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LMU 334 – DASH Diet Helps Prevent and Reverse Fatty Liver Problems in Type 2 Diabetics

LMU-334

DASH Diet Helps Prevent and Reverse Fatty Liver Problems in Type 2 Diabetics

Source: Diabetes, Obesity and Metabolism (April 2024)

Lifestyle Medicine Update (August 12, 2024)

Fatty liver problems not caused by alcohol consumption is a leading cause of liver disease world-wide, with an estimated 32% of adults afflicted with this condition. If left untreated, fatty liver problems can progress to liver fibrosis and life-threatening cirrhosis of liver cancer, all of which are on the increase. 

Type 2 diabetics are particularly prone to non-alcohol-induced fatty liver problems. As stated in the journal Diabetes, Obesity and Metabolism in April 2024, “the majority of individuals diagnosed with type 2 diabetes are overweight or obese and approximately 60% have metabolic dysfunction-associated steatolic liver disease (MASLD).”  (which means fatty liver disease) It is well documented that patients with higher levels of fat in their liver and around their internal organs (visceral fat) have in increased risk for cardiovascular, kidney and liver diseases.

In their study involving 335 diabetic patients the researchers collected dietary information from the participants and compared it to their levels of liver fat, visceral fat (fat around the abdominal organs), and subcutaneous fat (fat under the skin). The study showed that after 5-years of follow up the diabetic patients who most closely followed the DASH diet style of eating had significantly lower amounts of liver fat and visceral fat and tended to also have a lower body mass index and smaller waist circumference. The DASH Diet emphasizes fruit, vegetables, nuts and legumes, low-fat dairy products and whole grains, as well as low intake of sodium, sugar-sweetened beverages (SSB’s), red meat and processed meat. The diet allows lean protein foods such as poultry, fish, egg whites and soy products. And it allows some healthy fat from olive oil and avocado oil, as an example. The diet was originally designed to help patients reduce high blood pressure, where it has shown impressive outcomes. But the DASH Diet also provides an excellent guideline for overweight, obese patients and type 2 diabetic patients, and especially for patients showing signs of fatty liver problems. As the researchers indicated, this is not the first study to show that adherence to the DASH Diet can help reverse the amount of liver fat and visceral fat in various patient groups.

I provided a link below that explains the details of the DASH Diet in case you are not familiar with it. It is a very healthy approach to eating in general, in my view. Link to the DASH Diet details: https://medlineplus.gov/ency/patientinstructions/000784.htm#:~:text=The%20DASH%20diet%20is%20low,help%20lower%20high%20blood%20pressure.

I also provided a link to the research paper I cited today from the journal Diabetes, Obesity and Metabolism (April 2024).

References:

Schaefer E. et al. Adherence to the Dietary Approach to Stop Hypertension (DASH) diet is associated with lower visceral and hepatic lipid content in recent-onset type 1diabetes and type 2 diabetes. Diabetes, Obestity and Metabolism. 2024;1-12 https://dom-pubs.pericles-prod.literatumonline.com/doi/epdf/10.1111/dom.15772

Bhattcharya S. Can DASH Diet Reduce Liver Fat in Type 2 Diabetics? Medscape. August 12, 2024.
https://www.medscape.com/viewarticle/can-dash-diet-reduce-liver-fat-type-2-diabetes-2024a1000drp?ecd=wnl_tp10_daily_240728_MSCPEDIT_etid6699820&uac=342474MN&impID=6699820

Eat Smart, Live Well, Look Great,
Dr. Meschino

Recommended Supplements

Body-Burn-1

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 333 – 50% of Dementia Cases Preventable with These 14 Modifiable Risk Factors

LMU-333

50% of Dementia Cases Preventable with These 14 Modifiable Risk Factors

Source: The Lancet Commission on Dementia Prevention, Intervention, and Care (Medscape August 8, 2024)

Lifestyle Medicine Update (August 8, 2024)

We all know that we have an aging population, and that dementia and Alzheimer’s disease are becoming major health challenges in our society. As there are no specific genes that account for most dementia and Alzheimer’s disease cases, it’s not surprising to learn that diet and lifestyle factors are emerging as extremely important factors that appear to account for roughly 50% of the risk of developing these problems. In 2017 the Lancet Commission on Dementia Prevention, Intervention, and Care, cited 12 risk factors that accounted for many cases of dementia. But on July 31, 2024, they published new data showing that there are two additional risk factors that need to be added to the list. According to the 2024 report the authors state, “new compelling evidence” shows that untreated vision loss and an elevated LDL-cholesterol blood level need to be added the other 12 known risk factors for dementia. The good news is that all 14 of these risk factors can be largely controlled though a healthy diet, physical activity and proper attention to other brain health strategies.

So, the total list of modifiable risk factors for dementia now includes these 14 factors:

Hearing impairment (untreated)
Lower Level of Education
High Blood Pressure (Hypertension)
Smoking
Obesity
Depression
Physica Inactivity
Diabetes
Excess Alcohol Consumption
Traumatic Brain Injury (TBI)
Air Pollution
Social Isolation
Untreated Vision Loss
Elevated LDL-Cholesterol

The 2024 report also outlines 13 recommendations aimed at individuals and governments to help guard against dementia. They include preventing and treating hearing loss, vision loss, and depression; being cognitively active throughout life; using head protection in contact sports; reducing vascular risk factors (high cholesterol, diabetes, obesity, hypertension); improving air quality; and providing supportive community environments to increase social contact. In the Medscape Interview Shaheen Lakhan, MD, PhD, neurologist and researcher based in Miami, Florida, said “the addition of high cholesterol (to the list of dementia risk factors) is particularly noteworthy as it reinforces the intricate connection between vascular health and brain health — a link we’ve long suspected but can now target more effectively.” So, among other things, get those bad fats out of your diet that typically raise the LDL-cholesterol and get your LDL-cholesterol checked. It should be below 2.0 mmol/L (76 mg/dl). Have regular eye exams and hearing tests as you get older. Stay fit and follow the other advice outlined by the Lancet group. In addition, I believe that everyone over the age of 55 should take a supplement each day with ingredients shown to support memory function, which include:

CDP-choline
Huperzine A
Bacopa Monnieri
Phosphatidylserine.

The overarching message is that dementia does not have to be part of the normal aging process, and that we must look beyond genes as the cause of dementias. Once again, lifestyle medicine emerges as good medicine with the potential to cut dementia risk by roughly 50%. And don’t underestimate the benefits of memory support supplement ingredients like CDP-choline, Huperzine A, Bacopa Monnieri and Phosphatidylserine. I have seen this combination of nutrients provide significant benefit to older individuals. I have provided a link to the Medscape article outlining the 2024 findings and recommendations from the Lancet Commission on Dementia Prevention, Intervention and Care, as well as the link to The Lancet publication itself.

References:

Megan Brooks. Almost 50% of Global Dementia Cases May Be Preventable. Medscape. August 8, 2024. Almost 50% of Global Dementia Cases May Be Preventable (medscape.com)

Dementia prevention, intervention, and care 2024. The Lancet. July 31, 2024. Dementia prevention, intervention, and care 2024 (thelancet.com)

Eat Smart, Live Well, Look Great,
Dr. Meschino

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 332 – Boswellia Supplementation: Combating Malignant Brain Tumours and Radiation Side Effects

LMU-332

Boswellia Supplementation: Combating Malignant Brain Tumours and Radiation Side Effects

Source: Oncology Letter (2016) and Natural Medicine Journal (2020)

Lifestyle Medicine Update (July 31, 2024)

Brain and nervous system cancers are the 10th leading cause of death in North America. The cause of most brain cancers remains elusive. From the standpoint of nutritional medicine, what is noteworthy is the evidence showing that natural constituents derived from the Boswellia tree can cross the blood-brain-barrier and enter the brain. Within the brain these natural constituents, in particular boswellic acids, are shown to suppress inflammation (edema) and experimentally induce programmed cell death of certain human brain cancer cells (i.e., glioblastoma). As stated in the June 2016 Oncology Letter, “Boswellic acids (BA) have long been considered as useful adjunct pharmacological agents for the treatment of patients with malignant brain tumours, notably glioblastoma”. The study presented in this communication went on to show that boswellic acids, under experimental conditions, showed that it induced programmed cell death of nine different human brain cancer cell types known as gliomas (one type is glioblastoma). In this study boswellic acids also enhanced the brain tumour killing effects of a popular brain cancer chemotherapy drug called temozolomide (TMZ), and boswellic acids enhanced the brain cancer cell killing effect of radiation treatment, which is also commonly used to treat various brain tumours.

In 2020 an important human study was published that used Boswellia supplementation (4500 mg per day in divided doses, standardized to 32.2% boswellic acids) as an adjunctive treatment in 18 patients with newly diagnosed glioblastoma. These patients also received standard medical care, including surgery or biopsy, radiotherapy, and treatment with the chemotherapy drug temozolomide. Overall, the study showed that the use of Boswellia extract significantly reduced brain swelling (and related side effects) that typically result from the use of chemotherapy drugs and radiation of brain tumours. Brain swelling (edema) from chemo drugs and radiation often cause many unpleasant side effects. Medical doctors typically prescribe a drug called dexamethasone (similar to prednisone) to control brain swelling under these conditions, but dexamethasone treatment is known to counter the benefits of chemo drugs and radiation and increases brain tumour growth. Dexamethasone also produces an array of other very undesirable side effects. This study showed that Boswellia extract supplementation is a good substitution for dexamethasone in patients being treated for glioblastoma, as it not only suppresses brain swelling (edema), but boswellic acids exhibit brain cancer cell killing effects, which is synergistic to the chemo and radiation treatment protocol.

From my standpoint, it’s important to remember that the anti-inflammatory effects of boswellic acid have also shown efficacy in improving outcomes for patients with rheumatoid arthritis, Crohn’s disease, osteoarthritis and other inflammatory conditions. As we age the body naturally increases the synthesis and release of certain inflammation promoting chemicals (cytokines and prostaglandins). This makes us more prone to arthritic changes, joint and muscle swelling, and background pain and discomfort. Based on this, I have suggested that people over the age of 40 or 45 do what I do, and that is to take a supplement each day that combines four natural and effective anti-inflammatory agents; namely, Boswellia, Curcumin, White Willow Extract and Ginger Extract. These four natural agents work synergistically to help suppress inflammation in the body. Unlike aspirin and related drugs, these natural agents do not cause stomach irritation, ulcers, internal bleeding, high blood pressure, liver and kidney damage or congestive heart failure. As a bonus, the boswellic acids also cross the blood-brain-barrier, entering brain cells, where experimental evidence cited below suggests that they may help to block key steps in the development of some lethal brain cancers. Curcumin is also known to cross the blood-brain-barrier and is shown to provide some important neuroprotective effects as well. So, the combination of Boswellia Extract, Curcumin, White Willow Extract and Ginger Extract is not only good for your joints, but is also likely to be beneficial for your brain.

I have included the references on Boswellia and Brain Tumours in the text below.

References:

Schneider H and Weller M. Boswellic acid activity against glioblastoma stem-like cells. Oncology Letter. 2016, 11(6): 4187-4192. Boswellic acid activity against glioblastoma stem-like cells – PMC (nih.gov)

West K. Boswellia and brain tumors. Natural Medicine Journal. March 4, 2020. Boswellia and Brain Tumors | Natural Medicine Journal

Eat Smart, Live Well, Look Great,
Dr. Meschino

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Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 331 – Omega-3 Fat Supplements in Type 2 Diabetics Reduce Heart, Kidney, Eye, and Nerve Damage Complications and Risk Factors, Compared to Patients Not Using Omega-3 Supplements

LMU-331

Omega-3 Fat Supplements in Type 2 Diabetics Reduce Heart, Kidney, Eye, and Nerve Damage Complications and Risk Factors, Compared to Patients Not Using Omega-3 Supplements

Source: The Journal of Clinical Endocrinology & Metabolism (July 12, 2024)

Lifestyle Medicine Update (July 24, 2024)

A very large and important study was published in the Journal of Clinical Endocrinology & Metabolism in July 2024.  Using data from the UK Biobank Study, which followed over 20,000 type 2 diabetics for an average of 13.2 years, the study showed that type 2 diabetics who take omega-3 fat supplements daily had 10% lower risk of heart disease, peripheral artery disease, diabetic kidney disease, diabetic retinopathy and diabetic neuropathy. Type 2 diabetics who did not take omega-3 fat supplements did not see the same benefits. This is important because many type 2 diabetics die from heart attacks and they are very high risk for blindness from diabetic retinopathy (macular degeneration) and kidney disease requiring dialysis, as well as impaired circulation to the legs and feet (often causing intractable pain or leading to gangrene and amputation). They also have a high risk for nerve pain from diabetic neuropathy.

A 10% reduction in the risk of these complications and outcomes from simply taking an omega-3 supplement each day is a ground-breaking discovery. If they invented a drug that could reduce these complications and outcomes by 10% in type 2 diabetics, it would be all over the news and doctors would be prescribing it as regular or mandatory course of treatment. But, because we are talking about supplements, the chances are pretty good that most doctors will never see this research and patients will never know about it. That is why I am bringing this research to your attention today. The researchers on the study explained that omega-3 fats appear to be helpful because they lower blood fat levels and reduce circulating levels of inflammation-promoting chemicals (i.e., cytokines and prostaglandins) linked to vascular complications and nerve damage in all regions of the body. In previous updates I showed evidence that the safe and effective dosage of omega-3 fat supplementation is between 800 and 1200 mg per day. This remains a good target for type 2 diabetics. But it is also a good target for the rest of us as well, as this level of intake can help promote improved cardiovascular health and brain health for just about everyone. This is one more striking illustration that evidence-based nutrition and lifestyle medicine is good medicine.

I have provided a link to the research paper in the Journal of Clinical Endocrinology & Metabolism in the text below.

References:

Tian S et al. Fish oil, plasma n-3 PUFA, and risk of macro-and microvascular complications among individuals with type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism. July 12, 2024. Fish Oil, Plasma n-3 PUFAs, and Risk of Macro- and Microvascular Complications among Individuals with Type 2 Diabetes | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic (oup.com)

Choudhury J. Fish oil supplements cut diabetes complications risk. Medscape July 24, 2024. Fish Oil Supplements Cut Diabetes Complication Risk (medscape.com)

Eat Smart, Live Well, Look Great,
Dr. Meschino

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Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 330 – Huperzine A Improves Memory and Cognition in Early-stage Alzheimer’s disease and Shows Promise of Prevention

LMU-330

Huperzine A Improves Memory and Cognition in Early-stage Alzheimer’s disease and Shows Promise of Prevention

Source: The Journal of the Chinese Medical Association 2019 and the International Journal of Molecular Science 2022

Lifestyle Medicine Update (July 16, 2024)

It’s quite likely that you have never heard of the natural supplement Huperzine A, but it is an alkaloid that was discovered many years ago in the Huperzia Serrata plant in China. I bring it to your attention because Huperzine A shows proven effects on raising brain levels of the memory chemical (neurotransmitter) acetylcholine and it has been used successfully in a number of studies to improve early-stage Alzheimer’s disease – by reversing early-stage memory loss problems and improving cognition. The most recent human study was published in 2019, which included 50 Alzheimer’s patients and 50 healthy individuals. Prior to Huperzine A supplementation the Alzheimer’s patients showed deficits in cognition and task switching ability compared to healthy individuals. After just 8-weeks of Huperzine A supplementation the Alzheimer’s patients showed significant improvement in cognition and task switching abilities. https://journals.lww.com/jcma/fulltext/2019/01000/huperzine_a_response_to_cognitive_impairment_and.8.aspx

This is not the first study to show these kinds of impressive results in memory loss patients.  A large study published in 2002, involving 202 patients with mild to moderate Alzheimer’s disease, who were treated at 15 different health centre locations, showed that the patients given 400 mcg per day of Huperzine for 12-weeks realized significant improvement in cognitive test scores compared to the placebo group.

https://pubmed.ncbi.nlm.nih.gov/12181083/  In 2009 a review of all available Huperzine A studies was published in the Annals of Pharmacotherapy journal. The researchers stated that data suggest that Huperzine A may improve cognition within an 8-12-week period with objective improvements of 1-5 points on the Mini-Mental State Examination. https://pubmed.ncbi.nlm.nih.gov/19240260/ In 2022 a review of all Huperzine A studies involving animal trials was published in the International Journal of Molecular Science. The researchers showed that Huperzine A not only slows down the breakdown of the memory chemical acetylcholine (by inhibiting the enzyme acetylcholinesterase) but it also stimulates acetylcholine synthesis (by stimulating the enzyme choline acetyltransferase).Animal studies also show that Huperzine A improved memory performance using maze testing and it decreased beta-amyloid plaque build-up in the brain of these animals.  https://www.mdpi.com/1422-0067/23/23/15238  Other studies have shown additional neuroprotective effects of Huperzine A, such as protecting the brain against various toxins including organophosphates (which are insecticides with known brain-damaging effects) and reducing glutamate-induced brain cell death, as often occurs with head trauma and related concussion injuries. https://oce.ovid.com/article/00006489-200306000-00020  Other impressive neuroprotective effects of Huperzine A were published in the journal Trends in Pharmacological Sciences in 2006, which include boosting brain antioxidant protection, reducing brain cell death (apoptosis) and regulating the secretion of nerve growth factor (NGF) and NGF-signalling.  https://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147(06)00247-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0165614706002471%3Fshowall%3Dtrue

These are all important physiological effects that slow brain aging and reduce risk of memory loss. On balance, we known that once ingested Huperzine A easily crosses the blood-brain-barrier and enters brain cells. Once inside brain cells Huperzine A can help to increase levels of the memory chemical acetylcholine, which is critically important to patients with early memory loss problems. And Huperzine A also shows other impressive neuroprotective effects linked to Alzheimer’s disease prevention. I believe that it is a good idea for most people over the age of 55 to take a memory support supplement each day that contains:

Huperzine A
CDP-Choline
Phosphatidylserine
Bacopa Monnieri

These four natural agents work together to help support memory function as the brain ages, and each of these ingredients has been shown to reverse memory loss and cognitive deficits in patients with mild cognitive impairment and other early -stage dementias, including Alzheimer’s disease. I think that when it comes to Alzheimer’s disease, prevention is a key component and this supplement combination, along with other brain support measures, should be a strong consideration for anyone 55 years of age or older in my view.

I have included the main Huperzine A references in the text below.

References:

Amara G et al. Huperzine-A response to cognitive impairment and task switching deficits in patients with Alzheimer’s disease. Journal of the Chinese Medical Association. 2019, 82(1): 40-43. https://journals.lww.com/jcma/fulltext/2019/01000/huperzine_a_response_to_cognitive_impairment_and.8.aspx

Zhang Z. et al. Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer’s disease, a placebo-controlled, double-blind, randomized trial. 2002, 82(14): 941-944. https://pubmed.ncbi.nlm.nih.gov/12181083/

Desilets A.R. et al. Role of huperzine A in the treatment of Alzheimer’s disease. Ann Pharmacother. 2009, 43(3): 514-518. https://pubmed.ncbi.nlm.nih.gov/19240260/

Yan Ye-Pioa et al. Disease-modifying activity of huperzine A on Alzheimer’s disease: Evidence from preclinical studies on rodent models. Int J Mole Sci. 2022, 23(23): 15238. https://www.mdpi.com/1422-0067/23/23/15238

 

Eat Smart, Live Well, Look Great,
Dr. Meschino

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Memory Support Complex

Memory Support Complex

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 329 – Fish Oil and Heart Health Update 2024: How much omega-3 fat is safe and effective?

LMU-329

Fish Oil and Heart Health Update 2024: How much omega-3 fat is safe and effective?

Sources: Medscape June 4, 2024 (Dr Joann E Manson) and Frontiers of Medicine Feb 2, 2022.

Lifestyle Medicine Update (July 9, 2024)

Today’s question is how much omega-3 fat is safe and effective to take via supplementation.  The large UK Biobank study and some other studies have shown that high dose omega-3 fat supplementation (above 1800 mg per day) may increase risk of atrial fibrillation, which is a major risk factor for stroke and heart failure. On the other hand, a number of well controlled human intervention studies have shown that lower dose supplementation with omega-3 fats, in the range of 800-1200 mg per day, can help to lower risk of heart attack (myocardial infarction) by about 30%, as well as reducing cardiovascular deaths from other causes. Doses below 800 mg per day have not shown any cardiovascular benefit. So, my suggestion is that you consider using an omega-3 supplement, using a daily dosage of no more than 1200 mg and no less than 800 mg per day.

I personally take an essential fatty acid supplement each day that contains 400 mg each of fish, flaxseed and borage seed oil. The fish and flaxseed oil provide the omega-3 fat content. One capsule yields 448 mg of omega-3 fat. I generally take and recommend two capsules per day, which yields 856 mg of omega-3 fat – exactly in the safe and effective range. The borage seed oil is 22% gamma-linolenic acid, which the body uses to produce anti-inflammatory prostaglandin-series 1, which is particularly important to improving skin texture and suppressing joint inflammation.

Regarding other ways to prevent atrial fibrillation, a number of studies have shown that CoQ10 supplementation, especially after age 45 or 50, may reduce risk of atrial fibrillation and heart failure ( https://pubmed.ncbi.nlm.nih.gov/25919281/) . The herb hawthorn also shows anti-arrhythmic effects and has been used to improve cases of heart failure (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321072/). There is also evidence that L-taurine (an amino acid supplement) can help prevent heart arrhythmias via its effects on the heart muscle. What is noteworthy is that our body produces less CoQ10 and L-Taurine as we age, which are likely factors that lead to the age-related increased risk of atrial fibrillation and other dangerous arrhythmias. After age 45, I think that taking a supplement containing CoQ10, Hawthorn and L-Taurine makes sense as one more way to preserve heart health and help guard against atrial fibrillation and arrythmia problems.

Of course, remaining fit, not smoking, remaining at your ideal body weight, keeping your blood pressure and cholesterol levels in the healthy range, are foundational strategies in preventing atrial fibrillation and heart disease in general (https://www.mayoclinic.org/diseases-conditions/atrial-fibrillation/symptoms-causes/syc-20350624).

But when it comes to omega-3 fat supplementation, the sweet spot for safety and efficacy appears to be 800-1200 mg per day. I have included the references for omega-3 fat and atrial fibrillation in the text below.

References:
Medscape: Who Benefits From Omega-3/Fish Oil Supplements. J. E Manson. June 2, 2024. Who Benefits From Omega-3/Fish Oil Supplements? (medscape.com)

Shen S et al. Omega-3 fatty acid supplementation and coronary heart disease risks: A meta-analysis of randomized controlled clinical trials. Frontiers of Nutrition. 2022, 9: 809311. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850984/#:~:text=Both%20the%20results%20of%20VITAL,by%2028%25%20(13).

Eat Smart, Live Well, Look Great,
Dr. Meschino

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Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 328 – Vitamin B12 Receptor Autoimmunity Increases Risk and Severity of MS and Psychiatric Conditions

LMU-328

Vitamin B12 Receptor Autoimmunity Increases Risk and Severity of MS and Psychiatric Conditions

Source: J Translational Medicine (June 2024)

Lifestyle Medicine Update (July 3, 2024)

A remarkable study published in Translational Medicine on June 26, 2024, showed that many patients with multiple sclerosis, various psychiatric conditions and lupus (SLE), who showed progressive neurological decline and degeneration, had normal blood levels of vitamin B12, but very low brain levels of vitamin B12. When these patients were provided with immunosuppressant drugs and high-dose vitamin B12 therapy their brain levels of vitamin B12 increased, and remarkably their neurological symptoms greatly improved.

So, why can someone have normal blood levels of B12 and yet have low brain levels of B12?  The answer, we are discovering, is that some people produce antibodies (autoantibodies) that destroy the receptor that allows vitamin B12 to enter the brain. The receptor is known as the CD320 receptor. So far, this problem has been identified in a number of patients showing neurological decline, who also have multiple sclerosis, lupus (SLE) and a variety of neuropsychiatric conditions. The good news is that once the brain level of B12 is restored there is significant reversal of the neurological problems and improved psychiatric outcomes for patients with various mental health problems. Interestingly, some people who produce antibodies against the B12 brain receptor (CD320 receptor) do not develop neurological problems or psychiatric problems because their brains are able to use an alternative method to get B12 into the brain (LDL-receptor).

Over the years various studies have shown that low blood vitamin B12 levels increase the risk of dementia and Alzheimer’s disease, as well as depression in the elderly (as well as younger individuals – see reference no 5 below).  But we are learning now that it may be important to also assess brain levels of vitamin B12 (not just blood levels), which may be much lower than blood levels in individuals who produce B12 receptor (CD320 receptor) antibodies. I think the take-away message is that you should ensure that your vitamin B12 intake can help overcome some inherent brain B12 absorption obstacles that may be present.  I personally like taking a high-potency multiple vitamin and mineral each day that includes a B-50 complex (which would include 50 ug of vitamin B12). That is a good start for most people. If neuropsychiatric problems or neurological decline problems begin to surface, I would suggest having your doctor check your blood for CD320 autoantibodies and/or assess the vitamin B12 level of your cerebral spinal fluid. This appears to be one more way to fight mental health problems and neurological decline tied to some serious neurological disorders.

I have included the references for this information in the text below.

References:

Pluvinage J.V. et al. Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Translational Medicine. 2024, 16(753): Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency | Science Translational Medicine

Alam A et al. Structural basis of the transcobalamin recognition by human CD320 receptor. Nature Communiations. July 14, 2016. https://www.nature.com/articles/ncomms12100#Sec17

Hicks L. Form of B12 deficiency affecting the central nervous system may be new autoimmune disease. Medscape. July 1, 2024. Form of B12 Deficiency in CNS May Be New Autoimmune Disease (medscape.com)

Michelakos T et al. Serum folate and B12 levels in association with cognitive impairment among seniors: Results from the VELESTINO study in Greece and meta-analysis. J Aging Health. 2013, 25(4): 589-616. https://pubmed.ncbi.nlm.nih.gov/23569157/

Kennedy D.O. B vitamins and the brain: Mechanisms, doses and efficacy – A Review. 2028, 8(2): 68 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/#B118-nutrients-08-00068

 

Eat Smart, Live Well, Look Great,
Dr. Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 327 – Melatonin Supplementation Shown to Prevent and Treat Macular Degeneration – the leading cause of blindness after 55 years of age

LMU-327

Melatonin Supplementation Shown to Prevent and Treat Macular Degeneration – the leading cause of blindness after 55 years of age

Sources: JAMA Ophthalmology (Oct. 2024) and Ann NY Acad. Sci (Dec. 2005)

Lifestyle Medicine Update (June 26, 2024)

Melatonin is not only important for a good night’s sleep, but it also possesses other properties that are shown to slow many aspects of aging and help prevent various age-related diseases. One of those age-related diseases is macular degeneration, which is the leading cause of vision loss in people over the age of 55. Dating back to 2005 we saw an important study showing that melatonin supplementation (3 gm per evening) could halt or slow the progression of macular degeneration in 100 patients who had either dry or wet (the complicated) forms of macular degeneration. The majority of these patients, who were given the melatonin supplement, showed objective improvement in the structure of the visual centre in the back of the eye, with stabilization of their vision.  In 2024, reporting in JAMA Ophthalmology a large study showed that individuals who regularly take melatonin supplements at night as a sleep aid showed a 58% decreased risk of developing macular degeneration compared with those not using a melatonin supplement. This arm of the study followed over 120,000 patients, over 50 years of age, from 2008 to 2024, who had no history of macular degeneration at the onset of the study.  Those who took melatonin daily, had a 58% reduction in developing macular degeneration as the years went by. The study also noted that in the patient group that already had early-stage macular degeneration, those taking a melatonin supplement daily showed a 56% slower progression of their disease.

This all makes sense when you consider that melatonin is an antioxidant that can help protect the optic nerve and other components of retina from free radical damage stemming from UV-light, alcohol and cigarettes. Melatonin is also shown to control eye pigmentation and thereby regulate the amount of light reaching the photoreceptors of the eye. It also prevents retinal pigment epithelial cells from free radical damage (oxidation) and it quenches free radicals in the back of the eye. (see reference 1 for more details). For a long time, I have suggested the people over the age of 40 take a melatonin supplement one hour before bedtime.  By age 40 your melatonin levels have decline markedly, which means that you lose the deep sleep-facilitating effects of melatonin that help to produce daily renewal of your being and you lose melatonin’s immune modulating effects, anti-cancer effects, antioxidant effects, and anti-inflammatory effects, unless you take a supplement each day to restore your melatonin status.

I personally take a natural sleep aid supplement each night that contains the combination of:

Melatonin
5 HTP
GABA
Bacopa Monnieri

These four natural agents work together to help you fall asleep, reach deep, renewing levels of sleep, while also supporting your memory and a variety of other health-promoting processes.  The melatonin also appears to be important in helping to prevent age-related macular degeneration, as I have cited today. This is just another illustration that nutritional and lifestyle medicine is good medicine, when applied by following the scientific evidence. I have included the references for melatonin in macular degeneration prevention and treatment in the text below.

References:

Yi C. et al. Effects of melatonin in age-related macular degeneration. Ann N Y Acad Sci. 2005 December:1057: 384-92
https://pubmed.ncbi.nlm.nih.gov/16399908/#:~:text=Melatonin%20has%20been%20shown%20to,RPE)%20cells%20from%20oxidative%20damage.

Hutton D. Melatonin may reduce risk of age-related macular degeneration. JAMA Ophthalmology June 11, 2024. https://www.ophthalmologytimes.com/view/melatonin-may-reduce-risk-of-age-related-macular-degeneration

Marcus A. Melatonin may cut risk of age-related eye disease. Medscape June 6, 2024. Melatonin May Cut Risk for Age-Related Eye Disease (medscape.com)

 

Eat Smart, Live Well, Look Great,
Dr. James Meschino

Recommended Supplements

Sleep-E Naturals

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Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 326 – L-Carnitine: A novel supplement to help prevent and treat congestive heart failure?

LMU-326

L-Carnitine: A novel supplement to help prevent and treat congestive heart failure?

Source: BMC Cardiovascular Disorders (July 21, 2014)

Lifestyle Medicine Update (June 25, 2024)

Congestive heart failure is a leading cause of hospital admissions in people over the age of 65, but the diet and lifestyle practice you employ when you are younger largely determines if this serious, life-threatening problem will develop when you get older. As of 2012, 4.3% of North Americans 65-70 years of age had congestive heart failure, and projections estimate that this percentage will increase to 8.5% by the year 2030. So, things are getting worse. There has been a rise in the incidence of congestive heart failure in recent years. Clogging up your coronary arteries with cholesterol is a leading cause of congestive heart failure (ischemic heart disease), but there are other causes (COPD, emphysema etc.). One intriguing factor is that the body makes less L-Carnitine and Coenzyme Q10 as we age. And studies show that when these supplements are given to congestive heart failure patients they often improve -meaning that their heart pump gets stronger, which helps to reverse the condition. I have provided many updates on Coenzyme Q10 in the past that you can search under my name, but today I want to address the lesser-known supplement known as L-carnitine.

The heart muscle and other tissues in the body rely on L-carnitine to transport fat into the energy factory of the cell (mitochondria). Once in the mitochondria, natural processes occur that convert these fat molecules into energy (ATP); energy the heart muscle uses for its pumping action. Thus, a deficiency in L-carnitine (which is not uncommon in the aging process) impedes the heart muscles’ ability to generate optimal energy.

As a result, the heart pump becomes weak, fluids back up in the system, the lungs fill with fluid making it hard to breath, ankles swell, and other problems occur.  As of 2024, there is no cure for congestive heart failure. Patients are given drugs to help manage it, but the 5-year survival rate is only about 50% (https://www.medicalnewstoday.com/articles/321538#faq) So, in addition to a healthy diet and exercise, I recommend that individuals begin taking a supplement containing CoQ10, Hawthorn, L-Taurine and Quercetin by about age 45, to help keep the heart muscle strong. These four nutrients have proven value in helping to optimize energy production in the heart muscle and they support cardiovascular health in other ways. But studies show that in patients who are showing early signs of congestive heart failure, the further addition of 2-3 gm of L-carnitine supplementation each day may be also be a wise thing to do.

As reported in the summary paper found in BMC Cardiovascular Disorders in 2014, L-carnitine supplementation has improved many cases of congestive heart failure. This supplement has been shown to increase energy production in the heart muscle, re-strengthening the heart pump mechanism. It also shows other benefits. The researchers cite an important systematic review paper showing that L-carnitine administration was associated with a significant reduction in all-cause mortality, ventricular arrhythmias, and angina in the setting of acute myocardial infarction (heart attack). So, keep L-carnitine in mind, as it may benefit you one day. Certainly, around age 45 I believe it’s a good idea to support your heart’s pumping mechanisms by taking a supplement each day that provides CoQ10, Hawthorn, L-Taurine and Quercetin. L-carnitine is a further consideration for some people.

I have included the references for congestive heart failure and L-carnitine in the text below.

References:

Causes and Diagnosis of Congestive Heart Failure: National Library of Medicine: Congestive Heart Failure https://www.ncbi.nlm.nih.gov/books/NBK430873/#:~:text=Congestive%20heart%20failure%20(CHF)%20is,blood%20to%20the%20systemic%20circulation.

Shang R et al. Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systemic review and meta-analysis. BMC Cardiovascular Disorders. July 21, 2014. Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis | BMC Cardiovascular Disorders | Full Text (biomedcentral.com)

Roger V.L. Epidemiology of Heart Failure.  Circulation Research. 2021. 128 (10): https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318172

Mayo Clinic Proceedings. Congestive Heart Failure: Insights from Epidemiology, Implications for Treatment. https://www.mayoclinicproceedings.org/article/S0025-6196(12)60078-0/fulltext

 

Eat Smart, Live Well, Look Great,
Dr. Meschino

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 325 – Functional MRI Predicts Alzheimer’s Disease Onset with Over 80 Percent Accuracy: An Absolute Breakthrough

LMU-325

Functional MRI Predicts Alzheimer’s Disease Onset with Over 80 Percent Accuracy: An Absolute Breakthrough

Source: Nature Mental Health (June 6, 2024)

Lifestyle Medicine Update (June 13, 2024)

As you know, with our aging population the incidence of Alzheimer’s disease is increasing quite rapidly. There are a variety of blood tests and other tests that may help to identify people who are at risk for this disease, but no one test has been established as the gold standard. And some of the tests are quite invasive, such as drawing out fluid from the spine’s cerebrospinal fluid with a needle. So, the study published on June 6, 2024, in the journal Nature Mental Health, appears to be a true game-changer.

Reporting on subjects who are part of the large UK Biobank Study the study utilized functional MRI of the brain, evaluating over 1100 subjects, mean age 70.4 years of age. Using a machine learning tool (AI) that looked for specific changes in the brain region known as the default-mode network (DMN) the learning tool was able to identify with 82% accuracy which subjects would develop clinical dementia over the next 9 years.  The baseline fMRI’s were performed between the years 2006 and 2010. By the year 2024 the researchers had their results. The great thing about this is that functional MRI assessment is non-invasive and there is no radiation exposure. There are no needles, risk of bleeding or infection, or puncturing a nerve, no radiation risk (unlike mammograms), or risk of colon rupture (which can occur during colonoscopies).

However, the question remains what to do if you see changes on the MRI that suggest a high-risk of future dementia. Well, the FDA just approved a new drug (Donanemab) that helps to breakdown plaque and was shown to slow early-stage Alzheimer’s’ s progression by about 30%.

But it’s not a cure, and there are some serious adverse effects (including death from brain bleeds) that can occur with IV administration of this drug. So, it still comes down to nutrition and lifestyle practices that give you the best chance of not developing dementia and Alzheimer’s disease.

Let’s quickly recap what those strategies include:

Ideally, keep your cholesterol level below 3.9 mmol/L (150 mg/dl) and your LDL-cholesterol below 1.5 mmol/ (58 mg/dl). This can be accomplished in most cases by a prudent diet and regular exercise.

Keep your fasting blood sugar below 5 mmol/L (90mg/dl)

Remain at or near your ideal body weight

Avoid brain-damaging chemicals (including alcohol and cigarettes)

Keep your brain active and engaged

Avoid head injuries (wear a helmet during high-risk sports)

Keep your blood pressure at or below 120/70

Participate in regular endurance exercise

Drink Green Tea daily, if possible

Regarding Supplementation I suggest that you:
Take a high potency multiple vitamin and mineral each day that contains a B-50 complex and enriched levels of antioxidants and 1,000 IU of Vitamin D

Take an Essential Fatty Acid Supplement daily that contains fish, flaxseed and borage seed oils

At age 40 and beyond take a supplement each night that contains .5 mg – 3 mg of melatonin (Find a dose that helps you get a goodnights sleep)

At age 55 and beyond add an additional supplement that contains:
CDP-choline
Phosphatidylserine
Bacopa Monnieri
Huperzine A

These four nutrients work together to help maintain optimal levels of the brain’s memory chemical, (acetylcholine), which typically declines after the age of 55.

Ok, I have provided a link to the research paper that explains the breakthrough dementia detecting functional MRI study I reported on in this update, as well as a link to the FDA approval of the drug Donanemab. Thanks for watching and I encourage to employ the nutritional and lifestyle medicine strategies shown to protect your brain against the development of dementia, as best you can.

References:

Ereira S et al. Early detection of dementia with default-mode network effective connectivity. Nature Mental Health. June 6, 2024. Early detection of dementia with default-mode network effective connectivity | Nature Mental Health

FDA Advisers Endorse Eli Lilly’s Early-Stage Alzheimer’s Drug. FDA advisers endorse Eli Lilly’s early-stage Alzheimer’s drug donanemab | CNN

FDA Panel Backs Donanemab: New Hope for Early Alzheimer’s Treatment – Neuroscience News

Eat Smart, Live Well, Look Great,
Dr. James Meschino

Recommended Supplements

Memory Support Complex

Memory Support Complex

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.