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LMU – 184 Revitalizing with Hyperbaric Oxygen Therapy: Unlocking Anti-Aging Potential

LMU-184

LMU – 184 Revitalizing with Hyperbaric Oxygen Therapy: Unlocking Anti-Aging Potential

Source: Journal “Aging” (2020)

Lifestyle Medicine Update (Dec 4, 2020)

Introduction:

In the realm of medical innovation, hyperbaric oxygen therapy (HBOT) has emerged as a compelling approach, offering a unique blend of comfort and therapeutic promise. This treatment entails reclining in a sealed chamber, complete with expansive windows for scenic views and the luxury of watching TV or movies on a large screen. Inside this chamber, the air becomes saturated with pure oxygen—a striking contrast to the 21% oxygen content typically found in the air we breathe. But what makes HBOT truly intriguing is its ability to increase atmospheric pressure, sometimes up to 3 or 4 times the norm, depending on the specific health condition being addressed. The result is an hour-long journey that, when repeated over 40 to 60 sessions (often daily), can unleash remarkable therapeutic benefits.

In the Canadian province of Ontario, where this author resides, the government health plan extends coverage for HBOT to address 14 distinct health conditions with a proven track record of efficacy. Among these conditions are chronic anemia, chronic non-healing wounds, delayed radiation injury, gangrene, osteomyelitis, and thermal burns. Yet, researchers continually explore HBOT’s potential applications, seeking to harness its healing powers for a broader range of health concerns.

Unveiling the Anti-Aging Potential of HBOT

One of the foremost researchers in the field of hyperbaric oxygen therapy, Professor Shai Efrati of the Sackler School of Medicine, has paved the way for groundbreaking advancements. His work has not only transformed our understanding of HBOT but has also opened new doors in the realm of anti-aging.

In a groundbreaking 2020 study, published in the journal Aging, Dr. Efrati and his colleagues embarked on an ambitious quest to evaluate the impact of HBOT on aging. Their study involved 35 healthy individuals, all aged 64 or older, who underwent an intensive series of 60 hyperbaric sessions over a span of 90 days. Throughout the treatment journey, participants provided blood samples at key intervals—before, during, and after the series of HBOT sessions. These samples were then subjected to rigorous analysis, focusing on various immune cells present in the bloodstream.

The Astonishing Anti-Aging Discoveries

The study’s findings unveiled two profoundly significant anti-aging effects of hyperbaric oxygen therapy:

  1. Telomere Lengthening: Telomeres, protective caps at the ends of DNA strands, are known to shorten with age. This natural process leads to immune cells and other body cells becoming inactive, a phenomenon known as senescence. Lengthening telomeres can reverse the aging of these cells, enhancing their efficiency in combating viruses, bacteria, pathogens, and even emerging cancer cells. Telomere extension is considered a coveted achievement in the realm of anti-aging, and HBOT demonstrated the potential to lengthen telomeres by an astonishing 20-38% in specific types of immune cells. This groundbreaking discovery aligns with the quest for the “Holy Grail” of anti-aging biology.
  2. Reduction in Senescent Cells: Another striking revelation emerged with the reduction of senescent or inactive immune cells by 11-37% following the HBOT sessions. This signifies that participants emerged from the treatment with a greater number of active and functional immune cells—an essential boost for the immune system. The implications are significant, as the immune system typically experiences a noticeable decline after the age of 50-60, increasing the risk of cancer and making individuals more susceptible to life-threatening infections.

While certain dietary habits, lifestyle choices, and specific supplements have been shown to slow or reverse aspects of immune system decline, this new research illuminates the potential of HBOT as an additional tool for older individuals seeking to fortify their immunity. Though the prospect of HBOT being covered by healthcare plans for this purpose may remain distant due to the need for consecutive treatments, the time and expense involved, it nonetheless offers a proactive intervention for those dedicated to preserving vitality and health as they age.

Conclusion: Embracing the Power of Hyperbaric Oxygen Therapy

Hyperbaric oxygen therapy, once reserved for specific medical conditions, is transcending boundaries to reveal its anti-aging potential. The journey within the sealed chamber, saturated with pure oxygen and amplified pressure, is proving to be an intriguing avenue for reversing the effects of aging on immune cells. With telomere lengthening and a reduction in senescent cells, HBOT has carved a niche in the quest for a more youthful and robust immune system.

While the road to realizing the full potential of HBOT as an anti-aging tool may be marked by logistical and financial considerations, it stands as a testament to the ever-evolving landscape of health and wellness. As the pursuit of vitality and longevity continues, hyperbaric oxygen therapy emerges as an intriguing addition to the arsenal of anti-aging enthusiasts.

References:

  1. Yafit Hachmo, Amir Hadanny, Ramzia Abu Hamed, Malka Daniel-Kotovsky, Merav Catalogna, Gregory Fishlev, Erez Lang, Nir Polak, Keren Doenyas, Mony Friedman, Yonatan Zemel, Yair Bechor, Shai Efrati. Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. Aging, 2020. [Read more](https://www.aging-us.com/article/202188/text)
  2. ScienceDaily. (2020, November 20). Hyperbaric oxygen therapy increases longevity and prevents cognitive decline, Tel Aviv University study shows. [Read more](https://www.sciencedaily.com/releases/2020/11/201120150728.htm)
  3. National Center for Biotechnology Information. (2019). Astragalus and Telomeres. [Read more](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755196/)
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 183 The Vegan and Vegetarian Diet Dilemma: Health Benefits and Nutritional Pitfalls

LMU-183

LMU – 183 The Vegan and Vegetarian Diet Dilemma: Health Benefits and Nutritional Pitfalls

Source: German Science Journal: Aerzteblatte.de

Lifestyle Medicine Update (November 27, 2020)

Introduction:

In recent years, the allure of plant-based diets, specifically vegan and vegetarian lifestyles, has surged in popularity across Germany and beyond. As more individuals opt to abstain from animal-derived foods, it’s crucial to examine the multifaceted impact of these dietary choices. A 2020 German study, published in Deutsches Aerzteblatt Online, offers a revealing glimpse into the health benefits and potential nutrient deficiencies associated with vegan and vegetarian diets. Let’s embark on a journey through the realm of plant-based nutrition and explore the findings that could reshape our dietary choices.

Plant-Based Diets on the Rise: A Growing Trend

The study opens with a snapshot of the dietary landscape in Germany, where the appeal of veganism and vegetarianism has steadily grown. Presently, nearly 6 million Germans adhere to a vegetarian diet, while close to 1 million embrace veganism—a lifestyle devoid of all animal-derived foods, including dairy and eggs. In a country with a population of 83 million, this translates to a significant percentage—almost 8.5% of the population—choosing plant-based diets. The motivation behind these choices often stems from ethical concerns, environmental considerations, and the pursuit of enhanced health and well-being.

Scientific Backing: The Health Benefits of Plant-Based Diets

The scientific community has long been intrigued by the potential health benefits of plant-based diets. Citing data from the 7-day Adventist Health Study in the US, the researchers highlight the positive effects of these diets in mitigating obesity, high blood pressure, diabetes, and cardiovascular mortality in males. Moreover, a recent meta-analysis underscores the advantages of vegetarian diets, demonstrating a reduced risk of ischemic heart disease and cancer compared to meat-eaters, even after accounting for key confounding factors such as smoking and body mass index. The conclusion is clear: a meat-free diet stands as a desirable choice for the overall population, promoting both individual health and the broader goals of food security and climate change mitigation.

The Nutritional Tightrope: Nutrient Deficiencies in Plant-Based Diets

While the health merits of vegan and vegetarian diets are evident, they come with a unique set of challenges—nutrient deficiencies. To shed light on these potential pitfalls, German researchers delved into the dietary intake, laboratory parameters, vitamin status, and trace-mineral status of 36 vegans and 36 omnivores. Each group, consisting of 18 men and 18 women aged 30–60, provided valuable insights into the nutritional landscape of plant-based diets.

The results painted a nuanced picture. Among vegans, lower blood concentrations of critical nutrients were observed, including vitamin B2, vitamin B3, vitamin E, vitamin A, selenium, and zinc. Additionally, 24-hour urine samples revealed a reduced excretion of iodine and calcium compared to omnivores. While many vegans are aware of the risk of vitamin B12 deficiency and supplement accordingly, this study unveils other potential nutrient deficiencies that may fly under the radar, such as vitamin B2, vitamin B3, Vitamin E, vitamin A, selenium, zinc, and calcium.

Vitamin D levels were also a concern among vegans, highlighting the need for supplementation to maintain adequate levels, especially for individuals living above or below the 40th-degree latitude.

Navigating the Plant-Based Path: Practical Recommendations

The study’s findings underscore the importance of a thoughtful and informed approach to plant-based diets. While these diets offer a wealth of health benefits, they also demand vigilance in ensuring adequate nutrient intake. Embracing a diverse array of vegetables, legumes, fruits, and nuts is essential. Soy products, unless allergies or sensitivities are present, can be a valuable addition.

For those eschewing dairy, calcium intake from fortified foods and supplements is prudent to mitigate the risk of osteoporosis. Vitamin D supplementation becomes a necessity, particularly for individuals residing in regions with limited sun exposure.

Conclusion:

In conclusion, the appeal of a plant-based diet is undeniable, with its potential to shield against various degenerative diseases. However, the study and others like it emphasize the need for vigilance against nutrient deficiencies. A high-potency multiple vitamin and mineral supplement emerges as a crucial consideration, serving as a nutritional safety net for vegans and, to some extent, vegetarians.

References:

Cornelia Weikert, Iris Trefflich, Juliane Menzel, Rima Obeid, Alessa Longree, Jutta Dierkes, Klaus Meyer, Isabelle Herter-Aeberli, Knut Mai, Gabriele I. Stangl, Sandra M. Müller, Tanja Schwerdtle, Alfonso Lampen, Klaus Abraham. Vitamin and mineral status in a vegan diet. Deutsches Aerzteblatt Online, 2020. 

[Read more](https://www.aerzteblatt.de/int/archive/article/215079)

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 182 Discover the Power of Selenium: A Mineral with Immune-Supporting Superpowers

LMU-182

LMU – 182 Discover the Power of Selenium: A Mineral with Immune-Supporting Superpowers

Source: J Frontiers in Nutrition 2020 and Others (See Below)

Lifestyle Medicine Update (November 21, 2020)

Introduction:

In the ever-evolving landscape of health and wellness, the spotlight often falls on various vitamins and minerals, each hailed for its unique contributions to our well-being. Among these, selenium—a mineral with remarkable immune-boosting potential—takes center stage. The September 2020 issue of the esteemed journal Frontiers in Nutrition unveiled a comprehensive review of studies exploring selenium’s pivotal role in immune function. This mineral, often overlooked, emerges as a potent shield against viral infections, pathogens, and even cancer. Join us as we delve into the intricate world of selenium and its profound impact on our health.

Selenium’s Role in Immunity: A Deep Dive into Research

The research published in Frontiers in Nutrition meticulously analyzed the body of evidence surrounding selenium’s influence on immune function. It drew attention to the alarming consequences of selenium deficiency in animals and low selenium status in humans. These conditions not only heighten vulnerability to viruses and other pathogens but may also raise the spectre of cancer.

Selenium and Viral Resilience: A Silver Lining

One of the most compelling findings was the impact of selenium supplementation on patients living with the HIV virus. The study revealed that providing selenium supplements could slow the progression of the disease and bolster T-Helper Cell numbers—a critical component in maintaining the health and functionality of these patients.

Beyond HIV, other studies showcased selenium’s potential in mitigating the effects of various viral and serious infections. It’s a testament to selenium’s longstanding recognition as a nutrient that supports immune function. Selenium plays a pivotal role in optimizing antioxidant protection within cells, particularly immune cells. However, its influence extends beyond that, encompassing a multifaceted array of effects that aid immune function and prevent viruses from mutating and becoming more virulent.

A Defining Moment: Selenium’s Impact on COVID-19

In an era dominated by the COVID-19 pandemic, the connection between selenium and viral resilience takes on newfound significance. The research alludes to a study conducted in China, where patients with superior selenium status demonstrated significantly better recovery rates from COVID-19 than those with suboptimal selenium levels. This suggests that maintaining a higher-than-normal selenium status could offer protective benefits against the detrimental effects of the viral infection.

Germany also yielded compelling data, with serum selenium levels strongly correlated with COVID-19 outcomes in hospitalized patients. Astonishingly, a significant percentage of patients exhibited very low serum selenium status, and those with the lowest levels faced a considerably higher risk of mortality. In light of these findings, the authors of the review paper advocate for encouraging adults to incorporate selenium supplements into their daily regimen to enhance immunity and reduce the virulence of COVID-19-related viruses until a vaccine becomes widely available.

Selenium and Cancer: A Complex Relationship

Turning our attention to the realm of cancer, selenium emerges as a multifaceted ally in the fight against this formidable disease. While some clinical trials have indicated limited benefit in using selenium to prevent cancer, an abundance of evidence suggests that selenium and its compounds can serve as potent anti-cancer agents under specific circumstances.

Interestingly, selenium supplementation exhibits promise in amplifying the anti-cancer effects of several chemotherapy drugs commonly employed in cancer treatment. Numerous observational studies, known as epidemiological studies, have linked higher serum selenium levels and toenail selenium concentrations (a more reliable long-term indicator of selenium status) to a reduced risk of various types of cancer.

Balancing the Selenium Equation

In the grand tapestry of dietary intake, selenium is not an exotic mineral. In fact, most North Americans are believed to obtain the recommended daily amount of selenium from their diets, which is set at 55 micrograms (mcg) per day. However, the Frontiers in Nutrition journal article paints a different picture. It suggests that as individuals age, higher selenium intake may be necessary to optimize immune function and reduce viral infections. With age comes a greater need for immune support, and selenium may hold the key to bolstering defences.

Many individuals in modern society augment their selenium intake through high-potency multivitamin and mineral supplements, which typically provide an additional 50-200 mcg of selenium per day.

Conclusion: Selenium—A Guardian of Health

In a world where viral threats and cancer loom large, selenium emerges as a formidable ally in our pursuit of health and longevity. Its immune-boosting capabilities, coupled with its potential to mitigate the impact of viral infections, position it as a mineral of extraordinary significance. As the global community grapples with the ongoing challenges posed by COVID-19, the wisdom of incorporating selenium supplementation into our daily routine offers a ray of hope.

Selenium, once relegated to the background, now rightfully takes its place on the stage of health and wellness. From HIV to COVID-19 and the battle against cancer, this unassuming mineral is rewriting the narrative of our immune defences. As we navigate the complexities of modern life, the power of choice is evident: embrace the potential of selenium and unlock a future where immunity reigns supreme.

References:

  1. Hiffler L et al. Selenium and RNA virus interactions: Potential implications for SARS-CoV-2 infection (COVID-19). Frontiers of Nutrition, September 2020. [Read more](https://www.frontiersin.org/articles/10.3389/fnut.2020.00164/full)
  2. Tan HW et al. Selenium species: Current status and potentials in cancer prevention and therapy. International Journal of Molecular Sciences, 2019; 20(1):75. [Read more](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337524/)
  3. National Institutes of Health: Office of Dietary Supplements. Selenium. [Learn more](https://ods.od.nih.gov/factsheets/Selenium-HealthProfes%20sional/)
 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 181 The Power of Anti-Inflammatory Diets: Shielding Your Heart and Brain

LMU-181

LMU – 181 The Power of Anti-Inflammatory Diets: Shielding Your Heart and Brain

Source: Journal of the American College of Cardiology (Nov. 2020)

Lifestyle Medicine Update (November 14, 2020)

Introduction:

In the quest for a healthier, longer life, scientific research continues to reveal the profound impact of our dietary choices on our well-being. A groundbreaking study, published in the prestigious Journal of the American College of Cardiology in November 2020, unveiled startling insights into the link between what we eat and our heart health. This comprehensive investigation, tracking the lives of 210,000 individuals over an astounding 32 years, uncovered a remarkable finding: those who embraced an anti-inflammatory diet enjoyed a staggering 46% lower risk of developing heart disease and a significant 28% lower risk of experiencing a stroke.

The Silent Threat: Chronic Inflammation and Cardiovascular Disease

Chronic inflammation, a silent assassin lurking within our bodies, plays a pivotal role in the development of two of the leading causes of mortality worldwide—heart disease and stroke. It is an intricate web of inflammatory biomarkers, such as interleukins, chemokines, and adhesion molecules, that can pave the way for the early and late stages of atherosclerosis, the narrowing of arteries due to plaque buildup.

Connecting the Dots: Diet, Inflammation, and Health Outcomes

This landmark study embarked on a journey to connect the dots between dietary habits, inflammatory markers, and cardiovascular health. More than 200,000 participants were scrutinized, their diets dissected, and their health journeys meticulously tracked, including heart attacks, angina, and strokes. The results were unequivocal: those who regularly indulged in inflammation-promoting foods exhibited elevated inflammatory markers in their bloodstream and faced a significantly higher risk of heart disease and stroke.

Foods That Fan the Flames: Inflammation Promoters

Diving into the details, the study uncovered the culprits behind inflammation within our bodies. These dietary villains included:

  1. Red Meat: From succulent steaks to all-beef products, excessive red meat consumption emerged as a potent inflammation promoter.
  2. Processed Meats: The allure of processed meats like sausages and bacon can be irresistible, but they come at a cost to your heart health.
  3. Organ Meats: Liver and other organ meats, while rich in nutrients, can fan the flames of inflammation.
  4. Refined Sugars and Grains: White bread and sugary breakfast cereals, among others, were found to be contributors to inflammation.
  5. Fried Foods: The golden, crispy delight of fried foods can lead to golden opportunities for inflammation.
  6. Sugary Soft Drinks: These sugary delights can not only wreak havoc on your waistline but also stoke the fires of inflammation.

Nature’s Defenders: Foods That Tame Inflammation

On the flip side, the study shed light on foods that act as staunch defenders against inflammation, thanks to their high levels of antioxidants and fiber:

  1. Green Leafy Vegetables: Kale, spinach, cabbage, and arugula emerged as nutritional powerhouses in the fight against inflammation.
  2. Yellow Vegetables: Pumpkin, yellow peppers, beans, and carrots bring a splash of color to your plate and an arsenal against inflammation.
  3. Whole Grains: Incorporating whole grains into your diet can be a game-changer for inflammation control.
  4. Beverages with Benefits: Coffee, tea, and even wine, when consumed in moderation, can help curb inflammation.

The Walnut Wonder: Nut Consumption and Inflammation Reduction

While the benefits of nut consumption in reducing heart disease risk and lowering cholesterol have been well-documented, the connection to inflammation was previously underexplored. In another compelling facet of this study, researchers sought to understand how walnuts might influence inflammatory biomarkers.

A cohort of 634 participants was divided into two groups: one followed a diet without walnuts, while the other incorporated 30-60 grams of walnuts into their daily routine. After a two-year follow-up, the results spoke volumes. Those who had integrated walnuts into their diet displayed significantly reduced levels of inflammation in six out of ten inflammatory biomarkers tested.

Words of Wisdom from the Experts

Dr. Ramon Estruch, MD, Ph.D., a senior consultant in the department of internal medicine at Hospital Clinic in Barcelona, Spain, eloquently encapsulated the essence of these findings, stating, “When choosing foods in our diet, we should indeed beware of their pro-inflammatory and anti-inflammatory potential.” This sage advice underscores the importance of our daily food choices in shaping our health destinies.

Beyond the Usual Suspects: Inflammation as an Independent Risk Factor

While high blood pressure, elevated cholesterol levels, and smoking have long been recognized as cardinal risk factors for cardiovascular disease, studies like this one illuminate the role of inflammation within the blood vessel wall and the stickiness of blood as equally important contributors. Pro-inflammatory foods have now emerged as independent risk factors for heart disease and stroke. In contrast, the regular consumption of anti-inflammatory foods has shown the potential to reduce inflammatory markers in the bloodstream, offering a promising avenue for mitigating the risk of these life-threatening cardiovascular diseases.

Conclusion: The Power of Choice

In a world where health-conscious choices are often overshadowed by the allure of indulgence, this monumental study serves as a beacon of hope. It unequivocally demonstrates the profound impact of our dietary choices on our cardiovascular health. By embracing an anti-inflammatory diet rich in fruits, vegetables, whole grains, and the occasional cup of tea or glass of wine, we hold the power to shield our hearts and brains from the devastating consequences of chronic inflammation.

So, as we stand at the crossroads of culinary temptation, let us remember the wisdom gleaned from this study—a simple choice can make all the difference between a life marked by vitality and one marred by disease.

Reference:

Jun Li, Dong Hoon Lee, Jie Hu, Fred K. Tabung, Yanping Li, Shilpa N. Bhupathiraju, Eric B. Rimm, Kathryn M. Rexrode, JoAnn E. Manson, Walter C. Willett, Edward L. Giovannucci, Frank B. Hu. Dietary Inflammatory Potential and Risk of Cardiovascular Disease Among Men and Women in the U.S. Journal of the American College of Cardiology, 2020; 76 (19): 2181 

[Link](https://www.sciencedirect.com/science/article/abs/pii/S0735109720371904?via%3Dihub)

Eat Smart, Live Well, Look Great,

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 180 Unlocking the Potential of Vitamin D: A Mother’s Gift to Her Child’s IQ

LMU-180

LMU – 180 Unlocking the Potential of Vitamin D: A Mother's Gift to Her Child's IQ

Source: Journal of Nutrition (November 2020)

Liestyle Medicine Update (November 5, 2020)

Introduction:

In the realm of maternal health, few factors are as crucial as a mother’s well-being during pregnancy. While the importance of proper nutrition is widely acknowledged, a lesser-known hero has emerged on the stage of prenatal care – vitamin D. In a groundbreaking study published in the Journal of Nutrition in November 2020, researchers shed light on the profound influence of maternal vitamin D levels during pregnancy on a child’s IQ at 4-6 years of age. This revelation not only underscores the critical role of vitamin D in fetal brain development but also unveils the startling prevalence of vitamin D deficiency among expectant mothers.

A Symphony of Development: Vitamin D’s Role in Fetal Brain

The intricate journey of human development commences long before birth, with the prenatal period playing a pivotal role in shaping a child’s future. Central to this process is vitamin D, a nutrient that holds the key to a child’s cognitive potential. The significance of vitamin D in fetal brain development cannot be overstated, with the mammalian brain boasting vitamin D receptors as early as the 12th day after conception. The developing fetal brain relies on vitamin D for a myriad of essential processes, making maternal vitamin D levels a critical factor in ensuring optimal neurocognitive development.

CANDLE Study: Illuminating the Path

To unravel the intricate relationship between maternal vitamin D levels and a child’s IQ, researchers turned to the CANDLE Study (Conditions Affecting Neurocognitive Development and Learning in Early Childhood). This comprehensive study encompassed over 1500 pregnant women in their second trimester of a single-fetus healthy pregnancy. The study’s premise was clear: to investigate how maternal vitamin D levels during pregnancy impact a child’s IQ, both verbal and non-verbal, at ages 4-6 years.

A Stark Reality: Prevalence of Vitamin D Deficiency

As the study unveiled its findings, a startling reality emerged – 46% of the pregnant women involved in the study exhibited deficient levels of vitamin D in their blood. This alarming statistic was drawn from a U.S.-based study, where vitamin D deficiency is defined by a blood level below 20 ng/ml (50 nmol/L). However, this threshold, originally established to ensure adequate bone health, might not suffice to support optimal fetal brain development or combat a range of diseases influenced by suboptimal vitamin D levels. Among these, conditions such as cancer, diabetes, Alzheimer’s disease, and other ailments lurk in the shadows, awaiting their moment to manifest.

The Looming Shadow of Vitamin D Deficiency

While the issue of vitamin D deficiency affects a wide demographic, it casts a particularly ominous shadow over Black American women. Within the study, these women exhibited an average vitamin D blood level of a mere 19.8 ng/ml (49.5 nmol/L). In stark contrast, Caucasian women demonstrated an average vitamin D blood level of 25.9 ng/ml (62.5 nmol/L). Melissa Melough, the lead researcher, highlights a disconcerting fact – up to 80% of Black pregnant women in the U.S. may find themselves grappling with vitamin D deficiency. This issue, however, extends its reach beyond the United States, encompassing women of childbearing age worldwide, especially those with darker skin tones. The higher melanin content in their skin acts as a barrier to ultraviolet light, impeding the skin’s ability to produce vitamin D efficiently.

A Level Playing Field: Maternal Vitamin D’s Universal Impact

One of the most striking revelations of the study is its demonstration of the universality of maternal vitamin D’s influence, irrespective of race. Across all participants, regardless of skin color, a clear trend emerged – the higher the mother’s blood vitamin D level during the second trimester of pregnancy, the higher the child’s IQ at ages 4-6. More specifically, for every 10 ng/mL (25 nmol/l) increase in maternal vitamin D levels, the child’s Full-Scale IQ saw a 1.17-point boost, accompanied by a 1.17-point increase in Verbal IQ and a 1.03-point rise in Nonverbal IQ. These findings resonate beyond the realm of IQ, as they hint at far-reaching implications, with potential impacts on future life outcomes. The economic sphere, for instance, mirrors these changes, with each IQ point decrement translating to a 1.93% decrease in lifetime earnings for males and a 3.23% decrease for females.

Chasing the Optimal Threshold: Rethinking Vitamin D Intake

The study’s revelations extend to the realm of recommended vitamin D intake during pregnancy. The researchers argue that the current recommendations might fall short of addressing the widespread issue of vitamin D deficiency effectively. Popular prenatal supplements, typically containing 400–600 IU vitamin D, may prove inadequate in correcting deficiencies. Based on randomized controlled trials, daily supplementation of 800 to 1000 IU may be necessary for repletion during pregnancy, with some cases of severe deficiency warranting doses as high as 4000 IU. Nevertheless, the absence of a consensus regarding optimal vitamin D concentrations during pregnancy underscores the need for further research, potentially leading to population-specific guidelines for addressing deficiency in pregnancy. In the absence of universal guidelines, aiming for a blood vitamin D level between 30 ng/mL (75 nmol/L) and 50 ng/mL (125 nmol/L) may serve as a prudent target for pregnant women, safeguarding not only their health but also the cognitive potential of the next generation.

References:

  1. Melissa M Melough, Laura E Murphy, J Carolyn Graff, Karen J Derefinko, Kaja Z LeWinn, Nicole R Bush, Daniel A Enquobahrie, Christine T Loftus, Mehmet Kocak, Sheela Sathyanarayana, Frances A Tylavsky. *Maternal Plasma 25-Hydroxyvitamin D during Gestation Is Positively Associated with Neurocognitive Development in Offspring at Age 4–6 Years*. The Journal of Nutrition, 2020.                                                    [Read more](https://academic.oup.com/jn/advance-article/doi/10.1093/jn/nxaa309/5951845)
 
Eat Smart, Live Well, Look Great
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 179 Unlocking the Power of Vitamin D: A Beacon of Hope Amidst COVID-19

LMU-179

LMU – 179 Unlocking the Power of Vitamin D: A Beacon of Hope Amidst COVID-19

Source: J Steroid Biochem Mol Biol (October 2020)

Lifestyle Medicine Update (October 30, 2020)

Introduction:

In the ever-evolving landscape of healthcare, the quest for effective treatments against COVID-19 continues to be at the forefront. As the world grapples with the pandemic, emerging evidence suggests that a humble nutrient, vitamin D, could hold the key to better outcomes for patients battling the virus. In this article, we delve into the intriguing findings that shed light on the role of vitamin D in the fight against COVID-19.

The Vitamin D Connection: From Respiratory Distress to COVID-19

In previous explorations within the realm of Lifestyle Medicine Updates, we delved into the significance of vitamin D in preventing acute respiratory distress syndrome (ARDS). It became evident that optimal blood levels of vitamin D could serve as a shield against this life-threatening condition. But could this shield extend its protective reach to encompass COVID-19 as well? A growing body of research hinted at this possibility, with studies from various countries suggesting that individuals with lower vitamin D levels were more vulnerable to severe COVID-19 infections and faced a higher risk of mortality.

The Spanish Hospital Study: A Glimmer of Hope

To put this theory to the test, a pioneering study was undertaken in a Spanish hospital. This study embarked on a mission to decipher the impact of vitamin D supplementation on COVID-19 patients. Seventy-six patients, all bearing the undeniable mark of laboratory-confirmed COVID-19, became the subjects of this critical investigation. The approach was methodical, employing computer-generated randomization to eliminate any potential doctor bias. Out of these 76 patients, 50 were provided with vitamin D supplementation, while the remaining 26 received standard medical treatment for COVID-19 without vitamin D. The results unveiled a compelling narrative.

Vitamin D: A Shield Against Intensive Care

Among the cohort of 26 patients who did not receive vitamin D supplementation, a startling fifty percent, equivalent to 13 individuals, saw their COVID-19 infections escalate to a critical point, necessitating admission to the intensive care unit (ICU). Tragically, two of these patients succumbed to the virus. In stark contrast, within the group of 50 patients who received vitamin D as part of their treatment, only one patient required ICU admission, and miraculously, none of them lost the battle against COVID-19. The chasm in outcomes was undeniable, and the implications profound.

Vitamin D’s Immune Arsenal: Unveiling the Mechanism

The question arises: What transforms vitamin D into a potent defender against COVID-19? The answer lies in the realm of immune function. Vitamin D plays a pivotal role in empowering immune cells to synthesize agents with the remarkable ability to obliterate invading viruses upon contact. These immune warriors include cathelicidin peptide, defensins, and the TLR co-receptor CD14. These agents form the frontline of the immune system’s defence, mounting a rapid and effective counterattack against pathogens. With vitamin D in their arsenal, immune cells are fortified, enabling them to strike down viruses with unparalleled efficiency.

A Glimpse into the Future: The Upcoming Multi-Center Trial

While this study represents a significant step forward, it is essential to acknowledge its limitations due to its relatively small sample size. However, the encouraging results have catalyzed a more extensive, multi-center trial spanning 15 hospitals across Spain. This comprehensive study will enrol COVID-19 patients and administer vitamin D or a placebo alongside other approved COVID-19 treatments. These treatments encompass a spectrum of approaches, including hydroxychloroquine, azithromycin, and, in cases with pneumonia, broad-spectrum antibiotics. For patients on ventilators, the addition of the steroid drug dexamethasone, known to reduce mortality in such cases, is part of the protocol. Intriguingly, these drugs were administered uniformly across all 76 COVID-19 patients in the initial study, but the introduction of vitamin D supplementation led to significantly improved outcomes compared to those who did not receive it.

The Pursuit of Optimal Vitamin D Levels

As we navigate the intricate landscape of COVID-19, a crucial lesson emerges – the importance of maintaining optimal vitamin D levels in the bloodstream. A range between 85-125 nmol/L (34 ng/ml – 50 ng/ml) is the sweet spot, enabling immune cells to launch a potent defence against invading viruses and pathogens. While the quest for effective treatments against COVID-19 continues, the role of vitamin D stands as a shining beacon of hope in the relentless fight against the pandemic.

References:

  1. Castillo ME et al. *Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot study.* J Biochem Mol Biol. 2020; 203:105751                          [Read more](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/)
 
Eat Smart, Live Well, Look Great
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 178 Unlocking the Brain’s Memory Vault: Choline’s Role in Cognitive Health

LMU-178

LMU – 178 Unlocking the Brain's Memory Vault: Choline's Role in Cognitive Health

Main Sources: Journal Nutrients (2019) and the American Journal of Clinical Nutrition (2011)

Lifestyle Medicine Update (October 24, 2020)

Introduction:

In the mysterious realm of our minds, memory reigns supreme. At the heart of this cognitive wonderland lies a remarkable chemical known as acetylcholine, the guardian of our memories. But, to craft this vital molecule, our brain cells need a steady supply of a humble nutrient called choline. Surprisingly, choline remains a stranger to many, concealed within the folds of various foods. Yet, for most individuals, daily choline intake falls short of the recommendations set by health authorities. Today, we embark on a journey to uncover the profound impact of choline on our cognitive well-being and the secrets it holds in the realm of memory.

Choline and Cognitive Health: A Crucial Bond

In the intricate tapestry of cognitive health, choline emerges as a central figure. Research has persistently unveiled the pivotal role of choline in safeguarding memory and cognitive function. The contours of this narrative come to life through the renowned Framingham Heart Study, where over 1,400 participants embarked on a voyage of dietary analysis, neuropsychological assessments, and brain MRI studies. At an average age of 61, these individuals ventured into uncharted territory, revealing astonishing findings. Those who consistently included substantial choline in their diets emerged as champions of memory, boasting superior test scores and fewer MRI signs of cognitive decline.

The White Matter Connection: Choline’s Neurological Shield

In the intricate landscape of our brains, white matter hyperintensity (WMH) serves as an ominous harbinger of cognitive decline and brain atrophy. Here, the protective influence of choline reveals its potency. High choline intake correlates with reduced WMH, shielding the brain from degeneration. This effect is attributed to choline’s dual role – not only does it bolster memory by increasing acetylcholine levels, but it also fortifies the outer skin of brain cells, preserving their integrity and functionality. As a result, choline stands as a formidable guardian, fending off brain cell degeneration and mortality.

The Intricate Dance: Choline and Saturated Fat

However, this tale of choline’s heroics carries a caveat. In those who indulge in excessive saturated fat consumption, choline’s protective mantle falters. The deleterious impact of saturated fats neutralizes choline’s memory-enhancing powers and its ability to safeguard the brain on MRI scans. The message is clear – while choline is a beacon of cognitive well-being, it thrives in synergy with prudent dietary choices. Opt for choline-rich foods, while simultaneously moderating saturated fat intake. This dietary harmony is a key to preserving memory and cognitive health.

Choline’s Multifaceted Defence

Choline’s role transcends memory preservation. It also emerges as a sentinel against elevated homocysteine levels, a known risk factor for Alzheimer’s disease. Choline contributes to homocysteine reduction, partially through its conversion to betaine in the liver. In the annals of animal studies, choline showcases its prowess by curbing the menacing accumulation of amyloid plaque, an ominous hallmark of Alzheimer’s disease. Furthermore, it quells brain inflammation, often seen in this condition, by taming inflammation-promoting brain cells known as microglia. Thus, choline emerges as a guardian of memory and brain health, wielding a multifaceted defence against cognitive decline.

Choline’s Daily Quota: How Much is Enough?

The voyage to memory preservation through choline requires a calculated course. Health authorities recommend a daily choline intake of 550 mg for men, 425 mg for women, and elevated levels for pregnant and breastfeeding women. However, the stark reality reveals a different narrative. On average, men ingest only about 380 mg of choline daily, while women hover around 275 mg. This shortfall accumulates over time, culminating in sub-optimal choline levels within the brain. The consequence? An increased risk of dementia and Alzheimer’s disease.

Nutritional Allies: Choline-Rich Foods

To traverse the path of memory preservation, one must be well-acquainted with the allies of choline-rich foods. These nutritional champions stand as beacons of cognitive well-being:

  • Tofu: A 150 gm serving packs 160 mg of Choline.
  • Chicken Breast: A 75 gm serving delivers 80 mg of Choline.
  • Fish (most varieties): A 3 oz serving contains 71 mg of Choline.
  • Soybeans: A ¾ cup serving provides 60 mg of Choline.
  • Other Beans and Peas: A ¾ cup serving boasts 57 mg of Choline.
  • Lentils: A ¾ cup serving offers 45 mg of Choline.
  • Nuts (peanuts, pistachios, almonds, cashews): A ¼ cup serving contributes 23 mg of Choline.
  • Non-fat or 1% Milk: A 1 cup serving supplies 43 mg of Choline.
  • Cottage Cheese: A 1 cup serving yields 42 mg of Choline.
  • Non-fat or 1% Yogurt: A ¾ cup serving provides 27 mg of Choline.
  • Broccoli, Brussel Sprouts, Cauliflower, Collard Greens: A ½ cup serving contains 35 mg of Choline.
  • Avocado: Half an avocado delivers 14 mg of Choline.
  • Banana: A medium banana contributes 12 mg of Choline.
  • Potato: A large potato contains 57 mg of Choline.
  • Brown Rice: A cup of cooked brown rice provides 19 mg of Choline.
  • Whole Grain Bread and Pita: A large piece offers 17 mg of Choline.
  • Tangerines and Kiwi Fruit: Half a cup of each provides 7-10 mg of Choline.
  • Carrots: A ½ cup serving boasts 6 mg of Choline.
  • Wheat Germ: A 30 gm serving, approximately 1 oz, delivers 54 mg of Choline.
  • Quinoa: A ½ cup serving supplies 23 mg of Choline.

Lecithin: A Convenient Choline Source

Navigating the labyrinth of choline-rich foods may seem challenging. To simplify this journey, some choose to embrace lecithin supplements. Each 1200 mg capsule of lecithin contains approximately 160 mg of choline, making it a convenient way to bolster choline intake. Moreover, lecithin boasts other phospholipids that contribute to brain, liver, and kidney health, as well as the overall well-being of most body cells. However, it’s worth noting that lecithin in granule form, despite containing a substantial 250 mg of choline per tablespoon, may deter many due to its pungent fishy odour and taste.

Conclusion: Cultivating Cognitive Vigilance

In the grand tapestry of cognitive health, choline assumes the role of a silent hero. Its contributions extend beyond memory preservation to shield the brain from Alzheimer’s disease and cognitive decline. However, achieving the recommended choline intake presents a formidable challenge, as many fall short through diet alone. To safeguard our cognitive legacy, let us embark on a journey of culinary exploration, embracing choline-rich foods. And for those seeking a streamlined path, lecithin supplements offer a convenient solution. In this quest to preserve memory and cognitive function, choline emerges as a vital ally, inviting us to explore the boundless potential of our minds.

References:

  1. Poly C et al. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham offspring cohort. Am J Clin Nutr. 2011; 94(6):1584-1591                                                                                                                                                                                    [Read more](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252552)
  2. Bekdash RA. Neuroprotective effects of choline and other methyl donors. Nutrients. 2019; 11, 2995.                                                                    [Read more](https://www.mdpi.com/2072-6643/11/12/2995)
  3. Velazquez R et al. Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation. Aging Cell, 2019.                                                                                                                                                                          [Read more](https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13037)
 
Eat Smart, Live Well, Look Great
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 177 Unlocking the Power of Diet and Lifestyle: Shielding Against Colon Cancer

LMU-177

LMU – 177 Unlocking the Power of Diet and Lifestyle: Shielding Against Colon Cancer

Source: British Medical Journals “Gut” (September 2020)

Lifestyle Medicine Update (October 17, 2020)

Introduction:

Colon cancer, the second leading cause of cancer-related deaths in most developed nations, wields a significant impact on public health. Over the years, an increasing body of research has pointed to the undeniable influence of diet and lifestyle factors on the development of this malignancy. In this article, we delve into a compelling study published in the British Medical Journal, “Gut,” which meticulously scrutinizes the link between diet, lifestyle, and colon cancer.

The Foundation of Colon Cancer Risk

Before we dive into the protective and detrimental aspects of diet and lifestyle, it’s crucial to understand the foundational role they play in the risk of colon cancer. Numerous studies have unequivocally demonstrated that our daily choices significantly influence our susceptibility to this formidable disease.

Dietary Heroes: Magnesium, Folic Acid, Dairy, Fiber, and More

This comprehensive analysis uncovered a lineup of dietary superheroes, each armed with the power to shield against colon cancer. Magnesium, with an intake of at least 255 mg/day, emerged as a formidable defender, reducing the risk of colon cancer by a substantial 23%. Equally potent was the B-vitamin folic acid, showing its protective might with a 12-15% risk reduction. The stalwart presence of dairy products, associated with a 13% to 19% lower risk, can be attributed to their calcium content, as corroborated by other studies.

Dietary Fiber and Plant-Based Potency

Fiber, often hailed as a nutritional champion, demonstrated its prowess by contributing to a striking 22%-43% reduction in colon cancer risk. However, the real star of the show was fruit and vegetable intake, linked to a remarkable up to 52% lower risk[^1^]. Furthermore, for every additional 100 g/day (3.5 ounces) increase in intake, the protective effect gained momentum. The consumption of soybeans and soy products, spanning all varieties, was no less heroic, presenting an 8-15% decrease in the risk of colon cancer.

The Dark Side of Diet: Red Meat and Processed Meats

As with every epic saga, there is a dark side to this narrative. Red meat and processed meats emerge as antagonists in the battle against colon cancer, driving a 12-21% increase in risk. The ominous nature of this threat becomes even more apparent when considering a dose-dependent effect. Each additional 100 gm/d of red meat consumed escalates the risk, underscoring the dire consequences of unchecked consumption.

Alcohol – A Double-Edged Sword

The study’s findings underline the ambivalent nature of alcohol consumption concerning colon cancer risk. Even modest alcohol intake, ranging from 1-2 drinks per day, ushers in an elevated risk. This revelation adds nuance to our understanding of the relationship between alcohol and colon cancer, urging caution even among light to moderate drinkers.

A Synthesis of Established Wisdom

The revelations uncovered in this extensive review serve as a poignant reminder of the pivotal role our dietary and lifestyle choices play in preventing the second most prevalent cause of cancer-related deaths: colorectal cancer. While early detection through colonoscopies and fecal occult blood analysis remains crucial, proactive individuals dedicated to wellness should also be fervently committed to implementing practices that proactively ward off colon polyps and malignant tumours. The insights gained from this study offer a refined perspective on how to fine-tune our colon cancer prevention strategies.

Conclusion: Empowering the Fight Against Colon Cancer

In conclusion, the symbiotic relationship between diet, lifestyle, and colon cancer risk is undeniable. The findings elucidated in this study illuminate a path toward empowerment. By harnessing the protective potential of magnesium, folic acid, dairy, fiber, plant-based foods, and soy products, and vigilantly moderating red and processed meat intake as well as alcohol consumption, individuals can actively fortify their defences against colon cancer. As we navigate the complex terrain of colon cancer prevention, each dietary choice and lifestyle decision becomes a weapon in our arsenal to combat this formidable adversary.

Reference:

  1. Chapelle N, Martel M et al. *Recent advances in clinical practice: colorectal cancer chemoprevention in the average-risk population.* British Medical Journals – Gut. September 2020                                                                                                                                                                              [Read more](https://gut.bmj.com/content/early/2020/09/08/gutjnl-2020-320990)
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 176 Unlocking the Power of Vitamin C: A Game-Changer in COVID-19 Treatment

LMU-176

LMU – 176 Unlocking the Power of Vitamin C: A Game-Changer in COVID-19 Treatment

Source: Chinese Journal of Infectious Diseases

Lifestyle Medicine Update (October 9, 2020)

Introduction:

In previous updates, we’ve explored the remarkable role that vitamin C plays in supporting immune system function and its potential to combat the life-threatening cytokine storm associated with severe respiratory tract infections. In this article, we delve into a groundbreaking publication from the Chinese Journal of Infectious Diseases, titled “Comprehensive treatment and management of coronavirus disease 2019: expert consensus statement from Shanghai,” which introduces a fascinating element to the arsenal against COVID-19 – intravenous vitamin C therapy.

Shanghai’s Expert Consensus on COVID-19

The Shanghai Clinical Treatment Expert Group for COVID-19, drawing from a wealth of experience in preventing and controlling the virus, has meticulously fine-tuned their treatment approach. Their expert consensus statement encompasses the etiology, epidemiology, clinical characteristics, diagnosis, and treatment of COVID-19.

 The Intriguing Role of Vitamin C

Of particular interest within their comprehensive treatment protocol is the integration of intravenous vitamin C therapy. This innovative approach is recommended not only for patients with mild COVID-19 symptoms but also for those grappling with moderate to severe cases. The foundation for this recommendation arises from a pivotal study they conducted, involving a cohort of 358 COVID-19 patients, among whom fifty exhibited moderate to severe infections.

 Promising Results of Intravenous Vitamin C

The study’s findings offer an encouraging glimpse into the potential of intravenous vitamin C in COVID-19 treatment. Every patient who received this therapy experienced significant improvement, with no fatalities recorded. What’s more, their hospital stay was abbreviated by 3-5 days compared to those who did not receive vitamin C treatment.

Dosing Recommendations

The consensus panel advocates for a specific dosing regimen involving intravenous vitamin C. For hospitalized COVID-19 patients, they recommend administering 50-100 mg/kg of body weight continuously over a 24-hour period. However, when dealing with patients in the throes of a cytokine storm and more severe disease, the dosage is elevated to 200 mg/kg, following the same continuous infusion schedule. To put this into perspective, a person weighing 154 lbs (70 kg) would receive a daily intravenous vitamin C dosage of up to 7,000 mg (7gm). In cases where a cytokine storm rages, the dosage might escalate to 14,000 mg (14 gm). It’s noteworthy that some authorities combating respiratory infections with vitamin C suggest even higher daily intravenous dosages, reaching up to 25,000 mg (25 gm).

Insights into Vitamin C’s Mechanism of Action

To appreciate why vitamin C exhibits such promise in COVID-19 treatment, it’s essential to understand its role in immune function. Numerous immune cells heavily rely on vitamin C for optimal performance. During infections, vitamin C is rapidly consumed, leading to depletion. This depletion weakens the immune system, heightening oxidative damage within the lungs and internal organs. Moreover, it triggers the release of neutrophil extravascular traps (NETs), known culprits behind cytokine storms. Therefore, the continuous intravenous infusion of vitamin C serves as a lifeline for immune cells, ensuring an uninterrupted supply to enhance their viral-fighting capabilities. This approach minimizes lung tissue damage from free radicals and curtails the secretion of NETs from neutrophils, thereby mitigating the onset of a cytokine storm.

 A Glimpse into the Future

As COVID-19 studies unfold in North America and other Western developed nations, it will be intriguing to observe how widely the Chinese recommendations regarding intravenous vitamin C are adopted into treatment protocols. The impact of vitamin C on bolstering immune defences and its potential to subdue cytokine storms make it a powerful contender in the battle against this formidable virus.

Conclusion: A New Frontier in COVID-19 Treatment

In conclusion, the inclusion of intravenous vitamin C therapy in the expert consensus statement from Shanghai marks a significant advancement in COVID-19 treatment strategies. The compelling results from their study offer a glimmer of hope, demonstrating that this readily available nutrient may play a pivotal role in reducing the severity of the disease and expediting recovery. As the world grapples with the ongoing pandemic, embracing innovative approaches like intravenous vitamin C therapy could be a game-changer in our quest to conquer COVID-19.

References:

  1. Comprehensive treatment and management of coronavirus disease 2019: expert consensus statement from Shanghai. Chinese J Infect Dis, 2020                                                                                                                                                                                                                                                              [Read more](http://rs.yiigle.com/yufabiao/1189815.htm)
  2. Intravenous ascorbic acid for supportive treatment in hospitalized Covid-19 patients. International Society of Orthomolecular Medicine 2020, 35 (1)                                                                                                                                                                                                                                                        [Read more](https://isom.ca/article/intravenous-ascorbic-acid-for-supportive-treatment-in-hospitalized-covid-19-patients/)
 
Eat Smart. Live Well, Look Great,
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 175 Unlocking the Crucial Role of Vitamin E in Pregnancy Success

LMU-175

LMU – 175 Unlocking the Crucial Role of Vitamin E in Pregnancy Success

Sources: Multiple Peer-reviewed Medical and Scientific Journals

Lifestyle Medicine Update (October 1, 2020)

Introduction:

In the intricate journey of pregnancy, the significance of vitamin E, specifically alpha-tocopherol, has recently come to the forefront. Over the past decade, a series of compelling studies has underscored the pivotal role that this essential nutrient plays in ensuring a successful pregnancy. In this article, we will delve into the science behind vitamin E and its profound impact on the various stages of pregnancy.

The Link Between Vitamin E and Miscarriage

In a groundbreaking study from 2015, researchers illuminated a concerning association between vitamin E deficiency and the risk of miscarriage during the first trimester of pregnancy. Women with vitamin E blood levels below 12 umol/L faced nearly double the risk of experiencing a miscarriage, highlighting the critical role of this nutrient during early pregnancy[^1^].

The Mechanisms Behind Vitamin E’s Role

Understanding why vitamin E is indispensable during pregnancy requires a closer look at the mechanisms it influences. Studies have revealed that vitamin E serves as a linchpin for several vital functions in the endometrium during pregnancy[^2^]. Particularly in the first trimester, vitamin E orchestrates the synthesis of Interleukin-6 (IL-6) and Vascular Endothelial-Derived Growth Factor (VEGF). These factors are instrumental in fostering the growth of new blood vessels within the endometrium, creating an optimal environment for the embryo’s implantation. Additionally, vitamin E plays a pivotal role in modulating key aspects of immune function, reducing the risk of the mother’s body rejecting the developing embryo.

Vitamin E and Fetal Brain Development

The significance of vitamin E extends beyond the mother’s well-being, encompassing the development of the growing fetus. Vitamin E deficiency can lead to lipid peroxidation, which disrupts normal fetal brain development and the crucial process of methylation[^3^]. Just as folic acid is essential to prevent neural tube defects, vitamin E ensures that the fetus receives an adequate supply of choline for methylation reactions. This deficiency not only puts the fetus at risk for neural tube and brain-related issues but also elevates free radical damage in the fetal brain and body.

Fetal Growth, Lung Development, and Asthma Risk

A study in 2008 unveiled a compelling correlation between a mother’s vitamin E blood levels and fetal growth, as well as lung development[^4^]. Higher vitamin E levels were associated with increased fetal growth and improved lung development in utero. Furthermore, five years after birth, children born to mothers with low vitamin E blood levels during the first trimester exhibited a higher predisposition to asthma and scored lower on respiratory function tests.

The Alarming Reality of Vitamin E Deficiency

As evidence accumulates, it becomes increasingly apparent that maintaining adequate vitamin E levels is crucial for a successful pregnancy. Shockingly, reports suggest that approximately 96% of American women fail to meet recommended daily intake levels for vitamin E[^5^]. This stark reality underscores the urgency for women planning to conceive or already pregnant to undergo a vitamin E blood test to ensure their levels exceed 12 umol/L (5.5-18.0 mg/L).

Recognizing the Rarity of Severe Vitamin E Deficiency

While vitamin E deficiency remains rare in modern society, individuals with malabsorption issues related to intestinal ailments are most vulnerable[^6^]. However, findings from the National Health and Nutrition Examination Survey III (NHANES III) revealed that about one-third of all American participants had blood concentrations of vitamin E (α-tocopherol) below 20 μmol/L, a value historically associated with decreased cardiovascular disease risk.

Conclusion: Empowering Pregnancy with Vitamin E

In conclusion, vitamin E emerges as a potent ally in ensuring a successful pregnancy journey. Its multifaceted roles in preventing miscarriage, promoting fetal brain and lung development, and mitigating asthma risk underscore its importance. With a significant portion of women failing to meet recommended vitamin E intake levels, requesting a vitamin E blood test (alpha-tocopherol) becomes imperative for those planning to conceive or already pregnant. In striving for healthy pregnancies, vitamin E stands as a powerful safeguard for both mothers and their precious unborn children.

References:

  1. American Journal of Clinical Nutrition. 2015; 101(2):294.                                                                                                                                                            [Read more](https://academic.oup.com/ajcn/article/101/2/294/4494385)
  2. PubMed. 2012; 22819759.                                                                                                                                                                                                                              [Read more](https://pubmed.ncbi.nlm.nih.gov/22819759/) 
  3. Nature Scientific Reports. 2020; 10(1):1-10.                                                                                                                                                                                          [Read more](https://www.nature.com/articles/s41598-020-71760-x)
  4. PubMed. 2010; 20435859.                                                                                                                                                                                                                            [Read more](https://pubmed.ncbi.nlm.nih.gov/20435859/)
  5. Health and Science. 2021.                                                                                                                                                                                                                            [Read more](https://www.healthandscience.eu/index.php?option=com_content&view=article&id=1114:lack-of-vitamin-e-is-widespread-and-it-increases-the-risk-of-fetal-damage-and-miscarriage-us&lang=us&Itemid=363)
  6. Linus Pauling Institute, Oregon State University.                                                                                                                                                                              [Read more](https://lpi.oregonstate.edu/mic/vitamins/vitamin-E)
 
Eat Smart, Live Well, Look Great
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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