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LMU 291 – Folic Acid Supplementation Improves Efficacy of Anti-Depression Drugs

LMU-291

Enhancing Antidepressant Treatment: The Role of Methylfolate Supplementation

Source: Journal of Clinical Psychiatry (2023)

Lifestyle Medicine Update (June 6, 2023)

Introduction:

In May 2023, the Journal of Clinical Psychiatry published a comprehensive review paper examining the potential of methylfolate, a specialized form of the B-vitamin folic acid, as an adjunctive therapy for major depressive disorder. This review aims to synthesize findings from various studies investigating methylfolate’s efficacy in individuals who do not respond adequately to traditional antidepressant medications alone.

Key Findings:

The review highlights several significant findings:

  • The addition of methylfolate to antidepressant drug therapy significantly improves treatment response rates in individuals previously resistant to antidepressant medications.
  • Methylfolate plays a vital role in synthesizing neurotransmitters, particularly serotonin, which is essential for mood regulation. Unlike antidepressants, which primarily slow serotonin breakdown, methylfolate facilitates serotonin synthesis, offering a unique mechanism for treatment augmentation.
  • Methylfolate supplementation is particularly beneficial for patients with drug-resistant major depression, especially those who are overweight or exhibit high levels of inflammatory blood markers. Overweight individuals often have elevated inflammatory chemicals, which can impede serotonin synthesis and reduce antidepressant efficacy. Methylfolate helps counteract these effects, enabling the normalization of serotonin synthesis.
  • The recommended effective dosage of methylfolate for individuals unresponsive to antidepressant drugs is 15 mg per day. Psychiatrists are encouraged to consider adding methylfolate to the treatment regimen for such patients.

Implications and Recommendations:

The review underscores the broader importance of nutritional support in mental health:

  • Various vitamins and minerals, including B-vitamins (folic acid, vitamin B12, B6, B3, and pantothenic acid), vitamin C, and magnesium, are essential for neurotransmitter synthesis and overall brain function. Consideration of high-potency multivitamin and mineral supplements, along with increased antioxidant dosages, is recommended to support mental health.

Clinical application:

Individuals with depression, especially those who have not responded adequately to antidepressant medications, should discuss the potential benefits of methylfolate supplementation (15 mg/day) with their healthcare providers. Elevated levels of markers such as blood homocysteine, ESR, and CRP may indicate potential responsiveness to methylfolate supplementation.

Conclusion:

The review emphasizes the importance of considering natural supplements, such as methylfolate, as adjunctive treatments for depression. By addressing underlying nutritional deficiencies and supporting neurotransmitter synthesis, these supplements offer promising avenues for enhancing antidepressant efficacy and promoting brain health.

References:

 
Eat Smart, Live Well, Look Great,

Dr. Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 290 – Reishi Mushroom Extract Bolsters Immune Function in Post-operative Breast and Colon Cancer Patients, Improving Overall Outcomes: An important finding for those over 50

LMU-290

Boosting Immune Function with Reishi Mushroom Extract: Insights from Cancer Patients

Source: Journal of Clinical and Translational Oncology (2021)

Lifestyle Medicine Update (May 31, 2023)

Introduction: Enhancing Immune Function in Cancer Patients

A study published in Clinical and Translational Oncology in 2021 sheds light on the immune-boosting effects of Reishi Mushroom Extract in breast and lung cancer patients post-surgery. Strengthening the immune system is crucial for cancer patients’ overall survival and well-being.

Study Findings: Reishi Mushroom Extract and Immune Response

Patients receiving Reishi Mushroom Extract demonstrated heightened immune function compared to those without supplementation. They exhibited increased levels of T-lymphocytes, crucial for combating cancer and infections, along with reduced levels of immune-suppressing prostaglandins and cytokines. Additionally, Reishi Mushroom Extract improved key ratios indicative of cancer progression and survival.

Clinical Implications: Reishi Mushroom Extract for Immune Support

The study underscores the potential of Reishi Mushroom Extract to enhance immune function, benefiting not only cancer survivors but also individuals over 50. Aging compromises thymus gland function, leading to diminished T-lymphocyte activity and increased susceptibility to infections and cancer. Supplementation with Reishi Mushroom Extract and other immune-modulating agents post-50 can fortify immune defenses and support overall health.

Recommendations: Consider Immune Support After 50

Given the decline in immune function with age, incorporating immune-supportive supplements like Reishi Mushroom Extract, astragalus, indole-3-carbinol, and Milk Thistle may be beneficial. These supplements have shown promise in bolstering immune function and detoxification enzyme activity, promoting longevity and vitality.

Conclusion: Harnessing Nature’s Immune-Boosting Power

Studies like this highlight the potential of natural supplements like Reishi Mushroom Extract in strengthening immune function and mitigating cancer risk. By prioritizing immune support, especially after 50, individuals can optimize their defense mechanisms and maintain overall well-being.

References:

  1. Deng Y. et al. Dynamic biomarkers indicate the immunological benefits provided by Ganoderma spore powder in post-operative breast and lung cancer patients. Clinical and Translational Oncology. 2021; 23: 1481-1490 [Link](https://link.springer.com/article/10.1007/s12094-020-02547-9)
  2. AG Ratio [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706002/)
  3. NL Ratio [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998851/#:~:text=The%20neutrophil%2Dto%2Dlymphocyte%20ratio%20(NLR)%2C%20calculated,supported%20by%20lymphocytes%20%5B1%5D.)
 
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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 289 – NAC Administration Improves Parkinson’s Disease: The importance of preventing the age-related decline in brain glutathione

LMU-289

NAC: A Promising Supplement for Parkinson's Disease

Source: J Clinical Pharmacology & Therapeutics (2019)

Lifestyle Medicine Update (November 15, 2022)

Introduction: Unveiling the Role of Glutathione in Brain Health

The decline in brain glutathione levels with age has been linked to various neurodegenerative diseases, including Alzheimer’s and Parkinson’s. Glutathione serves a crucial role in protecting brain cells from free radical damage and supporting overall brain function.

Study Findings: NAC for Parkinson’s Disease

A 2019 study published in Clinical Pharmacology & Therapeutics explored the effects of N-acetylcysteine (NAC) supplementation on Parkinson’s disease symptoms. Patients receiving NAC exhibited significant improvement in Parkinson’s symptoms over a three-month period compared to those on standard care alone. Additionally, brain imaging revealed enhanced dopamine transporter activity, crucial for maintaining optimal dopamine levels and symptom relief in Parkinson’s patients.

Understanding the Mechanisms: NAC and Glutathione

NAC not only boosts brain glutathione levels, safeguarding against free radical damage, but also enhances dopamine transporter function. This dual action may contribute to improved symptom management and disease progression in Parkinson’s patients.

Implications for Brain Health: Preventing Age-Related Decline

Age-related decline in glutathione levels poses a significant risk for neurodegenerative diseases. Given the vulnerability of brain cells to oxidative stress, maintaining optimal glutathione levels becomes crucial for preserving cognitive function and mitigating disease risk.

Recommendations: Glutathione-Boosting Supplements

Taking a daily supplement containing NAC, along with alpha-lipoic acid, L-glutamine, and Milk Thistle standardized to 80% Silymarin Flavonoid Content, could help maintain glutathione levels after the age of 40. These supplements have demonstrated efficacy in raising blood and tissue glutathione levels, offering a proactive approach to brain health and aging.

Conclusion: A Step Towards Cognitive Wellness

Incorporating NAC supplementation alongside other glutathione-boosting nutrients presents a promising strategy for preserving brain health and combating neurodegenerative diseases. By addressing age-related glutathione decline, individuals can enhance their chances of healthy aging and sustained cognitive function.

References:

  1. Monti D et al. N-acetyl cysteine is associated with dopaminergic improvement in Parkinson’s disease. Clin Pharmacol Ther. 2019;106(4): 884-890 [Link](https://pubmed.ncbi.nlm.nih.gov/31206613/)
  2. Aoyama K. Glutathione in the brain. Int J Mol Sci. 2021, 22(9): 5010 [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125908/)
  3. Iskusnykh I.Y. et al. Glutathione in brain disorders and aging. J Molecules. 2022, 27(1): 324 [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746815/#:~:text=Impairment%20of%20glutathione%20function%20in,%2C%20stroke%2C%20and%20Alzheimer’s%20disease.)
  4. Ikeda K et al. Dopamine transporter imaging in Parkinson Disease: Progressive changes and therapeutic modification after anti-parkinsonian medication. [Link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630131/#:~:text=Clinical%20Role%20of%20Dopamine%20Transporter%20Imaging&text=DAT%20is%20the%20most%20important,release%20from%20the%20presynaptic%20terminal.)
  5. Dopamine Transporter (DAT) [Link](https://en.wikipedia.org/wiki/Dopamine_transporter)
 
Eat Smart, Live Well, Look Great,

Dr. Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU – 288 Supplement Formula Shown to Improve Early Alzheimer’s Disease

LMU-288

Supporting Cognitive Health: Insights from a Nutritional Approach for Early-Stage Alzheimer's Patients

Source: American Journal of Alzheimer’s Disease (2009)

Lifestyle Medicine Update (May 17, 2023)

Introduction: Understanding the Study

A recent study published in the American Journal of Alzheimer’s Disease sheds light on the potential benefits of a specific natural supplement regimen for individuals in the early stages of Alzheimer’s disease. This one-year study, followed by a caregiver extension of an additional four months, showcased notable improvements in various cognitive parameters among participants.

Study Findings: Promising Results

Participants who received the natural supplement demonstrated enhancements in cognitive assessments, including the Dementia Rating Scale and Clock-drawing Tests. Additionally, caregivers reported improvements in neuropsychiatric parameters and observed maintenance of performance in daily activities among the participants. Even after the 16-month period, those who continued the supplement regimen exhibited sustained improvement, as noted by their caregivers.

Understanding the Supplement Composition

The natural supplement consisted of essential B-vitamins such as Folic Acid and Vitamin B6, along with Vitamin E, SAMe, N-acetylcysteine, and Acetyl-L-Carnitine. Each component plays a crucial role in supporting brain health and function.

Scientific Rationale: Targeting Key Mechanisms

The researchers highlighted the significance of the supplement’s ingredients. Folic acid, SAMe, and Vitamin B6 are essential for neurotransmitter production and homocysteine regulation, addressing established risk factors for Alzheimer’s disease. Vitamin E serves as a potent antioxidant, protecting brain cells from oxidative stress. Moreover, N-acetylcysteine boosts glutathione levels, critical for combating free radical damage, while Acetyl-L-Carnitine supports mitochondrial function and neurotransmitter synthesis.

Implications for Alzheimer’s Management

The study underscores the importance of integrating nutritional interventions alongside conventional Alzheimer’s treatment. While pharmaceutical approaches often overlook critical aspects of the disease, targeted natural supplements offer a multifaceted approach to preserve cognitive function and slow disease progression. Considering the limited efficacy of Alzheimer’s drugs alone, supplementing with nutrients tailored to address key disease mechanisms is a promising avenue for mild cognitive impairment and early-stage Alzheimer’s patients.

Recommendations for Cognitive Health

In addition to the supplement investigated in the study, individuals over 50 may benefit from incorporating other cognitive support nutrients like CDP-choline, Phosphatidylserine, Huperzine A, and Bacopa monnieri into their daily regimen. These nutrients have shown promise in reversing mild cognitive impairment and may serve as preventive measures against age-related memory decline.

Conclusion: A Holistic Approach to Cognitive Wellness

As research continues to uncover the intricate mechanisms underlying cognitive decline, embracing a holistic approach that combines targeted nutritional supplementation with conventional treatments holds immense promise in supporting cognitive health and enhancing quality of life for individuals affected by Alzheimer’s disease.

Reference:

Chan A et al. Efficacy of a vitamin/nutraceutical formulation for early-stage Alzheimer’s disease: A 1-year, open-label pilot study with a 16-month caregiver extension. Am J Alzheimer’s Disease. 2009; 23(6): 571-585.
[Link](https://journals.sagepub.com/doi/epdf/10.1177/1533317508325093)

 

Eat Smart, Live Well, Look Great,

Dr. Meschino


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Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 287 – Glutathione Helps Guard Against Age-Related Decline in Kidney Function

LMU-287

Nurturing Kidney Health: Vital Strategies for Aging Well

Source: American Journal of Tanslational Research (2021)

Lifestyle Medicine Update (May 11, 2023)

Understanding Age-Related Kidney Decline

As we age, our kidneys naturally experience a decline in function, becoming one of the fastest aging organs. This decline typically commences around age 30-40 and accelerates into our 50s and 60s. Alarmingly, over 50% of individuals aged over 75 undergo a significant decline in kidney function, often unnoticed. This deterioration, known as mild insufficiency or chronic kidney disease, significantly heightens the risk of heart attacks.

The Significance of Kidney Health

Kidney disease claims more lives annually than breast and prostate cancer combined. Advanced kidney disease may necessitate dialysis or even a kidney transplant, emphasizing the critical importance of preserving kidney function for prolonged well-being.

Identifying Kidney Risk Factors

Numerous factors contribute to kidney disease, including high blood pressure, diabetes, kidney stones, family history, prolonged use of pain medications, and age over 60. Certain autoimmune conditions also elevate the risk of kidney damage and declining function.

Combatting Kidney Decline with Antioxidants

Research suggests that free radical damage to kidney cells significantly contributes to age-related kidney function decline and is associated with conditions such as diabetes and autoimmune disorders. Studies indicate that higher free radical levels correlate with accelerated kidney function decline as we age.

Harnessing Supplements for Kidney Protection

Thankfully, targeted dietary supplements can aid in preventing or reversing kidney function decline. Research has shown that supplements like N-acetylcysteine (NAC) can boost glutathione synthesis in kidney cells, improving kidney function and reducing inflammation. Additionally, supplements such as alpha-lipoic acid, silymarin (from Milk thistle), L-glutamine, Coenzyme Q10, and choline (found in lecithin capsules) elevate kidney glutathione levels, providing additional protection against kidney damage.

Recommended Supplement Regimen

Consider supplementing with a combination containing:

Incorporating CoQ10 and lecithin capsules into your regimen can further bolster kidney health.

Taking Proactive Steps for Kidney Health

Individuals over 40-50 should consider supplementing to support kidney function. Consult with your healthcare provider, especially if you have existing kidney disease. Regular kidney function screening through blood tests is essential. Share the provided references with your healthcare professional to facilitate informed discussions about incorporating these supplements into your health regimen.

Thanks for watching and I’ll see you next time.

References:

National Kidney Foundation: Decline in Kidney Function with Aging and Incidence of Kidney Disease
https://www.kidney.org/news/monthly/wkd_aging#:~:text=Kidney%20disease%20can%20develop%20at,believed%20to%20have%20kidney%20disease.

Aging and Kidney Function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744545/

Decreased Glutathione in Aging:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457589/

NAC Supplementation and Kidney Function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129408/

Silymarin in Diabetic Nephropathy
https://pubmed.ncbi.nlm.nih.gov/25340091/

Alpha Lipoic Acid in Renal Damage – Ferroptosis
https://www.frontiersin.org/articles/10.3389/fphys.2021.680544/full

Alpha Lipoic Acid in Diabetic Nephropathy
https://pubmed.ncbi.nlm.nih.gov/23531536/

L-Glutamine Raises Glutathione Levels
https://biomedres.us/pdfs/BJSTR.MS.ID.002293.pdf

CoQ10 Supplementation in Kidney Disease
https://pubmed.ncbi.nlm.nih.gov/35643375/#:~:text=Oral%20Coenzyme%20Q10%20supplementation%20leads,to%20primary%20Coenzyme%20Q10%20deficiency

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587473/

Betaine in Kidney and Liver Function:
https://karger.com/cpb/article/32/Suppl.%201/32/71803/Betaine-Transport-in-Kidney-and-Liver-Use-of

Betaine in Kidney Function (osmoprotectant)
https://karger.com/cpb/article/32/Suppl.%201/32/71803/Betaine-Transport-in-Kidney-and-Liver-Use-of


Eat Smart, Live Well, Look Great,

Dr. Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 286 – Probiotic Supplement Decrease Inflammation and Free Radical Damage Normally Caused by Chronic Sleep Deprivation

LMU-286

Safeguarding Brain Health: The Role of Probiotics Against Sleep Deprivation

Source: Journal Nutrients (2023)

Lifestyle Medicine Update (May 2, 2023)

Understanding the Study

A 2023 study published in Nutrients by researchers at the University of Camerino in Italy illuminates the potential benefits of a multi-strain probiotic supplement in counteracting the detrimental effects of sleep deprivation on brain health. Chronic sleep deprivation can exacerbate brain free radical damage and inflammation, but probiotic supplementation may offer a solution.

Unraveling the Link Between Sleep Deprivation and Inflammation

Chronic sleep restriction, defined as sleeping less than seven hours per night, can incite low-grade inflammation in the body and brain. Insufficient sleep also fosters the accumulation of free radicals, which pose extensive damage to brain cells and are linked to neurodegenerative diseases like Alzheimer’s and Parkinson’s.

The Role of Probiotic Supplements

Probiotic supplementation exhibits promise in reducing inflammation through various pathways, including rebalancing gut flora, enhancing gut barrier integrity, and modulating immune function. Additionally, probiotics bolster the function of brain immune cells, microglia, thereby curtailing brain inflammation.

Unveiling the Mechanism of Sleep Deprivation-Induced Inflammation

Sleep deprivation can disrupt gut bacteria composition and compromise gut barrier integrity, facilitating the entry of bacteria and their byproducts into the bloodstream. This process triggers inflammatory responses in the body and brain.

Study Findings

In the 2023 study, mice subjected to chronic sleep restriction were administered a multi-strain probiotic supplement. Results indicated that the probiotic supplement bolstered brain antioxidant function, curbing free radical damage and inflammation in both the brain and bloodstream.

Practical Takeaways

  1. Prioritize Adequate Sleep: Chronic sleep deprivation has deleterious effects on gut and brain health, escalating inflammation and free radical damage, which can lead to various health issues including neurodegenerative diseases and compromised immunity.
  2. Consider Probiotic Supplementation: Incorporating a multi-strain probiotic supplement into daily routines may support gut health, diminish inflammation, and fortify brain antioxidant protection. Combining probiotics with a digestive enzyme-prebiotic supplement may offer additional benefits by nurturing friendly gut bacteria.

Conclusion

Recognizing the impact of sleep deprivation on gut and brain health underscores the importance of proactive measures to bolster overall well-being. Embracing probiotic supplementation as a simple yet effective strategy may help mitigate the detrimental effects of sleep deprivation on brain health.

References:

  1. Zheng Y et al. “Probiotics supplementation attenuates inflammation and oxidative stress induced by chronic sleep restriction.” Nutrients. 2023; 15(6):1518. [Link](https://www.mdpi.com/2072-6643/15/6/1518)
  2. “Probiotic supplementation reduces inflammation and oxidative stress caused by chronic sleep loss.” Neuroscience News.com. April 15, 2023. [Link](https://neurosciencenews.com/probiotics-inflammation-sleep-23021/)
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 285 – Strength Training Seniors Gain Muscle, Multiple Health Benefits and Enhanced Independ Living Ability

LMU-285

Reversing Age-Related Muscle Loss: The Power of Strength Training

Source: J Cell Physiology (2022)

Lifestyle Medicine Update (April 25, 2023)

Understanding Age-Related Muscle Loss

As individuals age, declining hormone levels contribute to the loss of muscle mass and strength, leading to weakness and frailty. This decline increases the risk of falls, fractures, and loss of independent living. Research indicates that muscle mass begins to decrease around age 35, accelerating after reaching 60 years of age, with a potential annual loss of up to 3%.

Strength Training: A Solution for Aging Muscles

Strength training, often associated with younger individuals, offers significant benefits even for people over 60 or 65. A remarkable study published in the journal Cell Physiology in 2022 demonstrated substantial improvements in muscle mass, strength, and connective tissues among older participants (average age 72) after just an 8-week strength training program. Notably, individuals aged 86-90 experienced remarkable strength gains of 174% and increased thigh quadricep muscle mass by 9%.

Overcoming Resistance: Addressing Barriers to Strength Training

Despite its benefits, only 9% of individuals over 75 engage in regular strength training. However, a 2019 study suggests that as little as one hour of strength training per week can enhance walking speed, leg strength, and the ability to stand up from a chair. The recommended approach involves performing one to three sets of eight to 15 repetitions per exercise, focusing on multi-joint movements like squats, overhead press, chest press, rowing, and lat pulldowns.

Practical Tips for Success

For those new to strength training, seeking guidance from a personal trainer or fitness professional to develop a simple 30-minute program is advisable. Consistency is key, with at least two sessions per week recommended to see noticeable improvements in muscle strength and functionality.

Enhancing Results with Whey Protein 

Supplementing with whey protein, coupled with strength training, can expedite and enhance results. Whey protein contains essential amino acids crucial for building muscle and connective tissue, aiding in muscle recovery and repair, particularly in seniors.

Embracing Strength Training for All Ages

Strength training, along with whey protein supplementation, is essential for maintaining a healthy lifestyle at any age. Encouraging both young and older individuals to embrace strength training can significantly contribute to preserving independence, functionality, and overall well-being.

References:

  1. Soendenbroe C et al. “Human skeletal muscle acetylcholine receptor gene expression in elderly males performing heavy resistance training.” Cell Physiology. 2022; 323,1. [Link](https://journals.physiology.org/doi/full/10.1152/ajpcell.00365.2021)
  2. “How Old is too Old to Start Strength Training?” Medscape. April 24, 2023. [Link](https://www.medscape.com/viewarticle/990794?ecd=wnl_tp10_daily_230421_MSCPEDIT_etid5360138&uac=342474MN&impID=5360138)
  3. Oikawa SY, et al. “A randomized controlled trial of the impact of protein supplementation on leg lean mass and integrated muscle protein synthesis during inactivity and energy restriction in older persons.” The American Journal of Clinical Nutrition, 2018. [Link](https://www.sciencedirect.com/science/article/pii/S0002916522030246?via%3Dihub)
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 284 – Glutathione Status Emerging as a Key Marker for Postpartum Suicide Risk

LMU-284

Unveiling the Role of Glutathione in Postpartum Suicide Risk

Source: Frontiers in Psychiatry Journal (Feb. 2023)

Lifestyle Medicine Update (April 18, 2023)

Insights from Research: Glutathione and Suicide Risk

A study published in February 2023 in the journal Frontiers in Psychiatry highlights a significant connection between glutathione (GSH) levels and the risk of suicide in women at 18 months postpartum. Lower serum glutathione levels were notably associated with higher suicide risk among postpartum women.

Understanding Glutathione

Glutathione serves as a crucial antioxidant in the brain, protecting brain cells from damage caused by free radicals. Free radical damage is implicated in various mental health disorders, making glutathione levels pivotal for brain health. Boosting brain glutathione levels, often achieved through supplementation with N-acetylcysteine (NAC), has shown positive effects on conditions like major depressive disorder, bipolar disorder, and schizophrenia.

