

The researchers conducted experiments on albino rats to investigate artichoke extracts’ hypoglycemic and hypocholesterolemic effects. The artichoke leaf extract (ALE) and head extract (AHE) were administered orally to the rats at different concentrations. The results demonstrated that the Green Globe artichoke leaf extract (LEG) had the most hypoglycemic effect. Additionally, artichoke extracts positively impacted total cholesterol levels, reduced LDL (low-density lipoprotein) and triglyceride levels, increased glutathione peroxides, and lowered malondialdehyde (MDA) levels in the rat serum.

Mechanisms of Action

Artichoke leaf extract has been proposed to be antiatherogenic, which means it may help prevent atherosclerosis, a condition characterized by plaque buildup in the arteries. The extract’s lipid-reducing and antioxidant effects play a vital role. Studies suggest that artichoke leaf extract inhibits cholesterol biosynthesis in hepatocytes and decreases the oxidation of LDL. Moreover, ALE enhances the biliary excretion of cholesterol and increases its conversion to bile acids, reducing cholesterol levels. Furthermore, the extract disrupts the intestinal microflora, affecting the absorption of various compounds, including cholesterol. This dual mechanism of action contributes to its hypocholesterolemic activity.

Luteolin, one of the major phenolic compounds in artichoke extracts, modulates the activity of HMG-CoA reductase, a key enzyme in the cholesterol biosynthesis pathway. This, along with the antioxidant properties of chlorogenic acid and luteolin, contributes to inhibiting LDL oxidation. These effects further support the hypocholesterolemic activity of artichoke extracts, making them a potential preventive treatment for mild hypercholesterolemia.

Health Benefits and Recommendations

The findings of the study underscore the potential health benefits of artichoke extracts. Regularly consuming artichoke heads, hearts, or leaves can help lower cholesterol and blood sugar levels, support liver health, and boost antioxidant defenses due to their rich antioxidant content. Artichokes are also a great source of dietary fiber, making them a healthy addition to any diet.

Conclusion

In conclusion, artichoke extracts have demonstrated significant hypoglycemic and hypocholesterolemic effects in rats, particularly those from the Green Globe variety. Active phenolic compounds contribute to these beneficial effects. The antioxidant properties of artichoke extracts may also help prevent atherosclerosis by reducing LDL oxidation. Considering these findings, incorporating artichoke heads, hearts, or leaves into the diet may be a wise choice for individuals seeking to improve their cholesterol and glucose levels while enjoying artichokes’ additional health benefits. However, further research is warranted to validate these effects in humans and establish appropriate dosages for supplementation.

References

  1. Study Abstract
  2. Artichoke is a superfood

Eat Smart, Live Well, Look Great!

Dr. James Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
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LMU – 01 The Protective Effect of Vegetarianism Against Prostate Cancer

LMU-01

LMU 01 - The Protective Effect of Vegetarianism Against Prostate Cancer

Source: American Journal of Clinical Nutrition (January, 2016)

Nutrition / Natural Medicine Update (February , 2016)

Introduction:

Prostate cancer remains a significant health concern for men worldwide, accounting for 27% of all male cancers and the second most common cancer among men (excluding skin cancers). In January 2016, the American Journal of Clinical Nutrition published a groundbreaking study that explored the association between vegetarianism and prostate cancer risk. This large-scale study, conducted on over 26,000 men as part of the Adventists Health Study-2, revealed compelling evidence suggesting that a vegan diet could confer considerable protection against prostate cancer. This article aims to delve into the study’s key findings, the potential mechanisms behind this protective effect, and the phytonutrients found in plant-based foods that may be crucial in inhibiting prostate cancer development.

The Study’s Key Findings:

The research conducted by Tantamango-Bartley et al. involved a comprehensive analysis of a large cohort of men, with 1079 cases of prostate cancer identified during the study period. Of particular interest were the findings related to vegan men, who exhibited an impressive 35% lower risk of developing prostate cancer than their non-vegan counterparts. This observation suggests a protective association between vegan diets and prostate cancer risk. The study also noted that this protective effect was particularly pronounced among white male vegans, with a similar, albeit slightly weaker, trend observed in black male vegans.

Mechanisms Behind the Protective Effect:

The reduced risk of prostate cancer observed among vegan men can be attributed, at least in part, to the presence of various phytonutrients abundant in plant-based foods. These bioactive compounds have been shown to possess potent anti-cancer properties, particularly for prostate cancer. Some of the critical mechanisms include:

  1. Cruciferous Vegetables: Cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage, cauliflower, bok choy, and turnips, contain indole-3 carbinol and sulforaphane. These compounds have demonstrated powerful anti-cancer effects, including inhibiting prostate cancer cell growth and the induction of cancer cell death.
  2. Cooked Tomatoes: Tomatoes are a rich source of lycopene, a carotenoid pigment with potent antioxidant properties. Numerous studies have linked lycopene consumption to a reduced risk of prostate cancer.
  3. Soy Products: Soybeans and soy-based products are abundant in isoflavones and protease inhibitors, which have shown promise in preventing prostate cancer or improving outcomes in prostate cancer patients.
  4. Legumes: Peas and beans are excellent sources of lignans and protease inhibitors, compounds that may play a role in reducing prostate cancer risk.
  5. Green Tea: Green tea contains catechins, a type of polyphenol with potent antioxidant and anti-cancer properties. Studies suggest that regular green tea consumption may lower the risk of developing prostate cancer.
  6. Pomegranate Juice: Pomegranate juice is rich in ellagic acid, a compound with potential anti-cancer effects, inhibiting prostate cancer cell growth.
  7. Ground Flaxseed: Flaxseed is a source of enterolactone and enterodiol, associated with preventing pre-cancerous prostate cells from progressing into full-blown cancer.

Supporting Studies:

The findings from this study align with a growing body of evidence from various research endeavors. Numerous studies have independently validated the protective effects of these plant-based nutrients against prostate cancer. Consistent consumption of foods rich in these compounds has been associated with a lower risk of prostate cancer in diverse populations. Furthermore, scientists have synthesized some of these beneficial nutrients into supplements, showing promising results as adjunctive interventions for prostate cancer patients or preventive measures.

Conclusion

The study’s results published in the American Journal of Clinical Nutrition present compelling evidence supporting the association between vegan diets and a lower risk of prostate cancer. Although not everyone may adopt a strict vegan lifestyle, incorporating more plant-based foods with proven anti-cancer properties represents a prudent approach to reducing the risk of prostate cancer.

Additionally, it is essential to recognize that many of the same plant-based foods and phytonutrients shown to lower prostate cancer risk have also demonstrated protective effects against breast cancer in various studies. Therefore, these dietary recommendations may extend to women as well.

As with any health-related advice, individuals should consult with their healthcare providers before significantly changing their diets or lifestyles.

Reference

Tantamango-Bartley Y, Knutsen SF et al. Are strict vegetarians protected against prostate cancer? American Journal of Clinical Nutrition, vol 103, issue 1. 2016. (Link: http://ajcn.nutrition.org/content/103/1/153.abstract).


Eat Smart, Live Well, Look Great!

Dr. James Meschino

Introduction:

Prostate cancer remains a significant health concern for men worldwide, accounting for 27% of all male cancers and the second most common cancer among men (excluding skin cancers). In January 2016, the American Journal of Clinical Nutrition published a groundbreaking study that explored the association between vegetarianism and prostate cancer risk. This large-scale study, conducted on over 26,000 men as part of the Adventists Health Study-2, revealed compelling evidence suggesting that a vegan diet could confer considerable protection against prostate cancer. This article aims to delve into the study’s key findings, the potential mechanisms behind this protective effect, and the phytonutrients found in plant-based foods that may be crucial in inhibiting prostate cancer development.

The Study’s Key Findings:

The research conducted by Tantamango-Bartley et al. involved a comprehensive analysis of a large cohort of men, with 1079 cases of prostate cancer identified during the study period. Of particular interest were the findings related to vegan men, who exhibited an impressive 35% lower risk of developing prostate cancer than their non-vegan counterparts. This observation suggests a protective association between vegan diets and prostate cancer risk. The study also noted that this protective effect was particularly pronounced among white male vegans, with a similar, albeit slightly weaker, trend observed in black male vegans.

Mechanisms Behind the Protective Effect:

The reduced risk of prostate cancer observed among vegan men can be attributed, at least in part, to the presence of various phytonutrients abundant in plant-based foods. These bioactive compounds have been shown to possess potent anti-cancer properties, particularly for prostate cancer. Some of the critical mechanisms include:

  1. Cruciferous Vegetables:  Cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage, cauliflower, bok choy, and turnips, contain indole-3 carbinol and sulforaphane. These compounds have demonstrated powerful anti-cancer effects, including inhibiting prostate cancer cell growth and the induction of cancer cell death.
  2. Cooked Tomatoes: Tomatoes are a rich source of lycopene, a carotenoid pigment with potent antioxidant properties. Numerous studies have linked lycopene consumption to a reduced risk of prostate cancer.
  3. Soy Products:  Soybeans and soy-based products are abundant in isoflavones and protease inhibitors, which have shown promise in preventing prostate cancer or improving outcomes in prostate cancer patients.
  4. Legumes: Peas and beans are excellent sources of lignans and protease inhibitors, compounds that may play a role in reducing prostate cancer risk.
  5. Green Tea: Green tea contains catechins, a type of polyphenol with potent antioxidant and anti-cancer properties. Studies suggest that regular green tea consumption may lower the risk of developing prostate cancer.
  6. Pomegranate Juice: Pomegranate juice is rich in ellagic acid, a compound with potential anti-cancer effects, inhibiting prostate cancer cell growth.
  7. Ground Flaxseed: Flaxseed is a source of enterolactone and enterodiol, associated with preventing pre-cancerous prostate cells from progressing into full-blown cancer.

Supporting Studies:

The findings from this study align with a growing body of evidence from various research endeavors. Numerous studies have independently validated the protective effects of these plant-based nutrients against prostate cancer. Consistent consumption of foods rich in these compounds has been associated with a lower risk of prostate cancer in diverse populations. Furthermore, scientists have synthesized some of these beneficial nutrients into supplements, showing promising results as adjunctive interventions for prostate cancer patients or preventive measures.

Conclusion

The study’s results published in the American Journal of Clinical Nutrition present compelling evidence supporting the association between vegan diets and a lower risk of prostate cancer. Although not everyone may adopt a strict vegan lifestyle, incorporating more plant-based foods with proven anti-cancer properties represents a prudent approach to reducing the risk of prostate cancer.

Additionally, it is essential to recognize that many of the same plant-based foods and phytonutrients shown to lower prostate cancer risk have also demonstrated protective effects against breast cancer in various studies. Therefore, these dietary recommendations may extend to women as well.

As with any health-related advice, individuals should consult with their healthcare providers before significantly changing their diets or lifestyles.

Reference

Tantamango-Bartley Y, Knutsen SF et al. Are strict vegetarians protected against prostate cancer? American Journal of Clinical Nutrition, vol 103, issue 1. 2016. (Link: http://ajcn.nutrition.org/content/103/1/153.abstract).

Eat Smart, Live Well, Look Great!

Dr. James Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements