Posted on

LMU 279 – Illuminating Insights: Vitamin D’s Guardian Role Against Dementia

LMU-279

Illuminating Insights: Vitamin D's Guardian Role Against Dementia

Source: Journal Alzheimer’s & dementia: Diagnosis, Assessment & Disease Monitoring. March 1, 2023

Lifestyle Medicine Update (March 15, 2023)

Introduction:

In a groundbreaking study published on March 1, 2023, in Alzheimer’s and Dementia, the power of vitamin D in defending against dementia in older adults was unveiled. Over a decade, 12,388 participants experienced a 40% reduction in dementia cases with daily vitamin D supplementation. Gender differences and genetic factors, notably the APOEe4 gene, played significant roles. The study also explored a holistic defense, including brain-supporting mushrooms and a comprehensive supplement regimen. This nutritional odyssey emphasizes the multifaceted approach to dementia prevention.

A Beacon of Hope: March 2023 Vitamin D Revelation

  • Unveiling the Study
  • In the ever-evolving landscape of health, a beacon of hope emerged with a groundbreaking study published on March 1, 2023, in the esteemed journal Alzheimer’s and Dementia: Diagnosis, Assessment & Disease Monitoring. This study revealed a robust association
    between daily vitamin D supplementation and the remarkable defence against dementia in older adults.

The Radiant Shield: Vitamin D’s Protective Symphony

  • Living Dementia-Free: A Prolonged Prelude
  • The study, spanning a decade and embracing 12,388 participants, aged 71 on average, embarked on an exploration of vitamin D’s protective prowess. The findings resonated with a resounding declaration—those who embraced vitamin D supplements lived dementia-free for an extended period. Astonishingly, a 40% reduction in reported dementia cases gleamed among avid vitamin D supplement users.

  • Gendered Resonance: A Note on Significance
  • The effects echoed with a nuanced melody, revealing a more pronounced impact on women. A harmonious symphony unfolded, underscoring the gender-specific dimensions of vitamin D’s shield against dementia.

  • Genetics in the Spotlight: APOEe4 Gene’s Interplay
  • The stage widened to illuminate the interplay with genetics. A poignant revelation surfaced—the protective effects of vitamin D were notably amplified in individuals devoid of the APOEe4 gene, a notorious harbinger of heightened Alzheimer’s risk.

 A Mosaic of Defence: The Holistic Tapestry

  • Mushrooms and Beyond: A Comprehensive Defence
  •  The narrative unfolded beyond theconfines of vitamin D. A panoramic view encompassed the multifaceted defence against Alzheimer’s, weaving a tapestry that embraced brain-supporting mushrooms—Lion’s Mane, golden mushroom, oyster mushroom, shiitake mushroom, and white button mushroom.

  • Supplemental Symphony: Beyond Vitamin D

    The symphony extended to the realm of supplements—an ensemble that harmonized with longevity. A daily regimen, post-55, included lecithin, a high-potency multiple vitamin and mineral, essential fatty acids, and a memory support supplement featuring CDP-choline, Phosphatidylserine, Huperzine A, and Bacopa monnieri.

Beyond the Horizon: Nutritional Odyssey

  • Culmination of Wisdom: A Comprehensive Strategy
  • As the study on vitamin D unfolded, it beckoned us to appreciate the mosaic of prevention—an amalgamation of lifestyle choices, learning, exercise, and meticulous management of cholesterol, homocysteine, and blood pressure.

References:

  1. Ghahremani M. et al. [Vitamin D supplementation and the incident dementia: Effects of sex, APOE, and baseline cognitive status.](https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/dad2.12404) Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. March 1, 2023.
  2. Taking vitamin D could help prevent dementia.[Neurosciencenews.com](https://neurosciencenews.com/vitamin-d-dementia-22684/)
  3. Mori K et al.[Improving effects of the mushroom Yamabushitaki (Hericium erinaceus) on mild cognitive impairments: a double-blind placebo-controlled clinical trial.](https://pubmed.ncbi.nlm.nih.gov/18844328/) Phytother Res. 2009; 23 (3): 367-72.
  4. Lei Feng, Irwin Kee-Mun Cheah, Maisie Mei-Xi Ng, Jialiang Li, Sue Mei Chan, Su Lin Lim, Rathi Mahendran, Ee-Heok Kua, Barry Halliwell. [The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore.](https://doi.org/10.3233/JAD-180959) Journal of Alzheimer’s Disease, 2019.

Eat Smart, Live Well, Look Great,

Dr Meschino

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Posted on

LMU 278 – Revitalizing the Mind: Navigating Alzheimer’s with Nicotinamide Ribose

LMU-278

Revitalizing the Mind: Navigating Alzheimer's with Nicotinamide Ribose

Source: Journal Aging Cell (December 14, 2022)

Lifestyle Medicine Update (March 8, 2023)

Introduction:

In the intricate tapestry of health, an elixir known as Nicotinamide Ribose (NR) emerges as a protagonist in the quest against Alzheimer’s disease. The tale begins with an illuminating study in the December 2022 edition of Aging Cell, revealing NR’s journey across the blood-brain barrier, weaving a narrative of hope in preventing cognitive decline.

The Symphony of Energy: NAD+ and the Brain

    • The Dance of Niacin (B3)

Niacin, a humble nutrient, transforms into Nicotinamide Adenine Dinucleotide (NAD+) within our cells, orchestrating a symphony crucial for energy production. As we age, however, this symphony falters, with declining NAD+ levels compromising optimal energy
production and the activation of longevity genes.

    •  NR’s Entrance: A 2022 Overture

The 2022 study in Aging Cell whispers tales of NR’s entrance, showing promise in raising brain NAD+ levels. A daily supplement of 500 mg of Nicotinamide Ribose for six weeks painted a canvas of lower inflammation biomarkers, reduced amyloid plaque, and inhibited tau protein breakdown—key players in the Alzheimer’s narrative.

Decoding the Alzheimer’s Enigma: NAD+ and Brain Health

    • Sirtuins: The Epigenetic Guardians

Sirtuin genes, akin to epigenetic guardians, modulate brain genes, curbing inflammation, and thwarting the synthesis of amyloid plaque and tau protein coalescence. The decline in NAD+ levels sets the stage for Alzheimer’s hallmarks—brain inflammation, amyloid plaque synthesis, and tau protein entanglement.

    • NR’s Impact: A Symphony in the Blood

In a mesmerizing turn of events, NR supplementation demonstrated a significant decline in Alzheimer’s biomarkers within extracellular vesicles for neuronal origin (NEVs). These NEVs, originating from the brain, provided a window into the reduced risk of Alzheimer’s disease after NR’s six-week serenade.

A Glimpse into Tomorrow: NR and Alzheimer’s Prevention

    • Cognitive Aging and Research: A Beacon of Hope

The Delaware Center for Cognitive Aging and Research ventures further into the unknown, exploring NR’s potential to reverse early-stage memory loss. This ongoing exploration holds the promise of a groundbreaking chapter in Alzheimer’s prevention.

    • The Niacin Trilogy: NR, Nicotinamide, NMN

Beyond NR’s limelight, its cousins, nicotinamide and Nicotinamide Mononucleotide (NMN), join the stage, hinting at a trio of nutrients showing great promise in raising NAD+ levels.

The Personal Symphony: A Supplemental Prelude

    • Personal Wellness Symphony

In the personal symphony of health, a high-potency multiple vitamin and mineral supplement enriched with antioxidants becomes a daily overture. A B-50 complex, featuring 50 mg of niacin, takes center stage, showcasing its potential in preventing Alzheimer’s disease.

    • Sublingual Serenade: The Future of Nutrient Delivery

The stage is set for sublingual supplements—offering a lower dosage but direct absorption into the bloodstream. A future episode will delve into this novel nutrient delivery method, unlocking new possibilities for optimal health.

Epilogue: Niacin’s Melody in Alzheimer’s Prevention

As the curtain falls on this chapter, the promise of niacin supplementation, its metabolites, and the enchanting Nicotinamide Ribose echoes as a melody of hope in the symphony against Alzheimer’s disease.

References:

  1. Vreones M et al. [Oral nicotinamide ribose raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin.](https://onlinelibrary.wiley.com/doi/10.1111/acel.13754) Aging Cell. December 14, 2022.
  2. Nicotinamide Ribose supplement linked to reduced biomarkers for Alzheimer’s disease. [Neurosciencenews.com February 23, 2023](https://neurosciencenews.com/nicotinamide-riboside-alzheimers-22550/)
 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Posted on

LMU 277 – The Power of Lion’s Mane: Boosting Memory and Nerve Growth

LMU-277

The Power of Lion's Mane: Boosting Memory and Nerve Growth

Source: J Neurochemistry (2023)

Lifestyle Medicine Update (February 28, 2023)

Introduction:

Since the early 2000s, a humble fungus named Lion’s Mane mushroom, scientifically known as Hericium erinaceus, has been weaving its magic in the realm of memory enhancement. This captivating tale unfolds through studies revealing the mushroom’s ability to stimulate the
production of Nerve Growth Factor (NGF) and brain-derived neurotrophic factor (BDNF), promising hope for healing certain neuropathies and combating memory loss.

The Human Canvas: A 2009 Cognitive Symphony

In a mesmerizing 2009 study, individuals aged 50-80, grappling with mild cognitive impairment, experienced a cognitive symphony. Half of the participants indulged in the enchanting melody of Lion’s Mane mushroom supplementation, while the others danced to a placebo tune. Those consuming Lion’s Mane showcased a significant improvement in cognitive function scores, painting a vivid picture of the mushroom’s potential
to enhance mental clarity.

Animal Adventures: Lion’s Mane and the Alzheimer’s Quest

Embarking on animal adventures, researchers uncovered the mushroom’s prowess in slowing beta-amyloid plaque production—a key player in Alzheimer’s disease. Lion’s Mane emerged as a guardian, shielding brain cells against damage induced by cerebral artery occlusion. In mice with age-related cognitive decline, the mushroom performed a memory waltz, enhancing recognition memory by promoting nerve cell generation
in the hippocampus, the orchestrator of memory conversion from short-term to long-term.

Illuminating 2023: Lion’s Mane and the Neurochemistry Expedition

In the dawn of 2023, scientists from the University of Queensland embarked on a neurochemistry expedition. Their quest unveiled two active compounds in Lion’s Mane—Hericene A and polysaccharides—that not only traversed the blood-brain barrier but also orchestrated a symphony of nerve growth and memory boost in mice. The revelation marked a significant milestone, attributing the active constituent Hericene A as the enchanting catalyst behind improved memory and neurotrophic magic.

Your Journey with Lion’s Mane: A Symphony of Health

As the curtain rises on the magical properties of Lion’s Mane, incorporating it into your daily routine becomes a captivating prospect. The mushroom’s inclusion in medicinal blends, alongside reishi, shiitake, cordyceps, turkey tail, and others, becomes a harmonious choice. Beyond the age of 45-50, when the body’s immune system starts to wane, these mushroom blends become not only immune-modulators but also potential supporters of memory function.

Wisdom Beyond 55: A Memory Support Supplement

In the grand ballad of life, the age of 55 ushers in the wisdom of memory support supplements. A daily dose featuring CDP-choline, Huperzine A, Phosphatidylserine, and Bacopa monnieri becomes the orchestral finale, weaving a tapestry of memory preservation.

Conclusion: The Symphony Continues

As we embrace the enchanting story of Lion’s Mane, let the mushroom’s symphony resonate in your journey toward vibrant health. With each sip of a mushroom blend or a memory support supplement, you become a part of the captivating melody, unlocking the secrets of memory preservation and embracing the magic within Lion’s Mane.

References:

  1. Martinez-Marmol R et al. [Hericerin derivatives activate a pan-neurotrophic pathway in central hippocampal neurons converging
    to ERK1/2 signaling enhancing spatial memory.](https://pubmed.ncbi.nlm.nih.gov/36660878/) J Neurochemistry. January 20, 2023.
  2. Active compound in Lion’s Mane mushroom improves nerve growth and memory. [News Medical Life Sciences. Feb 13, 2023.](https://www.news-medical.net/news/20230213/Active-compound-in-Lione28099s-Mane-mushroom-improves-nerve-growth-and-memory.aspx#:~:text=In%20a%20recent%20study%20published,nerve%20growth%20and%20boost%20memory)
  3. Tsai-Teng T, et al. [Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in
    APPswe/PS1dE9 transgenic mice.](https://pubmed.ncbi.nlm.nih.gov/27350344/) J Biomed Sci. 2016; 23 (1): 49.
  4. Mori K et al. [Improving effects of the mushroom Yamabushitaki (Hericium erinaceus) on mild cognitive impairments: a double-blind placebo-controlled clinical trial.](https://pubmed.ncbi.nlm.nih.gov/18844328/) Phytother Res. 2009; 23 (3): 367-72.
  5. Ratto D et al. [Hericium erinaceus improves recognition memory and induces hippocampal and cerebellar neurogenesis in frail mice during aging.](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521003/) Nutrients. 2019; 11 (4): 715.
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Posted on

LMU 276 – Unveiling the Power of N-Acetyl Cysteine (NAC): A Hidden Health Gem

LMU-276

Unveiling the Power of N-Acetyl Cysteine (NAC): A Hidden Health Gem

Source: J Cell (2017)

Lifestyle Medicine Update (February 6, 2023)

Introduction:

In the realm of nutritional supplements, there’s a quiet hero that often goes unnoticed — N-acetyl cysteine, or simply NAC. Despite its low profile, NAC packs a punch, offering significant health benefits in our fast-paced, modern world. Let’s delve into the captivating research surrounding NAC and discover its remarkable contributions to our well-being.

Glutathione Boost: A Cellular Shield

In 2017, the journal Cell shed light on NAC, highlighting studies showcasing its ability to significantly increase the body’s synthesis of a crucial antioxidant known as glutathione. Glutathione stands as a formidable defender, shielding our cells from the damaging onslaught of free radicals. These free radicals, if unchecked, can trigger cancerous gene mutations, hasten aging, and contribute to brain changes linked to Alzheimer’s and Parkinson’s diseases.

Diabetes Defence and Fertility Enhancer

NAC doesn’t stop at bolstering glutathione; it also emerges as a guardian against diabetes. Studies reveal that NAC improves the function of insulin receptors, aiding in lowering blood sugar levels, particularly in individuals with type 2 diabetes and pre-diabetes.

For women grappling with polycystic ovarian disease (PCOD), NAC becomes a crucial ally. When combined with the drug clomiphene citrate, NAC enhances treatment efficacy, establishing a normalized ovarian cycle and increasing the chances of pregnancy. Its unique role in breaking down the mucus barrier allows sperm to penetrate the cervix, facilitating fertilization.

Liver Guardian: A Critical Role in Acetaminophen Use

For those relying on acetaminophen for pain control, NAC serves as a vital guardian for the liver. Acetaminophen metabolism requires glutathione in liver cells, preventing its conversion into a toxic compound that can lead to liver failure. Considering acetaminophen’s prevalence and its association with liver failure, NAC supplementation significantly reduces the risk, prompting discussions about its inclusion in medications containing acetaminophen.

Neuroprotective Marvel: Guarding Against Neurodegenerative Diseases

Experimental studies highlight NAC’s preventive potential against key steps in brain cell deterioration, potentially mitigating the risk of Parkinson’s and Alzheimer’s diseases. Beyond its role in boosting glutathione, NAC possesses its own antioxidant properties, fortifying our cellular defences against free radicals.

A Personal Approach: A Daily Supplement Routine

Personally, I incorporate NAC into my daily supplement routine, synergistically combining it with three other natural ingredients—Alpha lipoic acid, L-glutamine, and Silymarin from Milk thistle. This combination aims not only to enhance glutathione synthesis but also to address broader health aspects such as glucose regulation, liver detoxification, fertility enhancement, and potential reduction in the risk of neurodegenerative diseases.

The Wisdom of Dr. Denham Harman

Drawing inspiration from the renowned Dr. Denham Harman, a pioneer in the free radical theory of aging, who swore by alpha-lipoic acid, I believe that the combination of alpha lipoic acid with NAC, L-glutamine, and Silymarin from Milk thistle presents a superior approach. This strategy goes beyond isolated supplementation, offering a comprehensive defence against free radicals and a spectrum of health benefits.

Conclusion

As we unravel the mysteries of NAC, its multifaceted contributions to our health become increasingly evident. From cellular protection and diabetes defence to fertility enhancement and neuroprotection, NAC emerges as a hidden gem in the realm of nutritional supplements, providing a valuable tool for a vibrant and resilient life.

Reference:

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Posted on

LMU 275 – Unveiling the Power of Choline: A Key Player in Memory Health

LMU-275

Unveiling the Power of Choline: A Key Player in Memory Health

Source: J Aging Cell (January 15, 2023)

Lifestyle Medicine Update (February 1, 2023)

Introduction:

For years, the importance of choline in maintaining cognitive health has been a focal point of discussions among students, colleagues, patients, and the public. Now, a groundbreaking research paper published in the journal Aging Cell in January 2023 adds another layer of evidence to support the claim that sufficient choline intake is integral to preventing age-related memory loss, Alzheimer’s disease, and various common health issues.

The Crucial Role of Choline

As researchers from Arizona State University highlight, choline plays a pivotal role in producing acetylcholine, the memory chemical in the brain. Alarmingly, studies indicate that more than 90% of Americans fall short of the recommended daily choline intake, set at 425 mg/d for adult women and 550 mg/d for adult men. The researchers not only emphasize the widespread deficiency but also propose that the recommended intake levels should be higher for individuals aiming to ward off Alzheimer’s disease over their lifetime.

Insights from Mouse Studies

The researchers induced choline deficiency in both normal mice and mice genetically predisposed to Alzheimer’s disease. Strikingly, choline deficiency resulted in liver damage, heart enlargement, and neurological alterations, showcasing increased development of amyloid plaque and breakdown of the tau protein—common features in human Alzheimer’s disease. Lack of choline also led to significant weight gain, blood sugar regulation issues, diabetes, and motor skill deficits in both normal and genetically predisposed mice.

The Human Connection

The researchers underscore the twofold problem faced by humans: inadequate daily choline intake and suboptimal recommended levels. They explain how choline deficiency compromises learning and memory in humans. While animal-based foods like egg yolks, beef, salmon, and poultry boast the highest choline concentrations, those opting for a more plant-based diet can find appreciable amounts in soybeans, brussels sprouts, cauliflower, peanut butter, almonds, oat bran, beans, peas, broccoli, whole wheat toast, wheat germ, and soy lecithin.

Practical Advice for Choline Intake

For those seeking a supplemental approach, taking two lecithin capsules per day (1200 mg per capsule) can provide 180 mg of choline per capsule. After the age of 55, supplementing with CDP-choline, Huperzine A, Phosphatidylserine, and Bacopa monnieri becomes prudent. Crossing the blood-brain barrier becomes more challenging with age, and these nutrients have shown promise in supporting memory function, particularly in older individuals.

Conclusion

Choline emerges as a key player in memory health, with the 2023 study providing compelling evidence of its significance. Whether through dietary adjustments or targeted supplements, ensuring adequate choline intake becomes a proactive step toward maintaining cognitive well-being.

Reference:

 

Nikhil Dave et al. [Dietary choline intake is necessary to prevent systems‐wide organ pathology and reduce Alzheimer’s disease hallmarks.](https://onlinelibrary.wiley.com/doi/10.1111/acel.13775) Aging Cell, 2023.

 

Eat Smart, Live Well, Look Great,


Dr. Meschino

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Posted on

LMU 274 – Brown Rice Much Superior to White Rice for Health Outcomes

LMU-274

The Rice Dilemma: Brown vs. White - Unveiling the Healthier Choice

Source: International Journal of Molecular Science (January 2023)

Lifestyle Medicine Update (January 25, 2023)

Introduction:

The choice between white rice and brown rice often seems inconsequential in our daily meals. However, recent research has shed light on the significant health disparities between the two, highlighting brown rice as a superior choice. Let’s delve into the findings that showcase the remarkable health benefits of opting for brown rice.

The Diabetes Connection: Brown Rice Triumphs

In 2019, a study published in the British Journal of Nutrition brought forth compelling evidence. Overweight individuals with type 2 diabetes who consumed brown rice instead of white rice for three months experienced notable improvements in health parameters. The brown rice
group exhibited a significant drop in hemoglobin A1c, a marker for blood sugar control, along with reductions in bad cholesterol (LDL cholesterol) and inflammatory blood markers.

Moreover, epidemiology studies consistently associate white rice consumption with an increased risk of developing type 2 diabetes, while the reverse holds true for brown rice. Studies dating back to 2014 further support the notion that substituting brown rice for white rice improves blood sugar regulation, cholesterol levels, and inflammatory markers in diabetic subjects.

Antioxidant Boost: A Unique Molecule in Brown Rice

In January 2023, the International Journal of Molecular Science presented a groundbreaking study highlighting the antioxidant potential of brown rice. Unlike white rice, brown rice contains a unique molecule known as CAF (cycloartenyl ferulate), a polyphenol and phytosterol substance. CAF demonstrated impressive antioxidant properties, triggering the synthesis of another crucial antioxidant in the body, heme
oxygenase-1 (HO-1). The study showcased that CAF significantly reduced free radical damage in mouse hepatoma cells, demonstrating its robust antioxidant capabilities.

Additionally, brown rice houses various vitamin E compounds, adding another layer of antioxidant protection. It’s worth noting that 100 gm (3.5 oz) of brown rice provides 1.6-2.0 gm of fiber, compared to the meager 0.4 gm in the same amount of white rice. The insoluble fiber in brown rice supports bowel regularity, and some studies suggest that choosing brown rice over white rice may aid in weight loss.

The Bottom Line

The 2023 study and a wealth of previous research converge on a clear conclusion: brown rice outshines white rice in numerous health aspects. Beyond its well-documented benefits for blood sugar, cholesterol, and inflammation, brown rice surprises us with unexpected antioxidant support. This antioxidant boost is associated with slowing the aging process and protecting against cellular damage from free radicals linked
to various degenerative diseases.

In the ongoing rice dilemma, the evidence is clear—choose brown for a healthier and more robust lifestyle.

References:

  1. Malik V.S. et al. [Substituting brown rice for white rice on diabetes risk factors in India: a randomized controlled study.](https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/substituting-brown-rice-for-white-rice-on-diabetes-risk-factors-in-india-a-randomised-controlled-trial/A0778FC028F6F25D0E6A73787EECECC4) British J Nutrition. 2019; 12 (12): 1389-1397.
  2. Hongyan Wu et al. [Cycloartenyl Ferulate Is the Predominant Compound in Brown Rice Conferring Cytoprotective Potential against Oxidative Stress-Induced Cytotoxicity.](https://www.mdpi.com/1422-0067/24/1/822) International Journal of Molecular Sciences, 2023; 24 (1): 822.
  3. Mohan V et al. [Effect of brown rice, white rice and brown rice with legumes on blood glucose and insulin responses in overweight Indians: A randomized controlled trial.](https://pubmed.ncbi.nlm.nih.gov/24447043/) Diabetes Technol Ther. 2014; 16(5): 17-25.
  4. [Brown vs White Rice – Is one better for your health?](https://www.healthline.com/nutrition/brown-vs-white-rice) Healthline August 16, 2021.
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Posted on

LMU 273 – Unveiling the Protective Power of Vitamin D Against Melanoma

LMU-273

Unveiling the Protective Power of Vitamin D Against Melanoma

Source: J Melanoma Research (December 2022)

Lifestyle Medicine Update (January 18, 2023)

Introduction:

Melanoma, a highly lethal form of skin cancer, has been on the rise in recent years, making it crucial for us to explore effective ways to protect ourselves. According to the American Cancer Society, the risk of developing melanoma is significant, with 1 in 38 Caucasians and 1 in 1000 Black people likely to face this challenge in their lifetime. While conventional wisdom encourages us to minimize UV-light exposure and safeguard our skin with clothing, hats, sunglasses, and sunscreen, a groundbreaking study in Melanoma Research, published in December 2022, brings an additional perspective to the table.

The Vitamin D Connection

The 2022 study in Melanoma Research suggests that regular use of vitamin D supplements alone may play a pivotal role in reducing the risk of melanoma by more than 50%. This finding is particularly significant as it controlled statistically for other crucial risk factors. The study focused on nearly 500 dermatology patients, aged 21-79, who were already at an increased risk of melanoma development, including 96 immune-compromised patients. The results revealed that those who regularly used vitamin D supplements experienced more than a 50% lower incidence of developing melanoma compared to non-users.

Supporting Evidence

The researchers pointed out that other recent studies have also highlighted the benefits of vitamin D in melanoma prevention. These studies show an association between vitamin D supplementation and less aggressive melanoma lesions. Notably, the 2022 study was conducted in Finland, an area with a high incidence of melanoma.

Dosage Recommendations

While the researchers did not specify the exact dosage of vitamin D, it is reasonable for most individuals to consider a daily intake of 1,000 – 2,000 IU. This dosage is likely to bring blood levels into a protective range against various health conditions. The recommended blood level of vitamin D, unless otherwise advised by your doctor, is 85-150 nmol/L or 34 – 60 ng/ml.

Conclusion

In conclusion, the study’s findings suggest that regular use of vitamin D supplements may be an impressive and potentially life-saving strategy in reducing the development of melanoma. While the study did not find a significant impact on other skin conditions, the focus on melanoma prevention brings hope for a proactive and accessible approach to skin cancer risk reduction.

References:

  1. Kanasuo E et al. [Regular use of vitamin D supplement is associated with fewer melanoma cases compared to non-use: a cross-sectional study in 498 adult subjects at risk for skin cancers.](https://journals.lww.com/melanomaresearch/Abstract/9900/Regular_use_of_vitamin_D_supplement_is_associated.51.aspx) J Melanoma Research. 2022.
  2. [Science Daily. Fewer cases of melanoma among people taking vitamin D supplements. January 8, 2023.](https://www.sciencedaily.com/releases/2023/01/230109112555.htm)
 
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Posted on

LMU 272 – Unveiling Insights: Lifestyle and Diet’s Impact on Colorectal Cancer

LMU-272

Unveiling Insights: Lifestyle and Diet's Impact on Colorectal Cancer

Source: European Prospective Investigation into Cancer and Nutrition Study (Am J Gastroenterology, December 2022)

Lifestyle Medicine Update (January 11, 2023)

Introduction:

 In a groundbreaking update from December 2022, the European Prospective Investigation into Cancer and Nutrition Study illuminated the intricate ties between colorectal cancer and lifestyle factors. Examining nearly 300,000 individuals across ten European countries for 7.8 years, the study unveiled a compelling correlation between a Healthy Lifestyle Index (HLI) score, encompassing factors like smoking, alcohol, BMI, and physical activity, and a 23% lower risk of colorectal cancer. Additionally, dietary insights emphasized the protective role of plant-based foods and the detrimental impact of ultra-processed foods. These findings underscore the pivotal role of lifestyle and diet in preventing colorectal cancer, the second leading cause of cancer death.


Exploring the European Prospective Investigation into Cancer and Nutrition Study

In a riveting December 2022 update, the European Prospective Investigation into Cancer and Nutrition Study shed light on the intricate relationship between colorectal cancer and various lifestyle factors. Following nearly 300,000 individuals aged 35 to 70, residing across ten European countries, for an average of 7.8 years, the researchers delved into the nexus of colorectal cancer incidence, nutrition, lifestyle, and body weight (BMI) measurements.

Healthy Lifestyle Index and Colorectal Cancer Risk

At the study’s commencement, researchers computed a Healthy Lifestyle Index (HLI) score for each participant, considering smoking status, alcohol consumption, BMI, and physical activity. Astonishingly, a favorable healthy lifestyle score correlated with a remarkable 23% lower risk of developing colorectal cancer compared to an unfavourable score. This implies that individuals who refrained from smoking, consumed minimal alcohol, maintained an ideal body weight, and engaged in regular exercise experienced a significantly reduced risk of colorectal cancer.

Dietary Insights: The Plant-Based Advantage

Adding another layer to the discussion, a November 2022 study published in BMC Medicine revealed that men with the highest intake of plant-based foods enjoyed a 22% lower risk of colon cancer. The study emphasized the role of plant foods in increasing fiber and antioxidants associated with cancer prevention. Building on this, a review in the British Medical Journal in August 2022 linked high consumption of ultra-processed foods to a 29% increased risk of colorectal cancer in men, reinforcing the pivotal role of diet in cancer prevention.

The Significance of 2022 Studies

Collectively, the studies from 2022 underscore the pivotal role of lifestyle and dietary choices in colorectal cancer prevention. With colorectal cancer ranking as the second leading cause of cancer death, these findings hold immense importance. While early detection through methods like colonoscopy is crucial, adopting a colon cancer-prevention diet and lifestyle, as highlighted by these studies, emerges as a proactive
measure to ward off the development of colon cancer.

References:

  1. Edorardo B et al. [Changes in lifestyle and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition.](https://journals.lww.com/ajg/Abstract/9900/Changes_in_Lifestyle_and_Risk_of_Colorectal_Cancer.550.aspx) Am J Gastroenterol. Dec 2, 2022.
  2. Medscape Review of Article: [Medscape Article](https://www.medscape.com/viewarticle/986379?src=wnl_recnlnew3_ous_230102_MSCPEDIT_&uac=342474MN&impID=5055634
  3. Kim J et al. [Plant-based dietary patterns defined by a priori indices and colorectal cancer risk by sex and race/ethnicity: the Multiethnic Cohort Study.](https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02623-71) BMC Medicine. November 2022.
  4. Wang L et al. [Association of ultra-processed food consumption with colorectal cancer risk among adults: Results from three prospective US cohort studies.](https://www.bmj.com/content/378/bmj-2021-068921) BMJ August 2022.
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Posted on

LMU 271 – Kiwifruit vs. Psyllium Husk Fiber: A Breakthrough in Treating Constipation

LMU-271

Kiwifruit vs. Psyllium Husk Fiber: A Breakthrough in Treating Constipation

Source: American Journal of Gastroenterology (December 2022)

Lifestyle Medicine Update (January 5, 2023)

Introduction

In a groundbreaking study published in the American Journal of Gastroenterology in December 2022, researchers explored the efficacy of green kiwifruit as a treatment for functional constipation and constipation associated with irritable bowel syndrome (IBS). The study compared kiwifruit consumption to psyllium husk fiber, a known remedy for constipation. The findings revealed not only a significant improvement in bowel movement frequency but also a remarkable enhancement in stool consistency, ease of elimination, and overall abdominal comfort with kiwifruit consumption.

The Study

The multicenter trial involved over 180 patients across Japan, Italy, and New Zealand. Participants were divided into two groups—one instructed to consume two green kiwifruits daily for four weeks and the other to consume 7.5 grams of psyllium husk fiber per day. After the initial treatment period, a washout period of four weeks followed, during which no treatment was administered. The groups then switched, participating in a cross-over trial.

Results and Insights

The study demonstrated that kiwifruit intake provided similar benefits in increasing bowel movement frequency as psyllium husk fiber. However, kiwifruit offered additional advantages, including softer stools, easier elimination, heightened abdominal comfort, and reduced symptoms of indigestion and reflux. Researchers attributed these benefits to the fiber in kiwifruit cell walls, which swells and holds water in the intestinal tract, softening stools and increasing bowel movement frequency. Additionally, certain components in kiwifruit, such as raphides, were found to alter mucin production, resulting in improved laxation.

Expert Opinions

In a post-study interview published on Medscape, researchers emphasized that kiwifruit not only improved bowel regularity but also alleviated symptoms of indigestion, reflux, and abdominal pain. The conclusion drawn from the study was clear: the consumption of two green kiwifruits per day can be safely recommended as an effective treatment for constipation in individuals with functional gastrointestinal disorders.

Significance of the Research

The importance of this research is underscored by the prevalence of chronic functional constipation, affecting 9-20% of the adult U.S. population, as highlighted in a 2020 publication in the American Journal of Gastroenterology. With approximately 11% of the population suffering from irritable bowel syndrome, the addition of two green kiwifruits to the daily diet emerges as a promising and natural solution for a widespread health concern.

Other Natural Approaches

While kiwifruit offers a novel remedy, it’s essential to consider other natural approaches to improve bowel function and overall health. A plant-based diet, increased fiber intake, regular exercise, and adequate fluid consumption remain integral components of maintaining a healthy digestive system.

References:

  1. Richard G et al. [Consumption of two green kiwifruit daily improves constipation and abdominal comfort – results of an international multicenter randomized controlled trial.](https://journals.lww.com/ajg/Abstract/9900/Consumption_of_two_green_kiwifruit_daily_improves.592.aspx) Am J Gastroenterol. December 2022.
  2. Medscape Interview: [Kiwifruit found effective for constipation.](https://www.medscape.com/viewarticle/986297?src=wnl_recnlnew2_ous_230102_MSCPEDIT_&uac=342474MN&impID=5055634#vp_2) Medscape. January 3, 2023. Harrison L.
  3. Oh S.J et al. [Chronic constipation in the United States: Results from a population-based survey assessing healthcare seeking and use of pharmacotherapy.](https://journals.lww.com/ajg/fulltext/2020/06000/chronic_constipation_in_the_united_states__results.19.aspx) Am J Gastroenterol. June 2020.
  4. Bellini M et al. [Irritable bowel syndrome and chronic constipation: Fact and fiction.](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616212/) World J Gastroenterol. 2015; 21(40): 11362-11370.

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Posted on

LMU 270 – Unveiling the Secrets of Caffeine: Health Benefits, Risks, and a Heart-Healthy Alternative

LMU-270

Unveiling the Secrets of Caffeine: Health Benefits, Risks, and a Heart-Healthy Alternative

Source: American Heart Association Study (December 2022)

Lifestyle Medicine Update (December 27, 2022)

Introduction:

Recent research reveals the surprising health benefits of regular caffeine consumption from coffee and tea. Beyond providing an energy boost, caffeine may reduce the risk of age-related dementia, liver cancer, and inflammation. It inhibits the mTOR pathway, lowering cancer risk, and activates the Sirtuin 1 gene, promoting longevity. Caffeine also enhances blood sugar regulation and supports cardiovascular health. However, individuals with high blood pressure should opt for green tea over coffee to minimize cardiovascular risk. Enjoy these beverages without added sugars or cream for maximum health benefits.

The Power of Caffeinated Coffee and Tea

In recent years, research has unveiled the remarkable potential of regular caffeinated coffee consumption as a health ally. It’s not just about that morning pick-me-up; it’s about fostering well-being and potentially reducing the risk of age-related dementia, liver cancer, and non-alcoholic steatohepatitis (NASH), a condition affecting the liver.

Reducing Cancer Risk and More

Caffeine, found in coffee and tea, wields multiple health-boosting abilities. One of its incredible feats is inhibiting the mTOR pathway, a biological process strongly associated with a decreased risk of several common cancers, including stomach and colon cancer. But caffeine is more than a cancer risk modulator; it also showcases impressive anti-inflammatory properties.

Caffeine can significantly reduce the release of inflammatory chemicals called cytokines, which are prevalent in various forms of arthritis. Moreover, it delves deep into cells to help thwart emerging tumor cells. These multifaceted qualities underline caffeine’s potential as a valuable ally in the battle against cancer and inflammatory conditions (source).

Unleashing Longevity with Sirtuin 1

Caffeine doesn’t stop there. It’s an activator, and its target is the Sirtuin 1 gene – the key to enhanced longevity. When activated, this gene kicks your body into high gear, bolstering your metabolism and fat-burning capabilities. It also amps up the production of new energy factories in your brain cells (mitochondria biogenesis). In the realm of inflammation, caffeine works wonders by curbing the release of cytokines, which are known culprits in arthritis and heart disease.

In the arena of blood sugar regulation, caffeine proves to be a valuable asset. By increasing insulin sensitivity, it aids in the management and prevention of type 2 diabetes and metabolic syndrome. It doesn’t stop there – caffeine demonstrates its prowess in optimizing blood cholesterol and lipid levels, contributing to a lower risk of cardiovascular disease. But the story doesn’t end here. The Sirtuin 1 gene, activated by caffeine, excels at DNA repair and elongating telomeres – the protective caps at the ends of our DNA strands. These effects are not only tied to cancer prevention but also to the elusive promise of anti-aging (source).

Caffeine and High Blood Pressure: The Unveiling of a Key Study

You may be wondering if this elixir of energy is safe to consume when you’re grappling with high blood pressure (hypertension). It’s no secret that caffeine is a stimulant, and stimulants can nudge heart rate and blood pressure upwards. Well, a substantial study, published in the Journal of the American Heart Association in December 2022, comes to the rescue. This comprehensive research explored data from more than 18,000 subjects aged 40 to 75 in Japan. Over a span of 19 years, the study kept a close watch on the subjects’ blood pressure measurements and tracked their caffeine consumption from coffee and green tea.

The findings unveiled a noteworthy insight: for individuals with blood pressure readings at or above 160-179 over 100-109 mm Hg (grade 2 hypertension), higher coffee consumption (2-3 cups per day) was linked to a doubling of the risk of cardiovascular disease-related death compared to subjects with similar blood pressure readings who abstained from coffee.

So, what’s the takeaway from this? Normal blood pressure registers at less than 130 over 85 mm Hg, while high-normal readings range from 130-139 over 85-89 mm Hg. On the other hand, grade 1 hypertension, which signifies high blood pressure, is recorded at 140-159 over 90-99 mm Hg. Fascinatingly, green tea, despite its caffeine content, did not contribute to an increased risk of cardiovascular disease-related deaths for those with normal blood pressure or any degree of high blood pressure. In essence, it emerges as a safer choice for individuals with high blood pressure concerns (source).

Brewing up Health: Coffee, Tea, and Your Heart

To recap, for most people, enjoying two to three cups of caffeinated coffee daily can unlock a host of remarkable health benefits. Green tea, and likely black tea, also join the ranks as powerful allies. But for individuals contending with high blood pressure, it may be prudent to steer clear of caffeinated coffee. Green tea, with its plethora of health benefits, emerges as an enticing alternative for those who wish to maintain a heart-healthy lifestyle. Let’s not forget the sage advice to enjoy these beverages in their natural form – adding cream, sugar, or other embellishments can dilute their health benefits and potentially elevate cholesterol and blood sugar levels.

As you savor that cup of coffee or tea, know that you’re indulging in more than just a warm, comforting drink. You’re tapping into a world of health potential, an elixir that may invigorate your body and prolong your vitality.

References:

  1. Teramoto M et al. Coffee and green tea consumption and cardiovascular disease mortality among people with and without hypertension. J Am Heart Assoc (December 21, 2022) (source).
  2. Medscape: Greater Coffee Intake in Severe HTN Tied to Higher CV Mortality. Marilynn Larkin (December 22, 2022) (source).
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

 

Recommended Supplements

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.