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LMU 299 – White Willow Extract Effective in Arthritis: 2022 Update

LMU-299

Unveiling the Healing Power of White Willow Extract: Nature's Remedy for Pain and Inflammation

Source: Drugs.com (2022)

Lifestyle Medicine Update (August 15, 2023)

Introduction

In the quest for effective pain relief without the distressing side effects often associated with synthetic drugs, nature has often provided remarkable solutions. Among these natural remedies, white willow extract stands out as a potent healer with a history spanning over millennia. What started as an ancient herbal tradition has evolved into a scientifically validated treatment for a spectrum of ailments, from arthritis to menstrual cramps. Let’s embark on a journey through the fascinating world of white willow extract and uncover its therapeutic potential.

The Origins of Aspirin: From Willow Bark to Salicin

Centuries before the advent of modern medicine, civilizations across the globe turned to nature for remedies to alleviate pain and inflammation. In this pursuit, the white willow bark extract emerged as a prominent healer, containing a compound known as salicin. This natural ingredient served as the precursor to acetylsalicylic acid (ASA), the active component of aspirin. While aspirin has become a household name in pain relief, it’s essential to recognize the roots of its origin in the humble white willow bark extract.

The Healing Power of Salicin

Salicin, the primary medicinal constituent found in white willow extract, has been revered for its remarkable efficacy in treating various ailments. Unlike its synthetic counterpart, aspirin, salicin offers a host of benefits without the adverse side effects commonly associated with non-steroidal anti-inflammatory drugs (NSAIDs). Studies have demonstrated salicin’s effectiveness in addressing joint inflammatory conditions, such as rheumatoid arthritis, with minimal risk of stomach irritation or intestinal bleeding.

Unlocking the Therapeutic Potential

Recent research has shed light on the multifaceted benefits of white willow extract beyond pain relief. Polyphenols and flavonoids present in the extract exhibit anti-cancer properties, offering potential avenues for combating malignancies. Moreover, salicin’s ability to inhibit inflammation-promoting enzymes and cytokines underscores its significance in managing autoimmune conditions like rheumatoid arthritis.

Evidence-Based Insights

Clinical trials have yielded promising results, highlighting the efficacy of white willow extract in mitigating pain and inflammation associated with osteoarthritis and dysmenorrhea. Notably, patients experienced comparable relief to conventional NSAIDs but with fewer reported side effects. Furthermore, longitudinal studies underscore the sustained efficacy and tolerability of white willow extract, making it a compelling alternative for individuals seeking natural remedies.

Navigating Usage and Precautions

While white willow extract offers a natural alternative to traditional pain relievers, certain precautions should be observed. Individuals taking anticoagulant medications like warfarin or with aspirin allergies should avoid its use. Additionally, pregnant or lactating women, as well as individuals with specific medical conditions such as severe asthma or peptic ulcers, should exercise caution. Children under 16 should refrain from white willow extract to mitigate the risk of Reye’s syndrome.

Harnessing Nature’s Synergy

For individuals grappling with joint inflammatory issues, a holistic approach combining natural anti-inflammatory compounds can offer comprehensive relief. Integrating white willow extract with synergistic agents like curcumin, ginger, and boswellia can potentiate its therapeutic effects, providing a holistic solution to address inflammatory conditions effectively.

Conclusion

White willow extract stands as a testament to nature’s enduring wisdom, offering a safe and effective alternative to conventional pain relievers. With its rich history rooted in ancient healing traditions and validated by modern research, this botanical remedy continues to redefine the landscape of pain management. By harnessing the power of nature’s bounty, we pave the way for a healthier, more sustainable approach to well-being.

Reference:

[Drugs.com – Willow Bark](https://www.drugs.com/npp/willow-bark.html)

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

 

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 298 – Omega-3 Fats Slow Age-Related Decline in Lung Function

LMU-298

Preserving Lung Health: The Role of Omega-3 Fatty Acids

Source: American Journal of Respiratory and Critical Care Medicine (2023)

Lifestyle Medicine Update (August 10, 2023)

Introduction: Understanding the Decline in Lung Function

As we age, many aspects of our health undergo subtle changes, including our lung function. Despite the vital role our lungs play in sustaining life, it’s often overlooked that lung capacity gradually diminishes over time. However, recent research suggests that there may be a way to slow down this decline and preserve lung health well into our later years.

Unlocking the Secrets of Lung Health: Insights from the NIH Study

In 2023, the National Heart, Lung, and Blood Institute (NHLBI) embarked on a groundbreaking two-part study aimed at unraveling the mysteries of lung function decline and its potential mitigation. Tracking over 15,000 healthy non-smoking Americans with an average age of 56 for an average of seven years, the study yielded fascinating insights into the impact of omega-3 fatty acids on lung health.

Omega-3 Fatty Acids: Nature’s Lung Protectors

The findings of the NHLBI study revealed a compelling association between higher levels of omega-3 fats in the blood and a reduced rate of lung function decline. Particularly, the omega-3 fatty acid docosahexaenoic acid (DHA), abundant in fatty fish like salmon, tuna, and sardines, emerged as a key player in preserving lung function. The study underscored the potential benefits of incorporating DHA-rich foods or fish oil supplements into one’s diet to support lung health.

Genetic Insights and European Participants: A Global Perspective

In a complementary aspect of the study, researchers analyzed genetic data from over 500,000 European participants enrolled in the UK Biobank study. The results mirrored those of the American cohort, reaffirming the positive association between omega-3 fatty acids, particularly DHA, and better lung function. Dr. James P. Kiley, director of the NHLBI’s Division of Lung Diseases, emphasized the significance of these findings, suggesting that nutrients with anti-inflammatory properties may play a crucial role in maintaining lung health.

Looking Ahead: Omega-3 Fatty Acids and Chronic Respiratory Conditions

While the study did not include individuals with chronic obstructive pulmonary disease (COPD), promising avenues for future research have been illuminated. Previous studies suggest that antioxidants like vitamins C and E, CoQ10, vitamin D, and medicinal mushrooms may offer benefits for COPD patients. Whether omega-3 fat supplements can complement these interventions remains an area ripe for exploration.

Personal Testimony: Harnessing the Power of Omega-3 Fats

Echoing the findings of the NIH study, individuals like myself have integrated omega-3 fatty acid supplements into their daily regimen to optimize lung health. By leveraging the combined benefits of fish, flaxseed, and borage seed oil, we endeavor to maintain robust lung function well into our later years.

Conclusion: Nurturing Lung Health for Lifelong Vitality

As we navigate the complexities of aging, prioritizing lung health emerges as a cornerstone of longevity. With omega-3 fatty acids offering a promising avenue for preserving lung function, individuals are empowered to take proactive steps towards a future marked by vitality and well-being.

References:

 
Eat Smart, Live Well, Look Great,

Dr. Meschino

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Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 297 – Higher Life Essential Scores Translates into a Longer and Healthier Life (UK Biobank study)

LMU-297

Unlocking the Secrets to a Long and Healthy Life: Insights from the AHA's Essential Recommendations

Source: JAMA Internal Medicine (February 20230)

Lifestyle Medicine Update (August 2, 2023)

Introduction: The Quest for Lifelong Health

In a world where the pursuit of longevity is paramount, the American Heart Association (AHA) has unveiled a roadmap to optimal health. With its Eight Life Essential Recommendations, the AHA aims to empower individuals to chart a course towards a vibrant and disease-free existence.

The Pillars of Wellness: A Closer Look

Diving into the core principles of the AHA’s recommendations reveals a tapestry of lifestyle choices that serve as the foundation for longevity:

  1. Not Smoking: A cornerstone of good health, abstaining from smoking is paramount in safeguarding the body against a myriad of diseases.
  2. Regular Physical Activity: Engaging in moderate endurance activities for at least 150 minutes per week not only invigorates the body but also fortifies the spirit.
  3. Maintaining a Healthy Weight: Striving for a body mass index (BMI) near 25 ensures optimal physical well-being.
  4. Embracing Healthy Sleep Patterns: With 7-9 hours of restorative sleep each night, the body rejuvenates and prepares for the challenges of the day ahead.
  5. Maintaining Healthy Blood Pressure and Glucose Levels: Keeping blood pressure under 130/80 and blood glucose levels around 90 mg/dl fosters cardiovascular health and wards off chronic diseases.
  6. Ensuring Optimal Non-HDL Cholesterol Levels: By maintaining non-HDL cholesterol, especially LDL-cholesterol, within the ideal range, individuals mitigate the risk of heart disease and stroke.

The Revelations of the UK Biobank Study

In a groundbreaking study published in the JAMA Internal Medicine journal, the UK Biobank sheds light on the transformative impact of adhering to the AHA’s recommendations. Following over 135,000 adults for several years, researchers discovered a profound correlation between adherence to the Life Essential Recommendations and overall health outcomes.

The Power of Lifestyle Medicine: A Testament to Transformation

As individuals embraced healthier diets and lifestyles, their cardiovascular health scores soared, leading to longer life expectancies and fewer years plagued by chronic diseases. Regardless of sociodemographic backgrounds, the benefits of adopting the AHA’s recommendations were unequivocal, underscoring the universal appeal of a lifestyle rooted in wellness.

A Vegetarian Revolution: The Role of Diet in Cardiovascular Health

In a stunning revelation, a study published in JAMA underscored the pivotal role of dietary choices in cardiovascular health. Transitioning to a healthier, more vegetarian diet yielded significant improvements in LDL-cholesterol, blood pressure, and body weight, heralding a new era in preventive medicine.

Conclusion: A Call to Action for Lifelong Wellness

Armed with the insights gleaned from these seminal studies, individuals are empowered to seize control of their health destinies. By embracing the Eight Life Essential Recommendations and adopting healthier dietary habits, they pave the way for a future marked by vitality, longevity, and unparalleled well-being.

References:

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

  1. Not Smoking
  2. Regular Physical Activity – 150 mins per week of moderate endurance activity/exercise
  3. Healthy Weight – at or near body mass index of 25
  4. Healthy Sleep Patterns – 7-9 hours per night
  5. Blood Pressure in healthy range – under 130/80
  6. Blood Glucose in a healthy range – close to 90 mg/dl (5 mmol/l)
  7. HbA1c around 5.1 (to prevent sugar-coating blood proteins linked to heart disease and stroke)
  8. Non-HDL cholesterol in a healthy range (especially LDL-cholesterol) – LDL-cholesterol no higher than 2 mmol/l or (76 mg/dl) or preferably below 1.5 mmol/l (57 mg/dl)

Based on these recommendations the UK Biobank Study published results of their findings in the February 2023 issue of JAMA Internal Medicine journal. The UK Biobank Study followed 135,199 adults, average age 55, who were free of chronic diseases such as cardiovascular disease, cancer, diabetes, and dementia at the outset of the study. The participants were divided into three groups based on their AHA 8 Life Essentials Score – low, moderate, and high scores. High scores being the most desirable. They also gave each participant a cardiovascular health score of low, moderate, and high, with a high cardiovascular health score being the most desirable. After following these patients for many years the results showed that a high cardiovascular health score was associated with substantially longer life expectancy and remaining free of 4 major chronic diseases (cardiovascular disease, diabetes, cancer, and dementia) in both men and women.  This was true for people of all sociodemographic backgrounds, meaning that higher education and income did not change the results. Individuals who had healthier diets and lifestyles, who naturally scored higher on measurements of cardiovascular health (blood pressure, blood sugar, LDL-cholesterol, regular exercise) had exceptionally better health overall, as the years went by, compared to those with lower cardiovascular health scores. As one of the researchers commented, “Men with high cardiovascular health scores tended to have an additional 7 years of life expectancy, free of chronic disease, compared with those who had lower scores. In women, the difference was about 9.5 years between high scores and lower scores. Also, the number of years lived with chronic disease was compressed in those with high cardiovascular health scores. They tended to have fewer years living with those chronic diseases but more years living free of chronic diseases. This is called quality of life or health span or healthy life expectancy. It all means the same thing. It translates into putting in the effort, through diet, exercise, and other lifestyle practices, to maintain a highly functioning body and mind for as long as possible.

The UK Biobank Study tells us that healthy diet matters (avoiding saturated fats, trans-fats, fried foods, super sugary foods, alcohol etc.) and that 150-minutes of moderate endurance exercise makes a difference. As does keeping your blood pressure and LDL-cholesterol in the ideal range through healthy diet, healthy weight, and regular exercise habits (and medication if necessary). In the words of Dr. Joann Manson MD Ph.D, a lead researcher and professor at Harvard Medical School and Brigham and Women’s Hospital, “Overall, the findings make a compelling case for the importance of lifestyle factors in extending health span and years free of chronic disease. It can be motivating to tell our patients that a healthy lifestyle not only extends life expectancy but also extends years of health, free of chronic disease.

What’s interesting is that a few months later (July 2023) JAMA published the results of another large study showing that in patients at high risk for cardiovascular disease, the meta-analysis shows that switching to a healthy, more vegetarian diet for just 6-months reduced the bad cholesterol (LDL-cholesterol), HbA1c (another important risk factor for heart disease) and body weight to a significant degree.  The healthy dietary change also reduced the need for medication. The researchers remind patients that not all vegetarian diets are healthy. For instance, deep-fried foods like French fries and potato chips are vegetarian, but they are not healthy choices. The same is true for foods with palm and coconut oil (like the Beyond Meat products). Some of the healthier, more vegetarian diets that produced good results included diets allowing egg whites, and non-fat dairy products, as well as seafood and some fish, along of course with more vegetables, legumes (beans and peas), including soy products, some nuts and fruit and whole grain products. There is now convincing evidence that switching to a healthier, more vegetarian diet can appreciably improve your cardiovascular health score, as it lowers LDL-cholesterol, blood pressure and body fat. According to the UK Biobank Study these improved health markers bode well for more years of disease-free living, a longer life span and healthy life expectancy.

Once again lifestyle medicine is good medicine. So, I would encourage you to keep the 8 Life Essentials outlined by the AHA top of mind in your quest for optimal health and longevity. I have included the references for this information in the text below.

References:

Wang X et al. Association of cardiovascular health with life expectancy free of cardiovascular disease, diabetes, cancer, and dementia in UK adults. JAMA Internal Medicine. Feb 27, 2023 https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2801750

Life’s Essential 8: Higher Scores Extend Health Span. Medscape, March 27. 2023. Dr JoAnn E. Manson MD DrPH. https://www.medscape.com/viewarticle/989752?ecd=mkm_ret_230801_mscpmrk-OUS_InFocus_etid5692664&uac=342474MN&impID=5692664

Life’s Essential 8 – American Heart Association https://www.heart.org/en/healthy-living/healthy-lifestyle/lifes-essential-8

Wang T et al. Vegetarian dietary patterns and cardiometabolic risk in people with or at high risk of cardiovascular disease. JAMA (July 23, 2023) https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2807597

Vegetarian Diets Can Improve High-Risk Cardiovascular Disease. Nancy A. Melville. Medscape, July 23, 2023 Vegetarian Diets Can Improve High-Risk Cardiovascular Disease (medscape.com)

 

Eat Smart, Live Well, Look Great,
Dr. Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 296 – Low-level Laser Therapy Effective for Tinnitus

LMU-296

Shedding Light on Tinnitus: A Breakthrough Treatment

Source: Journal of Personalized Medicine (March 2023)

Lifestyle Medicine Update (July 25, 2023)

Introduction: The Phantom Symphony:

Tinnitus, the relentless ringing or buzzing in the ears, torments approximately 14% of adults worldwide. For a staggering 20% of these individuals, the severity of this auditory phantom wreaks havoc on their lives. With no definitive understanding of its origins and a dearth of effective treatments, tinnitus poses a formidable challenge to those afflicted, compromising their quality of life.

The Elusive Quest for Relief:

Conventional therapies for tinnitus, ranging from sedatives to antidepressants, offer scant solace, leaving many sufferers in a perpetual state of distress. The search for a panacea has been futile, leaving a trail of frustration in its wake.

A Ray of Hope: The Laser Revolution:

In a watershed moment, a glimmer of hope emerges from the depths of despair. A study published in the Journal of Personalized Medicine in March 2023 heralds a paradigm shift in tinnitus treatment. Researchers from the Optics and Photonics Research Center (CEPOF) in Brazil unveil a groundbreaking discovery—the remarkable efficacy of low-level laser therapy in assuaging the torment of tinnitus.

Unveiling Laser’s Healing Touch:

Embarking on a quest to unravel the mysteries of tinnitus, the researchers conducted a meticulous study, enlisting 100 men and women grappling with the affliction. Over a span of four weeks, patients underwent a regimen of ten diverse treatments, each administered twice weekly. The results? A resounding affirmation of the transformative power of low-level laser therapy. When directed at specific acupuncture points on the ear or penetrating the tympanic membrane itself, the laser emerges as a potent ally, significantly reducing the severity of tinnitus symptoms.

The Mechanisms of Laser Therapy: Unlocking Nature’s Resilience:

Delving into the inner workings of low-level laser therapy, the researchers uncover a trove of physiological marvels. From its anti-inflammatory prowess to its ability to enhance peripheral irrigation and stimulate inner ear cell proliferation, the laser emerges as a multifaceted healer. By harnessing its capacity to bolster ATP energy production, foster inner ear blood flow, and activate hair cell mitochondria, low-level laser therapy offers a glimmer of hope to those ensnared in the clutches of tinnitus.

A Pathway to Liberation:

Armed with the promise of low-level laser therapy, individuals plagued by tinnitus or Meniere’s disease embark on a journey of liberation. With the guidance of knowledgeable practitioners, the flicker of hope kindled by the laser illuminates the path to relief, promising respite from the relentless cacophony that plagues their existence.

Conclusion: Illuminating the Path to Tranquility:

As the echoes of tinnitus reverberate through the corridors of despair, the advent of low-level laser therapy heralds a dawn of hope. With its transformative potential to assuage the torment of tinnitus, the laser emerges as a beacon of light in the darkness, guiding sufferers towards a symphony of tranquility and reclaiming the melody of silence.

References:

Eat Smart, Live Well, Look Great,

Dr. Meschino

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Dr. James Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 295 – Glucosamine Linked to Reduced Cancer Risk in Large UK Biobank Study (2022)

LMU-295

Glucosamine: A Potential Shield Against Cancer

Source: Journal, Frontiers of Nutrition (November 2022)

Lifestyle Medicine Update (July 18, 2023)

Introduction: The Glucosamine Revelation:

In the labyrinth of health supplements, glucosamine emerges as a beacon of hope, offering not just joint support but also a surprising defense against cancer. In a groundbreaking revelation unveiled in 2020, the Annals of Rheumatology disclosed that regular intake of glucosamine supplements was linked to a substantial reduction in cancer mortality alongside a myriad of other health benefits. This tantalizing discovery set the stage for further exploration into glucosamine’s anti-cancer properties, leading to a pivotal update from the UK Biobank study in 2022.

UK Biobank Study: Unveiling Glucosamine’s Cancer Armor:

Heralded as one of the largest population studies globally, the UK Biobank study embarked on a mission to unravel the mysteries of glucosamine’s potential as a shield against cancer. With a cohort exceeding 500,000 individuals, ranging from 38 to 73 years old, the study meticulously traced their health trajectories from 2006 to 2010 until March 2021, none bearing the burden of cancer at the study’s inception. The resounding verdict? Glucosamine users exhibited a remarkable array of benefits, including a 5% reduction in overall cancer risk and staggering declines in specific cancer mortalities, such as kidney, lung, and rectal cancers.

Glucosamine’s Anti-Cancer Arsenal:

Delving deeper into the realm of molecular biology, glucosamine unveils a potent arsenal against cancer. In laboratory settings, glucosamine flexes its anti-cancer muscles, inhibiting the proliferation of various human cancer cells, orchestrating programmed cell death (apoptosis), thwarting tumor drug resistance, impeding tumor blood vessel formation, and curtailing cancer cell invasion into neighboring tissues. The synergy of these mechanisms paints a compelling picture of glucosamine’s prowess in combating cancer’s insidious advance.

Glucosamine Availability and Usage: Empowering the Masses:

Accessible as both a prescription drug in Europe and an over-the-counter supplement in Australia, the US, and Canada, glucosamine offers a versatile armor against cancer to a global audience. While usage rates vary across regions, with approximately 20% of Australian adults embracing glucosamine, its adoption remains relatively modest in the US and Canada. However, armed with the knowledge of its anti-cancer potential, a surge in its usage may be on the horizon.

Complementary Natural Agents: Enhancing Glucosamine’s Arsenal:

Some glucosamine formulations marry its might with three natural anti-inflammatory agents—Quercetin, Bromelain, and MSM—each boasting their own anti-cancer properties. This synergistic blend not only fortifies glucosamine’s anti-cancer armamentarium but also amplifies its overall health benefits.

Recommendation: Harnessing Glucosamine’s Potential:

As the body’s natural glucosamine production wanes around the age of 40, embracing a glucosamine supplement enriched with natural anti-inflammatory allies may serve as a proactive step towards cancer prevention and overall well-being. With mounting evidence illuminating glucosamine’s multifaceted benefits, its integration into daily health regimens emerges as a prudent choice for individuals seeking to defy the odds of cancer mortality.

References:

Eat Smart, Live Well, Look Great,

Dr. Meschino

Glucosamine and Reduced Cancer Risk

In 2020, a published paper in the Annals of Rheumatology reported that regular use of glucosamine supplements was associated with:

  • A significantly reduced risk of dying from cancer, cardiovascular, respiratory, and intestinal tract diseases.
  •  A 15% reduction in all-cause mortality compared to non-users of glucosamine supplements.

The data was derived from approximately 500,000 individuals being followed in the UK Biobank study.

UK Biobank Study Update on Glucosamine and Cancer

  • In November 2022, the UK Biobank study was updated and published in the Frontiers of Nutrition journal, with a specific focus on glucosamine’s potential protective role against cancer.
  • The UK Biobank study is one of the largest population studies in the world, aiming to improve disease prevention, diagnosis, and treatment, as well as promote health across society.
  • The original study included over 500,000 participants from the UK, aged 38 to 73, who were followed from 2006 to 2010 until March 2021. None of the participants had cancer at the study’s beginning.
  • After controlling for other cancer risk factors, the study showed that individuals who routinely took glucosamine supplements exhibited significant benefits:
    1. 5% decrease in overall cancer risk
    2. 32% lower risk of kidney cancer mortality
    3. 16% lower risk of lung cancer mortality
    4. 24% lower risk of rectal cancer mortality

Glucosamine and Anti-Cancer Properties

Glucosamine has shown important anti-cancer properties in experimental and animal studies, including:

    • Inhibition of proliferation in various types of human cancer cells
    • Inducing programmed cell death (apoptosis) in many cancer cell types
    • Reversal of tumor drug-resistance
    • Inhibition of tumor blood vessel formation (anti-tumorigenesis)
    • Blocking cancer cells’ ability to invade neighboring tissues by inhibiting destructive enzymes (matrix metalloproteinases)

Several epidemiological studies in the US and the UK have indicated that glucosamine is linked to reduced cancer mortality, with some studies reporting a 15% reduction in overall cancer risk.

Glucosamine Availability and Usage

  • Glucosamine is available as a prescription drug in most European countries but as an over-the-counter supplement in Australia, the US, and Canada.
  • Usage rates vary, with about 20% of Australian adults using glucosamine supplements, approximately 2% of US adults, and an estimated 5-7% of the adult population in Canada.

Complementary Natural Agents

Some glucosamine supplements contain three natural anti-inflammatory agents (Quercetin, Bromelain, and MSM), which have their own unique anti-cancer properties in various studies.

Recommendation

  • Based on the evidence, it may be beneficial for individuals to consider taking a glucosamine supplement with natural anti-inflammatory agents around the age of 40, as this is the time when the body naturally produces less glucosamine.

References

  1. Zhou J et al. Association between glucosamine use and cancer mortality: A large prospective cohort study. Front Nutr. 2022. 9 Link
  2. Li Z-H et al. Associations of regular glucosamine use with all-cause and specific mortality: a large prospective cohort study. Ann Rheum Dis. 2020; 79(6): 829-863. Link
  3. Bromelain Anti-cancer Properties: Link
  4. Quercetin Anti-Cancer Properties: Link
  5. MSM Anti-Cancer Properties: Link

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Dr. James Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 294 – Protecting Against Parkinson’s: The Role of Glutathione

LMU-294

Defending Against Parkinson’s Disease: The Promise of Glutathione Supplementation

Source: International Journal of Molecular Science (2021)

Lifestyle Medicine Update (July 5, 2023)

Introduction: Parkinson’s Disease – A Looming Challenge:

Parkinson’s disease, the second most prevalent neurodegenerative disorder following Alzheimer’s, casts a shadow over the lives of one in every five hundred individuals aged fifty and above. With aging populations burgeoning worldwide, it is estimated that by 2030, around nine million people will grapple with this debilitating condition. A blend of genetic predisposition and environmental influences underpins its onset, with oxidative stress—unbridled free radicals—playing a pivotal role in its pathogenesis.

The Role of Free Radicals and Glutathione:

Within the brain cells responsible for producing dopamine, an excessive accumulation of free radicals spells doom, heralding the demise of these cells and kickstarting Parkinson’s disease. As individuals age, dwindling levels of brain glutathione contribute to heightened oxidative stress, escalating the vulnerability to Parkinson’s disease and other neurodegenerative afflictions.

Glutathione Treatment as a Viable Strategy:

In the quest to fortify brain cells against free radical onslaught and manage Parkinson’s disease, researchers have fervently explored avenues to bolster brain glutathione levels in older individuals. A meta-analysis in 2021 corroborated the efficacy of glutathione treatment in ameliorating muscle and movement impairments, including tremor reduction, in Parkinson’s patients. Moreover, glutathione treatment not only alleviates the symptoms but also disrupts the disease’s underlying pathological processes.

Optimizing Glutathione Levels:

Although oral glutathione supplements often succumb to breakdown within the intestinal tract, N-acetylcysteine (NAC) emerges as a potent stimulator of glutathione synthesis, effortlessly traversing the blood-brain barrier to elevate brain glutathione levels. Additionally, nutrients like Alpha-lipoic acid, Silymarin from Milk thistle, and L-Glutamine furnish alternative routes to augment blood and tissue glutathione levels.

The Imperative of Glutathione Supplementation:

Given the age-related decline in glutathione levels and its pivotal role in neutralizing detrimental free radicals within the body and brain cells, supplementation becomes imperative around the age of 45-50. A judiciously formulated supplement encapsulating NAC, Alpha-lipoic acid, Silymarin, and L-Glutamine promises to synergistically elevate glutathione levels, ushering in a cascade of anti-aging and health-enhancing benefits.

Conclusion:

As the specter of Parkinson’s disease looms large, the spotlight shifts to glutathione supplementation as a beacon of hope in the battle against neurodegeneration. Armed with its antioxidant prowess, glutathione stands as a formidable fortress, shielding brain cells from the ravages of oxidative stress and extending a lifeline to those grappling with Parkinson’s disease. With meticulous supplementation strategies, individuals can bolster their defenses, fortifying themselves against the scourge of aging-related cognitive decline and embracing a future brimming with vitality and vigor.

References:

 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Parkinson’s Disease – A Growing Concern

Parkinson’s disease, the second most common neurodegenerative condition after Alzheimer’s, affects one in five hundred
adults over fifty. By the year 2030, approximately nine million people are estimated to be afflicted with this condition as aging populations grow in many countries. The disease is caused by a combination of genetic and environmental factors, with unmitigated free radicals (oxidative stress) playing a significant role in its development.

The Role of Free Radicals and Glutathione

  • High levels of free radicals within dopamine-producing brain cells lead to their death, triggering the onset and progression of Parkinson’s disease.
  • Age-related decline in brain glutathione levels contributes to elevated free radicals during the aging process, increasing the risk of Parkinson’s disease and other neurodegenerative conditions.

Glutathione Treatment as an Effective Approach

  • Researchers have been investigating ways to increase brain glutathione levels in older subjects to protect brain cells from free radical damage and manage existing cases of Parkinson’s disease.
  • A 2021 meta-analysis confirmed that glutathione treatment is effective in improving muscle and movement function, including tremor reduction, in Parkinson’s patients.
  • Glutathione treatment not only reduces Parkinson’s disease symptoms but also inhibits steps involved in the underlying cause of the disease.

Optimizing Glutathione Levels

The Importance of Glutathione Supplementation

References:

  1. Wang H-L et al. Potential use of glutathione as a treatment for Parkinson’s disease. Exp Ther Med. 2021;21(2): 125 Link
  2. Smeyne M. Glutathione metabolism and Parkinson’s disease. Free Radic Biol Med. 2013; 62: 13-25
  3. Aoyama K. Glutathione in the brain. Int J Mol Sci. 2021; 22(9): 5010 Link

Eat Smart, Live Well, Look Great,

Dr. Meschino

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Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 293 – Bacopa Monnieri Supplementation for Memory Support and Improvement in Aging

LMU-293

Unlocking Memory Power: The Potential of Bacopa Monnieri for Aging Brains

Source: Frontiers of Aging Neuroscience Journal (2021)

Lifestyle Medicine Update (June 20, 2023)

Introduction:

As we age, memory lapses and cognitive struggles can dim the luster of our golden years. However, amidst the challenges, a lesser-known herb from India, Bacopa monnieri, emerges as a promising ally in the fight against memory decline. In this article, we delve into the potential of Bacopa monnieri supplementation to preserve and enhance memory in aging individuals, supported by both experimental and human clinical studies.

Bacosides A and B: The Brain’s Guardians:

Within Bacopa monnieri lie two potent compounds—Bacosides A and B—that hold the keys to memory preservation. These compounds possess the remarkable ability to penetrate the blood-brain barrier, where they embark on a mission to safeguard brain cells. Acting as neuroprotectors, they fortify memory, repair damaged neurons, and even rid brain cells of toxic metals. Bacopa’s arsenal includes powerful antioxidants that combat free radicals, reduce brain inflammation, enhance blood flow to the brain, and elevate levels of acetylcholine, the brain’s memory messenger. Moreover, Bacopa monnieri boosts the brain’s defense mechanisms by ramping up protective antioxidants like Superoxide Dismutase, Catalase, and Glutathione Peroxidase.

Human Clinical Studies: Unveiling Bacopa’s Memory Magic:

In a compelling study published in Frontiers of Aging and Neuroscience in 2021, multiple human clinical trials underscored Bacopa monnieri’s prowess in memory enhancement. These trials revealed that supplementation with Bacopa monnieri not only improved immediate and delayed recall memory but also supercharged brain processing speed and sustained attention within as little as 12 weeks to 3 months of supplementation initiation. The rapid onset of these effects hints at Bacopa’s quick action in rejuvenating aging brains.

Combination with Other Supplements: Powering Up Memory Defense:

Crossing the age threshold of 50-55 poses challenges in maintaining optimal levels of acetylcholine—the brain’s memory fuel—due to the waning effectiveness of the blood-brain barrier. Here, Bacopa monnieri teams up with other memory-support supplements to mount a formidable defense. Pairing Bacopa with CDP-choline, Phosphatidylserine, and Huperzine A fortifies the brain’s defenses against age-related decline. This synergistic combination acts as a bulwark, safeguarding against cognitive deterioration, executive function decline, and sluggish processing speed.

Conclusion: Unlocking the Fountain of Memory Youth:

Bacopa monnieri emerges as a beacon of hope in the quest for age-defying memory. Its ability to breach the blood-brain barrier and shield brain cells sets it apart as a potent memory enhancer. Armed with antioxidants and memory-boosting properties, Bacopa monnieri stands as a stalwart guardian of brain health. For individuals navigating the maze of aging, a daily regimen incorporating Bacopa monnieri, CDP-choline, Phosphatidylserine, and Huperzine A presents a compelling strategy to combat cognitive decline and reclaim the vibrant tapestry of memory and cognition.

In the journey towards cognitive vitality, Bacopa monnieri offers a glimmer of hope—a testament to nature’s profound wisdom and the boundless potential of the human mind.

Eat Smart, Live Well, Look Great,

Dr. Meschino

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Memory Support Complex

Memory Support Complex

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 292 – Exercise and Diabetes Prevention: Insights from a 2023 Study

LMU-292

Exercise: A Powerful Defense Against Type 2 Diabetes

Source: British Journal of Sports Medicine (2023)

Lifestyle Medicine Update (June 14, 2023)

Introduction

In today’s fast-paced world, health has become a paramount concern for individuals of all ages. Among various health-promoting practices, exercise stands out as one of the most effective preventive measures against a myriad of chronic diseases, including type 2 diabetes. The significance of exercise as preventive medicine has repeatedly been reiterated by healthcare professionals and researchers. In this context, the study published in the British Journal of Sports Medicine in 2023 by M. Luo et al. sheds new light on the association between exercise and diabetes risk, supplying valuable insights that can positively change public health policies and individual lifestyle choices.

Study Details

The research by M. Luo and colleagues involved a comprehensive analysis of data from the UK Biobank study. The UK Biobank, a large-scale biomedical database, has extensive health information from over 500,000 participants, including genetic data, lifestyle factors, and medical history. For this specific study, 59,325 adults were selected as the participants, making it one of the largest studies to investigate the relationship between physical activity and diabetes risk.

Researchers employed ultramodern technology to gather correct and reliable data on participants’ physical activity. Each participant was asked to wear an accelerometer, a small and portable device that accurately measures movements and physical activity levels. The accelerometers were worn for a prolonged period of seven years, allowing for a detailed examination of the participants’ daily activity patterns.

 Key Findings

The results of the study unveiled a striking correlation between physical activity and type 2 diabetes risk. Participants who engaged in moderate-to-vigorous physical activity for over one hour per day experienced a remarkable 74% reduction in the risk of developing type 2 diabetes compared to those who engaged in less than 5 minutes per day of such activity. This finding emphasizes the importance of incorporating regular, sustained, and moderately intense physical activity into daily routines to safeguard against the development of this prevalent metabolic disorder.

 Furthermore, the research delved deeper into the influence of genetic factors on diabetes risk. It is well-established that genetic predisposition plays a role in deciding an individual’s susceptibility to type 2 diabetes. However, the study’s intriguing revelation was that even individuals with a high genetic risk for type 2 diabetes could substantially mitigate their risk through consistent and substantial physical activity. Typically, individuals with a high genetic risk are believed to be 2.4 times more likely to develop type 2 diabetes; yet, the protective effects of exercise were still clear in this subgroup, offering hope and motivation for those who may be at higher risk due to their genetic makeup.

Comments from Researchers

One of the researchers involved in the study expressed enthusiasm over the potential implications of their findings. They said, We are unable to control our genetic risk and family history, but this finding provides promising and positive news that through an active lifestyle, one can ‘fight off’ much of the excessive risk for type 2 diabetes. This optimistic outlook resonates with the growing body of research that underscores the transformative power of lifestyle interventions.

Benefits of Moderate-to-Vigorous Exercise for Diabetes Prevention

The study findings raise the question: How does moderate-to-vigorous exercise exert its protective effects against diabetes? To answer this, we must explore the physiological changes that occur during physical activity:

  1. Improving Insulin Sensitivity:Insulin, a hormone produced by the pancreas, plays a crucial role in regulating blood glucose levels. Insulin sensitivity refers to how effectively our cells respond to insulin’s action in transporting glucose from the bloodstream into cells. Regular exercise enhances insulin sensitivity, which allows the body to use glucose more efficiently, ultimately reducing blood sugar levels and lowering the risk of diabetes.
  2. Enhancing Fat-Burning:Obesity and excess body weight are proven risk factors for insulin resistance, a condition where cells become less responsive to insulin. Engaging in moderate-to-vigorous physical activity promotes fat burning and helps prevent weight gain, thus reducing the risk of developing insulin resistance and type 2 diabetes.
  3. Activation of Sirtuin Longevity Genes:Sirtuins are a group of proteins that regulate various cellular processes, including those involved in metabolism and aging. Some sirtuins are known to be involved in regulating insulin sensitivity and glucose metabolism. Exercise activates these longevity genes, positively affecting overall cardiometabolic health and reducing the likelihood of developing diabetes.

Conclusion

The findings of the 2023 study published in the British Journal of Sports Medicine reinforce the idea that our genes do not solely decide our destiny. While genetic factors can influence disease risk, lifestyle choices and behaviors have the power to modulate gene expression and influence health outcomes significantly. Regular, moderate-to-vigorous physical activity can combat the risk of type 2 diabetes and improve overall health and quality of life.

These insights hold profound implications for public health initiatives, healthcare providers, and individuals alike. Encouraging and promoting physical activity should be a cornerstone of preventive healthcare strategies to tackle the growing burden of diabetes and other chronic diseases. The integration of exercise into daily routines is not only an investment in individual health but also an investment in the well-being of societies at large.

In conclusion, the study serves as a clarion call to action, urging individuals to embrace an active lifestyle and empowering them to take charge of their health destinies. As we navigate the challenges of modern living, let us not forget the simple yet transformative power of exercise in promoting health, longevity, and a vibrant quality of life.

References:

Luo M et al. Accelerometer-measured intensity-specific physical activity, genetic risk, and incident type 2 diabetes: A prospective study. Br J Sports Med. (2023) Accelerometer-measured intensity-specific physical activity, genetic risk, and incident type 2 diabetes: a prospective cohort study | British Journal of Sports Medicine (bmj.com)
[Link](https://bjsm.bmj.com/content/early/2023/03/06/bjsports-2022-104787)

Exercise Mitigates Genetic Risk for Type 2 Diabetes. NeuroscienceNews.com (June 5, 2023) Exercise Mitigates Genetic Risk for Type 2 Diabetes – Neuroscience News [Link](https://neurosciencenews.com/exercise-genetic-diabetes-19155/)

 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Recommended Supplements

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
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LMU 291 – Folic Acid Supplementation Improves Efficacy of Anti-Depression Drugs

LMU-291

Enhancing Antidepressant Treatment: The Role of Methylfolate Supplementation

Source: Journal of Clinical Psychiatry (2023)

Lifestyle Medicine Update (June 6, 2023)

Introduction:

In May 2023, the Journal of Clinical Psychiatry published a comprehensive review paper examining the potential of methylfolate, a specialized form of the B-vitamin folic acid, as an adjunctive therapy for major depressive disorder. This review aims to synthesize findings from various studies investigating methylfolate’s efficacy in individuals who do not respond adequately to traditional antidepressant medications alone.

Key Findings:

The review highlights several significant findings:

  • The addition of methylfolate to antidepressant drug therapy significantly improves treatment response rates in individuals previously resistant to antidepressant medications.
  • Methylfolate plays a vital role in synthesizing neurotransmitters, particularly serotonin, which is essential for mood regulation. Unlike antidepressants, which primarily slow serotonin breakdown, methylfolate facilitates serotonin synthesis, offering a unique mechanism for treatment augmentation.
  • Methylfolate supplementation is particularly beneficial for patients with drug-resistant major depression, especially those who are overweight or exhibit high levels of inflammatory blood markers. Overweight individuals often have elevated inflammatory chemicals, which can impede serotonin synthesis and reduce antidepressant efficacy. Methylfolate helps counteract these effects, enabling the normalization of serotonin synthesis.
  • The recommended effective dosage of methylfolate for individuals unresponsive to antidepressant drugs is 15 mg per day. Psychiatrists are encouraged to consider adding methylfolate to the treatment regimen for such patients.

Implications and Recommendations:

The review underscores the broader importance of nutritional support in mental health:

  • Various vitamins and minerals, including B-vitamins (folic acid, vitamin B12, B6, B3, and pantothenic acid), vitamin C, and magnesium, are essential for neurotransmitter synthesis and overall brain function. Consideration of high-potency multivitamin and mineral supplements, along with increased antioxidant dosages, is recommended to support mental health.

Clinical application:

Individuals with depression, especially those who have not responded adequately to antidepressant medications, should discuss the potential benefits of methylfolate supplementation (15 mg/day) with their healthcare providers. Elevated levels of markers such as blood homocysteine, ESR, and CRP may indicate potential responsiveness to methylfolate supplementation.

Conclusion:

The review emphasizes the importance of considering natural supplements, such as methylfolate, as adjunctive treatments for depression. By addressing underlying nutritional deficiencies and supporting neurotransmitter synthesis, these supplements offer promising avenues for enhancing antidepressant efficacy and promoting brain health.

References:

 
Eat Smart, Live Well, Look Great,

Dr. Meschino

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All-in-One Multi-Vitamin & Mineral

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
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LMU 290 – Reishi Mushroom Extract Bolsters Immune Function in Post-operative Breast and Colon Cancer Patients, Improving Overall Outcomes: An important finding for those over 50

LMU-290

Boosting Immune Function with Reishi Mushroom Extract: Insights from Cancer Patients

Source: Journal of Clinical and Translational Oncology (2021)

Lifestyle Medicine Update (May 31, 2023)

Introduction: Enhancing Immune Function in Cancer Patients

A study published in Clinical and Translational Oncology in 2021 sheds light on the immune-boosting effects of Reishi Mushroom Extract in breast and lung cancer patients post-surgery. Strengthening the immune system is crucial for cancer patients’ overall survival and well-being.

Study Findings: Reishi Mushroom Extract and Immune Response

Patients receiving Reishi Mushroom Extract demonstrated heightened immune function compared to those without supplementation. They exhibited increased levels of T-lymphocytes, crucial for combating cancer and infections, along with reduced levels of immune-suppressing prostaglandins and cytokines. Additionally, Reishi Mushroom Extract improved key ratios indicative of cancer progression and survival.

Clinical Implications: Reishi Mushroom Extract for Immune Support

The study underscores the potential of Reishi Mushroom Extract to enhance immune function, benefiting not only cancer survivors but also individuals over 50. Aging compromises thymus gland function, leading to diminished T-lymphocyte activity and increased susceptibility to infections and cancer. Supplementation with Reishi Mushroom Extract and other immune-modulating agents post-50 can fortify immune defenses and support overall health.

Recommendations: Consider Immune Support After 50

Given the decline in immune function with age, incorporating immune-supportive supplements like Reishi Mushroom Extract, astragalus, indole-3-carbinol, and Milk Thistle may be beneficial. These supplements have shown promise in bolstering immune function and detoxification enzyme activity, promoting longevity and vitality.

Conclusion: Harnessing Nature’s Immune-Boosting Power

Studies like this highlight the potential of natural supplements like Reishi Mushroom Extract in strengthening immune function and mitigating cancer risk. By prioritizing immune support, especially after 50, individuals can optimize their defense mechanisms and maintain overall well-being.

References:

  1. Deng Y. et al. Dynamic biomarkers indicate the immunological benefits provided by Ganoderma spore powder in post-operative breast and lung cancer patients. Clinical and Translational Oncology. 2021; 23: 1481-1490 [Link](https://link.springer.com/article/10.1007/s12094-020-02547-9)
  2. AG Ratio [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706002/)
  3. NL Ratio [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998851/#:~:text=The%20neutrophil%2Dto%2Dlymphocyte%20ratio%20(NLR)%2C%20calculated,supported%20by%20lymphocytes%20%5B1%5D.)
 
Eat Smart, Live Well, Look Great,

Dr. Meschino

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Immuno-Detox Prime

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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