Practical Steps: Supplementing with N-Acetylcysteine (NAC)

Raising glutathione levels is achievable through supplementation with N-acetylcysteine (NAC), which has demonstrated positive effects on various psychiatric conditions. Additionally, a combination supplement containing NAC, Alpha-Lipoic Acid, L-Glutamine, and Silymarin (from Milk thistle) can synergistically support glutathione status in both the body and the brain.

Age-Related Considerations: Preserving Youthful Glutathione Levels

Given that glutathione levels decline with age, especially after 50, supplementation to maintain optimal levels becomes increasingly important. Preserving youthful glutathione levels is not only beneficial for mental health but also contributes to overall well-being and longevity.

Implications for Postpartum Health

The study underscores the emerging role of glutathione as a potential biomarker for identifying postpartum women at risk of suicide. Therefore, evaluating glutathione status, particularly in women experiencing postpartum depression, could be crucial for early intervention and support.

Conclusion: Prioritizing Glutathione for Mental Wellness

Understanding the significance of glutathione in mental health underscores the importance of proactive measures to support its levels. Whether through targeted supplementation or routine evaluation, prioritizing glutathione status offers a promising avenue for safeguarding mental wellness, especially in vulnerable populations like postpartum women.

References:

  1. Da Silva Schmidt P.M. et al. “Can glutathione be a biomarker for suicide risk in women 18 months postpartum?” Frontiers in Psychiatry. February 9, 2023. [Link](https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1142608/full)
  2. Medscape: “Glutathione as potential biomarker for postpartum suicide.” [Link](https://www.medscape.com/viewarticle/990552?ecd=mkm_ret_230415_mscpmrk-OUS_IntStories&uac=342474MN&impID=5332796&faf=1)

Eat Smart, Live Well, Look Great,

Dr. Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 283 – Periodontal Disease Increases Risk of Heart Failure

LMU-283

Understanding the Connection Between Gum Disease and Heart Failure

Source: Journal of the American College of Cardiology (2022)

Lifestyle Medicine Update (April 11, 2023)

Introduction: Recognizing the Link

Gum disease, often underestimated, is now acknowledged as a significant contributor to heart failure risk. A pivotal 2022 study published in the Journal of the American College of Cardiology sheds light on this association, revealing a compelling correlation between periodontal disease and the likelihood of heart failure development.

Insights from the ARIC Study

Researchers conducted an extensive investigation involving nearly 7,000 participants aged approximately sixty-three, spanning from 1996 to 2018, as part of the Atherosclerosis Risk in Communities (ARIC) study. This study aimed to elucidate the relationship between periodontal disease and heart failure risk.

Periodontal Disease and Heart Health

While prior research has established links between gum disease and conditions like coronary artery disease, stroke, and diabetes, the 2022 study underscores the heightened risk of heart failure associated with periodontal disease. With heart failure already on the rise due to factors like aging, diabetes, obesity, and metabolic syndrome, identifying additional risk factors becomes crucial.

Oral Dysbiosis: A Contributing Factor

Periodontal disease, characterized by tissue destruction and oral microbial dysbiosis, emerges as a pivotal factor in heart failure risk. Dysbiosis, an imbalance of harmful and beneficial bacteria in the mouth, triggers inflammation and potentially harmful bacterial endotoxins, which can adversely affect heart and vascular health.

Bridging the Gap with Inflammatory Markers

Elevated inflammatory markers in the bloodstream, a hallmark of heart failure, are associated with oral dysbiosis and periodontal disease. Successful periodontal treatment and reversal of oral dysbiosis have been shown to reduce inflammation markers in the blood, such as C-reactive protein (CRP).

Prioritizing Oral Health for Heart Health

Maintaining good oral hygiene through regular dental check-ups, professional cleanings, and daily home care is critical for cardiovascular health maintenance. These measures not only prevent gum disease but also contribute to overall heart health, as evidenced by the findings of the 2022 ARIC study.

Supplementation for Heart Health

Supplementation with Coenzyme Q10 (CoQ10) and Hawthorn after middle age may offer additional support for heart health by optimizing heart function and potentially preventing and managing heart failure.

Conclusion: Adopting a Holistic Approach

Recognizing the intricate link between gum disease and heart failure underscores the importance of holistic health management. Prioritizing oral hygiene alongside dietary and lifestyle interventions significantly contributes to maintaining cardiovascular wellness and reducing the risk of heart failure.

Reference:

Mokinsky R.L. et al. “Periodontal status, C-reactive protein, NT-proBNP, and incident heart failure.” JACC Heart Fail. 2022;10(10):731-741. [Link](https://www.medscape.com/viewarticle/989492?ecd=wnl_recnlnew3_ous_230327_MSCPEDIT_&uac=342474MN&impID=5282701)

 

Eat Smart, Live Well, Look Great,


Dr. Meschino

Recommended Supplements

Cardio Essentials

Cardio Essentials

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 282 – Natural Supplement (Phosphatidylserine) Shown to Revere Memory Loss and Slow Key Aspects of Brain Aging

LMU-282

Nurturing Your Memory: The Power of Phosphatidylserine and Memory Support

Source: Frontiers in Aging Neuroscience (2022)

Lifestyle Medicine Update (April 5, 2023)

Understanding the Link: Phosphatidylserine and Memory Loss

As we age, our memory can sometimes falter, partly due to declining levels of phosphatidylserine—a crucial phospholipid found in brain cells’ outer membrane. Normally constituting 5-10% of brain phospholipids, maintaining adequate levels of phosphatidylserine throughout life is vital for youthful brain function.

Insights from Research: Phosphatidylserine Supplementation

A comprehensive review published in the journal Frontiers in Aging Neuroscience delved into the potential of phosphatidylserine supplementation in supporting brain health and tackling memory-related issues. The review highlights phosphatidylserine’s role in binding to various brain proteins, positively impacting brain function. Furthermore, it notes the association between abnormal phosphatidylserine regulation and neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, major depressive disorder, stroke, and autism spectrum disorder.

Evidence of Efficacy: Phosphatidylserine in Action

Numerous studies cited in the review demonstrate phosphatidylserine supplementation’s benefits for conditions like Alzheimer’s disease, major depressive disorder, Parkinson’s disease, and ADHD. Notably, phosphatidylserine supplementation has shown to reduce neuroinflammation, a common feature in neurodegenerative disorders. Moreover, clinical trials have indicated improvements in cognitive function and memory loss in older individuals, Alzheimer’s patients, and those with Parkinson’s disease.

Practical Applications: Memory Support Supplements

Considering the evidence, it’s suggested that individuals aged 50-55 or older consider incorporating memory support supplements containing phosphatidylserine, CDP-choline, Huperzine A, and Bacopa monnieri. These natural ingredients synergize to maintain youthful acetylcholine levels, inhibit age-related brain changes, and potentially alleviate memory loss associated with conditions like Mild Cognitive Impairment, early-stage Alzheimer’s, and Parkinson’s disease.

Looking Ahead: Proactive Memory Care

Rather than waiting for memory issues to arise, adopting a proactive approach by supplementing with memory support formulations after age 50 or 55 can be beneficial. These supplements not only guard against memory loss but also support overall brain function as one ages.

References:

  1. Ma X et al. “Phosphatidylserine, inflammation, and central nervous system disease.” Frontiers in Aging Neuroscience. 2022: 14 (August 3, 2022). [Link](https://www.frontiersin.org/articles/10.3389/fnagi.2022.975176/full)
  2. Kim BK and Park SK. “Phosphatidylserine modulates response to oxidative stress through hormesis and increases lifespan via DAF-16 in Caenorhabditis elegans.” Biogerontology. 2020; 21 (2): 231-244. [Link](https://pubmed.ncbi.nlm.nih.gov/31915963/#:~:text=Phosphatidylserine%20is%20one%20of%20the,Alzheimer’s%20disease%20in%20the%20elderly)
 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Recommended Supplements

Memory Support Complex

Memory Support Complex

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements