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LMU 286 – Probiotic Supplement Decrease Inflammation and Free Radical Damage Normally Caused by Chronic Sleep Deprivation

LMU-286

Safeguarding Brain Health: The Role of Probiotics Against Sleep Deprivation

Source: Journal Nutrients (2023)

Lifestyle Medicine Update (May 2, 2023)

Understanding the Study

A 2023 study published in Nutrients by researchers at the University of Camerino in Italy illuminates the potential benefits of a multi-strain probiotic supplement in counteracting the detrimental effects of sleep deprivation on brain health. Chronic sleep deprivation can exacerbate brain free radical damage and inflammation, but probiotic supplementation may offer a solution.

Unraveling the Link Between Sleep Deprivation and Inflammation

Chronic sleep restriction, defined as sleeping less than seven hours per night, can incite low-grade inflammation in the body and brain. Insufficient sleep also fosters the accumulation of free radicals, which pose extensive damage to brain cells and are linked to neurodegenerative diseases like Alzheimer’s and Parkinson’s.

The Role of Probiotic Supplements

Probiotic supplementation exhibits promise in reducing inflammation through various pathways, including rebalancing gut flora, enhancing gut barrier integrity, and modulating immune function. Additionally, probiotics bolster the function of brain immune cells, microglia, thereby curtailing brain inflammation.

Unveiling the Mechanism of Sleep Deprivation-Induced Inflammation

Sleep deprivation can disrupt gut bacteria composition and compromise gut barrier integrity, facilitating the entry of bacteria and their byproducts into the bloodstream. This process triggers inflammatory responses in the body and brain.

Study Findings

In the 2023 study, mice subjected to chronic sleep restriction were administered a multi-strain probiotic supplement. Results indicated that the probiotic supplement bolstered brain antioxidant function, curbing free radical damage and inflammation in both the brain and bloodstream.

Practical Takeaways

  1. Prioritize Adequate Sleep: Chronic sleep deprivation has deleterious effects on gut and brain health, escalating inflammation and free radical damage, which can lead to various health issues including neurodegenerative diseases and compromised immunity.
  2. Consider Probiotic Supplementation: Incorporating a multi-strain probiotic supplement into daily routines may support gut health, diminish inflammation, and fortify brain antioxidant protection. Combining probiotics with a digestive enzyme-prebiotic supplement may offer additional benefits by nurturing friendly gut bacteria.

Conclusion

Recognizing the impact of sleep deprivation on gut and brain health underscores the importance of proactive measures to bolster overall well-being. Embracing probiotic supplementation as a simple yet effective strategy may help mitigate the detrimental effects of sleep deprivation on brain health.

References:

  1. Zheng Y et al. “Probiotics supplementation attenuates inflammation and oxidative stress induced by chronic sleep restriction.” Nutrients. 2023; 15(6):1518. [Link](https://www.mdpi.com/2072-6643/15/6/1518)
  2. “Probiotic supplementation reduces inflammation and oxidative stress caused by chronic sleep loss.” Neuroscience News.com. April 15, 2023. [Link](https://neurosciencenews.com/probiotics-inflammation-sleep-23021/)
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 285 – Strength Training Seniors Gain Muscle, Multiple Health Benefits and Enhanced Independ Living Ability

LMU-285

Reversing Age-Related Muscle Loss: The Power of Strength Training

Source: J Cell Physiology (2022)

Lifestyle Medicine Update (April 25, 2023)

Understanding Age-Related Muscle Loss

As individuals age, declining hormone levels contribute to the loss of muscle mass and strength, leading to weakness and frailty. This decline increases the risk of falls, fractures, and loss of independent living. Research indicates that muscle mass begins to decrease around age 35, accelerating after reaching 60 years of age, with a potential annual loss of up to 3%.

Strength Training: A Solution for Aging Muscles

Strength training, often associated with younger individuals, offers significant benefits even for people over 60 or 65. A remarkable study published in the journal Cell Physiology in 2022 demonstrated substantial improvements in muscle mass, strength, and connective tissues among older participants (average age 72) after just an 8-week strength training program. Notably, individuals aged 86-90 experienced remarkable strength gains of 174% and increased thigh quadricep muscle mass by 9%.

Overcoming Resistance: Addressing Barriers to Strength Training

Despite its benefits, only 9% of individuals over 75 engage in regular strength training. However, a 2019 study suggests that as little as one hour of strength training per week can enhance walking speed, leg strength, and the ability to stand up from a chair. The recommended approach involves performing one to three sets of eight to 15 repetitions per exercise, focusing on multi-joint movements like squats, overhead press, chest press, rowing, and lat pulldowns.

Practical Tips for Success

For those new to strength training, seeking guidance from a personal trainer or fitness professional to develop a simple 30-minute program is advisable. Consistency is key, with at least two sessions per week recommended to see noticeable improvements in muscle strength and functionality.

Enhancing Results with Whey Protein 

Supplementing with whey protein, coupled with strength training, can expedite and enhance results. Whey protein contains essential amino acids crucial for building muscle and connective tissue, aiding in muscle recovery and repair, particularly in seniors.

Embracing Strength Training for All Ages

Strength training, along with whey protein supplementation, is essential for maintaining a healthy lifestyle at any age. Encouraging both young and older individuals to embrace strength training can significantly contribute to preserving independence, functionality, and overall well-being.

References:

  1. Soendenbroe C et al. “Human skeletal muscle acetylcholine receptor gene expression in elderly males performing heavy resistance training.” Cell Physiology. 2022; 323,1. [Link](https://journals.physiology.org/doi/full/10.1152/ajpcell.00365.2021)
  2. “How Old is too Old to Start Strength Training?” Medscape. April 24, 2023. [Link](https://www.medscape.com/viewarticle/990794?ecd=wnl_tp10_daily_230421_MSCPEDIT_etid5360138&uac=342474MN&impID=5360138)
  3. Oikawa SY, et al. “A randomized controlled trial of the impact of protein supplementation on leg lean mass and integrated muscle protein synthesis during inactivity and energy restriction in older persons.” The American Journal of Clinical Nutrition, 2018. [Link](https://www.sciencedirect.com/science/article/pii/S0002916522030246?via%3Dihub)
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

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Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 284 – Glutathione Status Emerging as a Key Marker for Postpartum Suicide Risk

LMU-284

Unveiling the Role of Glutathione in Postpartum Suicide Risk

Source: Frontiers in Psychiatry Journal (Feb. 2023)

Lifestyle Medicine Update (April 18, 2023)

Insights from Research: Glutathione and Suicide Risk

A study published in February 2023 in the journal Frontiers in Psychiatry highlights a significant connection between glutathione (GSH) levels and the risk of suicide in women at 18 months postpartum. Lower serum glutathione levels were notably associated with higher suicide risk among postpartum women.

Understanding Glutathione

Glutathione serves as a crucial antioxidant in the brain, protecting brain cells from damage caused by free radicals. Free radical damage is implicated in various mental health disorders, making glutathione levels pivotal for brain health. Boosting brain glutathione levels, often achieved through supplementation with N-acetylcysteine (NAC), has shown positive effects on conditions like major depressive disorder, bipolar disorder, and schizophrenia.

Practical Steps: Supplementing with N-Acetylcysteine (NAC)

Raising glutathione levels is achievable through supplementation with N-acetylcysteine (NAC), which has demonstrated positive effects on various psychiatric conditions. Additionally, a combination supplement containing NAC, Alpha-Lipoic Acid, L-Glutamine, and Silymarin (from Milk thistle) can synergistically support glutathione status in both the body and the brain.

Age-Related Considerations: Preserving Youthful Glutathione Levels

Given that glutathione levels decline with age, especially after 50, supplementation to maintain optimal levels becomes increasingly important. Preserving youthful glutathione levels is not only beneficial for mental health but also contributes to overall well-being and longevity.

Implications for Postpartum Health

The study underscores the emerging role of glutathione as a potential biomarker for identifying postpartum women at risk of suicide. Therefore, evaluating glutathione status, particularly in women experiencing postpartum depression, could be crucial for early intervention and support.

Conclusion: Prioritizing Glutathione for Mental Wellness

Understanding the significance of glutathione in mental health underscores the importance of proactive measures to support its levels. Whether through targeted supplementation or routine evaluation, prioritizing glutathione status offers a promising avenue for safeguarding mental wellness, especially in vulnerable populations like postpartum women.

References:

  1. Da Silva Schmidt P.M. et al. “Can glutathione be a biomarker for suicide risk in women 18 months postpartum?” Frontiers in Psychiatry. February 9, 2023. [Link](https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1142608/full)
  2. Medscape: “Glutathione as potential biomarker for postpartum suicide.” [Link](https://www.medscape.com/viewarticle/990552?ecd=mkm_ret_230415_mscpmrk-OUS_IntStories&uac=342474MN&impID=5332796&faf=1)

Eat Smart, Live Well, Look Great,

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 283 – Periodontal Disease Increases Risk of Heart Failure

LMU-283

Understanding the Connection Between Gum Disease and Heart Failure

Source: Journal of the American College of Cardiology (2022)

Lifestyle Medicine Update (April 11, 2023)

Introduction: Recognizing the Link

Gum disease, often underestimated, is now acknowledged as a significant contributor to heart failure risk. A pivotal 2022 study published in the Journal of the American College of Cardiology sheds light on this association, revealing a compelling correlation between periodontal disease and the likelihood of heart failure development.

Insights from the ARIC Study

Researchers conducted an extensive investigation involving nearly 7,000 participants aged approximately sixty-three, spanning from 1996 to 2018, as part of the Atherosclerosis Risk in Communities (ARIC) study. This study aimed to elucidate the relationship between periodontal disease and heart failure risk.

Periodontal Disease and Heart Health

While prior research has established links between gum disease and conditions like coronary artery disease, stroke, and diabetes, the 2022 study underscores the heightened risk of heart failure associated with periodontal disease. With heart failure already on the rise due to factors like aging, diabetes, obesity, and metabolic syndrome, identifying additional risk factors becomes crucial.

Oral Dysbiosis: A Contributing Factor

Periodontal disease, characterized by tissue destruction and oral microbial dysbiosis, emerges as a pivotal factor in heart failure risk. Dysbiosis, an imbalance of harmful and beneficial bacteria in the mouth, triggers inflammation and potentially harmful bacterial endotoxins, which can adversely affect heart and vascular health.

Bridging the Gap with Inflammatory Markers

Elevated inflammatory markers in the bloodstream, a hallmark of heart failure, are associated with oral dysbiosis and periodontal disease. Successful periodontal treatment and reversal of oral dysbiosis have been shown to reduce inflammation markers in the blood, such as C-reactive protein (CRP).

Prioritizing Oral Health for Heart Health

Maintaining good oral hygiene through regular dental check-ups, professional cleanings, and daily home care is critical for cardiovascular health maintenance. These measures not only prevent gum disease but also contribute to overall heart health, as evidenced by the findings of the 2022 ARIC study.

Supplementation for Heart Health

Supplementation with Coenzyme Q10 (CoQ10) and Hawthorn after middle age may offer additional support for heart health by optimizing heart function and potentially preventing and managing heart failure.

Conclusion: Adopting a Holistic Approach

Recognizing the intricate link between gum disease and heart failure underscores the importance of holistic health management. Prioritizing oral hygiene alongside dietary and lifestyle interventions significantly contributes to maintaining cardiovascular wellness and reducing the risk of heart failure.

Reference:

Mokinsky R.L. et al. “Periodontal status, C-reactive protein, NT-proBNP, and incident heart failure.” JACC Heart Fail. 2022;10(10):731-741. [Link](https://www.medscape.com/viewarticle/989492?ecd=wnl_recnlnew3_ous_230327_MSCPEDIT_&uac=342474MN&impID=5282701)

 

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 282 – Natural Supplement (Phosphatidylserine) Shown to Revere Memory Loss and Slow Key Aspects of Brain Aging

LMU-282

Nurturing Your Memory: The Power of Phosphatidylserine and Memory Support

Source: Frontiers in Aging Neuroscience (2022)

Lifestyle Medicine Update (April 5, 2023)

Understanding the Link: Phosphatidylserine and Memory Loss

As we age, our memory can sometimes falter, partly due to declining levels of phosphatidylserine—a crucial phospholipid found in brain cells’ outer membrane. Normally constituting 5-10% of brain phospholipids, maintaining adequate levels of phosphatidylserine throughout life is vital for youthful brain function.

Insights from Research: Phosphatidylserine Supplementation

A comprehensive review published in the journal Frontiers in Aging Neuroscience delved into the potential of phosphatidylserine supplementation in supporting brain health and tackling memory-related issues. The review highlights phosphatidylserine’s role in binding to various brain proteins, positively impacting brain function. Furthermore, it notes the association between abnormal phosphatidylserine regulation and neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, major depressive disorder, stroke, and autism spectrum disorder.

Evidence of Efficacy: Phosphatidylserine in Action

Numerous studies cited in the review demonstrate phosphatidylserine supplementation’s benefits for conditions like Alzheimer’s disease, major depressive disorder, Parkinson’s disease, and ADHD. Notably, phosphatidylserine supplementation has shown to reduce neuroinflammation, a common feature in neurodegenerative disorders. Moreover, clinical trials have indicated improvements in cognitive function and memory loss in older individuals, Alzheimer’s patients, and those with Parkinson’s disease.

Practical Applications: Memory Support Supplements

Considering the evidence, it’s suggested that individuals aged 50-55 or older consider incorporating memory support supplements containing phosphatidylserine, CDP-choline, Huperzine A, and Bacopa monnieri. These natural ingredients synergize to maintain youthful acetylcholine levels, inhibit age-related brain changes, and potentially alleviate memory loss associated with conditions like Mild Cognitive Impairment, early-stage Alzheimer’s, and Parkinson’s disease.

Looking Ahead: Proactive Memory Care

Rather than waiting for memory issues to arise, adopting a proactive approach by supplementing with memory support formulations after age 50 or 55 can be beneficial. These supplements not only guard against memory loss but also support overall brain function as one ages.

References:

  1. Ma X et al. “Phosphatidylserine, inflammation, and central nervous system disease.” Frontiers in Aging Neuroscience. 2022: 14 (August 3, 2022). [Link](https://www.frontiersin.org/articles/10.3389/fnagi.2022.975176/full)
  2. Kim BK and Park SK. “Phosphatidylserine modulates response to oxidative stress through hormesis and increases lifespan via DAF-16 in Caenorhabditis elegans.” Biogerontology. 2020; 21 (2): 231-244. [Link](https://pubmed.ncbi.nlm.nih.gov/31915963/#:~:text=Phosphatidylserine%20is%20one%20of%20the,Alzheimer’s%20disease%20in%20the%20elderly)
 

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Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 281 – Significant Weight-Loss Effect Shown with HCA Supplementation

LMU-281

Exploring Hydroxycitric Acid (HCA) as a Natural Weight Loss Aid

Source: Journal – Royal Society of Chemistry (2019)

Lifestyle Medicine Update (March 28, 2023)

Introduction: Unveiling the Potential of HCA

Hydroxycitric Acid (HCA), found in the Garcinia Cambogia fruit native to Southeast Asia, has emerged as a promising natural supplement for weight loss.

Understanding the Mechanism: How HCA Works

HCA supplementation inhibits the ATP citrate lyase enzyme, hindering the conversion of carbohydrates into fat. It also acts as an appetite suppressant and influences metabolism to promote the reduction of excess body fat.

No Jitters: The Safe Profile of HCA

Unlike stimulants, HCA does not induce palpitations, high blood pressure, or insomnia.

Evidence from Studies: The Weight Loss Effects of HCA 

A 2019 study published in the Journal of the Royal Society of Chemistry examined the effects of HCA supplementation on 100 obese individuals over three months. Results showed significant reductions in body fat and body mass index, as well as decreased cholesterol and triglyceride levels. Moreover, HCA supplementation facilitated lean mass gain, combating age-related muscle loss.

Synergistic Effects: Enhancing HCA’s Efficacy

Combining HCA with chromium and ECGC from decaffeinated green tea extract enhances its efficacy, promoting the shedding of excess body fat and potentially improving blood sugar, cholesterol, and triglyceride levels.

Exploring Further: The 2019 Review Article

The 2019 article in the Journal of the Royal Society of Chemistry offers a comprehensive review of past research on HCA for those interested in delving deeper into the subject.

Conclusion: A Promising Approach to Weight Management

HCA presents a promising avenue for natural weight loss supplementation, offering a holistic approach to managing weight and promoting overall well-being when combined with chromium and ECGC.

Reference:

Tomar M et al. “A clinical and computational study on anti-obesity effects of hydroxycitric acid.” Journal of the Royal Society of Chemistry, 2019. [Link](https://pubs.rsc.org/en/content/articlehtml/2019/ra/c9ra01345h)

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Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 280 – Navigating Cannabis: Understanding the Impact of THC and CBD on Anxiety and Heart Health

LMU-280

Navigating Cannabis: Understanding the Impact of THC and CBD on Anxiety and Heart Health

Source: Medscape (February 13, 2023)

Lifestyle Medicine Update (March 23, 2023)

Introduction

In a noteworthy study highlighted on Medscape on March 20, 2023, the intricate relationship between marijuana components, THC and CBD, takes center stage. This research delves into their impact on anxiety levels and heart rate, especially among individuals with cardiovascular risk factors. With marijuana product legalization in Canada since 2018, comprehending these findings becomes paramount.

Unpacking Competing Claims: CBD’s Role Re-examined

  • Myths and Realities

    • Amid claims that CBD can counteract THC’s adverse effects, recent research challenges this narrative. Both THC and CBD vie for the same detoxification enzymes in the liver. Rather than mitigating THC effects, CBD slows down THC detoxification, causing a rapid THC surge in the bloodstream. This surge heightens anxiety, stimulating CB1 receptors in the cardiovascular system and significantly elevating heart rate.

The CBD-THC Interaction: A Closer Look

  • Debunking Common Beliefs

    • Contrary to popular belief, CBD doesn’t mellow THC’s impact but accentuates it. Studies demonstrate that the THC-CBD combination intensifies unpleasant symptoms, notably anxiety. This duo also dramatically heightens heart rate and THC blood levels, surpassing the effects of THC alone.

Considerations for Wise Consumption: CBD and THC Use

  • Navigating the Cannabis Landscape

    • While CBD alone carries benefits, combining it with THC demands caution. For those inclined towards THC, opting for edibles containing solely THC (zero grams of CBD) minimizes potential discomfort and curtails negative impacts on heart health.

A Thoughtful Conclusion: Prioritizing Well-Being

  • Informed Choices for Health

    • Understanding the interplay between THC and CBD is pivotal for making informed decisions about marijuana product consumption. CBD doesn’t neutralize THC effects and may, in some instances, exacerbate anxiety, posing cardiac risks. Individuals must remain mindful of these factors, putting their overall well-being at the forefront of their cannabis product choices.

Reference:

Medscape, March 20, 2023. [“Joint Effect: CBD not just an innocent bystander in weed.”] F. Perry Wilson, MD, MSCE.


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Introduction

An important study cited on Medscape on March 20, 2023, sheds light on the effects of marijuana products containing both THC and CBD on individuals prone to anxiety. This study reveals significant findings regarding anxiety levels and heart rate, particularly among those with cardiovascular disease risk factors. It is essential to understand these implications, especially considering the legalization of marijuana products in Canada in 2018.

Competing Claims on CBD’s Effects

Some proponents of marijuana have argued that CBD can counteract the undesirable effects of THC, such as anxiety and an accelerated heart rate. However, recent research has challenged this belief, showing that both THC and CBD compete for the same detoxification enzymes in the liver. Consequently, the presence of CBD slows down the detoxification of THC, leading to a rapid rise of THC in the bloodstream. This sudden increase in THC levels can trigger anxiety and stimulate CB1 receptors in the cardiovascular system, significantly increasing heart rate.

The Reality of CBD and THC Interaction

Contrary to popular claims, CBD does not temper the effects of THC but rather accentuates them. Studies have demonstrated that the combination of THC and CBD leads to more pronounced unpleasant symptoms, particularly anxiety, and significantly elevates heart rate and THC blood levels compared to using cannabis products containing only THC without CBD.

Considerations for CBD and THC Use

While CBD alone can offer benefits, such as pain reduction and medicinal value, combining CBD with THC requires caution. Individuals interested in using cannabis products with THC should opt for edibles containing only THC (with zero grams of CBD) to minimize potential unpleasantness and reduce the negative impact on heart health.

Conclusion

Understanding the interplay between THC and CBD is crucial for making informed decisions about marijuana product consumption. CBD’s presence does not mitigate THC’s effects, and in some cases, it may exacerbate anxiety and pose cardiac risks. Individuals should be mindful of these factors when choosing cannabis products, prioritizing their overall well-being.

Reference:

Medscape March 20, 2023. “Joint Effect: CBD not just an innocent bystander in weed.” F. Perry Wilson, MD, MSCE. Click here

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Key Points to Consider:

  • A study revealed that marijuana products containing both THC and CBD can worsen anxiety and significantly increase heart rate, especially in those with cardiovascular risk factors.
  • CBD does not counteract THC’s effects but rather competes with it for liver detoxification enzymes, leading to a rapid rise of THC in the bloodstream.
  • THC and CBD together can cause more unpleasant symptoms, such as anxiety, and have a greater impact on heart rate compared to using THC alone.
  • CBD taken alone can offer medicinal benefits, but when combined with THC, it requires caution, and individuals may opt for THC-only edibles to minimize risks.
  • Making informed decisions about cannabis product consumption is essential for overall well-being.

Some marijuana proponents have claimed that the CBD component of marijuana helps to tame some of the undesirable effects of THC that can trigger anxiety, a racing heart, and some other unpleasantness. But research is showing that this is just a myth. In fact, both THC and CBD compete for the same detoxification enzymes in the liver. As such, the presence of CBD actually slows down the detoxification of THC, it appears. This results in a more sudden and rapid rise of THC in the bloodstream, which can trigger feelings of anxiety and stimulate CB1 receptors in the cardiovascular system which in turn, significantly increase heart rate. Studies show that THC taken with CBD tends to create more unpleasant symptoms for many people (like anxiety), and it increases the heart rate and THC blood levels to a much greater degree than taking a cannabis product that contains only THC (no CBD).

So, we are learning that CBD does not temper the effects of THC, but rather accentuates the effects of THC, and sometimes in a way that creates unpleasant symptoms and/or cardiac risk. CBD taken alone can help to reduce pain and has some other medicinal value. But taking CBD with THC is something you may want to be wary of. So, if cannabis products with THC are something you are interested in, you may want to find an edible product that contains only THC (zero gm of CBD) to reduce some of the unpleasantness and the negative impact on your heart.

I have included the reference for this information in the text below.

Reference:

Medscape March 20, 2023. Joint Effect: CBD not jus and innocent bystander in weed. F. Perry Wilson, MD, MSCE. https://www.medscape.com/viewarticle/988181#vp_2

 

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Dr. Meschino

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ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 279 – Illuminating Insights: Vitamin D’s Guardian Role Against Dementia

LMU-279

Illuminating Insights: Vitamin D's Guardian Role Against Dementia

Source: Journal Alzheimer’s & dementia: Diagnosis, Assessment & Disease Monitoring. March 1, 2023

Lifestyle Medicine Update (March 15, 2023)

Introduction:

In a groundbreaking study published on March 1, 2023, in Alzheimer’s and Dementia, the power of vitamin D in defending against dementia in older adults was unveiled. Over a decade, 12,388 participants experienced a 40% reduction in dementia cases with daily vitamin D supplementation. Gender differences and genetic factors, notably the APOEe4 gene, played significant roles. The study also explored a holistic defense, including brain-supporting mushrooms and a comprehensive supplement regimen. This nutritional odyssey emphasizes the multifaceted approach to dementia prevention.

A Beacon of Hope: March 2023 Vitamin D Revelation

  • Unveiling the Study

    • In the ever-evolving landscape of health, a beacon of hope emerged with a groundbreaking study published on March 1, 2023, in the esteemed journal Alzheimer’s and Dementia: Diagnosis, Assessment & Disease Monitoring. This study revealed a robust association
    between daily vitamin D supplementation and the remarkable defence against dementia in older adults.

The Radiant Shield: Vitamin D’s Protective Symphony

  • Living Dementia-Free: A Prolonged Prelude

    • The study, spanning a decade and embracing 12,388 participants, aged 71 on average, embarked on an exploration of vitamin D’s protective prowess. The findings resonated with a resounding declaration—those who embraced vitamin D supplements lived dementia-free for an extended period. Astonishingly, a 40% reduction in reported dementia cases gleamed among avid vitamin D supplement users.

  • Gendered Resonance: A Note on Significance

    • The effects echoed with a nuanced melody, revealing a more pronounced impact on women. A harmonious symphony unfolded, underscoring the gender-specific dimensions of vitamin D’s shield against dementia.

  • Genetics in the Spotlight: APOEe4 Gene’s Interplay

    • The stage widened to illuminate the interplay with genetics. A poignant revelation surfaced—the protective effects of vitamin D were notably amplified in individuals devoid of the APOEe4 gene, a notorious harbinger of heightened Alzheimer’s risk.

 A Mosaic of Defence: The Holistic Tapestry

  • Mushrooms and Beyond: A Comprehensive Defence

    •  The narrative unfolded beyond theconfines of vitamin D. A panoramic view encompassed the multifaceted defence against Alzheimer’s, weaving a tapestry that embraced brain-supporting mushrooms—Lion’s Mane, golden mushroom, oyster mushroom, shiitake mushroom, and white button mushroom.

  • Supplemental Symphony: Beyond Vitamin D

    The symphony extended to the realm of supplements—an ensemble that harmonized with longevity. A daily regimen, post-55, included lecithin, a high-potency multiple vitamin and mineral, essential fatty acids, and a memory support supplement featuring CDP-choline, Phosphatidylserine, Huperzine A, and Bacopa monnieri.

Beyond the Horizon: Nutritional Odyssey

  • Culmination of Wisdom: A Comprehensive Strategy

    • As the study on vitamin D unfolded, it beckoned us to appreciate the mosaic of prevention—an amalgamation of lifestyle choices, learning, exercise, and meticulous management of cholesterol, homocysteine, and blood pressure.

References:

  1. Ghahremani M. et al. [Vitamin D supplementation and the incident dementia: Effects of sex, APOE, and baseline cognitive status.](https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/dad2.12404) Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. March 1, 2023.
  2. Taking vitamin D could help prevent dementia.[Neurosciencenews.com](https://neurosciencenews.com/vitamin-d-dementia-22684/)
  3. Mori K et al.[Improving effects of the mushroom Yamabushitaki (Hericium erinaceus) on mild cognitive impairments: a double-blind placebo-controlled clinical trial.](https://pubmed.ncbi.nlm.nih.gov/18844328/) Phytother Res. 2009; 23 (3): 367-72.
  4. Lei Feng, Irwin Kee-Mun Cheah, Maisie Mei-Xi Ng, Jialiang Li, Sue Mei Chan, Su Lin Lim, Rathi Mahendran, Ee-Heok Kua, Barry Halliwell. [The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore.](https://doi.org/10.3233/JAD-180959) Journal of Alzheimer’s Disease, 2019.

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Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

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LMU 278 – Revitalizing the Mind: Navigating Alzheimer’s with Nicotinamide Ribose

LMU-278

Revitalizing the Mind: Navigating Alzheimer's with Nicotinamide Ribose

Source: Journal Aging Cell (December 14, 2022)

Lifestyle Medicine Update (March 8, 2023)

Introduction:

In the intricate tapestry of health, an elixir known as Nicotinamide Ribose (NR) emerges as a protagonist in the quest against Alzheimer’s disease. The tale begins with an illuminating study in the December 2022 edition of Aging Cell, revealing NR’s journey across the blood-brain barrier, weaving a narrative of hope in preventing cognitive decline.

The Symphony of Energy: NAD+ and the Brain

    • The Dance of Niacin (B3)

Niacin, a humble nutrient, transforms into Nicotinamide Adenine Dinucleotide (NAD+) within our cells, orchestrating a symphony crucial for energy production. As we age, however, this symphony falters, with declining NAD+ levels compromising optimal energy
production and the activation of longevity genes.

    •  NR’s Entrance: A 2022 Overture

The 2022 study in Aging Cell whispers tales of NR’s entrance, showing promise in raising brain NAD+ levels. A daily supplement of 500 mg of Nicotinamide Ribose for six weeks painted a canvas of lower inflammation biomarkers, reduced amyloid plaque, and inhibited tau protein breakdown—key players in the Alzheimer’s narrative.

Decoding the Alzheimer’s Enigma: NAD+ and Brain Health

    • Sirtuins: The Epigenetic Guardians

Sirtuin genes, akin to epigenetic guardians, modulate brain genes, curbing inflammation, and thwarting the synthesis of amyloid plaque and tau protein coalescence. The decline in NAD+ levels sets the stage for Alzheimer’s hallmarks—brain inflammation, amyloid plaque synthesis, and tau protein entanglement.

    • NR’s Impact: A Symphony in the Blood

In a mesmerizing turn of events, NR supplementation demonstrated a significant decline in Alzheimer’s biomarkers within extracellular vesicles for neuronal origin (NEVs). These NEVs, originating from the brain, provided a window into the reduced risk of Alzheimer’s disease after NR’s six-week serenade.

A Glimpse into Tomorrow: NR and Alzheimer’s Prevention

    • Cognitive Aging and Research: A Beacon of Hope

The Delaware Center for Cognitive Aging and Research ventures further into the unknown, exploring NR’s potential to reverse early-stage memory loss. This ongoing exploration holds the promise of a groundbreaking chapter in Alzheimer’s prevention.

    • The Niacin Trilogy: NR, Nicotinamide, NMN

Beyond NR’s limelight, its cousins, nicotinamide and Nicotinamide Mononucleotide (NMN), join the stage, hinting at a trio of nutrients showing great promise in raising NAD+ levels.

The Personal Symphony: A Supplemental Prelude

    • Personal Wellness Symphony

In the personal symphony of health, a high-potency multiple vitamin and mineral supplement enriched with antioxidants becomes a daily overture. A B-50 complex, featuring 50 mg of niacin, takes center stage, showcasing its potential in preventing Alzheimer’s disease.

    • Sublingual Serenade: The Future of Nutrient Delivery

The stage is set for sublingual supplements—offering a lower dosage but direct absorption into the bloodstream. A future episode will delve into this novel nutrient delivery method, unlocking new possibilities for optimal health.

Epilogue: Niacin’s Melody in Alzheimer’s Prevention

As the curtain falls on this chapter, the promise of niacin supplementation, its metabolites, and the enchanting Nicotinamide Ribose echoes as a melody of hope in the symphony against Alzheimer’s disease.

References:

  1. Vreones M et al. [Oral nicotinamide ribose raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin.](https://onlinelibrary.wiley.com/doi/10.1111/acel.13754) Aging Cell. December 14, 2022.
  2. Nicotinamide Ribose supplement linked to reduced biomarkers for Alzheimer’s disease. [Neurosciencenews.com February 23, 2023](https://neurosciencenews.com/nicotinamide-riboside-alzheimers-22550/)
 

Eat Smart, Live Well, Look Great,

Dr. Meschino

Recommended Supplements

All-in-One Multi-Vitamin & Mineral

All-in-One Multi-Vitamin & Mineral

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements
Posted on by

LMU 277 – The Power of Lion’s Mane: Boosting Memory and Nerve Growth

LMU-277

The Power of Lion's Mane: Boosting Memory and Nerve Growth

Source: J Neurochemistry (2023)

Lifestyle Medicine Update (February 28, 2023)

Introduction:

Since the early 2000s, a humble fungus named Lion’s Mane mushroom, scientifically known as Hericium erinaceus, has been weaving its magic in the realm of memory enhancement. This captivating tale unfolds through studies revealing the mushroom’s ability to stimulate the
production of Nerve Growth Factor (NGF) and brain-derived neurotrophic factor (BDNF), promising hope for healing certain neuropathies and combating memory loss.

The Human Canvas: A 2009 Cognitive Symphony

In a mesmerizing 2009 study, individuals aged 50-80, grappling with mild cognitive impairment, experienced a cognitive symphony. Half of the participants indulged in the enchanting melody of Lion’s Mane mushroom supplementation, while the others danced to a placebo tune. Those consuming Lion’s Mane showcased a significant improvement in cognitive function scores, painting a vivid picture of the mushroom’s potential
to enhance mental clarity.

Animal Adventures: Lion’s Mane and the Alzheimer’s Quest

Embarking on animal adventures, researchers uncovered the mushroom’s prowess in slowing beta-amyloid plaque production—a key player in Alzheimer’s disease. Lion’s Mane emerged as a guardian, shielding brain cells against damage induced by cerebral artery occlusion. In mice with age-related cognitive decline, the mushroom performed a memory waltz, enhancing recognition memory by promoting nerve cell generation
in the hippocampus, the orchestrator of memory conversion from short-term to long-term.

Illuminating 2023: Lion’s Mane and the Neurochemistry Expedition

In the dawn of 2023, scientists from the University of Queensland embarked on a neurochemistry expedition. Their quest unveiled two active compounds in Lion’s Mane—Hericene A and polysaccharides—that not only traversed the blood-brain barrier but also orchestrated a symphony of nerve growth and memory boost in mice. The revelation marked a significant milestone, attributing the active constituent Hericene A as the enchanting catalyst behind improved memory and neurotrophic magic.

Your Journey with Lion’s Mane: A Symphony of Health

As the curtain rises on the magical properties of Lion’s Mane, incorporating it into your daily routine becomes a captivating prospect. The mushroom’s inclusion in medicinal blends, alongside reishi, shiitake, cordyceps, turkey tail, and others, becomes a harmonious choice. Beyond the age of 45-50, when the body’s immune system starts to wane, these mushroom blends become not only immune-modulators but also potential supporters of memory function.

Wisdom Beyond 55: A Memory Support Supplement

In the grand ballad of life, the age of 55 ushers in the wisdom of memory support supplements. A daily dose featuring CDP-choline, Huperzine A, Phosphatidylserine, and Bacopa monnieri becomes the orchestral finale, weaving a tapestry of memory preservation.

Conclusion: The Symphony Continues

As we embrace the enchanting story of Lion’s Mane, let the mushroom’s symphony resonate in your journey toward vibrant health. With each sip of a mushroom blend or a memory support supplement, you become a part of the captivating melody, unlocking the secrets of memory preservation and embracing the magic within Lion’s Mane.

References:

  1. Martinez-Marmol R et al. [Hericerin derivatives activate a pan-neurotrophic pathway in central hippocampal neurons converging
    to ERK1/2 signaling enhancing spatial memory.](https://pubmed.ncbi.nlm.nih.gov/36660878/) J Neurochemistry. January 20, 2023.
  2. Active compound in Lion’s Mane mushroom improves nerve growth and memory. [News Medical Life Sciences. Feb 13, 2023.](https://www.news-medical.net/news/20230213/Active-compound-in-Lione28099s-Mane-mushroom-improves-nerve-growth-and-memory.aspx#:~:text=In%20a%20recent%20study%20published,nerve%20growth%20and%20boost%20memory)
  3. Tsai-Teng T, et al. [Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in
    APPswe/PS1dE9 transgenic mice.](https://pubmed.ncbi.nlm.nih.gov/27350344/) J Biomed Sci. 2016; 23 (1): 49.
  4. Mori K et al. [Improving effects of the mushroom Yamabushitaki (Hericium erinaceus) on mild cognitive impairments: a double-blind placebo-controlled clinical trial.](https://pubmed.ncbi.nlm.nih.gov/18844328/) Phytother Res. 2009; 23 (3): 367-72.
  5. Ratto D et al. [Hericium erinaceus improves recognition memory and induces hippocampal and cerebellar neurogenesis in frail mice during aging.](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521003/) Nutrients. 2019; 11 (4): 715.
 
Eat Smart, Live Well, Look Great,
 

Dr. Meschino

Recommended Supplements

Memory Support Complex

Memory Support Complex

Dr. James Meschino

Dr. James Meschino

ABOUT THE AUTHOR

Dr. James Meschino, DC, MS, ROHP, is an educator, author, and researcher having lectured to thousands of healthcare professionals across North America. He holds a Master’s Degree in Science with specialties in human nutrition and biology and is recognized as an expert in the field of nutrition, anti-aging, fitness, and wellness as well as the author of numerous books.

Adeeva Supplements