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LMU 296 – Low-level Laser Therapy Effective for Tinnitus

LMU-296

Shedding Light on Tinnitus: A Breakthrough Treatment

Source: Journal of Personalized Medicine (March 2023)

Lifestyle Medicine Update (July 25, 2023)

Introduction: The Phantom Symphony:

Tinnitus, the relentless ringing or buzzing in the ears, torments approximately 14% of adults worldwide. For a staggering 20% of these individuals, the severity of this auditory phantom wreaks havoc on their lives. With no definitive understanding of its origins and a dearth of effective treatments, tinnitus poses a formidable challenge to those afflicted, compromising their quality of life.

The Elusive Quest for Relief:

Conventional therapies for tinnitus, ranging from sedatives to antidepressants, offer scant solace, leaving many sufferers in a perpetual state of distress. The search for a panacea has been futile, leaving a trail of frustration in its wake.

A Ray of Hope: The Laser Revolution:

In a watershed moment, a glimmer of hope emerges from the depths of despair. A study published in the Journal of Personalized Medicine in March 2023 heralds a paradigm shift in tinnitus treatment. Researchers from the Optics and Photonics Research Center (CEPOF) in Brazil unveil a groundbreaking discovery—the remarkable efficacy of low-level laser therapy in assuaging the torment of tinnitus.

Unveiling Laser’s Healing Touch:

Embarking on a quest to unravel the mysteries of tinnitus, the researchers conducted a meticulous study, enlisting 100 men and women grappling with the affliction. Over a span of four weeks, patients underwent a regimen of ten diverse treatments, each administered twice weekly. The results? A resounding affirmation of the transformative power of low-level laser therapy. When directed at specific acupuncture points on the ear or penetrating the tympanic membrane itself, the laser emerges as a potent ally, significantly reducing the severity of tinnitus symptoms.

The Mechanisms of Laser Therapy: Unlocking Nature’s Resilience:

Delving into the inner workings of low-level laser therapy, the researchers uncover a trove of physiological marvels. From its anti-inflammatory prowess to its ability to enhance peripheral irrigation and stimulate inner ear cell proliferation, the laser emerges as a multifaceted healer. By harnessing its capacity to bolster ATP energy production, foster inner ear blood flow, and activate hair cell mitochondria, low-level laser therapy offers a glimmer of hope to those ensnared in the clutches of tinnitus.

A Pathway to Liberation:

Armed with the promise of low-level laser therapy, individuals plagued by tinnitus or Meniere’s disease embark on a journey of liberation. With the guidance of knowledgeable practitioners, the flicker of hope kindled by the laser illuminates the path to relief, promising respite from the relentless cacophony that plagues their existence.

Conclusion: Illuminating the Path to Tranquility:

As the echoes of tinnitus reverberate through the corridors of despair, the advent of low-level laser therapy heralds a dawn of hope. With its transformative potential to assuage the torment of tinnitus, the laser emerges as a beacon of light in the darkness, guiding sufferers towards a symphony of tranquility and reclaiming the melody of silence.

References:

Eat Smart, Live Well, Look Great,

Dr. Meschino

Recommended Supplements

All-in-One Multi-Vitamin Mineral

All-in-One Multi-Vitamin Mineral

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 295 – Glucosamine Linked to Reduced Cancer Risk in Large UK Biobank Study (2022)

LMU-295

Glucosamine: A Potential Shield Against Cancer

Source: Journal, Frontiers of Nutrition (November 2022)

Lifestyle Medicine Update (July 18, 2023)

Introduction: The Glucosamine Revelation:

In the labyrinth of health supplements, glucosamine emerges as a beacon of hope, offering not just joint support but also a surprising defense against cancer. In a groundbreaking revelation unveiled in 2020, the Annals of Rheumatology disclosed that regular intake of glucosamine supplements was linked to a substantial reduction in cancer mortality alongside a myriad of other health benefits. This tantalizing discovery set the stage for further exploration into glucosamine’s anti-cancer properties, leading to a pivotal update from the UK Biobank study in 2022.

UK Biobank Study: Unveiling Glucosamine’s Cancer Armor:

Heralded as one of the largest population studies globally, the UK Biobank study embarked on a mission to unravel the mysteries of glucosamine’s potential as a shield against cancer. With a cohort exceeding 500,000 individuals, ranging from 38 to 73 years old, the study meticulously traced their health trajectories from 2006 to 2010 until March 2021, none bearing the burden of cancer at the study’s inception. The resounding verdict? Glucosamine users exhibited a remarkable array of benefits, including a 5% reduction in overall cancer risk and staggering declines in specific cancer mortalities, such as kidney, lung, and rectal cancers.

Glucosamine’s Anti-Cancer Arsenal:

Delving deeper into the realm of molecular biology, glucosamine unveils a potent arsenal against cancer. In laboratory settings, glucosamine flexes its anti-cancer muscles, inhibiting the proliferation of various human cancer cells, orchestrating programmed cell death (apoptosis), thwarting tumor drug resistance, impeding tumor blood vessel formation, and curtailing cancer cell invasion into neighboring tissues. The synergy of these mechanisms paints a compelling picture of glucosamine’s prowess in combating cancer’s insidious advance.

Glucosamine Availability and Usage: Empowering the Masses:

Accessible as both a prescription drug in Europe and an over-the-counter supplement in Australia, the US, and Canada, glucosamine offers a versatile armor against cancer to a global audience. While usage rates vary across regions, with approximately 20% of Australian adults embracing glucosamine, its adoption remains relatively modest in the US and Canada. However, armed with the knowledge of its anti-cancer potential, a surge in its usage may be on the horizon.

Complementary Natural Agents: Enhancing Glucosamine’s Arsenal:

Some glucosamine formulations marry its might with three natural anti-inflammatory agents—Quercetin, Bromelain, and MSM—each boasting their own anti-cancer properties. This synergistic blend not only fortifies glucosamine’s anti-cancer armamentarium but also amplifies its overall health benefits.

Recommendation: Harnessing Glucosamine’s Potential:

As the body’s natural glucosamine production wanes around the age of 40, embracing a glucosamine supplement enriched with natural anti-inflammatory allies may serve as a proactive step towards cancer prevention and overall well-being. With mounting evidence illuminating glucosamine’s multifaceted benefits, its integration into daily health regimens emerges as a prudent choice for individuals seeking to defy the odds of cancer mortality.

References:

Eat Smart, Live Well, Look Great,

Dr. Meschino

Glucosamine and Reduced Cancer Risk

In 2020, a published paper in the Annals of Rheumatology reported that regular use of glucosamine supplements was associated with:

  • A significantly reduced risk of dying from cancer, cardiovascular, respiratory, and intestinal tract diseases.
  •  A 15% reduction in all-cause mortality compared to non-users of glucosamine supplements.

The data was derived from approximately 500,000 individuals being followed in the UK Biobank study.

UK Biobank Study Update on Glucosamine and Cancer

  • In November 2022, the UK Biobank study was updated and published in the Frontiers of Nutrition journal, with a specific focus on glucosamine’s potential protective role against cancer.
  • The UK Biobank study is one of the largest population studies in the world, aiming to improve disease prevention, diagnosis, and treatment, as well as promote health across society.
  • The original study included over 500,000 participants from the UK, aged 38 to 73, who were followed from 2006 to 2010 until March 2021. None of the participants had cancer at the study’s beginning.
  • After controlling for other cancer risk factors, the study showed that individuals who routinely took glucosamine supplements exhibited significant benefits:
    1. 5% decrease in overall cancer risk
    2. 32% lower risk of kidney cancer mortality
    3. 16% lower risk of lung cancer mortality
    4. 24% lower risk of rectal cancer mortality

Glucosamine and Anti-Cancer Properties

Glucosamine has shown important anti-cancer properties in experimental and animal studies, including:

    • Inhibition of proliferation in various types of human cancer cells
    • Inducing programmed cell death (apoptosis) in many cancer cell types
    • Reversal of tumor drug-resistance
    • Inhibition of tumor blood vessel formation (anti-tumorigenesis)
    • Blocking cancer cells’ ability to invade neighboring tissues by inhibiting destructive enzymes (matrix metalloproteinases)

Several epidemiological studies in the US and the UK have indicated that glucosamine is linked to reduced cancer mortality, with some studies reporting a 15% reduction in overall cancer risk.

Glucosamine Availability and Usage

  • Glucosamine is available as a prescription drug in most European countries but as an over-the-counter supplement in Australia, the US, and Canada.
  • Usage rates vary, with about 20% of Australian adults using glucosamine supplements, approximately 2% of US adults, and an estimated 5-7% of the adult population in Canada.

Complementary Natural Agents

Some glucosamine supplements contain three natural anti-inflammatory agents (Quercetin, Bromelain, and MSM), which have their own unique anti-cancer properties in various studies.

Recommendation

  • Based on the evidence, it may be beneficial for individuals to consider taking a glucosamine supplement with natural anti-inflammatory agents around the age of 40, as this is the time when the body naturally produces less glucosamine.

References

  1. Zhou J et al. Association between glucosamine use and cancer mortality: A large prospective cohort study. Front Nutr. 2022. 9 Link
  2. Li Z-H et al. Associations of regular glucosamine use with all-cause and specific mortality: a large prospective cohort study. Ann Rheum Dis. 2020; 79(6): 829-863. Link
  3. Bromelain Anti-cancer Properties: Link
  4. Quercetin Anti-Cancer Properties: Link
  5. MSM Anti-Cancer Properties: Link

Recommended Supplements

Glucosamine Joint Formula

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 294 – Protecting Against Parkinson’s: The Role of Glutathione

LMU-294

Defending Against Parkinson’s Disease: The Promise of Glutathione Supplementation

Source: International Journal of Molecular Science (2021)

Lifestyle Medicine Update (July 5, 2023)

Introduction: Parkinson’s Disease – A Looming Challenge:

Parkinson’s disease, the second most prevalent neurodegenerative disorder following Alzheimer’s, casts a shadow over the lives of one in every five hundred individuals aged fifty and above. With aging populations burgeoning worldwide, it is estimated that by 2030, around nine million people will grapple with this debilitating condition. A blend of genetic predisposition and environmental influences underpins its onset, with oxidative stress—unbridled free radicals—playing a pivotal role in its pathogenesis.

The Role of Free Radicals and Glutathione:

Within the brain cells responsible for producing dopamine, an excessive accumulation of free radicals spells doom, heralding the demise of these cells and kickstarting Parkinson’s disease. As individuals age, dwindling levels of brain glutathione contribute to heightened oxidative stress, escalating the vulnerability to Parkinson’s disease and other neurodegenerative afflictions.

Glutathione Treatment as a Viable Strategy:

In the quest to fortify brain cells against free radical onslaught and manage Parkinson’s disease, researchers have fervently explored avenues to bolster brain glutathione levels in older individuals. A meta-analysis in 2021 corroborated the efficacy of glutathione treatment in ameliorating muscle and movement impairments, including tremor reduction, in Parkinson’s patients. Moreover, glutathione treatment not only alleviates the symptoms but also disrupts the disease’s underlying pathological processes.

Optimizing Glutathione Levels:

Although oral glutathione supplements often succumb to breakdown within the intestinal tract, N-acetylcysteine (NAC) emerges as a potent stimulator of glutathione synthesis, effortlessly traversing the blood-brain barrier to elevate brain glutathione levels. Additionally, nutrients like Alpha-lipoic acid, Silymarin from Milk thistle, and L-Glutamine furnish alternative routes to augment blood and tissue glutathione levels.

The Imperative of Glutathione Supplementation:

Given the age-related decline in glutathione levels and its pivotal role in neutralizing detrimental free radicals within the body and brain cells, supplementation becomes imperative around the age of 45-50. A judiciously formulated supplement encapsulating NAC, Alpha-lipoic acid, Silymarin, and L-Glutamine promises to synergistically elevate glutathione levels, ushering in a cascade of anti-aging and health-enhancing benefits.

Conclusion:

As the specter of Parkinson’s disease looms large, the spotlight shifts to glutathione supplementation as a beacon of hope in the battle against neurodegeneration. Armed with its antioxidant prowess, glutathione stands as a formidable fortress, shielding brain cells from the ravages of oxidative stress and extending a lifeline to those grappling with Parkinson’s disease. With meticulous supplementation strategies, individuals can bolster their defenses, fortifying themselves against the scourge of aging-related cognitive decline and embracing a future brimming with vitality and vigor.

References:

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Parkinson’s Disease – A Growing Concern

Parkinson’s disease, the second most common neurodegenerative condition after Alzheimer’s, affects one in five hundred
adults over fifty. By the year 2030, approximately nine million people are estimated to be afflicted with this condition as aging populations grow in many countries. The disease is caused by a combination of genetic and environmental factors, with unmitigated free radicals (oxidative stress) playing a significant role in its development.

The Role of Free Radicals and Glutathione

  • High levels of free radicals within dopamine-producing brain cells lead to their death, triggering the onset and progression of Parkinson’s disease.
  • Age-related decline in brain glutathione levels contributes to elevated free radicals during the aging process, increasing the risk of Parkinson’s disease and other neurodegenerative conditions.

Glutathione Treatment as an Effective Approach

  • Researchers have been investigating ways to increase brain glutathione levels in older subjects to protect brain cells from free radical damage and manage existing cases of Parkinson’s disease.
  • A 2021 meta-analysis confirmed that glutathione treatment is effective in improving muscle and movement function, including tremor reduction, in Parkinson’s patients.
  • Glutathione treatment not only reduces Parkinson’s disease symptoms but also inhibits steps involved in the underlying cause of the disease.

Optimizing Glutathione Levels

The Importance of Glutathione Supplementation

References:

  1. Wang H-L et al. Potential use of glutathione as a treatment for Parkinson’s disease. Exp Ther Med. 2021;21(2): 125 Link
  2. Smeyne M. Glutathione metabolism and Parkinson’s disease. Free Radic Biol Med. 2013; 62: 13-25
  3. Aoyama K. Glutathione in the brain. Int J Mol Sci. 2021; 22(9): 5010 Link

Eat Smart, Live Well, Look Great,

Dr. Meschino

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Ultimate GLX

Ultimate GLX

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 293 – Bacopa Monnieri Supplementation for Memory Support and Improvement in Aging

LMU-293

Unlocking Memory Power: The Potential of Bacopa Monnieri for Aging Brains

Source: Frontiers of Aging Neuroscience Journal (2021)

Lifestyle Medicine Update (June 20, 2023)

Introduction:

As we age, memory lapses and cognitive struggles can dim the luster of our golden years. However, amidst the challenges, a lesser-known herb from India, Bacopa monnieri, emerges as a promising ally in the fight against memory decline. In this article, we delve into the potential of Bacopa monnieri supplementation to preserve and enhance memory in aging individuals, supported by both experimental and human clinical studies.

Bacosides A and B: The Brain’s Guardians:

Within Bacopa monnieri lie two potent compounds—Bacosides A and B—that hold the keys to memory preservation. These compounds possess the remarkable ability to penetrate the blood-brain barrier, where they embark on a mission to safeguard brain cells. Acting as neuroprotectors, they fortify memory, repair damaged neurons, and even rid brain cells of toxic metals. Bacopa’s arsenal includes powerful antioxidants that combat free radicals, reduce brain inflammation, enhance blood flow to the brain, and elevate levels of acetylcholine, the brain’s memory messenger. Moreover, Bacopa monnieri boosts the brain’s defense mechanisms by ramping up protective antioxidants like Superoxide Dismutase, Catalase, and Glutathione Peroxidase.

Human Clinical Studies: Unveiling Bacopa’s Memory Magic:

In a compelling study published in Frontiers of Aging and Neuroscience in 2021, multiple human clinical trials underscored Bacopa monnieri’s prowess in memory enhancement. These trials revealed that supplementation with Bacopa monnieri not only improved immediate and delayed recall memory but also supercharged brain processing speed and sustained attention within as little as 12 weeks to 3 months of supplementation initiation. The rapid onset of these effects hints at Bacopa’s quick action in rejuvenating aging brains.

Combination with Other Supplements: Powering Up Memory Defense:

Crossing the age threshold of 50-55 poses challenges in maintaining optimal levels of acetylcholine—the brain’s memory fuel—due to the waning effectiveness of the blood-brain barrier. Here, Bacopa monnieri teams up with other memory-support supplements to mount a formidable defense. Pairing Bacopa with CDP-choline, Phosphatidylserine, and Huperzine A fortifies the brain’s defenses against age-related decline. This synergistic combination acts as a bulwark, safeguarding against cognitive deterioration, executive function decline, and sluggish processing speed.

Conclusion: Unlocking the Fountain of Memory Youth:

Bacopa monnieri emerges as a beacon of hope in the quest for age-defying memory. Its ability to breach the blood-brain barrier and shield brain cells sets it apart as a potent memory enhancer. Armed with antioxidants and memory-boosting properties, Bacopa monnieri stands as a stalwart guardian of brain health. For individuals navigating the maze of aging, a daily regimen incorporating Bacopa monnieri, CDP-choline, Phosphatidylserine, and Huperzine A presents a compelling strategy to combat cognitive decline and reclaim the vibrant tapestry of memory and cognition.

In the journey towards cognitive vitality, Bacopa monnieri offers a glimmer of hope—a testament to nature’s profound wisdom and the boundless potential of the human mind.

Eat Smart, Live Well, Look Great,

Dr. Meschino

Recommended Supplements

Memory Support Complex

Memory Support Complex

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
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LMU 292 – Exercise and Diabetes Prevention: Insights from a 2023 Study

LMU-292

Exercise: A Powerful Defense Against Type 2 Diabetes

Source: British Journal of Sports Medicine (2023)

Lifestyle Medicine Update (June 14, 2023)

Introduction

In today’s fast-paced world, health has become a paramount concern for individuals of all ages. Among various health-promoting practices, exercise stands out as one of the most effective preventive measures against a myriad of chronic diseases, including type 2 diabetes. The significance of exercise as preventive medicine has repeatedly been reiterated by healthcare professionals and researchers. In this context, the study published in the British Journal of Sports Medicine in 2023 by M. Luo et al. sheds new light on the association between exercise and diabetes risk, supplying valuable insights that can positively change public health policies and individual lifestyle choices.

Study Details

The research by M. Luo and colleagues involved a comprehensive analysis of data from the UK Biobank study. The UK Biobank, a large-scale biomedical database, has extensive health information from over 500,000 participants, including genetic data, lifestyle factors, and medical history. For this specific study, 59,325 adults were selected as the participants, making it one of the largest studies to investigate the relationship between physical activity and diabetes risk.

Researchers employed ultramodern technology to gather correct and reliable data on participants’ physical activity. Each participant was asked to wear an accelerometer, a small and portable device that accurately measures movements and physical activity levels. The accelerometers were worn for a prolonged period of seven years, allowing for a detailed examination of the participants’ daily activity patterns.

 Key Findings

The results of the study unveiled a striking correlation between physical activity and type 2 diabetes risk. Participants who engaged in moderate-to-vigorous physical activity for over one hour per day experienced a remarkable 74% reduction in the risk of developing type 2 diabetes compared to those who engaged in less than 5 minutes per day of such activity. This finding emphasizes the importance of incorporating regular, sustained, and moderately intense physical activity into daily routines to safeguard against the development of this prevalent metabolic disorder.

 Furthermore, the research delved deeper into the influence of genetic factors on diabetes risk. It is well-established that genetic predisposition plays a role in deciding an individual’s susceptibility to type 2 diabetes. However, the study’s intriguing revelation was that even individuals with a high genetic risk for type 2 diabetes could substantially mitigate their risk through consistent and substantial physical activity. Typically, individuals with a high genetic risk are believed to be 2.4 times more likely to develop type 2 diabetes; yet, the protective effects of exercise were still clear in this subgroup, offering hope and motivation for those who may be at higher risk due to their genetic makeup.

Comments from Researchers

One of the researchers involved in the study expressed enthusiasm over the potential implications of their findings. They said, We are unable to control our genetic risk and family history, but this finding provides promising and positive news that through an active lifestyle, one can ‘fight off’ much of the excessive risk for type 2 diabetes. This optimistic outlook resonates with the growing body of research that underscores the transformative power of lifestyle interventions.

Benefits of Moderate-to-Vigorous Exercise for Diabetes Prevention

The study findings raise the question: How does moderate-to-vigorous exercise exert its protective effects against diabetes? To answer this, we must explore the physiological changes that occur during physical activity:

  1. Improving Insulin Sensitivity:Insulin, a hormone produced by the pancreas, plays a crucial role in regulating blood glucose levels. Insulin sensitivity refers to how effectively our cells respond to insulin’s action in transporting glucose from the bloodstream into cells. Regular exercise enhances insulin sensitivity, which allows the body to use glucose more efficiently, ultimately reducing blood sugar levels and lowering the risk of diabetes.
  2. Enhancing Fat-Burning:Obesity and excess body weight are proven risk factors for insulin resistance, a condition where cells become less responsive to insulin. Engaging in moderate-to-vigorous physical activity promotes fat burning and helps prevent weight gain, thus reducing the risk of developing insulin resistance and type 2 diabetes.
  3. Activation of Sirtuin Longevity Genes:Sirtuins are a group of proteins that regulate various cellular processes, including those involved in metabolism and aging. Some sirtuins are known to be involved in regulating insulin sensitivity and glucose metabolism. Exercise activates these longevity genes, positively affecting overall cardiometabolic health and reducing the likelihood of developing diabetes.

Conclusion

The findings of the 2023 study published in the British Journal of Sports Medicine reinforce the idea that our genes do not solely decide our destiny. While genetic factors can influence disease risk, lifestyle choices and behaviors have the power to modulate gene expression and influence health outcomes significantly. Regular, moderate-to-vigorous physical activity can combat the risk of type 2 diabetes and improve overall health and quality of life.

These insights hold profound implications for public health initiatives, healthcare providers, and individuals alike. Encouraging and promoting physical activity should be a cornerstone of preventive healthcare strategies to tackle the growing burden of diabetes and other chronic diseases. The integration of exercise into daily routines is not only an investment in individual health but also an investment in the well-being of societies at large.

In conclusion, the study serves as a clarion call to action, urging individuals to embrace an active lifestyle and empowering them to take charge of their health destinies. As we navigate the challenges of modern living, let us not forget the simple yet transformative power of exercise in promoting health, longevity, and a vibrant quality of life.

References:

Luo M et al. Accelerometer-measured intensity-specific physical activity, genetic risk, and incident type 2 diabetes: A prospective study. Br J Sports Med. (2023) Accelerometer-measured intensity-specific physical activity, genetic risk, and incident type 2 diabetes: a prospective cohort study | British Journal of Sports Medicine (bmj.com)
[Link](https://bjsm.bmj.com/content/early/2023/03/06/bjsports-2022-104787)

Exercise Mitigates Genetic Risk for Type 2 Diabetes. NeuroscienceNews.com (June 5, 2023) Exercise Mitigates Genetic Risk for Type 2 Diabetes – Neuroscience News [Link](https://neurosciencenews.com/exercise-genetic-diabetes-19155/)

 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

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Body Burn

Body Burn

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
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LMU 291 – Folic Acid Supplementation Improves Efficacy of Anti-Depression Drugs

LMU-291

Enhancing Antidepressant Treatment: The Role of Methylfolate Supplementation

Source: Journal of Clinical Psychiatry (2023)

Lifestyle Medicine Update (June 6, 2023)

Introduction:

In May 2023, the Journal of Clinical Psychiatry published a comprehensive review paper examining the potential of methylfolate, a specialized form of the B-vitamin folic acid, as an adjunctive therapy for major depressive disorder. This review aims to synthesize findings from various studies investigating methylfolate’s efficacy in individuals who do not respond adequately to traditional antidepressant medications alone.

Key Findings:

The review highlights several significant findings:

  • The addition of methylfolate to antidepressant drug therapy significantly improves treatment response rates in individuals previously resistant to antidepressant medications.
  • Methylfolate plays a vital role in synthesizing neurotransmitters, particularly serotonin, which is essential for mood regulation. Unlike antidepressants, which primarily slow serotonin breakdown, methylfolate facilitates serotonin synthesis, offering a unique mechanism for treatment augmentation.
  • Methylfolate supplementation is particularly beneficial for patients with drug-resistant major depression, especially those who are overweight or exhibit high levels of inflammatory blood markers. Overweight individuals often have elevated inflammatory chemicals, which can impede serotonin synthesis and reduce antidepressant efficacy. Methylfolate helps counteract these effects, enabling the normalization of serotonin synthesis.
  • The recommended effective dosage of methylfolate for individuals unresponsive to antidepressant drugs is 15 mg per day. Psychiatrists are encouraged to consider adding methylfolate to the treatment regimen for such patients.

Implications and Recommendations:

The review underscores the broader importance of nutritional support in mental health:

  • Various vitamins and minerals, including B-vitamins (folic acid, vitamin B12, B6, B3, and pantothenic acid), vitamin C, and magnesium, are essential for neurotransmitter synthesis and overall brain function. Consideration of high-potency multivitamin and mineral supplements, along with increased antioxidant dosages, is recommended to support mental health.

Clinical application:

Individuals with depression, especially those who have not responded adequately to antidepressant medications, should discuss the potential benefits of methylfolate supplementation (15 mg/day) with their healthcare providers. Elevated levels of markers such as blood homocysteine, ESR, and CRP may indicate potential responsiveness to methylfolate supplementation.

Conclusion:

The review emphasizes the importance of considering natural supplements, such as methylfolate, as adjunctive treatments for depression. By addressing underlying nutritional deficiencies and supporting neurotransmitter synthesis, these supplements offer promising avenues for enhancing antidepressant efficacy and promoting brain health.

References:

 
Eat Smart, Live Well, Look Great,

Dr. Meschino

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Nature’s Essential Oils

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
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LMU 290 – Reishi Mushroom Extract Bolsters Immune Function in Post-operative Breast and Colon Cancer Patients, Improving Overall Outcomes: An important finding for those over 50

LMU-290

Boosting Immune Function with Reishi Mushroom Extract: Insights from Cancer Patients

Source: Journal of Clinical and Translational Oncology (2021)

Lifestyle Medicine Update (May 31, 2023)

Introduction: Enhancing Immune Function in Cancer Patients

A study published in Clinical and Translational Oncology in 2021 sheds light on the immune-boosting effects of Reishi Mushroom Extract in breast and lung cancer patients post-surgery. Strengthening the immune system is crucial for cancer patients’ overall survival and well-being.

Study Findings: Reishi Mushroom Extract and Immune Response

Patients receiving Reishi Mushroom Extract demonstrated heightened immune function compared to those without supplementation. They exhibited increased levels of T-lymphocytes, crucial for combating cancer and infections, along with reduced levels of immune-suppressing prostaglandins and cytokines. Additionally, Reishi Mushroom Extract improved key ratios indicative of cancer progression and survival.

Clinical Implications: Reishi Mushroom Extract for Immune Support

The study underscores the potential of Reishi Mushroom Extract to enhance immune function, benefiting not only cancer survivors but also individuals over 50. Aging compromises thymus gland function, leading to diminished T-lymphocyte activity and increased susceptibility to infections and cancer. Supplementation with Reishi Mushroom Extract and other immune-modulating agents post-50 can fortify immune defenses and support overall health.

Recommendations: Consider Immune Support After 50

Given the decline in immune function with age, incorporating immune-supportive supplements like Reishi Mushroom Extract, astragalus, indole-3-carbinol, and Milk Thistle may be beneficial. These supplements have shown promise in bolstering immune function and detoxification enzyme activity, promoting longevity and vitality.

Conclusion: Harnessing Nature’s Immune-Boosting Power

Studies like this highlight the potential of natural supplements like Reishi Mushroom Extract in strengthening immune function and mitigating cancer risk. By prioritizing immune support, especially after 50, individuals can optimize their defense mechanisms and maintain overall well-being.

References:

  1. Deng Y. et al. Dynamic biomarkers indicate the immunological benefits provided by Ganoderma spore powder in post-operative breast and lung cancer patients. Clinical and Translational Oncology. 2021; 23: 1481-1490 [Link](https://link.springer.com/article/10.1007/s12094-020-02547-9)
  2. AG Ratio [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706002/)
  3. NL Ratio [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998851/#:~:text=The%20neutrophil%2Dto%2Dlymphocyte%20ratio%20(NLR)%2C%20calculated,supported%20by%20lymphocytes%20%5B1%5D.)
 
Eat Smart, Live Well, Look Great,

Dr. Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
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LMU 289 – NAC Administration Improves Parkinson’s Disease: The importance of preventing the age-related decline in brain glutathione

LMU-289

NAC: A Promising Supplement for Parkinson's Disease

Source: J Clinical Pharmacology & Therapeutics (2019)

Lifestyle Medicine Update (November 15, 2022)

Introduction: Unveiling the Role of Glutathione in Brain Health

The decline in brain glutathione levels with age has been linked to various neurodegenerative diseases, including Alzheimer’s and Parkinson’s. Glutathione serves a crucial role in protecting brain cells from free radical damage and supporting overall brain function.

Study Findings: NAC for Parkinson’s Disease

A 2019 study published in Clinical Pharmacology & Therapeutics explored the effects of N-acetylcysteine (NAC) supplementation on Parkinson’s disease symptoms. Patients receiving NAC exhibited significant improvement in Parkinson’s symptoms over a three-month period compared to those on standard care alone. Additionally, brain imaging revealed enhanced dopamine transporter activity, crucial for maintaining optimal dopamine levels and symptom relief in Parkinson’s patients.

Understanding the Mechanisms: NAC and Glutathione

NAC not only boosts brain glutathione levels, safeguarding against free radical damage, but also enhances dopamine transporter function. This dual action may contribute to improved symptom management and disease progression in Parkinson’s patients.

Implications for Brain Health: Preventing Age-Related Decline

Age-related decline in glutathione levels poses a significant risk for neurodegenerative diseases. Given the vulnerability of brain cells to oxidative stress, maintaining optimal glutathione levels becomes crucial for preserving cognitive function and mitigating disease risk.

Recommendations: Glutathione-Boosting Supplements

Taking a daily supplement containing NAC, along with alpha-lipoic acid, L-glutamine, and Milk Thistle standardized to 80% Silymarin Flavonoid Content, could help maintain glutathione levels after the age of 40. These supplements have demonstrated efficacy in raising blood and tissue glutathione levels, offering a proactive approach to brain health and aging.

Conclusion: A Step Towards Cognitive Wellness

Incorporating NAC supplementation alongside other glutathione-boosting nutrients presents a promising strategy for preserving brain health and combating neurodegenerative diseases. By addressing age-related glutathione decline, individuals can enhance their chances of healthy aging and sustained cognitive function.

References:

  1. Monti D et al. N-acetyl cysteine is associated with dopaminergic improvement in Parkinson’s disease. Clin Pharmacol Ther. 2019;106(4): 884-890 [Link](https://pubmed.ncbi.nlm.nih.gov/31206613/)
  2. Aoyama K. Glutathione in the brain. Int J Mol Sci. 2021, 22(9): 5010 [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125908/)
  3. Iskusnykh I.Y. et al. Glutathione in brain disorders and aging. J Molecules. 2022, 27(1): 324 [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746815/#:~:text=Impairment%20of%20glutathione%20function%20in,%2C%20stroke%2C%20and%20Alzheimer’s%20disease.)
  4. Ikeda K et al. Dopamine transporter imaging in Parkinson Disease: Progressive changes and therapeutic modification after anti-parkinsonian medication. [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630131/#:~:text=Clinical%20Role%20of%20Dopamine%20Transporter%20Imaging&text=DAT%20is%20the%20most%20important,release%20from%20the%20presynaptic%20terminal.)
  5. Dopamine Transporter (DAT) [Link](https://en.wikipedia.org/wiki/Dopamine_transporter)
 
Eat Smart, Live Well, Look Great,

Dr. Meschino

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 288 Supplement Formula Shown to Improve Early Alzheimer’s Disease

LMU-288

Supporting Cognitive Health: Insights from a Nutritional Approach for Early-Stage Alzheimer's Patients

Source: American Journal of Alzheimer’s Disease (2009)

Lifestyle Medicine Update (May 17, 2023)

Introduction: Understanding the Study

A recent study published in the American Journal of Alzheimer’s Disease sheds light on the potential benefits of a specific natural supplement regimen for individuals in the early stages of Alzheimer’s disease. This one-year study, followed by a caregiver extension of an additional four months, showcased notable improvements in various cognitive parameters among participants.

Study Findings: Promising Results

Participants who received the natural supplement demonstrated enhancements in cognitive assessments, including the Dementia Rating Scale and Clock-drawing Tests. Additionally, caregivers reported improvements in neuropsychiatric parameters and observed maintenance of performance in daily activities among the participants. Even after the 16-month period, those who continued the supplement regimen exhibited sustained improvement, as noted by their caregivers.

Understanding the Supplement Composition

The natural supplement consisted of essential B-vitamins such as Folic Acid and Vitamin B6, along with Vitamin E, SAMe, N-acetylcysteine, and Acetyl-L-Carnitine. Each component plays a crucial role in supporting brain health and function.

Scientific Rationale: Targeting Key Mechanisms

The researchers highlighted the significance of the supplement’s ingredients. Folic acid, SAMe, and Vitamin B6 are essential for neurotransmitter production and homocysteine regulation, addressing established risk factors for Alzheimer’s disease. Vitamin E serves as a potent antioxidant, protecting brain cells from oxidative stress. Moreover, N-acetylcysteine boosts glutathione levels, critical for combating free radical damage, while Acetyl-L-Carnitine supports mitochondrial function and neurotransmitter synthesis.

Implications for Alzheimer’s Management

The study underscores the importance of integrating nutritional interventions alongside conventional Alzheimer’s treatment. While pharmaceutical approaches often overlook critical aspects of the disease, targeted natural supplements offer a multifaceted approach to preserve cognitive function and slow disease progression. Considering the limited efficacy of Alzheimer’s drugs alone, supplementing with nutrients tailored to address key disease mechanisms is a promising avenue for mild cognitive impairment and early-stage Alzheimer’s patients.

Recommendations for Cognitive Health

In addition to the supplement investigated in the study, individuals over 50 may benefit from incorporating other cognitive support nutrients like CDP-choline, Phosphatidylserine, Huperzine A, and Bacopa monnieri into their daily regimen. These nutrients have shown promise in reversing mild cognitive impairment and may serve as preventive measures against age-related memory decline.

Conclusion: A Holistic Approach to Cognitive Wellness

As research continues to uncover the intricate mechanisms underlying cognitive decline, embracing a holistic approach that combines targeted nutritional supplementation with conventional treatments holds immense promise in supporting cognitive health and enhancing quality of life for individuals affected by Alzheimer’s disease.

Reference:

Chan A et al. Efficacy of a vitamin/nutraceutical formulation for early-stage Alzheimer’s disease: A 1-year, open-label pilot study with a 16-month caregiver extension. Am J Alzheimer’s Disease. 2009; 23(6): 571-585.
[Link](https://journals.sagepub.com/doi/epdf/10.1177/1533317508325093)

 

Eat Smart, Live Well, Look Great,

Dr. Meschino


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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 287 – Glutathione Helps Guard Against Age-Related Decline in Kidney Function

LMU-287

Nurturing Kidney Health: Vital Strategies for Aging Well

Source: American Journal of Tanslational Research (2021)

Lifestyle Medicine Update (May 11, 2023)

Understanding Age-Related Kidney Decline

As we age, our kidneys naturally experience a decline in function, becoming one of the fastest aging organs. This decline typically commences around age 30-40 and accelerates into our 50s and 60s. Alarmingly, over 50% of individuals aged over 75 undergo a significant decline in kidney function, often unnoticed. This deterioration, known as mild insufficiency or chronic kidney disease, significantly heightens the risk of heart attacks.

The Significance of Kidney Health

Kidney disease claims more lives annually than breast and prostate cancer combined. Advanced kidney disease may necessitate dialysis or even a kidney transplant, emphasizing the critical importance of preserving kidney function for prolonged well-being.

Identifying Kidney Risk Factors

Numerous factors contribute to kidney disease, including high blood pressure, diabetes, kidney stones, family history, prolonged use of pain medications, and age over 60. Certain autoimmune conditions also elevate the risk of kidney damage and declining function.

Combatting Kidney Decline with Antioxidants

Research suggests that free radical damage to kidney cells significantly contributes to age-related kidney function decline and is associated with conditions such as diabetes and autoimmune disorders. Studies indicate that higher free radical levels correlate with accelerated kidney function decline as we age.

Harnessing Supplements for Kidney Protection

Thankfully, targeted dietary supplements can aid in preventing or reversing kidney function decline. Research has shown that supplements like N-acetylcysteine (NAC) can boost glutathione synthesis in kidney cells, improving kidney function and reducing inflammation. Additionally, supplements such as alpha-lipoic acid, silymarin (from Milk thistle), L-glutamine, Coenzyme Q10, and choline (found in lecithin capsules) elevate kidney glutathione levels, providing additional protection against kidney damage.

Recommended Supplement Regimen

Consider supplementing with a combination containing:

Incorporating CoQ10 and lecithin capsules into your regimen can further bolster kidney health.

Taking Proactive Steps for Kidney Health

Individuals over 40-50 should consider supplementing to support kidney function. Consult with your healthcare provider, especially if you have existing kidney disease. Regular kidney function screening through blood tests is essential. Share the provided references with your healthcare professional to facilitate informed discussions about incorporating these supplements into your health regimen.

Thanks for watching and I’ll see you next time.

References:

National Kidney Foundation: Decline in Kidney Function with Aging and Incidence of Kidney Disease
https://www.kidney.org/news/monthly/wkd_aging#:~:text=Kidney%20disease%20can%20develop%20at,believed%20to%20have%20kidney%20disease.

Aging and Kidney Function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744545/

Decreased Glutathione in Aging:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457589/

NAC Supplementation and Kidney Function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129408/

Silymarin in Diabetic Nephropathy
https://pubmed.ncbi.nlm.nih.gov/25340091/

Alpha Lipoic Acid in Renal Damage – Ferroptosis
https://www.frontiersin.org/articles/10.3389/fphys.2021.680544/full

Alpha Lipoic Acid in Diabetic Nephropathy
https://pubmed.ncbi.nlm.nih.gov/23531536/

L-Glutamine Raises Glutathione Levels
https://biomedres.us/pdfs/BJSTR.MS.ID.002293.pdf

CoQ10 Supplementation in Kidney Disease
https://pubmed.ncbi.nlm.nih.gov/35643375/#:~:text=Oral%20Coenzyme%20Q10%20supplementation%20leads,to%20primary%20Coenzyme%20Q10%20deficiency

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587473/

Betaine in Kidney and Liver Function:
https://karger.com/cpb/article/32/Suppl.%201/32/71803/Betaine-Transport-in-Kidney-and-Liver-Use-of

Betaine in Kidney Function (osmoprotectant)
https://karger.com/cpb/article/32/Suppl.%201/32/71803/Betaine-Transport-in-Kidney-and-Liver-Use-of


Eat Smart, Live Well, Look Great,

Dr. Meschino

Recommended Supplements

Ultimate GLX

Ultimate GLX

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements