In a pivotal panel discussion held on January 10, 2022, renowned experts in the field of vitamin D, including Dr. Michael Holick and Dr. JoAnn Manson, provided a comprehensive update on the role of vitamin D in safeguarding human health. The discussion, moderated by Dr. Pam R. Taub, a distinguished cardiologist and professor of medicine at the University of California, San Diego, delved into various aspects of vitamin D’s impact on our well-being.

Vitamin D’s Crucial Role in Cancer Prevention

Dr. Michael Holick is celebrated for identifying the major circulating form of vitamin D in human blood, 25-hydroxyvitamin D3. His pioneering research over the past four decades has shed light on the myriad benefits of vitamin D, significantly raising its profile in healthcare. During the panel discussion, he, along with Dr. JoAnn Manson, another esteemed vitamin D researcher and a professor of medicine at Harvard Medical School, addressed the vital connection between vitamin D and cancer risk.

Insights from the VITAL Study

A focal point of their discussion was the **Vitamin D and OmegA-3-Trial (VITAL study)**, a large-scale, nationwide trial involving over 25,000 participants in the United States. Dr. Holick and Dr. Manson highlighted a significant finding: when individuals took 2,000 IU of vitamin D daily for at least two years, they experienced a remarkable 25% reduction in cancer-related deaths compared to those in the placebo group. This discovery is particularly noteworthy because several prior randomized trials had hinted at vitamin D’s potential in reducing cancer mortality. For example, a meta-analysis of five large-scale trials revealed a 13% decrease in cancer deaths among those taking vitamin D supplements compared to those on a placebo.

The Right Way to Take Vitamin D

Dr. Holick emphasized a crucial aspect of vitamin D supplementation. Current evidence indicates that taking vitamin D in large, infrequent doses—such as once a week or once a month—does not confer protection against cancer. On the other hand, individuals taking smaller daily doses, like 2,000 IU per day, exhibited a substantial reduction in cancer risk. While some doctors may recommend weekly or monthly doses as high as 50,000 IU for severely deficient individuals, this approach does not appear to reduce cancer risk based on available studies.

The Optimal Blood Level for Cancer Prevention

Both Dr. Holick and Dr. Manson emphasized the importance of achieving a specific blood level of vitamin D for effective cancer prevention. While the medical community often considers a blood level of 50 nmol/L (20 ng/mL) as adequate for bone health, achieving a level above 75 nmol (30 ng/mL) is critical for significant cancer prevention. To maximize protection, it is advisable for most individuals to maintain a blood vitamin D level between 85 – 140 nmol/L (32-56 ng/mL) by supplementing with 1,000 – 2,000 IU of vitamin D daily. Periodic monitoring of your vitamin D levels can help ensure you stay within the ideal range, with exceptions being made for specific medical conditions or infections that may require higher levels.

Conclusion

In summary, the insights shared by these experts underscore the remarkable potential of vitamin D in cancer prevention. By understanding the optimal supplementation strategies and target blood levels, individuals can harness the benefits of vitamin D to reduce their risk of cancer and enjoy improved overall health.

Reference:

Excerpts from Medscape Interview Published January 31, 2022: *Beyond Bone Health: Does Vitamin D Have a Role in Cancer, CVD, and COVID?* [Read more](https://www.medscape.com/viewarticle/959893?uac=342474MN&faf=1&sso=true&impID=3926885&src=wnl_tp10n_220106_mscpedit#vp_1)

Eat Smart, Live Well, Look Great,

Dr. Meschino